المؤلفون: Cave, Adele E., Chang, Dennis H., Münch, Gerald W.^{Aff1, Aff2}, Steiner-Lim, Genevieve Z.^{Aff1, Aff3, IDs13643023023016_cor4}

المصدر: Systematic Reviews. 12(1)

المؤلفون: Luolin Zhou, Tong Wu, Zhishan Zhong, Lichen Yi, Yuemei Li

المصدر: Frontiers in Neurology, Vol 14 (2023)

مصطلحات موضوعية: acupuncture therapy, painful diabetic peripheral neuropathy, alternative and complementary medicine, meta-analysis, systematic review, Neurology. Diseases of the nervous system, RC346-429

الوصف: BackgroundPainful Diabetic Peripheral Neuropathy (PDPN) is a common complication of diabetes, it severely affects the quality of life of patients. Acupuncture has been shown to be effective in the treatment of PDPN. To evaluate the efficacy and safety of acupuncture for pain relief in patients diagnosed with diabetic peripheral neuropathy, we conducted a systematic review and meta-analysis.MethodWe thoroughly searched specific databases, which included PUBMED, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, the Chinese National Knowledge Infrastructure, China Science and Technology Journal Database and the Wanfang Data. All randomized controlled trials of acupuncture therapy for PDPN with pain change scales were included. Included studies were assessed for methodological quality according to the risk of bias from the Cochrane handbook. Meta-analyses were carried out to analyze the outcomes, subgroup analyses, sensitivity analyses, and funnel plot analyses were undertaken.ResultsThis systematic review evaluated a total of 25 trials of acupuncture therapy in combination with conventional treatment, involving a total of 1,561 patients with PDPN. According to the results, among 16 trials using VAS scores with a total of 1,552 patients, 2 acupoint injection trials (MD −2.38, 95% CI: −2.76 to −2.01, p

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2023.1281485/full; https://doaj.org/toc/1664-2295

URL الوصول: https://doaj.org/article/f43248d7e80b4873be42d9e63d0cfe3a

المؤلفون: Weiqun Lin, Yongyi Zhao, Cuibing Liu, Yinghua Yan, Qiaowen Ou

المصدر: International Journal of Food Properties, Vol 25, Iss 1, Pp 2166-2183 (2022)

مصطلحات موضوعية: Quercetin, Muscular atrophy, Meta-analysis, Systematic review, Complementary medicine, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

الوصف: Muscle atrophy is a degenerative condition characterized by secondary inflammation, free radical injury, and metabolic dysregulation. Evidence regarding the effects of quercetin on skeletal muscle atrophy is currently controversial and unclear. We hypothesized that quercetin, a anti-inflammatory and antioxidant properties phytochemical, may play an important role in muscle atrophy, and we conducted a comprehensive systematic review and meta-analysis to summarize the effects of quercetin supplementation on muscular atrophy based on studies performed in animal models. Three atrophy biomarkers (muscle mass, fiber size, and function) with enough eligible studies (n = 6, 7, and 4, respectively) were combined in the final meta-analysis. Next, we calculated the overall and stratified effects of quercetin administration on muscular atrophy. No significant effects were observed on muscle mass and muscle function; however, we observed protective effects of quercetin on muscle fiber diameter and area [(Standardized Mean Difference (SMD): 0.82, 95% Confidence interval (CI): 0.36, 1.28), and (SMD: 0.94, 95% CI: 0.25, 1.62), respectively]. This study suggests that quercetin could have histological protection effect on muscle fiber. Thus, it could become a promising complementary therapy for muscle atrophy that occurs due to various clinical conditions.Abbreviations: SMD, Standardized Mean Difference; CI, Confidence interval; PRISMA-P, Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols; Nrf2, nuclear factor erythroid 2-related factor; HO-1, heme oxygenase-1; PPAR-γ, peroxisome proliferator-activated receptor-γ; SIRT-1, silent mating type information regulator 2 homolog 1; PGC-1α, PPAR-γ coactivator-1α; FABP4, fatty acid binding protein 4; DMD, Duchenne muscular dystrophy

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1094-2912; https://doaj.org/toc/1532-2386

URL الوصول: https://doaj.org/article/ecd7ec6f64fc472588ea69f13c5c5522

المؤلفون: Kate Davies, Milena Heinsch, Campbell Tickner, Caragh Brosnan, Amie Steel, Gupteswar Patel, Molly Marsh

المصدر: BMC Complementary Medicine and Therapies, Vol 22, Iss 1, Pp 1-13 (2022)

مصطلحات موضوعية: Complementary medicine, Patient consultation, Knowledge, Patient-centred, Systematic review, Other systems of medicine, RZ201-999

