نتائج البحث - "Lucio H. Freitas-Junior"

1

Expanding the Biological Application of Fluorescent Benzothiadiazole Derivatives: A Phenotypic Screening Strategy for Anthelmintic Drug Discovery Using Caenorhabditis elegans

المؤلفون: Pedro H. P. R. Carvalho, Lucio H. Freitas-Junior, Carolina B. Moraes, Giovana Aparecida de Souza Cintra, Brenno A. D. Neto

المصدر: SLAS Discovery. 24:755-765

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad418ec953bdf09d5670bdd711058dd0
https://doi.org/10.1177/2472555219851130

2

Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19

المؤلفون: Carolina B. Moraes, Patricia Nolasco, Lygia da Veiga Pereira, Juliana Borsoi, Lucio H. Freitas-Junior

المصدر: Genetics and Molecular Biology
Genetics and Molecular Biology, Vol 44, Iss 1 suppl 1 (2020)
Genetics and Molecular Biology, Volume: 44, Issue: 1 Supplement 1, Article number: e20200198, Published: 16 NOV 2020
Genetics and Molecular Biology v.44 n.1 suppl.1 2021
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be39dc697f9a03c3ddf96c77ba0d9da9
http://europepmc.org/articles/PMC7737100

3

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

المؤلفون: Flavio Di Pisa, Elisa Uliassi, Lucio H. Freitas-Junior, Maria Laura Bolognesi, Antonio Quotadamo, Maria Paola Costi, Claudia Danielli Pereira Bertolacini, Joachim Clos, Joanna Panecka-Hofman, Chiara Borsari, María Jesús Corral, G. Landi, Maria Kuzikov, Deepa Karunakaran, Pasquale Linciano, Wolfgang Müller, Birte Behrens, Kyriakos C. Prousis, Carolina B. Moraes, Lucia Dello Iacono, Markus Wolf, Oliver Keminer, Cecilia Pozzi, Rebecca C. Wade, Bruno dos Santos Pascoalino, José María Alunda, Stefania Ferrari, Martina Fenske, Alberto Venturelli, Sheraz Gul, Jeanette Reinshagen, Nuno Santarém, Matteo Santucci, Jennifer Leu, Stephen Wrigley, Ina Pöhner, Bethlehem Kebede, Theodora Calogeropoulou, Bernhard Ellinger, Stefano Mangani, Anabela Cordeiro-da-Silva, Gesa Witt

المساهمون: Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul, Publica

المصدر: Slas Discovery

مصطلحات موضوعية: Chagas disease, cell-based assays, Antiparasitic, medicine.drug_class, cell-based assay, Computational biology, liquid handling, Trypanosoma brucei, 01 natural sciences, Biochemistry, Article, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Trypanosomiasis, anti-infective drugs, Drug Discovery, parasitic diseases, medicine, Humans, compound repositories, enzyme assays or enzyme kinetics, Biotechnology, Molecular Medicine, 030304 developmental biology, 0303 health sciences, Biological Products, Natural product, biology, Drug discovery, Leishmaniasis, biology.organism_classification, medicine.disease, Trypanocidal Agents, anti-infective drug, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, chemistry, compound repositorie, Neglected tropical diseases, enzyme assays or enzyme kinetic

وصف الملف: ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b64ff9e20812ab96c4f3ad8331d20
https://hdl.handle.net/11380/1175165

4

Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps

المؤلفون: Wagner Fontes, Mariana S. Castro, Ana Carolina Martins Magalhães, César Augusto Prías-Márquez, Carlos André Ornelas Ricart, Rafaela Milan Bonotto, Denise Regina Bairros de Pilger, Alice da Cunha Morales Álvares, Osmindo Rodrigues Pires, Sonia Maria de Freitas, Agenor de Castro Moreira dos Santos Júnior, Diego A. Falico, Isabelle S. Luz, Carlos José Correia de Santana, Carolina B. Moraes, Lucio H. Freitas-Junior, Beatriz Dolabela de Lima

المصدر: Biomolecules, Vol 10, Iss 790, p 790 (2020)
Biomolecules
Volume 10
Issue 5

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ba7e74ff9a20abc5d0476fdae1116d
https://www.mdpi.com/2218-273X/10/5/790

5

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

المؤلفون: Thalita Camêlo da Silva Ferreira, Vanessa Fontana, Laura M. Alcântara, Carolina B. Moraes, Lucio H. Freitas-Junior, Eric Chatelain

المصدر: Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2551, p 2551 (2020)

مصطلحات موضوعية: THP-1 Cells, Phenotypic screening, 030231 tropical medicine, Antiprotozoal Agents, Drug Evaluation, Preclinical, Pharmaceutical Science, Biology, Article, Leishmania, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Mice, 0302 clinical medicine, lcsh:Organic chemistry, Species Specificity, Leishmania species, Drug Discovery, Multi species, medicine, leishmaniasis drug discovery, Animals, Humans, Physical and Theoretical Chemistry, Protriptyline, Leishmaniasis, 030304 developmental biology, 0303 health sciences, Drug discovery, Organic Chemistry, phenotypic screening, medicine.disease, biology.organism_classification, Phenotype, Small molecule, Biochemistry, Maprotiline, Chemistry (miscellaneous), Molecular Medicine, Leishmaniasis, Visceral

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40958fcafa258e8a1a7f3c6e4e965aa3
http://europepmc.org/articles/PMC7321149

Find this article in full text from ProQuest

6

UV-C (254 nm) lethal doses for SARS-CoV-2

المؤلفون: Fábio P. Sellera, Douglas Ferreira Sales-Medina, Martha S. Ribeiro, Caetano P. Sabino, Edison Luiz Durigon, Lucio H. Freitas-Junior, Rafael Rahal Guaragna Machado

