نتائج البحث - "Lucio H. Freitas-Junior"

1

Human induced pluripotent stem cells as a tool for disease modeling and drug screening for COVID-19

المؤلفون: Carolina B. Moraes, Patricia Nolasco, Lygia da Veiga Pereira, Juliana Borsoi, Lucio H. Freitas-Junior

المصدر: Genetics and Molecular Biology
Genetics and Molecular Biology, Vol 44, Iss 1 suppl 1 (2020)
Genetics and Molecular Biology, Volume: 44, Issue: 1 Supplement 1, Article number: e20200198, Published: 16 NOV 2020
Genetics and Molecular Biology v.44 n.1 suppl.1 2021
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be39dc697f9a03c3ddf96c77ba0d9da9
http://europepmc.org/articles/PMC7737100

2

Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps

المؤلفون: Wagner Fontes, Mariana S. Castro, Ana Carolina Martins Magalhães, César Augusto Prías-Márquez, Carlos André Ornelas Ricart, Rafaela Milan Bonotto, Denise Regina Bairros de Pilger, Alice da Cunha Morales Álvares, Osmindo Rodrigues Pires, Sonia Maria de Freitas, Agenor de Castro Moreira dos Santos Júnior, Diego A. Falico, Isabelle S. Luz, Carlos José Correia de Santana, Carolina B. Moraes, Lucio H. Freitas-Junior, Beatriz Dolabela de Lima

المصدر: Biomolecules, Vol 10, Iss 790, p 790 (2020)
Biomolecules
Volume 10
Issue 5

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ba7e74ff9a20abc5d0476fdae1116d
https://www.mdpi.com/2218-273X/10/5/790

3

Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes

المؤلفون: Nilmar Silvio Moretti, Laura M. Alcântara, Milena Botelho Pereira Soares, Sergio Schenkman, Rino Ragno, Carolina B. Moraes, Lucio H. Freitas-Junior, Nicola Mautone, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Antonello Mai, Caio Haddad Franco, Tanira Matutino Bastos

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3659, p 3659 (2020)
Volume 21
Issue 10

مصطلحات موضوعية: 0301 basic medicine, deacetylation, sirtuins, Trypanosoma cruzi, sirtuin inhibitors, Pharmacology, 01 natural sciences, lcsh:Chemistry, lcsh:QH301-705.5, Spectroscopy, Phylogeny, media_common, chemistry.chemical_classification, biology, Group III Histone Deacetylases, Drug Synergism, General Medicine, Trypanocidal Agents, Recombinant Proteins, Computer Science Applications, Molecular Docking Simulation, Benznidazole, Nitroimidazoles, Sirtuin, medicine.drug, Chagas disease, Drug, media_common.quotation_subject, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Inhibitory Concentration 50, medicine, Animals, Chagas Disease, Physical and Theoretical Chemistry, Nifurtimox, Molecular Biology, 010405 organic chemistry, Organic Chemistry, Epithelial Cells, biology.organism_classification, medicine.disease, Macaca mulatta, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, lcsh:Biology (General), lcsh:QD1-999, biology.protein, NAD+ kinase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be24b0eb23df1cb4b5d68310a7131e38
http://hdl.handle.net/11573/1401342

4

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections

المؤلفون: Maria Kuzikov, Gesa Witt, Bruno dos Santos Pascoalino, Caio Haddad Franco, Luca Costantino, Rosaria Luciani, Laura M. Alcantara, Nuno Santarém, Sara Macedo, Antonio Quotadamo, Lucio H. Freitas-Junior, Bernhard Ellinger, Carolina B. Moraes, Stefania Ferrari, Maria Paola Costi, Sheraz Gul, Anabela Cordeiro-da-Silva, Pasquale Linciano

المساهمون: Publica

المصدر: European Journal of Medicinal Chemistry. 146:423-434

مصطلحات موضوعية: Thiosemicarbazones, 0301 basic medicine, Trypanosoma, Stereochemistry, hERG, Antiprotozoal Agents, Trypanosoma brucei, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Parasitic Sensitivity Tests, Thiadiazoles, Early-toxicity, Leishmania infantum, pan-anti-trypanosomatidic activity, Thiosemicarbazone, Trypanosoma cruzi, Pharmacology, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, parasitic diseases, Drug Discovery, medicine, Humans, Chagas Disease, Amastigote, Semicarbazone, Dose-Response Relationship, Drug, Molecular Structure, biology, Macrophages, General Medicine, biology.organism_classification, medicine.disease, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, Mitochondrial toxicity, 030104 developmental biology, chemistry, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebcff45eb81d168c200819955e00630
https://doi.org/10.1016/j.ejmech.2018.01.043

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5

A comparative study of warheads for design of cysteine protease inhibitors

المؤلفون: Caio Haddad Franco, Josmar R. Rocha, Carolina B. Moraes, Antonio C. B. Burtoloso, Daniel G. Silva, Daniela De Vita, Carlos A. Montanari, Peter W. Kenny, Andrei Leitão, Jean F. R. Ribeiro, Lorenzo Cianni, Lucio H. Freitas-Junior

