المؤلفون: Richard A. Jensen, Denis Rybin, Jaakko Tuomilehto, Reedik Mägi, Inga Prokopenko, Jeffrey R. O'Connell, Marcus E. Kleber, Han Chen, Geoffrey A. Walford, Allan Linnenberg, Anke Tönjes, Francis S. Collins, Sonsoles Morcillo, Gemma Rojo-Martínez, Kenneth Rice, Jose C. Florez, Leif Groop, Manuel Serrano-Ríos, Josée Dupuis, Alisa K. Manning, Peter Kovacs, Torben Jørgensen, Graciela E. Delgado, Alena Stančáková, Hans-Ulrich Häring, Claudia Langenberg, Joshua P. Lewis, Norbert Stefan, Markku Laakso, Torben Hansen, Bruce M. Psaty, Jian'an Luan, Michael Stumvoll, Mark O. Goodarzi, Robert A. Scott, Oluf Pedersen, Ching-Ti Liu, Michael N. Weedon, Michael Boehnke, Ulf Smith, David S. Siscovick, Aaron Leong, Weijia Xie, James B. Meigs, Claes Landenvall, Anne U. Jackson, Joseph M. Zmuda, Mary L. Biggs, Jerome I. Rotter, Federico Soriguer, Winfried März, Zhongyang Zhang, May E. Montasser, Arturo Corbatón-Anchuelo, J M Gómez-Zumaquero, Günther Silbernagel, Kristine Færch, Karen L. Mohlke, Heikki A. Koistinen, Yii-Der Ida Chen, Jaeyoung Hong, Gracia María Martín-Núñez, María Teresa Martínez-Larrad, Emil V. R. Appel, Niels Grarup, Harald Staiger, Johanna Kuusisto, Lars Lind, Nicholas J. Wareham, Andreas Fritsche, Stefan Gustafsson, Andrew P. Morris, Richard N. Bergman, Mark Walker, Cecilia M. Lindgren, Erik Ingelsson, Jorge R. Kizer, Timothy M. Frayling, Fausto Machicao

المصدر: Diabetes
Walford, G A, Gustafsson, S, Rybin, D, Stančáková, A, Chen, H, Liu, C-T, Hong, J, Jensen, R A, Rice, K, Morris, A P, Mägi, R, Tönjes, A, Prokopenko, I, Kleber, M E, Delgado, G, Silbernagel, G, Jackson, A U, Appel, E V, Grarup, N, Lewis, J P, Montasser, M E, Landenvall, C, Staiger, H, Luan, J, Frayling, T M, Weedon, M N, Xie, W, Morcillo, S, Martínez-Larrad, M T, Biggs, M L, Ida Chen, Y-D, Corbaton-Anchuelo, A, Færch, K, Zumaquero, J M, Goodarzi, M O, Kizer, J, Koistinen, H A, Leong, A, Lind, L, Lindgren, C, Machicao, F, Manning, A K, Martín-Núñez, G M, Rojo-Martínez, G, Rotter, J I, Siscovick, D S, Zmuda, J M, Zhang, Z, Serrano-Rios, M, Smith, U, Soriguer, F, Hansen, T, Jørgensen, T J, Linnenberg, A, Pedersen, O, Walker, M, Langenberg, C, Scott, R A, Wareham, N J, Fritsche, A, Häring, H-U, Stefan, N, Groop, L, O'Connell, J R, Boehnke, M, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, März, W, Kovacs, P, Stumvoll, M, Psaty, B M, Kuusisto, J, Laakso, M, Meigs, J B, Dupuis, J, Ingelsson, E & Florez, J C 2016, ' Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci ', Diabetes, vol. 65, no. 10, pp. 3200-3211 . https://doi.org/10.2337/db16-0199
DIABETES

مصطلحات موضوعية: 0301 basic medicine, Male, Insulin Receptor Substrate Proteins, Endocrinology, Diabetes and Metabolism, Locus (genetics), Genome-wide association study, Polymorphism, Single Nucleotide, 03 medical and health sciences, Endocrinology & Metabolism, Insulin resistance, Genotype, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic association, Genetics, business.industry, Insulin sensitivity, Genetics/Genomes/Proteomics/Metabolomics, 11 Medical And Health Sciences, medicine.disease, IRS1, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Chemokines, CC, Female, Insulin Resistance, business, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb835e572112710c128ad103623be68

المؤلفون: Nicholas J. Timpson, Jackie F. Price, Henning Tiemeier, Caroline Hayward, Stephan J. L. Bakker, Christian Gieger, Tom Michoel, Catriona L. K. Barnes, Ville Karhunen, Peter K. Joshi, Katyayani Sukhavasi, Anubha Mahajan, Carol A. Wang, Igor Rudan, Maik Pietzner, Andrew P. Morris, Craig E. Pennell, Andrew A Crawford, Marjo-Riitta Järvelin, Henry Völzke, Harry Campbell, Johan L.M. Björkegren, Pim van der Harst, David W. Clark, Massimo Mangino, Claes Ohlsson, Tim D. Spector, Jari Lahti, Elisabeth Altmaier, Johan G. Eriksson, Alexander Neumann, Raili Ermel, Maria Nethander, Arno Ruusalepp, James R M Wilson, George Davey Smith, Nele Friedrich, Sean Bankier, Brian R. Walker, Stela McLachlan

