المؤلفون: Ingrid M. van der Meer, Jules Beekwilder, Suvi T. Häkkinen, Johanna C. Hakkert, Dirk Bosch, Katarina Cankar, Robert Sevenier, Michiel Theodoor Jan De Both, Paul Bundock

المصدر: Plant Biotechnology Journal
Cankar, K, Bundock, P, Sevenier, R, Häkkinen, S T, Hakkert, J C, Beekwilder, J, van der Meer, I M, de Both, M & Bosch, D 2021, ' Inactivation of the germacrene A synthase genes by CRISPR/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L. ', Plant Biotechnology Journal, vol. 19, no. 12, pp. 2442-2453 . https://doi.org/10.1111/pbi.13670
Plant Biotechnology Journal, 19(12), 2442-2453
Plant Biotechnology Journal 19 (2021) 12

مصطلحات موضوعية: 0106 biological sciences, Inulin, Farnesyl pyrophosphate, Plant Science, Biology, Sesquiterpene, 01 natural sciences, Lactones, Sesquiterpenes, Germacrane, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Cichorium, sesquiterpene lactones, genome editing, germacrene A synthase, Gene, Research Articles, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, chicory, food and beverages, Fructose, biology.organism_classification, Plant Breeding, chemistry, Biochemistry, Germacrene, BIOS Applied Metabolic Systems, Bioscience, CRISPR-Cas Systems, Sesquiterpenes, Agronomy and Crop Science, Research Article, 010606 plant biology & botany, Biotechnology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c377b14acd732a24f3a04f2ace32680
https://cris.vtt.fi/en/publications/510f9619-8b84-4a7c-9466-c1f9741a1fe9

المؤلفون: Catherine Rameau, Alexandre de Saint Germain, Jean-Bernard Pouvreau, Nicolas Arnaud, Philippe Le Bris, Jean-Paul Pillot, Florent Cornet

المصدر: New Phytologist. 232:1909-1916

مصطلحات موضوعية: 0106 biological sciences, 0303 health sciences, Oryza sativa, biology, Arabidopsis Proteins, Physiology, Mutant, Arabidopsis, food and beverages, Strigolactone, Plant Science, Meristem, biology.organism_classification, 01 natural sciences, Cell biology, Lactones, 03 medical and health sciences, Gene Expression Regulation, Plant, Arabidopsis thaliana, Plastochron, Plant hormone, Heterocyclic Compounds, 3-Ring, 030304 developmental biology, 010606 plant biology & botany

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ab80be69581f2de121e2f81d76c6d8
https://doi.org/10.1111/nph.17725

المؤلفون: Stephanie C. Kerr, Julie Saffar, Elizabeth A. Dun, Catherine Rameau, Jean-Paul Pillot, Suyash Bhimgonda Patil, Yannick Bellec, Christine A. Beveridge, Sylvie Citerne, Yasmine Ligerot, Alexandre de Saint Germain, Grégoire Aubert

المصدر: The Plant Journal. 107:1756-1770

مصطلحات موضوعية: 0106 biological sciences, Cytokinins, Mutant, Arabidopsis, Strigolactone, Plant Science, 01 natural sciences, Lactones, 03 medical and health sciences, chemistry.chemical_compound, Gene Expression Regulation, Plant, Loss of Function Mutation, Auxin, Gene expression, Genetics, Arabidopsis thaliana, Gene, Phylogeny, Plant Proteins, 030304 developmental biology, Feedback, Physiological, 2. Zero hunger, chemistry.chemical_classification, 0303 health sciences, Indoleacetic Acids, biology, Peas, food and beverages, Oryza, Cell Biology, Plants, Genetically Modified, biology.organism_classification, Cell biology, chemistry, Cytokinin, Co-Repressor Proteins, Heterocyclic Compounds, 3-Ring, Signal Transduction, 010606 plant biology & botany

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d709ca0bbae2374d9bda45fb1e593b0b
https://doi.org/10.1111/tpj.15415