الوصف: Abstract Background Complementary Medicine (CM) is widely used internationally but there is limited understanding of the forms of knowledge CM practitioners use in their clinical practice and how they use this knowledge in interactions with patients. This review aims to synthesise the existing evidence on the forms of knowledge that are mobilised, and the role of this knowledge in the interactions between practitioners and patients during CM consultations. It considered a diverse range of CM practice areas to develop a classification of CM practitioners’ knowledge use in consultations. Methods Systematic searches of health and sociology databases were conducted using core concepts, including complementary and alternative medicine, practitioners, and knowledge. Articles were included where they reported on data from recorded CM practitioner and patient consultations and offered insights into the types and applications of knowledge used in these consultations. 16 unique studies were included in the review. Data were extracted, coded and analysed thematically. Results Results demonstrate that diverse sources of knowledge were mobilised by practitioners, predominantly derived from the patients themselves –their bodies and their narratives. This reflected principles of patient-centredness. The use of discipline specific forms of knowledge and references to biomedical sources illustrated ongoing efforts towards legitimacy for CM practice. Conclusion CM practitioners are navigating tensions between what some might see as competing, others as complementary, forms of knowledge. The classification system provides a useful tool for promoting critically reflective practice by CM practitioners, particularly in relation to self-assessment of knowledge translation and patient interactions.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2662-7671

URL الوصول: https://doaj.org/article/ecfcf390fd59418d89c75cc6ed310a70

المؤلفون: Davies, Kate^{Aff1, IDs1290602203688w_cor1}, Heinsch, Milena^{Aff1, Aff2}, Tickner, Campbell, Brosnan, Caragh, Steel, Amie, Patel, Gupteswar, Marsh, Molly

المصدر: BMC Complementary Medicine and Therapies. 22(1)

المؤلفون: Brennan, Sue E.^{Aff1, IDs13643022020151_cor1}, McDonald, Steve, Murano, Melissa, McKenzie, Joanne E.

المصدر: Systematic Reviews. 11(1)

المؤلفون: Shirzad, Meysam, Abbassian, Alireza^{Aff1, IDs1296002200718z_cor2}

المصدر: Human Resources for Health. 20(1)

المؤلفون: Zitong Feng, Shaoyang Cui, Huijun Yang, Yixiao Wang, Xuan Zhou, John Wong, Liting Lai, Zeyu Yang, Bingjing Huang, Huiyan Zheng, Mingzhu Xu

المصدر: Frontiers in Neurology, Vol 13 (2023)

مصطلحات موضوعية: acupuncture, neuropathic pain, alternative and complementary medicine, systematic review, meta-analysis, Neurology. Diseases of the nervous system, RC346-429

الوصف: BackgroundNeuropathic pain (NP) is expected to increase due to the high risk of global population aging. Acupuncture has a definite clinical effect on NP. Therefore, a systematic review and meta-analysis were conducted to evaluate the effect on pain intensity and safety of acupuncture in patients with NP.MethodsAn encompassing search of specific authoritative databases in English, from their inception to 2022, was performed. The databases were as follows: Scopus, Ovid EMBASE, Ovid Cochrane Database of Systematic Reviews, Ovid Cochrane Central Register of Controlled Trials, Ovid MEDLINE(R) and Epub Ahead of Print, In-Process and Other Non-Indexed Citations, and Daily. All the randomized controlled trials regarding the acupuncture treatment of NP will be included. Methodological quality assessment of the included trials was assessed based on the risk of bias from the Cochrane handbook. A meta-analysis was performed for the main outcomes. In addition, sensitivity analysis, subgroup analysis, and funnel plot were also carried out.ResultsA total of 16 studies with 1,021 patients with NP were evaluated in a systematic review. According to the results of the overall meta-analysis in eight RCTs with 338 participants, the acupuncture group was better than the control group in improving changes in pain intensity (SMD −0.59, 95% CI: −0.95 to −0.23, P = 0.001). In subgroup analysis, five trials indicated that acupuncture was more effective in improving changes in pain intensity than sham acupuncture (SMD −0.54, 95% CI: −0.95 to −0.13, P = 0.01), two trials evaluated the effect on changes in pain intensity in the comparison of acupuncture and conventional treatments, no significant difference existed (SMD −0.61, 95% CI: −1.83 to 0.61, P = 0.33), and one trial compared acupuncture with blank control evaluating the effect of changes in pain intensity with a significant difference. Eleven studies mentioned the safety conditions and acupuncture-induced AEs were mild and reversible. Both the sensitivity analysis and funnel plot analysis showed that the meta-analysis was stable and irreversible without publication bias. The GRADE was rated as “very low.”ConclusionThe acupuncture group had higher effectiveness than sham intervention or blank control for changes in pain intensity, but there is no significant difference between acupuncture and conventional treatments in treating NP. The acupuncture-induced adverse events were mild and reversible. However, the interpretation of our results should be performed cautiously due to the low methodological quality of selected publications.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022306461.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.1076993/full; https://doaj.org/toc/1664-2295