المساهمون: Department of Psychology and Logopedics, University of Helsinki, Clinicum, Diabetes and Obesity Research Program, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Helsinki University Hospital Area, Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Child and Adolescent Psychiatry / Psychology

المصدر: Journal of human genetics
Journal of Human Genetics
Crawford, A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, van der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzne, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6SERPINA1 locusalters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expressionin peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics . https://doi.org/10.1038/s10038-020-00895-6
Journal of human genetics, 66(6), 625-636. Nature Publishing Group
Journal of Human Genetics, 66(6), 625-636. Nature Publishing Group
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Bjorkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M, Mclachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J, Rudan, I, Ruusalepp, A, Spector, T, Tiemeier, H, Völzke, H, Wilson, J F, Michoel, T, Timpson, N J, Smith, G D & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6
J. Hum. Genet. 66, 625–636 (2021)
Crawford, A A, Bankier, S, Altmaier, E, Barnes, C L K, Clark, D W, Ermel, R, Friedrich, N, Van Der Harst, P, Joshi, P K, Karhunen, V, Lahti, J, Mahajan, A, Mangino, M, Nethander, M, Neumann, A, Pietzner, M, Sukhavasi, K, Wang, C A, Bakker, S J L, Björkegren, J L M, Campbell, H, Eriksson, J, Gieger, C, Hayward, C, Jarvelin, M-R, McLachlan, S, Morris, A P, Ohlsson, C, Pennell, C E, Price, J F, Rudan, I, Ruusalepp, A, Spector, T D, Tiemeier, H, Völzke, H, Wilson, J R M, Michoel, T, Timpson, N J, Davey Smith, G & Walker, B R 2021, ' Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease ', Journal of Human Genetics, vol. 66, no. 6, pp. 625-636 . https://doi.org/10.1038/s10038-020-00895-6

مصطلحات موضوعية: 0301 basic medicine, Male, STRESS, LD SCORE REGRESSION, Myocardial Infarction, Adipose tissue, BLOOD-PRESSURE, 0302 clinical medicine, Transcortin, Adrenal Cortex Hormones, LOW-BIRTH-WEIGHT, Genetics (clinical), Morning, Biological Specimen Banks, education.field_of_study, biology, HERITABILITY, Middle Aged, INSULIN, 3142 Public health care science, environmental and occupational health, 3. Good health, Liver, Cardiovascular Diseases, Female, Adult, medicine.medical_specialty, 515 Psychology, Population, Quantitative Trait Loci, 030209 endocrinology & metabolism, Locus (genetics), Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, Genetics, medicine, Humans, Genetic Predisposition to Disease, education, METAANALYSIS, Genetic association, business.industry, Mendelian Randomization Analysis, United Kingdom, 030104 developmental biology, Endocrinology, Gene Expression Regulation, alpha 1-Antitrypsin, Expression quantitative trait loci, biology.protein, VISUALIZATION, business, RESPONSES, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2ad4a1427b991f093b00510444007b
http://europepmc.org/articles/PMC8144017

المؤلفون: John D. Isaacs, Darren Plant, Anne Barton, Syed Gilani, Kimme L. Hyrich, Nisha Nair, Anthony G. Wilson, James Bluett, Andrew P. Morris, Ann W. Morgan

المصدر: Pharmacogenomics

مصطلحات موضوعية: Male, rheumatoid arthritis, 0301 basic medicine, Oncology, medicine.medical_treatment, Severity of Illness Index, Arthritis, Rheumatoid, TNF inhibitors, 0302 clinical medicine, single nucleotide polymorphism, Treatment Failure, skin and connective tissue diseases, education.field_of_study, Middle Aged, TNF inhibitor, Treatment Outcome, Rheumatoid arthritis, biomarker, Molecular Medicine, Biomarker (medicine), Female, Research Article, Adult, musculoskeletal diseases, medicine.medical_specialty, Population, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Disease activity, 03 medical and health sciences, Internal medicine, Linear regression, Genetics, medicine, Humans, education, Aged, 030203 arthritis & rheumatology, Pharmacology, Tumor Necrosis Factor-alpha, business.industry, treatment response, medicine.disease, United Kingdom, 030104 developmental biology, Pharmacogenetics, Tumor Necrosis Factor Inhibitors, business, Biomarkers, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe126f309b7cd45260c0b2a67bffbb7
https://doi.org/10.2217/pgs-2020-0043

المؤلفون: Steve Eyre, Magnus Rattray, Peyman Zarrineh, Antony Adamson, Paul Martin, Jing Yang, Peter Fraser, Xiangyu Ge, Andrew P. Morris, Kate Duffus, Amanda McGovern

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Yang, J, Mcgovern, A, Martin, P, Duffus, K, Ge, X, Zarrineh, P, Morris, A, Adamson, A, Fraser, P, Rattray, M & Eyre, S 2020, ' Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis ', Nature Communications, vol. 11, 4402 . https://doi.org/10.1038/s41467-020-18180-7
Nature Communications