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0301 basic medicine, Nitrile, Stereochemistry, Cathepsin L, Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, 01 natural sciences, Biochemistry, Aldehyde, Cyclopropane, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Nitriles, Drug Discovery, Potency, ALDEÍDOS, Molecular Biology, chemistry.chemical_classification, Dipeptide, Covalent inhibitor, Cysteine protease, Oxime, Warhead, Cysteine Endopeptidases, Dipeptides, Drug Design, Kinetics, 010405 organic chemistry, Organic Chemistry, Orders of magnitude (mass), 0104 chemical sciences, 030104 developmental biology, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a458345f2b22da4227d15e544da7adc
https://doi.org/10.1016/j.bmcl.2017.10.002

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6

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

المساهمون: Publica

المصدر: ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
'ACS Omega ', vol: 2, pages: 5666-5683 (2017)
Linciano, P, Dawson, A, Pöhner, I, Costa, D M, Sa, M S, Cordeiro-Da-Silva, A, Luciani, R, Gul, S, Witt, G, Ellinger, B, Kuzikov, M, Gribbon, P, Reinshagen, J, Wolf, M, Behrens, B, Hannaert, V, Michels, P A M, Nerini, E, Pozzi, C, Di Pisa, F, Landi, G, Santarem, N, Ferrari, S, Saxena, P, Lazzari, S, Cannazza, G, Freitas-Junior, L H, Moraes, C B, Pascoalino, B S, Alcantara, L M, Bertolacini, C P, Fontana, V, Wittig, U, Müller, W, Wade, R C, Hunter, W N, Mangani, S, Costantino, L & Costi, M P 2017, ' Exploiting the 2‑Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery ', ACS Omega, vol. 2, no. 9, pp. 5666-5683 . https://doi.org/10.1021/acsomega.7b00473

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28935a981ead5c6c4b6475eb3f00313c
https://doi.org/10.1021/acsomega.7b00473

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7

Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues

المؤلفون: Caio Haddad Franco, Lucio H. Freitas-Junior, Denize C. Favaro, Fredson Torres Silva, Elizabeth Igne Ferreira, Carolina B. Moraes

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c52ca13b182cc48528df23eeb4f888
https://doi.org/10.1016/j.ejmech.2016.04.065

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8

Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

المؤلفون: Lucio H. Freitas-Junior, Eric Chatelain, Carolina B. Moraes, Caio Haddad Franco, Laura M. Alcântara

المصدر: Tropical Medicine and Infectious Disease; Volume 4; Issue 2; Pages: 82
Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease, Vol 4, Iss 2, p 82 (2019)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6a0e1644904b7564f4337743ad5a36

9

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

المؤلفون: Lavínia Maria Dal'Mas Romera, Caio Haddad Franco, Ana Claudia Torrecilhas, Ho Y.A. Au, Carolina B. Moraes, Hai Le, Bruno dos Santos Pascoalino, Tapan Bhattacharyya, Miriam A. Giardini, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, David C. Warhurst, Michael A. Miles

المصدر: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss, Pp 107-120 (2020)

مصطلحات موضوعية: 0301 basic medicine, Chagas disease, Trypanosoma cruzi, 030231 tropical medicine, Genes, Protozoan, Clone (cell biology), Drug resistance, CYP51, Biology, Ravuconazole, Article, Microbiology, lcsh:Infectious and parasitic diseases, Cell Line, 03 medical and health sciences, Sterol 14-Demethylase, 0302 clinical medicine, medicine, Animals, Pharmacology (medical), lcsh:RC109-216, Chagas Disease, Nifurtimox, Pharmacology, Triazoles, biology.organism_classification, medicine.disease, Trypanocidal Agents, Drug Resistance, Multiple, Multiple drug resistance, Thiazoles, 030104 developmental biology, Infectious Diseases, Benznidazole, 14-alpha Demethylase Inhibitors, Nitroimidazoles, Mutation, Parasitology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07255fa405b4307071d0f14febe7a257
https://pubmed.ncbi.nlm.nih.gov/32688218

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10

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections

المؤلفون: Maria Kuzikov, Maria Laura Bolognesi, Federica Belluti, Andrea Mazzanti, Bernhard Ellinger, Chiara Borsari, Sheraz Gul, Elisa Uliassi, Maria Paola Costi, Lorna Piazzi, Lucio H. Freitas-Junior, Carolina B. Moraes, Reto Brun, Marcel Kaiser

المساهمون: Uliassi, Elisa, Piazzi, Lorna, Belluti, Federica, Mazzanti, Andrea, Kaiser, Marcel, Brun, Reto, Moraes, Carolina B., Freitas-Junior, Lucio H., Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura

المصدر: ChemMedChem. 13(7)

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, protozoan parasitic infection, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Parasitic Sensitivity Tests, Drug Discovery, Cytochrome P-450 Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, media_common, Leishmania, biology, Molecular Structure, Drug discovery, 3. Good health, Molecular Medicine, privileged scaffold, Drug, Trypanosoma, media_common.quotation_subject, hERG, Plasmodium falciparum, Triazole, Antiprotozoal Agents, Phenylpiperazine, phenotypic screening, privileged scaffolds, protozoan parasitic infections, Small Molecule Libraries, 03 medical and health sciences, Phenothiazine, Cell Line, Tumor, Potassium Channel Blockers, Animals, Humans, Pharmacology, 010405 organic chemistry, Organic Chemistry, Cytochrome P450, Triazoles, biology.organism_classification, 0104 chemical sciences, Rats, 030104 developmental biology, chemistry, Pharmacology, Toxicology and Pharmaceutics (all), biology.protein

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74178d7e85de8ea8ef92a162b1f6a825
https://pubmed.ncbi.nlm.nih.gov/29451361

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