المؤلفون: Anuar Salazar-Gómez, Saudy Saret Pablo-Pérez, M. Elena Vargas-Dı́az, Julio C. Ontiveros-Rodríguez, Leticia Garduño-Siciliano

المصدر: South African Journal of Botany

مصطلحات موضوعية: IL-1β, interleukin 1 beta, 0106 biological sciences, GSH, reduced glutathione, Structural diversity, Review, Plant Science, 01 natural sciences, G6Pase, glucose-6-phosphatase, Hypolipidemic, chemistry.chemical_compound, Broad spectrum, IR, insulin resistance, TBARS, thiobarbituric acid reactive substances, FFA, free fatty acids, TNF-α, tumor necrosis factor alpha, AMPK, activated protein kinase, Medicinal plants, STAT1, signal transducer and activator of transcription 1, NF-κB, nuclear factor kappa B, GPx, glutathione peroxidase, SLns, sesquiterpene lactones, JNK, c-Jun N-terminal kinases, Biological activity, TG, triglycerides, Metabolic syndrome, IL-6, interleukin 6, iNOS, inducible nitric oxide synthase, LPS, lipopolysaccharide, MetS, metabolic syndrome, Sesquiterpene lactones, COX-2, cyclooxygenase 2, GK, glucokinase, MCP-1, monocyte chemoattractant protein 1, Computational biology, CVD, cardiovascular disease, Biology, Sesquiterpene, STZ, streptozotocin, Tc total cholesterol, ROS, reactive oxygen species, SOD, superoxide dismutase, AT, adipose tissue, medicine, LDL-C, low-density lipoprotein-cholesterol, Beneficial effects, FN, fibronectin, TLRs, Toll-like receptor, NO, nitric oxide, IFN-γ, interferon gamma, HDL-C, high-density lipoproteins-cholesterol, VLDL, very-low-density lipoprotein, T2DM, type 2 diabetes mellitus, Hypoglycemic, medicine.disease, ACE, angiotensin I-converting enzyme, 0104 chemical sciences, APOC3, apolipoprotein C3, TC, total cholesterol, TGF-β1, transforming growth factor beta, 010404 medicinal & biomolecular chemistry, Antidiabetic, chemistry, MAPK, mitogen-activated protein kinases, CAT, catalase, 010606 plant biology & botany

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512583e8aceec7a8d3995bc13c6d8a6c
https://doi.org/10.1016/j.sajb.2020.08.020

المؤلفون: Haoxin Wang, Jing Zhu, Peng Shi, Yaoyao Li, Yuemao Shen

المصدر: Journal of Natural Products. 84:1924-1929

مصطلحات موضوعية: China, Pharmaceutical Science, Polyenes, Computational biology, 01 natural sciences, Streptomyces, Analytical Chemistry, Lactones, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Gene cluster, Humans, Gene, Soil Microbiology, Selection (genetic algorithm), Pharmacology, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, biology.organism_classification, Polyene, Culture Media, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, Multigene Family, Fermentation, Molecular Medicine, Macrolides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6f876c13819fbfd8b27e12a7f127b2
https://doi.org/10.1021/acs.jnatprod.1c00144

المؤلفون: Gudisela Mura Reddy, G. Nagendra Reddy, K.R.S. Prasad, Gattu Sridhar

المصدر: Natural Product Research. 36:5416-5422

مصطلحات موضوعية: Alkylation, 010405 organic chemistry, Organic Chemistry, Grignard reaction, Total synthesis, Stereoisomerism, Plant Science, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, Lactones, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Organic chemistry, Macrolides, Propylene oxide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3e2ad9b20fd965072e1cf50cc2687d
https://doi.org/10.1080/14786419.2021.1941948

المؤلفون: Jennifer C. Obike, Mitchell P. Croatt, Cedric J. Pearce, Nicholas H. Oberlies, Huzefa A. Raja, Zeinab Y. Al Subeh

