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المؤلفون: Caiyong Lai, Guo Chen, Yan Chen, Naite Xi, Ling Tian, Mingrong Cao, Yongchang Zhang, Qi Feng, Congcong Chen, Shengbin Lin, Yanguan Guo, Li Yu, Jiaxin Tian, Jinye Mi, Jun Fan, Fan Zhang
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 643-652 (2021)
Neoplasia (New York, N.Y.)مصطلحات موضوعية: 0301 basic medicine, DNA Replication, Cancer Research, Antimetabolites, Antineoplastic, Ribonucleoside Diphosphate Reductase, DNA damage, Cell, Mechanistic Target of Rapamycin Complex 2, Deoxycytidine, Histones, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Ribonucleotide Reductases, medicine, EGFR, Epidermal growth factor receptor, Humans, Phosphorylation, NSCLC, Non-small cell lung cancer, dNTP, deoxyribonucleotide triphosphates, Ribonucleotide reductase, mTORC2, RC254-282, Original Research, Chemistry, DNA replication, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, DNA Replication Fork, DSB, Double-strand break, Gemcitabine, DNA replication stress, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Cancer cell, Cancer research, RNR, Ribonucleotide reductase, medicine.drug, DNA Damage, Protein Binding, Signal Transduction
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المؤلفون: Tetsushi Iida, Jun Sese, Takehiko Kobayashi, Naoko Iida
المصدر: Genes to Cells
مصطلحات موضوعية: Genome instability, RNase H, Ribonucleotide, DNA Repair, DNA damage, DNA polymerase, Ribonucleotide excision repair, Saccharomyces cerevisiae, Computational biology, medicine.disease_cause, Genome, 03 medical and health sciences, Mutation Rate, Genetics, medicine, Indel, 030304 developmental biology, 0303 health sciences, Mutation, biology, ribonucleotide, Original Articles, DNA, Cell Biology, Ribonucleotides, genome instability, indel, repair, biology.protein, Original Article, mutation, Genome, Fungal
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المؤلفون: Elisa Tomat, Rohit Kumar Sharma, Nahiara Alicea, Sofia C. Pérez Otero, Martin Kowaleff, Liz Hernandez-Matias, Eman A. Akam, Andrei V. Astashkin, Kavita Gaur, Sergio A. Loza-Rosas, Josué A. Benjamín-Rivera, Arthur D. Tinoco, Anthony V Washington, Alexandra M. Vázquez Salgado, Israel Rodríguez
المصدر: JACS Au, Vol 1, Iss 6, Pp 865-878 (2021)
Jacs Auمصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, ribonucleotide reductase inhibition, Chemistry, metal-based anticancer strategy, Protein subunit, DNA replication, Cell cycle, 010402 general chemistry, 01 natural sciences, Article, 0104 chemical sciences, 03 medical and health sciences, Enzyme, Ribonucleotide reductase, intracellular iron(III) transmetalation, Biochemistry, Transferrin, titanium(IV) binding of nucleotides, Titanium(IV) chemical transferrin mimetic complexes, Nucleotide, QD1-999, Intracellular, 030304 developmental biology
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المؤلفون: Stephen D. Larson, McKenzie Carter, Galadriel Hovel-Miner
المصدر: Parasitology
مصطلحات موضوعية: 0301 basic medicine, melarsoprol, T. brucei, 030106 microbiology, trypanothione, Trypanothione, γ-glutamylcysteine synthetase, Melarsoprol, Biology, ribonucleotide reductase, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Eflornithine, medicine, Trypanosomatids, chemistry.chemical_classification, DNA synthesis, fexinidazole, Cell cycle, Antitrypanosomal drugs, 030104 developmental biology, Infectious Diseases, Ribonucleotide reductase, Enzyme, Biochemistry, chemistry, Animal Science and Zoology, Parasitology, cell cycle, medicine.drug, Research Article
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المؤلفون: Aziz El Hage, Susana M. Cerritelli
المصدر: Curr Genet
Cerritelli, S M & El Hage, A 2020, ' RNases H1 and H2 : Guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis ', Current Genetics . https://doi.org/10.1007/s00294-020-01086-8مصطلحات موضوعية: DNA Replication, RNase H, DNA Repair, DNA repair, DNA damage, DNA polymerase, RNase P, Ribonucleotide excision repair, Ribonuclease H, Saccharomyces cerevisiae, ribonucleotide reductase, Article, Mice, 03 medical and health sciences, Genetics, Topoisomerase 1, Animals, Humans, 030304 developmental biology, 0303 health sciences, biology, 030302 biochemistry & molecular biology, ribonucleotide, General Medicine, Ribonucleotides, Cell biology, genomic DNA, Ribonucleotide reductase, DNA Topoisomerases, Type I, Mutagenesis, biology.protein, R-loop
وصف الملف: application/pdf
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المصدر: Science
مصطلحات موضوعية: 0301 basic medicine, Ribonucleotide, Protein Conformation, Stereochemistry, Protein subunit, 010402 general chemistry, 01 natural sciences, Article, 03 medical and health sciences, Protein structure, Oxidoreductase, Catalytic Domain, Ribonucleotide Reductases, Nucleotide, chemistry.chemical_classification, Multidisciplinary, biology, Escherichia coli Proteins, Cryoelectron Microscopy, Active site, 0104 chemical sciences, 030104 developmental biology, Enzyme, Ribonucleotide reductase, chemistry, Biocatalysis, biology.protein, Tyrosine, Holoenzymes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e43acaafa03ad27945f3ae178c547c