مصطلحات موضوعية: CRISPR-Cas9 genome editing, CD4-Positive T-Lymphocytes, 0301 basic medicine, genetic processes, Gene Expression, General Physics and Astronomy, Genome-wide association study, 02 engineering and technology, Arthritis, Rheumatoid, 0302 clinical medicine, Gene expression, Promoter Regions, Genetic, lcsh:Science, Genetics, 0303 health sciences, Multidisciplinary, Forkhead Box Protein O1, 021001 nanoscience & nanotechnology, Gene expression profiling, Chromatin, Enhancer Elements, Genetic, Regulatory sequence, 0210 nano-technology, Science, Primary Cell Culture, Quantitative Trait Loci, Quantitative trait locus, Biology, Chromatin structure, Article, General Biochemistry, Genetics and Molecular Biology, Autoimmune Diseases, 03 medical and health sciences, Genetic variation, Humans, Genetic Predisposition to Disease, natural sciences, Enhancer, Gene, 030304 developmental biology, Genetic association, Promoter, General Chemistry, Gene regulation, HEK293 Cells, 030104 developmental biology, Expression quantitative trait loci, lcsh:Q, PCR-based techniques, 030217 neurology & neurosurgery, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8528546d54e29ae24596ecc120fc0c11
https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d

المؤلفون: Adolfo Correa, David Van Den Berg, Sonja I. Berndt, Elizabeth R. Hauser, Anna Batorsky, Ethan M. Lange, Andrea A. Baccarelli, Leslie A. Lange, Fadi J. Charchar, Nora Franceschini, Steve Horvath, Mindy D. Szeto, James Eales, Stephan Beck, Xiao Jiang, Laura M. Raffield, Kathryn L. Evans, Russell P. Tracy, Andrew P. Morris, William E. Kraus, Xiaoguang Xu, Maciej Tomaszewski, Stephanie J. London, Daniel L. McCartney, Caroline Hayward, Hermant K Tiwari, Jerome I. Rotter, Josyf C. Mychaleckyj, Eric A. Whitsel, Mi Kyeong Lee, Peter Durda, Lifang Hou, Donna K. Arnett, Holly Kramer, Amit Patki, Marguerite R. Irvin, Riccardo E. Marioni, Rong Jiang, Yongmei Liu, Charles E Breeze, Svati H. Shah, Stephen S. Rich

المصدر: 2021, ' Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci ', Genome Medicine, vol. 13, no. 1, 74 . https://doi.org/10.1186/s13073-021-00877-z
Genome medicine, vol 13, iss 1
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Genome Medicine
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed MESA Multi-Omics Working Group 2021, ' Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci ', Genome Medicine, vol. 13, no. 1, 74, pp. 74 . https://doi.org/10.1186/s13073-021-00877-z

مصطلحات موضوعية: Epigenomics, Kidney Disease, Kidney development, QH426-470, Kidney, Kidney Function Tests, Epigenesis, Genetic, 0302 clinical medicine, Genetics (clinical), Regulation of gene expression, Genetics, 0303 health sciences, DNA methylation, Epigenetic, 3. Good health, Phenotype, 030220 oncology & carcinogenesis, Medicine, Molecular Medicine, Glomerular Filtration Rate, Population, Quantitative Trait Loci, Clinical Sciences, Renal and urogenital, Context (language use), Biology, Quantitative Trait, 03 medical and health sciences, Quantitative Trait, Heritable, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Kidney function, Genetic, Humans, Epigenetics, Heritable, Molecular Biology, 030304 developmental biology, Research, Human Genome, Racial Groups, Genetic Variation, dNaM, Epigenome, Gene regulation, Genetics, Population, Gene Expression Regulation, TOPMed MESA Multi-Omics Working Group, CpG Islands, Epigenesis, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128c672f4077cb7aa7ff1ee829272450
https://www.pure.ed.ac.uk/ws/files/253702926/Epigenome_wide_association_study_of_kidney_function_identifies_trans_ethnic_and_ethnic_specific_loci.pdf