URL الوصول: https://doaj.org/article/27992d5aa0e546189df6256fd0a9dc87

المؤلفون: Matthew J. Leach, Yasamin Veziari

المصدر: Integrative Medicine Research, Vol 11, Iss 4, Pp 100899- (2022)

مصطلحات موضوعية: Complementary medicine, Evidence-based practice, Evidence translation, Implementation science, Systematic review, Miscellaneous systems and treatments, RZ409.7-999

الوصف: Background: Despite the push for complementary medicine (CM) practitioners to engage in evidence implementation, and arguments in support of evidence-based practice (EBP), uptake of EBP amongst most CM professions remains low. This review aimed to synthesise the evidence examining the barriers and enablers to evidence implementation in CM. Methods: Any primary study examining enablers and barriers to evidence implementation in CM were eligible for inclusion. Eight databases and search engines were searched for eligible studies. Reference lists of included studies were screened, and authors of included studies were contacted to identify current or unpublished studies that met the inclusion criteria. Results: Thirty-nine published and unpublished studies were included in this review. The seven published qualitative studies and 25 published quantitative studies were rated as moderate to high quality. Fifty-two distinct barriers and 62 discrete enablers were identified. Reported barriers were predominantly structural (e.g. limited availability of time and clinical evidence) and cognitive (e.g. skills deficits), with relatively fewer studies reporting cultural (e.g. lack of industry support) or attitudinal barriers (e.g. lack of interest in, or relevance to CM). Enablers of evidence implementation largely focussed on improving access to bibliographic databases and evidence reviews, supporting skills acquisition, and cultivating leadership and interprofessional/interagency collaboration. Conclusions: The findings of this review highlight the diverse barriers and enablers to evidence implementation in CM that span multiple dimensions. The interplay between these various factors highlights the complexity of evidence implementation, and the need for a targeted multistakeholder, multidimensional solution to optimise evidence-based practice in CM. Study registration: The protocol of this review was registered at PROSPERO (CRD42022308527).

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221342202200066X; https://doaj.org/toc/2213-4220

URL الوصول: https://doaj.org/article/04f45880eb27477c91055f1c78ba54e6

المؤلفون: Yuebo Song, Qiuyang Jia, Xiaorui Guan, Sugimoto Kazuo, Jia Liu, Weisong Duan, Luda Feng, Chi Zhang, Ying Gao

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: amyotrophic lateral sclerosis, herbal medicine, motor neuron disease, meta-analysis, alternative and complementary medicine, systematic review, Therapeutics. Pharmacology, RM1-950

الوصف: Background: The effect of herbal medicine (HM) on amyotrophic lateral sclerosis (ALS) is controversial. Clinical trials investigating HMs continue; however, the use of HM is still questioned. We aimed to systematically review the literature pertaining to the effects and safety of HM in ALS.Methods: Randomised controlled trials (RCTs) that investigated the efficacy of HMs in ALS patients compared to any types of controls were identified. Nine databases and six registers were searched from their inception dates to 25 March 2022. Per the PRISMA guidelines, trials were identified and extracted. The risk of bias was evaluated using the Cochrane’s tool. Certainty of evidence was assessed as per the GRADE criteria. Forest plots were constructed to assess the effect size and corresponding 95% CIs using fixed-effect models, and random-effect models were employed when required. The primary outcome was the activity limitation measured by validated tools, such as the revised ALS Functional Rating Scale.Results: Twenty studies (N = 1,218) were eligible. Of these, only five studies were double-blinded, and two were placebo-controlled. Fourteen HMs (fifty-one single botanicals) were involved; Astragalus mongholicus Bunge, Atractylodes macrocephala Koidz., and Glycyrrhiza glabra L. were commonly used in nine, eight, and six trials, respectively. For delaying activity limitation, Jiweiling injection (MD, 2.84; 95% CI, 1.21 to 4.46; p = 0.0006) and Shenmai injection (SMD, 1.07; 0.69 to 1.45; p < 0.00001) were significantly more efficacious than Riluzole, but the evidence was low quality. For ameliorating motor neuron loss, Jiweiling injection [right abductor pollicis brevis (APB): MD, 32.42; 7.91 to 56.93; p = 0.01 and left APB: MD, 34.44; 12.85 to 56.03; p = 0.002] was favoured, but the evidence was very low quality. Nine studies reported one hundred and twenty-three adverse events, twenty-six of which occurred in the treatment groups and ninety-seven in the control groups.Conclusion: Very low to low quality of evidence suggests that HMs seem to produce superior treatment responses for ALS without increased risk of adverse events. Additional studies with homogeneous participants, reduced methodological issues, and more efficient outcome measures are required to provide confirmatory evidence.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021277443.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.946548/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/c58b6d966bf146a28545fe128942224e