نتائج البحث - "M. Abdullah Said"

المساهمون: Medical Informatics, Epidemiology, Internal Medicine, Weng, Lu-Chen [0000-0003-1475-4930], Hall, Amelia Weber [0000-0002-7915-0313], Tucker, Nathan R [0000-0002-5071-4218], Chaffin, Mark D [0000-0002-1234-5562], Roselli, Carolina [0000-0001-5267-6756], Barnes, Michael R [0000-0001-9097-7381], Mifsud, Borbala [0000-0003-3429-3094], Hayward, Caroline [0000-0002-9405-9550], Concas, Maria Pina [0000-0003-3598-2537], Boutin, Thibaud [0000-0003-4754-1675], Kolcic, Ivana [0000-0001-7918-6052], Rudan, Igor [0000-0001-6993-6884], Souza, Renan P [0000-0002-9479-4432], Giedraitis, Vilmantas [0000-0003-3423-2021], Ingelsson, Erik [0000-0003-2256-6972], Mahajan, Anubha [0000-0001-5585-3420], Morris, Andrew P [0000-0002-6805-6014], Hicks, Andrew A [0000-0001-6320-0411], Sundström, Johan [0000-0003-2247-8454], Nelson, Christopher P [0000-0001-8025-2897], Riaz, Muhammad B [0000-0002-5512-1745], Sinagra, Gianfranco [0000-0003-2700-8478], Mishra, Pashupati P [0000-0001-5177-3431], Caulfield, Mark J [0000-0001-9295-3594], Dominiczak, Anna [0000-0003-4913-3608], Risch, Lorenz [0000-0003-2692-6699], Joshi, Peter K [0000-0002-6361-5059], Wilson, James F [0000-0001-5751-9178], Isaacs, Aaron [0000-0001-5037-4834], van Duijn, Cornelia M [0000-0002-2374-9204], Gudnason, Vilmundur [0000-0001-5696-0084], Smith, Albert V [0000-0003-1942-5845], Loos, Ruth JF [0000-0002-8532-5087], Preuss, Michael H [0000-0001-5266-8465], Correa, Adolfo [0000-0002-9501-600X], Müller-Nurasyid, Martina [0000-0003-3793-5910], Waldenberger, Melanie [0000-0003-0583-5093], Mangino, Massimo [0000-0002-2167-7470], Rienstra, Michiel [0000-0002-2581-070X], van der Harst, Pim [0000-0002-2713-686X], Verweij, Niek [0000-0002-4303-7685], Fatkin, Diane [0000-0002-9010-9856], Brody, Jennifer A [0000-0001-8509-148X], Rice, Kenneth [0000-0002-3071-7278], Pattaro, Cristian [0000-0002-4119-0109], Wouter Jukema, J [0000-0002-3246-8359], Weiss, Stefan [0000-0002-3553-4315], Havulinna, Aki S [0000-0002-4787-8959], Sääksjärvi, Katri [0000-0002-5061-4911], Salomaa, Veikko [0000-0001-7563-5324], Rotter, Jerome I [0000-0001-7191-1723], Taylor, Kent D [0000-0002-2756-4370], Lakatta, Edward G [0000-0002-4772-0035], Lin, Honghuang [0000-0003-3043-3942], Lunetta, Kathryn L [0000-0002-9268-810X], Murray, Alison D [0000-0003-4915-4847], Porteous, David J [0000-0003-1249-6106], Smith, Blair H [0000-0002-5362-9430], Uitterlinden, André [0000-0002-7276-3387], Peters, Ulrike [0000-0001-5666-9318], Alonso, Alvaro [0000-0002-2225-8323], Ehret, Georg B [0000-0002-5730-0675], Soliman, Elsayed Z [0000-0001-5632-8150], Gogarten, Stephanie M [0000-0002-7231-9745], Kerr, Kathleen F [0000-0002-6438-9583], Abdullah Said, M [0000-0003-2920-7745], Orini, Michele [0000-0001-5773-0344], Ramirez, Julia [0000-0003-4130-5866], Van Duijvenboden, Stefan [0000-0001-8897-558X], Gudbjartsson, Daniel F [0000-0002-5222-9857], Sulem, Patrick [0000-0001-7123-6123], Thorolfsdottir, Rosa B [0000-0001-7475-0398], Benjamin, Emelia J [0000-0003-4076-2336], Stefansson, Kari [0000-0003-1676-864X], Ellinor, Patrick T [0000-0002-2067-0533], Jamshidi, Yalda [0000-0003-0151-6482], Lubitz, Steven A [0000-0002-9599-4866], Munroe, Patricia B [0000-0002-4176-2947], Apollo - University of Cambridge Repository, Medicum, Institute for Molecular Medicine Finland, Complex Disease Genetics, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Cardiovascular Centre (CVC), Ntalla, I., Weng, L. -C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O., Rudan, I., Araujo, N. M., Lima-Costa, M. F., Ribeiro, A. L. P., Souza, R. P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A. P., Del Greco M, F., Foco, L., Gogele, M., Hicks, A. A., Cook, J. P., Lind, L., Lindgren, C. M., Sundstrom, J., Nelson, C. P., Riaz, M. B., Samani, N. J., Sinagra, G., Ulivi, S., Kahonen, M., Mishra, P. P., Mononen, N., Nikus, K., Caulfield, M. J., Dominiczak, A., Padmanabhan, S., Montasser, M. E., O'Connell, J. R., Ryan, K., Shuldiner, A. R., Aeschbacher, S., Conen, D., Risch, L., Theriault, S., Hutri-Kahonen, N., Lehtimaki, T., Lyytikainen, L. -P., Raitakari, O. T., Barnes, C. L. K., Campbell, H., Joshi, P. K., Wilson, J. F., Isaacs, A., Kors, J. A., van