المؤلفون: Tove Fall, Anubha Mahajan, Dmitry Shungin, B. Balkau, Gerjan Navis, A. Metspalu, Anneli Pouta, Andrew A. Hicks, Ilja M. Nolte, Ian Ford, Aroon D. Hingorani, Stefan R Bornstein, Anuj Goel, Rona J. Strawbridge, Niek Verweij, Sarah H. Wild, Patricia B. Munroe, T.B. Harris, Jaana Lindström, Johnson Pcd., Nita G. Forouhi, Pierre Meneton, Patricia A. Peyser, Sarin A-P., Andrea Ganna, Timothy M. Frayling, Patrik K. E. Magnusson, Joanne M. Meyer, Yongmei Liu, Jeanette M. Stafford, Christian Herder, L Zudina, Maria G. Stathopoulou, May E. Montasser, Nicholas D. Hastie, Inês Barroso, Schwarz Peh., James B. Meigs, Perttu Salo, George Davey Smith, Gonneke Willemsen, Christopher J. Groves, Erik P A Van Iperen, M. A. Province, Veikko Salomaa, Naveed Sattar, Serena Sanna, Maria Dimitriou, Joop Jukema, Ulrika Krus, Albert V. Smith, Markku Laakso, James F. Wilson, George Nicholson, Loic Yengo, Tatijana Zemunik, Per Eriksson, Harold Snieder, Peter P. Pramstaller, Claudia Langenberg, R. Rauramaa, Alan R. Shuldiner, Pau Navarro, Veronique Vitart, Ross M. Fraser, Aaron Isaacs, C. Lecoeur, Jesper R. Gådin, Jackie F. Price, Letizia Marullo, L.F. Bielak, Sirkka Keinänen-Kiukaanniemi, Amélie Bonnefond, Michael Stumvoll, Alessia Faggian, Anke Tönjes, Tomohiro Tanaka, Wieland Kiess, Harry Campbell, Josée Dupuis, David Altshuler, João Fadista, Winfried März, G K Hovingh, Thomas Illig, Toby Johnson, H Grallert, Kari Stefansson, Reedik Mägi, Palmer Cna., de Geus Ejcn., Martina Müller-Nurasyid, Karen Kapur, Philippe Froguel, Dorret I. Boomsma, Anders Franco-Cereceda, Marcus E. Kleber, Boehnke M, Olga D. Carlson, Ozren Polasek, Andrew P. Morris, Alex S. F. Doney, Najaf Amin, Sara M. Willems, Vilmundur Gudnason, Jose C. Florez, Jeffery R. O'Connell, Nancy L. Pedersen, T. Saaristo, Wolffenbuttel Bhr., M. I. J. Uusitupa, Longda Jiang, Iva Miljkovic, James S. Pankow, Caroline Hayward, Hugh Watkins, Vasiliki Lagou, Johanna Kuusisto, Jaakko Tuomilehto, Alan F. Wright, Josephine M. Egan, Perry Jrb., C M van Duijn, Valeriya Lyssenko, Leif Groop, Stefania Bandinelli, Nigel W. Rayner, Tõnu Esko, Stela McLachlan, Momoko Horikoshi, Eric Boerwinkle, Rick Jansen, Richard N. Bergman, Gudmar Thorleifsson, Lyle J. Palmer, Vilmantas Giedraitis, Peter Kovacs, Nicholas J. Wareham, Luigi Ferrucci, N J Timpson, D Rybin, Anne U. Jackson, Tiinamaija Tuomi, Gonçalo R. Abecasis, Harst Pvd., Meena Kumari, Albert Hofman, Chiara Scapoli, Evelin Mihailov, Josine L. Min, Anders Hamsten, Hottenga J-J., Loos Rjf., Lars Lind, Ulf de Faire, Jaakko Kaprio, Guo Li, Beate St Pourcain, C Gieger, Amanda J. Bennett, Anna Ulrich, Nabila Bouatia-Naji, Satu Männistö, Antigone S. Dimas, Jarvelin M-R., Günther Silbernagel, F Karpe, A. Körner, David S. Siscovick, M Blüher, Rebecca J. Webster, Erik Ingelsson, Susan Campbell, Mika Kivimäki, Laura J. Rasmussen-Torvik, Heikki A. Koistinen, Sophie Visvikis-Siest, Bernhard O. Boehm, Inga Prokopenko, Ping An, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Kardia Slr., Richa Saxena, Igor Rudan, Richard M. Watanabe, Jian'an Luan, Marika Kaakinen, Shin S-Y., George Dedoussis, Panagiotis Deloukas, Mark I. McCarthy, Barbara Thorand, B.W.J.H. Penninx, Peter Vollenweider, Paul W. Franks, Leena Kinnunen, Markus Perola, Yvonne Boettcher, Timo A. Lakka, Nicole Soranzo, Stavroula Kanoni, Bakker Sjl., Winkelmann Br