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Photodiagnosis and Photodynamic Therapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef4dde24829c09d99a1842a2a510e4b

7

Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes

المؤلفون: Nilmar Silvio Moretti, Laura M. Alcântara, Milena Botelho Pereira Soares, Sergio Schenkman, Rino Ragno, Carolina B. Moraes, Lucio H. Freitas-Junior, Nicola Mautone, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Antonello Mai, Caio Haddad Franco, Tanira Matutino Bastos

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3659, p 3659 (2020)
Volume 21
Issue 10

مصطلحات موضوعية: 0301 basic medicine, deacetylation, sirtuins, Trypanosoma cruzi, sirtuin inhibitors, Pharmacology, 01 natural sciences, lcsh:Chemistry, lcsh:QH301-705.5, Spectroscopy, Phylogeny, media_common, chemistry.chemical_classification, biology, Group III Histone Deacetylases, Drug Synergism, General Medicine, Trypanocidal Agents, Recombinant Proteins, Computer Science Applications, Molecular Docking Simulation, Benznidazole, Nitroimidazoles, Sirtuin, medicine.drug, Chagas disease, Drug, media_common.quotation_subject, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Inhibitory Concentration 50, medicine, Animals, Chagas Disease, Physical and Theoretical Chemistry, Nifurtimox, Molecular Biology, 010405 organic chemistry, Organic Chemistry, Epithelial Cells, biology.organism_classification, medicine.disease, Macaca mulatta, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, lcsh:Biology (General), lcsh:QD1-999, biology.protein, NAD+ kinase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be24b0eb23df1cb4b5d68310a7131e38
http://hdl.handle.net/11573/1401342

8

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

المؤلفون: Maria Kuzikov, Gesa Witt, Bruno dos Santos Pascoalino, Caio Haddad Franco, Luca Costantino, Rosaria Luciani, Laura M. Alcantara, Nuno Santarém, Sara Macedo, Antonio Quotadamo, Lucio H. Freitas-Junior, Bernhard Ellinger, Carolina B. Moraes, Stefania Ferrari, Maria Paola Costi, Sheraz Gul, Anabela Cordeiro-da-Silva, Pasquale Linciano

المساهمون: Publica

المصدر: European Journal of Medicinal Chemistry. 146:423-434

مصطلحات موضوعية: Thiosemicarbazones, 0301 basic medicine, Trypanosoma, Stereochemistry, hERG, Antiprotozoal Agents, Trypanosoma brucei, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Parasitic Sensitivity Tests, Thiadiazoles, Early-toxicity, Leishmania infantum, pan-anti-trypanosomatidic activity, Thiosemicarbazone, Trypanosoma cruzi, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, parasitic diseases, Drug Discovery, medicine, Humans, Chagas Disease, Amastigote, Semicarbazone, Dose-Response Relationship, Drug, Molecular Structure, biology, Macrophages, General Medicine, biology.organism_classification, medicine.disease, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, Mitochondrial toxicity, 030104 developmental biology, chemistry, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebcff45eb81d168c200819955e00630
https://doi.org/10.1016/j.ejmech.2018.01.043

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9

A comparative study of warheads for design of cysteine protease inhibitors

المؤلفون: Caio Haddad Franco, Josmar R. Rocha, Carolina B. Moraes, Antonio C. B. Burtoloso, Daniel G. Silva, Daniela De Vita, Carlos A. Montanari, Peter W. Kenny, Andrei Leitão, Jean F. R. Ribeiro, Lorenzo Cianni, Lucio H. Freitas-Junior

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0301 basic medicine, Nitrile, Stereochemistry, Cathepsin L, Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, 01 natural sciences, Biochemistry, Aldehyde, Cyclopropane, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Nitriles, Drug Discovery, Potency, ALDEÍDOS, Molecular Biology, chemistry.chemical_classification, Dipeptide, Covalent inhibitor, Cysteine protease, Oxime, Warhead, Cysteine Endopeptidases, Dipeptides, Drug Design, Kinetics, 010405 organic chemistry, Organic Chemistry, Orders of magnitude (mass), 0104 chemical sciences, 030104 developmental biology, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a458345f2b22da4227d15e544da7adc
https://doi.org/10.1016/j.bmcl.2017.10.002

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10

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

المساهمون: Publica

المصدر: ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
'ACS Omega ', vol: 2, pages: 5666-5683 (2017)
Linciano, P, Dawson, A, Pöhner, I, Costa, D M, Sa, M S, Cordeiro-Da-Silva, A, Luciani, R, Gul, S, Witt, G, Ellinger, B, Kuzikov, M, Gribbon, P, Reinshagen, J, Wolf, M, Behrens, B, Hannaert, V, Michels, P A M, Nerini, E, Pozzi, C, Di Pisa, F, Landi, G, Santarem, N, Ferrari, S, Saxena, P, Lazzari, S, Cannazza, G, Freitas-Junior, L H, Moraes, C B, Pascoalino, B S, Alcantara, L M, Bertolacini, C P, Fontana, V, Wittig, U, Müller, W, Wade, R C, Hunter, W N, Mangani, S, Costantino, L & Costi, M P 2017, ' Exploiting the 2‑Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery ', ACS Omega, vol. 2, no. 9, pp. 5666-5683 . https://doi.org/10.1021/acsomega.7b00473

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28935a981ead5c6c4b6475eb3f00313c
https://doi.org/10.1021/acsomega.7b00473

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