المصدر: The Journal of Antibiotics

مصطلحات موضوعية: 0301 basic medicine, Molecular Conformation, 01 natural sciences, High-performance liquid chromatography, Article, Lactones, Structure-Activity Relationship, Fungal biology, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Drug Discovery, Organic chemistry, Moiety, Centrifugation, Protein Kinase Inhibitors, Chromatography, High Pressure Liquid, Pharmacology, Strain (chemistry), 010405 organic chemistry, Structure elucidation, Fungi, Stereoisomerism, Resorcinols, MAP Kinase Kinase Kinases, Semisynthesis, Anti-Bacterial Agents, Culture Media, 0104 chemical sciences, 030104 developmental biology, chemistry, Fermentation, Zearalenone, Enone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1bfe149f3cf4a430f192396a75679d
https://doi.org/10.1038/s41429-021-00432-3

المؤلفون: Ji-Quan Zhang, Yuan-Yong Yang, Fei Cheng, Gao-Feng Zhu, Li-Li Wang, Lei Tang, Bin Liu, Yuanhu Mao, Bing Guo, Yong-Xi Dong

المصدر: The Journal of Organic Chemistry. 86:8620-8629

مصطلحات موضوعية: Annulation, 010405 organic chemistry, Chemistry, Iron, Iron catalyzed, Organic Chemistry, Carboxylic Acids, Substrate (chemistry), 010402 general chemistry, 01 natural sciences, Environmentally friendly, Catalysis, 0104 chemical sciences, Lactones, Air atmosphere, Organic chemistry, Disulfides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b237ffaef345b99b90b46b9b5e3f9b3e
https://doi.org/10.1021/acs.joc.1c00284

المؤلفون: Shaochen Li, Hui Xu, Min Lv, Meng Hao, Zhiqiang Sun

المصدر: Journal of Agricultural and Food Chemistry. 69:6465-6474

مصطلحات موضوعية: 0106 biological sciences, Steric effects, Insecticides, Double bond, Diol, Ring (chemistry), 01 natural sciences, Medicinal chemistry, Lactones, Structure-Activity Relationship, chemistry.chemical_compound, Mythimna separata, Cnidium monnieri, Coumarins, Animals, Pesticides, chemistry.chemical_classification, Natural product, Molecular Structure, biology, 010401 analytical chemistry, Esters, General Chemistry, biology.organism_classification, 0104 chemical sciences, chemistry, General Agricultural and Biological Sciences, Lactone, 010606 plant biology & botany

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2b58a7dbeae302a995abf950f0e7a5
https://doi.org/10.1021/acs.jafc.1c01434

المؤلفون: Sanjun Ying, Fangyuan Guo, Weiyong Hong, Gensheng Yang, Ying Gao, Yunlong Jiao, Bang Lou, Xugang Ji, Anqin Li, Haiying Wang, Nan Yu, Xuefeng Zhou, Wenchao Wu

المصدر: International Journal of Nanomedicine

مصطلحات موضوعية: Biodistribution, Curcumin, mouse model, Biophysics, Biological Availability, Pharmaceutical Science, Antineoplastic Agents, Bioengineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Polyethylene Glycols, growth inhibition, Biomaterials, Lactones, Mice, chemistry.chemical_compound, International Journal of Nanomedicine, In vivo, Cell Line, Tumor, Lab-On-A-Chip Devices, Drug Discovery, Zeta potential, Animals, Humans, Nanotechnology, nanoparticle fabrication, Tissue Distribution, Particle Size, Cytotoxicity, Caproates, Original Research, enzyme targeting, Drug Carriers, Chromatography, Chemistry, Organic Chemistry, General Medicine, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Bioavailability, Targeted drug delivery, Drug delivery, Nanoparticles, 0210 nano-technology

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff21710c06e4ea3abe105b74106ad073
https://doi.org/10.2147/ijn.s303829