المساهمون: The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford [Oxford], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institute of Genomics [Tartu, Estonia], University of Tartu, Vrije Universiteit Amsterdam [Amsterdam] (VU), Vrije Universiteit Medical Centre (VUMC), Helmholtz-Zentrum München (HZM), University of Cambridge [UK] (CAM), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Università degli Studi di Ferrara (UniFE), Boston University [Boston] (BU), VU University Medical Center [Amsterdam], University of Bristol [Bristol], Biomedical Sciences Research Centre Alexander Fleming [Vari, Greece] (BSRC), Imperial College London, Karolinska Institutet [Stockholm], Institute for Molecular Bioscience, University of Queensland [Brisbane], Statens Serum Institut [Copenhagen], Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University [Maastricht], MRC Institute of Genetics and Molecular Medicine [Edinburgh] (IGMM), University of Edinburgh-Medical Research Council, National Institute on Aging [Baltimore, MD, USA] (NIH), University of Michigan [Ann Arbor], University of Michigan System, University of Maryland School of Medicine, University of Maryland System, The University of Western Australia (UWA), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Wake Forest University, National Institute for Health and Welfare [Helsinki], The Wellcome Trust Sanger Institute [Cambridge], University of Iceland [Reykjavik], University of Washington [Seattle], University of Groningen [Groningen], University of Glasgow, William Harvey Research Institute, Barts and the London Medical School, Université de Lausanne (UNIL), deCODE genetics [Reykjavik], Northwestern University Feinberg School of Medicine, Uppsala Universitet [Uppsala], University of Edinburgh, Medical Faculty [Mannheim], University of Graz, Ludwig-Maximilians-Universität München (LMU), Johannes Gutenberg - Universität Mainz (JGU), Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, Umeå University, Skane University Hospital [Malmo], Lund University [Lund], RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche [Roma] (CNR), University Medical Center Groningen [Groningen] (UMCG), Universität Leipzig [Leipzig], Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Split, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), University of Eastern Finland, Harokopio University of Athens, European Academy Bozen/Bolzano (EURAC), University of Kuopio, German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] (DZD), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Ninewells Hospital and Medical School [Dundee], University College of London [London] (UCL), University of Essex, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], University of Helsinki, Leiden University Medical Center (LUMC), Institute of Cardiovascular and Medical Sciences [Glasgow], University of Oulu, The University of Texas Health Science Center at Houston (UTHealth), University of Minnesota Medical School, University of Minnesota System, Keck School of Medicine [Los Angeles], University of Southern California (USC), Amsterdam UMC, University Hospital Carl Gustav Carus [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Universität Heidelberg [Heidelberg], King Abdulaziz University, Pirkanmaa Hospital District, Tampere University Hospital, Cedars-Sinai Medical Center, Danube University Krems, Harvard School of Public Health, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Hannover Medical School [Hannover] (MHH), Universität zu Lübeck [Lübeck], University of Exeter, Regeneron Pharmaceuticals [Tarrytown], University of Adelaide, Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Harvard T.H. Chan School of Public Health, John Radcliffe Hospital [Oxford University Hospital], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Université de Genève (UNIGE), Big Data Institute, University of Surrey (UNIS), University of Bergen (UiB), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Stanford Cardiovascular Institute, University of Liverpool, University of Manchester [Manchester], Institute of Biochemistry and Genetics of Ufa Scientific Centre, Russian Academy of Sciences [Moscow] (RAS), Experimental Vascular Medicine, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, SIEST, Sofia, PreciDIAB Institute, the holistic approach of personal diabets care - - PreciDIAB2018 - ANR-18-IBHU-0001 - IBHU - VALID, Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging - DYNAHEALTH - - H20202015-04-01 - 2019-03-31 - 633595 - VALID, Beyond the Genetics of Addiction - ADDICTION - - EC:FP7:ERC2011-12-01 - 2017-05-31 - 284167 - VALID, Rise of scientific excellence and collaboration for implementing personalised medicine in Estonia - ePerMed - - H20202016-01-01 - 2018-12-31 - 692145 - VALID, University of Oxford, Helmholtz Zentrum München = German Research Center for Environmental Health, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Ferrara = University of Ferrara (UniFE), Université de Lausanne = University of Lausanne (UNIL), Karl-Franzens-Universität Graz, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Amsterdam UMC - Amsterdam University Medical Center, Nanyang Technological University [Singapour], Universität zu Lübeck = University of Lübeck [Lübeck], Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Université de Genève = University of Geneva (UNIGE), ANR-18-IBHU-0001,PreciDIAB,PreciDIAB Institute, the holistic approach of personal diabets care(2018), European Project: 633595,H2020,H2020-PHC-2014-two-stage,DYNAHEALTH(2015), European Project: 284167,EC:FP7:ERC,ERC-2011-StG_20101124,ADDICTION(2011), European Project: 692145,H2020,H2020-TWINN-2015,ePerMed(2016), Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Functional Genomics, APH - Mental Health, Sociology and Social Gerontology, APH - Methodology, Hottenga, Jouke- Jan [0000-0002-5668-2368], Bouatia-Naji, Nabila [0000-0001-5424-2134], Jansen, Rick [0000-0002-3333-6737], Min, Josine L. [0000-0003-4456-9824], Faggian, Alessia [0000-0002-3799-9722], Bonnefond, Amélie [0000-0001-9976-3005], Isaacs, Aaron [0000-0001-5037-4834], Willems, Sara M. [0000-0002-6803-3007], Navarro, Pau [0000-0001-5576-8584], Jackson, Anne U. [0000-0002-9672-2547], Bielak, Lawrence F. [0000-0002-3443-8030], Saxena, Richa [0000-0003-2233-1065], Smith, Albert V. [0000-0003-1942-5845], Verweij, Niek [0000-0002-4303-7685], Goel, Anuj [0000-0003-2307-4021], Johnson, Paul C. D. [0000-0001-6663-7520], Strawbridge, Rona J. [0000-0001-8506-3585], Fall, Tove [0000-0003-2071-5866], Fraser, Ross M. [0000-0003-0488-2592], Kanoni, Stavroula [0000-0002-1691-9615], Giedraitis, Vilmantas [0000-0003-3423-2021], Kleber, Marcus E. [0000-0003-0663-7275], Müller-Nurasyid, Martina [0000-0003-3793-5910], Luan, Jian’an [0000-0003-3137-6337], Sanna, Serena [0000-0002-3768-1749], Nolte, Ilja M. [0000-0001-5047-4077], Zemunik, Tatijana [0000-0001-8120-2891], Kovacs, Peter [0000-0002-0290-5423], Wild, Sarah H. [0000-0001-7824-2569], McLachlan, Stela [0000-0003-0480-6143], Egan, Josephine [0000-0002-8945-0053], Hicks, Andrew A. [0000-0001-6320-0411], Thorand, Barbara [0000-0002-8416-6440], Hingorani, Aroon [0000-0001-8365-0081], Kivimaki, Mika [0000-0002-4699-5627], Koistinen, Heikki A. [0000-0001-7870-070X], Bakker, Stephan J. L. [0000-0003-3356-6791], Palmer, Colin N. A. [0000-0002-6415-6560], Jukema, J. Wouter [0000-0002-3246-8359], Sattar, Naveed [0000-0002-1604-2593], Snieder, Harold [0000-0003-1949-2298], Magnusson, Patrik K. [0000-0002-7315-7899], Blüher, Matthias [0000-0003-0208-2065], Wolffenbuttel, Bruce H. R. [0000-0001-9262-6921], Abecasis, Goncalo R. [0000-0003-1509-1825], Meigs, James B. [0000-0002-2439-2657], Wilson, James F. [0000-0001-5751-9178], Schwarz, Peter E. H. [0000-0001-6317-7880], Boehm, Bernhard O. [0000-0002-2706-7710], Metspalu, Andres [0000-0002-3718-796X], Deloukas, Panos [0000-0001-9251-070X], Körner, Antje [0000-0001-6001-0356], Wareham, Nicholas J. [0000-0003-1422-2993], Langenberg, Claudia [0000-0002-5017-7344], Männistö, Satu [0000-0002-8668-3046], Franks, Paul W. [0000-0002-0520-7604], Hayward, Caroline [0000-0002-9405-9550], Vitart, Veronique [0000-0002-4991-3797], Kaprio, Jaakko [0000-0002-3716-2455], Visvikis-Siest, Sophie [0000-0001-8104-8425], Altshuler, David [0000-0002-7250-4107], Rudan, Igor [0000-0001-6993-6884], van Duijn, Cornelia M. [0000-0002-2374-9204], Pramstaller, Peter P. [0000-0002-9831-8302], Boehnke, Michael [0000-0002-6442-7754], Frayling, Timothy M. [0000-0001-8362-2603], Peyser, Patricia A. [0000-0002-9717-8459], Harst, Pim van der [0000-0002-2713-686X], Smith, George Davey [0000-0002-1407-8314], Forouhi, Nita G. [0000-0002-5041-248X], Loos, Ruth J. F. [0000-0002-8532-5087], Salomaa, Veikko [0000-0001-7563-5324], Soranzo, Nicole [0000-0003-1095-3852], Boomsma, Dorret I. [0000-0002-7099-7972], Groop, Leif [0000-0002-0187-3263], Tuomi, Tiinamaija [0000-0002-8306-6202], Munroe, Patricia B. [0000-0002-4176-2947], Gudnason, Vilmundur [0000-0001-5696-0084], Lecoeur, Cecile [0000-0003-0075-6417], Jarvelin, Marjo-Riitta [0000-0002-2149-0630], Stefansson, Kari [0000-0003-1676-864X], Dermitzakis, Emmanouil T. [0000-0002-9302-6490], Lindgren, Cecilia M. [0000-0002-4903-9374], Froguel, Philippe [0000-0003-2972-0784], Kaakinen, Marika A. [0000-0002-9228-0462], Watanabe, Richard M. [0000-0003-1015-0531], Ingelsson, Erik [0000-0003-2256-6972], Dupuis, Josée [0000-0003-2871-3603], Barroso, Inês [0000-0001-5800-4520], Apollo - University of Cambridge Repository, Epidemiology, University Hospital Mannheim | Universitätsmedizin Mannheim, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Universität Leipzig, Universiteit Leiden, Universität Heidelberg [Heidelberg] = Heidelberg University, Karl-Franzens-Universität [Graz, Autriche], Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, General practice, APH - Digital Health, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Center for Liver, Digestive and Metabolic Diseases (CLDM), Value, Affordability and Sustainability (VALUE), Cardiovascular Centre (CVC), Hottenga, Jouke-Jan [0000-0002-5668-2368], Min, Josine L [0000-0003-4456-9824], Willems, Sara M [0000-0002-6803-3007], Jackson, Anne U [0000-0002-9672-2547], Bielak, Lawrence F [0000-0002-3443-8030], Smith, Albert V [0000-0003-1942-5845], Johnson, Paul CD [0000-0001-6663-7520], Strawbridge, Rona J [0000-0001-8506-3585], Fraser, Ross M [0000-0003-0488-2592], Kleber, Marcus E [0000-0003-0663-7275], Luan, Jian'an [0000-0003-3137-6337], Nolte, Ilja M [0000-0001-5047-4077], Wild, Sarah H [0000-0001-7824-2569], Hicks, Andrew A [0000-0001-6320-0411], Koistinen, Heikki A [0000-0001-7870-070X], Bakker, Stephan JL [0000-0003-3356-6791], Palmer, Colin NA [0000-0002-6415-6560], Jukema, J Wouter [0000-0002-3246-8359], Magnusson, Patrik K [0000-0002-7315-7899], Wolffenbuttel, Bruce HR [0000-0001-9262-6921], Abecasis, Goncalo R [0000-0003-1509-1825], Meigs, James B [0000-0002-2439-2657], Wilson, James F [0000-0001-5751-9178], Schwarz, Peter EH [0000-0001-6317-7880], Boehm, Bernhard O [0000-0002-2706-7710], Wareham, Nicholas J [0000-0003-1422-2993], Franks, Paul W [0000-0002-0520-7604], van Duijn, Cornelia M [0000-0002-2374-9204], Pramstaller, Peter P [0000-0002-9831-8302], Frayling, Timothy M [0000-0001-8362-2603], Peyser, Patricia A [0000-0002-9717-8459], Forouhi, Nita G [0000-0002-5041-248X], Loos, Ruth JF [0000-0002-8532-5087], Boomsma, Dorret I [0000-0002-7099-7972], Munroe, Patricia B [0000-0002-4176-2947], Dermitzakis, Emmanouil T [0000-0002-9302-6490], Lindgren, Cecilia M [0000-0002-4903-9374], Kaakinen, Marika A [0000-0002-9228-0462], Watanabe, Richard M [0000-0003-1015-0531], Tampere University, Tays Research Services, Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), Fysiologie, RS: FHML MaCSBio, RS: Carim - B01 Blood proteins & engineering

المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature Communications, 12(1):24, 1-18. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 12(1):24. Nature Publishing Group UK
Lagou, V, Mägi, R, Hottenga, J J, Jansen, R, Min, J L, Willemsen, G, De Geus, E J C N, Penninx, B W, Boomsma, D I, Barroso, I, Morris, A P, Prokopenko, I & MAGIC Collaboration 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24, pp. 1-18 . https://doi.org/10.1038/s41467-020-19366-9
Min, J L, St Pourcain, M U B, Timpson, N J, Davey Smith, G, Prokopenko, I & et al. 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, 24 . https://doi.org/10.1038/s41467-020-19366-9
2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-021-21276-3
Nature communications, vol. 12, no. 1, pp. 24
Nature Communications, 12(1). NATURE RESEARCH

مصطلحات موضوعية: Male, Anorexia Nervosa, medicine.medical_treatment, 45/43, Insulin Resistance/genetics, SUSCEPTIBILITY, Quantitative trait, Impaired glucose tolerance, 0302 clinical medicine, Architecture, LS2_1, IMPUTATION, Insulin, ComputingMilieux_MISCELLANEOUS, Fasting, Publisher Correction, 3. Good health, [SDV] Life Sciences [q-bio], Kruppel-Like Transcription Factors/blood, Endokrinologi och diabetes, Science & Technology - Other Topics, Adult, Blood Glucose, European Continental Ancestry Group, Female, Gene Expression, Genetic Loci, Genome-Wide Association Study, Glucose Intolerance, Humans, Insulin Receptor Substrate Proteins, Insulin Resistance, Kruppel-Like Transcription Factors, Middle Aged, Phenotype, Sex Characteristics, Sex Factors, Waist-Hip Ratio, Sex characteristics, medicine.medical_specialty, Science, 631/208/205/2138, Endocrinology and Diabetes, General Biochemistry, Genetics and Molecular Biology, White People, Gender-differences, 03 medical and health sciences, SDG 3 - Good Health and Well-being, 692/53/2421, GLYCEMIC TRAITS, GENOME-WIDE ASSOCIATION, Glycemic, GENDER-DIFFERENCES, Science & Technology, IDENTIFICATION, 692/699/2743/2815, Blood Glucose/metabolism, Diagnostic markers, medicine.disease, Anorexia Nervosa/blood, 030104 developmental biology, Endocrinology, Glucose, Insulin/blood, Anorexia Nervosa/ethnology, Anorexia Nervosa/genetics, Anorexia Nervosa/physiopathology, Fasting/blood, Glucose Intolerance/blood, Glucose Intolerance/ethnology, Glucose Intolerance/genetics, Glucose Intolerance/physiopathology, Insulin Receptor Substrate Proteins/blood, Insulin Receptor Substrate Proteins/genetics, Kruppel-Like Transcription Factors/genetics, 0301 basic medicine, Identification, [SDV]Life Sciences [q-bio], General Physics and Astronomy, Genome-wide association studies, Waist–hip ratio, LS4_5, RISK, ARCHITECTURE, Multidisciplinary, article, Type 2 diabetes, Multidisciplinary Sciences, MENDELIAN RANDOMIZATION, Pre-diabetes, Medical Genetics, Risk, PATHOPHYSIOLOGY, 030209 endocrinology & metabolism, 3121 Internal medicine, 692/163/2743/137/773, NO, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Mendelian randomization, 631/208/480, Medicinsk genetik, business.industry, General Chemistry, Impaired fasting glucose, business

وصف الملف: application/pdf; text/xml; application/zip; Electronic; fulltext

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5783e9d2579548e3deb52d1bbdf19db
https://hal.univ-lorraine.fr/hal-03105716

المؤلفون: Richard Fitzgerald, Richard M. Turner, Vanessa Fontana, Peng Yin, Andrew P. Morris, Daniel F. Carr, Munir Pirmohamed, Jieying E Zhang