https://doi.org/10.1126/science.aba6794 -
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المؤلفون: Liya Wang, Staffan Eriksson, Ren Sun
المصدر: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Molecular and Cell Biologyمصطلحات موضوعية: 0301 basic medicine, Mitochondrial DNA, Mitochondrial disease, Mitochondrion, Mitochondrial DNA depletion, DNA, Mitochondrial, Thymidine Kinase, dTMP synthesis, mtDNA, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytosol, Ribonucleotide Reductases, RNR, medicine, Thymidine Monophosphate, Thymidine kinase 2, Animals, lcsh:QH573-671, Muscle, Skeletal, Molecular Biology, Ribonucleotide reductase, chemistry.chemical_classification, Chemistry, lcsh:Cytology, Skeletal muscle, Brain, Heart, Cell Biology, medicine.disease, Mitochondria, Rats, 030104 developmental biology, Enzyme, medicine.anatomical_structure, Biochemistry, Liver, Organ Specificity, p53R2, Thymidylate synthase, Thymidine, Cell and Molecular Biology, 030217 neurology & neurosurgery, Spleen, Research Article
وصف الملف: application/pdf
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المصدر: Biochemistry. 59:1442-1453
مصطلحات موضوعية: Conformational change, Ribonucleotide, Ribonucleoside Diphosphate Reductase, Stereochemistry, Protein subunit, Biochemistry, Article, Cofactor, 03 medical and health sciences, Catalytic Domain, Ribonucleotide Reductases, Escherichia coli, Nucleotide, chemistry.chemical_classification, 0303 health sciences, biology, Nucleotides, Chemistry, Escherichia coli Proteins, 030302 biochemistry & molecular biology, Active site, Turnover number, Kinetics, Enzyme, biology.protein, Protein Binding
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المؤلفون: John K. Hall, Farid Moussavi-Harami, Stephen C. Kolwicz, Jeffrey S. Chamberlain, Stephen D. Hauschka, Xiolan Chen, Michael Regnier, Guy L. Odom
المصدر: JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 778-791 (2019)
JACC: Basic to Translational Scienceمصطلحات موضوعية: 0301 basic medicine, musculoskeletal diseases, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, lcsh:Diseases of the circulatory (Cardiovascular) system, Duchenne muscular dystrophy, Genetic enhancement, viruses, Cardiomyopathy, rAAV, recombinant adeno-associated viral vector, 030204 cardiovascular system & hematology, ribonucleotide reductase, dystrophin, 03 medical and health sciences, PRECLINICAL RESEARCH, 0302 clinical medicine, μDys, microdystrophin, Internal medicine, recombinant adeno-associated virus vectors, cTnT, cardiac troponin T, Medicine, Vector (molecular biology), biology, business.industry, dADP, deoxy-adenosine diphosphate, Cardiac muscle, Cardiac reserve, RNR, ribonucleotide reductase, CMV, cytomegalovirus, DMD, Duchenne muscular dystrophy, medicine.disease, 3. Good health, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Ribonucleotide reductase, lcsh:RC666-701, CK8, miniaturized murine creatine kinase regulatory cassette, biology.protein, diastolic dysfunction, dATP, deoxy-adenosine triphosphate, Cardiology and Cardiovascular Medicine, business, Dystrophin, cardiomyopathy, mdx, mouse muscular dystrophy model
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35da563ba80c05668887e4f5b7413550
http://www.sciencedirect.com/science/article/pii/S2452302X19301913 -
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المؤلفون: Peter J. Schaap, Rita J. M. Volkers, Pablo I. Nikel, Stefano Donati, Edoardo Saccenti, Linde F. C. Kampers, Maria Suarez-Diez, Vitor A. P. Martins dos Santos, Ruben G. A. van Heck
المصدر: Microbial Cell Factories, Vol 18, Iss 1, Pp 1-14 (2019)
Microbial Cell Factories, 18(1)
Microbial Cell Factories
Kampers, L F C, Van Heck, R G A, Donati, S, Saccenti, E, Volkers, R J M, Schaap, P J, Suarez-Diez, M, Nikel, P I & Martins Dos Santos, V A P 2019, ' In silico-guided engineering of Pseudomonas putida towards growth under micro-oxic conditions ', Microbial Cell Factories, vol. 18, no. 1, 179 . https://doi.org/10.1186/s12934-019-1227-5
Microbial Cell Factories 18 (2019) 1مصطلحات موضوعية: Oxidoreductases Acting on CH-CH Group Donors, Domainome analysis, Ribonucleotide, In silico, Dihydroorotate Dehydrogenase, lcsh:QR1-502, Bioengineering, medicine.disease_cause, Applied Microbiology and Biotechnology, lcsh:Microbiology, 03 medical and health sciences, Synthetic biology, Bacterial Proteins, Ribonucleotide Reductases, Constraint-based metabolic modelling, Escherichia coli, medicine, Systems and Synthetic Biology, Anaerobiosis, VLAG, 030304 developmental biology, Systeem en Synthetische Biologie, 0303 health sciences, Acetate kinase, biology, Microbial physiology, Acetate Kinase, Pseudomonas putida, 030306 microbiology, Chemistry, Research, Comparative genomics, Robustness (evolution), Genomics, biology.organism_classification, Oxygen, Lactobacillus, Metabolic Engineering, Biochemistry, Dihydroorotate dehydrogenase, Microorganisms, Genetically-Modified, Biotechnology
وصف الملف: application/octet-stream; application/pdf
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