المصدر: Turner, R M, Fontana, V, Zhang, J E, Carr, D, Yin, P, FitzGerald, R, Morris, A P & Pirmohamed, M 2020, ' A Genome-wide Association Study of Circulating Levels of Atorvastatin and Its Major Metabolites ', Clinical Pharmacology and Therapeutics, vol. 108, no. 2, pp. 287-297 . https://doi.org/10.1002/cpt.1820
Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Male, medicine.medical_specialty, Acute coronary syndrome, Pharmacogenomic Variants, Atorvastatin, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Risk Assessment, 030226 pharmacology & pharmacy, Gastroenterology, Lactones, 03 medical and health sciences, 0302 clinical medicine, Muscular Diseases, Risk Factors, Internal medicine, Cytochrome P-450 CYP3A, Humans, Medicine, Pharmacology (medical), Prospective Studies, Glucuronosyltransferase, Adverse effect, Biotransformation, CYP3A7, Pharmacology, biology, Liver-Specific Organic Anion Transporter 1, business.industry, Odds ratio, Middle Aged, medicine.disease, United Kingdom, Confidence interval, Pharmacogenetics, 030220 oncology & carcinogenesis, biology.protein, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, SLCO1B1, human activities, Genome-Wide Association Study, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1631ffa8c395802ce624136819b6b7
https://doi.org/10.1002/cpt.1820

المؤلفون: James J. Fryett, Heather J. Cordell, Andrew P. Morris

المصدر: Genetic Epidemiology
Fryett, J J, Morris, A P & Cordell, H J 2020, ' Investigation of prediction accuracy and the impact of sample size, ancestry, and tissue in transcriptome-wide association studies ', Genetic Epidemiology, vol. 44, no. 5, pp. 425-441 . https://doi.org/10.1002/gepi.22290

مصطلحات موضوعية: Elastic net regularization, Mixed model, Genotype, Epidemiology, Bayesian probability, complex traits, 03 medical and health sciences, transcriptome‐wide association study, Statistics, Humans, Research Articles, Genetics (clinical), 030304 developmental biology, Mathematics, Genetic association, 0303 health sciences, Models, Statistical, Models, Genetic, 030305 genetics & heredity, Reproducibility of Results, Bayes Theorem, Statistical model, Regression, Expression (mathematics), Pedigree, Phenotype, Sample size determination, Sample Size, gene expression, Transcriptome, Research Article, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00296f4bc59ba90686fbb43981a7f06
https://doi.org/10.1002/gepi.22290

المؤلفون: Bangfu Zhu, Jennifer C. H. Mak, Andrew P. Morris, Jeff W. Barclay, Anthony G Marson, Alan Morgan, Graeme J. Sills

المصدر: Epilepsia
Zhu, B, Mak, J C H, Morris, A P, Marson, A G, Barclay, J W, Sills, G J & Morgan, A 2020, ' Functional analysis of epilepsy-associated variants in STXBP1/Munc18-1 using humanized Caenorhabditis elegans ', Epilepsia, vol. 61, no. 4, pp. 810-821 . https://doi.org/10.1111/epi.16464

مصطلحات موضوعية: 0301 basic medicine, Pharyngeal pumping, nematode, Transgene, Vesicular Transport Proteins, Animals, Genetically Modified, 03 medical and health sciences, Munc18 Proteins, 0302 clinical medicine, synapse, Animals, Humans, CRISPR, STXBP1, Missense mutation, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Gene, Genetics, Epilepsy, biology, biology.organism_classification, Null allele, Disease Models, Animal, epileptic encephalopathy, 030104 developmental biology, Neurology, SNARE, Mutation, Full‐length Original Research, Neurology (clinical), exocytosis, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce98fe1ca265384b907e47bad3bb6627
https://doi.org/10.1111/epi.16464

المؤلفون: Yoonsu Cho, Jie Zheng, Tom R. Gaunt, Andrew P. Morris, George Davey Smith, Eleanor Sanderson, Philip C Haycock, Gibran Hemani

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Cho, Y, Haycock, P C, Sanderson, E, Gaunt, T R, Zheng, J, Morris, A P, Davey Smith, G & Hemani, G 2020, ' Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework ', Nature Communications, vol. 11, no. 1, 1010, pp. 1010 . https://doi.org/10.1038/s41467-020-14452-4
Cho, Y, Haycock, P C, Sanderson, E, Gaunt, T R, Zheng, J, Morris, A P, Davey Smith, G & Hemani, G 2020, ' Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework ', Nature Communications, vol. 11, 1010 (2020) . https://doi.org/10.1038/s41467-020-14452-4

مصطلحات موضوعية: 0301 basic medicine, Statistical methods, Epidemiology, Science, General Physics and Astronomy, Single-nucleotide polymorphism, Genome-wide association study, Computational biology, Biology, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pleiotropy, Genetics research, Databases, Genetic, Mendelian randomization, Genetic Pleiotropy, Humans, Computer Simulation, Disease, 030212 general & internal medicine, lcsh:Science, Genetic association study, Multidisciplinary, Models, Genetic, Instrumental variable, Genetic Variation, Mendelian Randomization Analysis, General Chemistry, Causality, genetics research, Phenotype, 030104 developmental biology, Disease/genetics, genetic association study, statistical methods, epidemiology, lcsh:Q, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a20ef8033e0796f7681ec4bd283796
http://link.springer.com/article/10.1038/s41467-020-14452-4