Duijn, C. M., Huang, P. L., Gudnason, V., Harris, T. B., Launer, L. J., Smith, A. V., Bottinger, E. P., Loos, R. J. F., Nadkarni, G. N., Preuss, M. H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Muller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T. D., Rienstra, M., van de Vegte, Y. J., van der Harst, P., Verweij, N., Kaab, S., Schramm, K., Sinner, M. F., Strauch, K., Cutler, M. J., Fatkin, D., London, B., Olesen, M., Roden, D. M., Benjamin Shoemaker, M., Gustav Smith, J., Biggs, M. L., Bis, J. C., Brody, J. A., Psaty, B. M., Rice, K., Sotoodehnia, N., De Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P. P., Ford, I., Wouter Jukema, J., Macfarlane, P. W., Trompet, S., Dorr, M., Felix, S. B., Volker, U., Weiss, S., Havulinna, A. S., Jula, A., Saaksjarvi, K., Salomaa, V., Guo, X., Heckbert, S. R., Lin, H. J., Rotter, J. I., Taylor, K. D., Yao, J., de Mutsert, R., Maan, A. C., Mook-Kanamori, D. O., Noordam, R., Cucca, F., Ding, J., Lakatta, E. G., Qian, Y., Tarasov, K. V., Levy, D., Lin, H., Newton-Cheh, C. H., Lunetta, K. L., Murray, A. D., Porteous, D. J., Smith, B. H., Stricker, B. H., Uitterlinden, A., van den Berg, M. E., Haessler, J., Jackson, R. D., Kooperberg, C., Peters, U., Reiner, A. P., Whitsel, E. A., Alonso, A., Arking, D. E., Boerwinkle, E., Ehret, G. B., Soliman, E. Z., Avery, C. L., Gogarten, S. M., Kerr, K. F., Laurie, C. C., Seyerle, A. A., Stilp, A., Assa, S., Abdullah Said, M., Yldau van der Ende, M., Lambiase, P. D., Orini, M., Ramirez, J., Van Duijvenboden, S., Arnar, D. O., Gudbjartsson, D. F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R. B., Thorsteinsdottir, U., Benjamin, E. J., Tinker, A., Stefansson, K., Ellinor, P. T., Jamshidi, Y., Lubitz, S. A., Munroe, P. B., Fysiologie, RS: FHML MaCSBio, RS: Carim - B01 Blood proteins & engineering, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Verkfræði- og náttúruvísindasvið (HÍ), School of Engineering and Natural Sciences (UI), Háskóli Íslands, University of Iceland

المصدر: Nature Communications, 11(1). Nature Publishing Group
Nature Communications, 11(1):2542. Nature Publishing Group
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 11(1). NATURE PUBLISHING GROUP
Ntalla, I, Weng, L-C, Cartwright, J H, Hall, A W, Sveinbjornsson, G, Tucker, N R, Choi, S H, Chaffin, M D, Roselli, C, Barnes, M R, Mifsud, B, Warren, H R, Hayward, C, Marten, J, Cranley, J J, Concas, M P, Gasparini, P, Boutin, T, Kolcic, I, Rudan, I, Araujo, N M, Lima-Costa, M F, Ribeiro, A L P, Souza, R P, Tarazona-Santos, E, Giedraitis, V, Ingelsson, E, Mahajan, A, Morris, A P, Del Greco M, F, Foco, L, Gögele, M, Hicks, A A, Lind, L, Lindgren, C M, Sundström, J, Nelson, C P, Riaz, M B, Samani, N J, Sinagra, G, Ulivi, S, Kähönen, M, Mishra, P P, Mononen, N, Nikus, K, Caulfield, M J, Dominiczak, A, Padmanabhan, S, Montasser, M E, O'Connell, J R, Ryan, K, Shuldiner, A R, Aeschbacher, S, Conen, D, Risch, L, Thériault, S, Hutri-Kähönen, N, Lehtimäki, T, Lyytikäinen, L-P, Raitakari, O T, Barnes, C L K, Campbell, H, Joshi, P K, Wilson, J, Isaacs, A, Kors, J A, van Duijn, C M, Huang, P L, Gudnason, V, Harris, T B, Launer, L J, Smith, A V, Bottinger, E P, Loos, R J F, Nadkarni, G N, Preuss, M H, Correa, A, Mei, H, Wilson, J, Meitinger, T, Müller-Nurasyid, M, Peters, A, Waldenberger, M, Mangino, M, Spector, T D, Rienstra, M, van de Vegte, Y J, van der Harst, P, Verweij, N, Kääb, S, Schramm, K, Sinner, M F, Strauch, K, Cutler, M J, Fatkin, D, London, B, Olesen, M, Roden, D M, Benjamin Shoemaker, M, Gustav Smith, J, Biggs, M L, Bis, J C, Brody, J A, Psaty, B M, Rice, K, Sotoodehnia, N, De Grandi, A, Fuchsberger, C, Pattaro, C, Pramstaller, P P, Ford, I, Wouter Jukema, J, Macfarlane, P W, Trompet, S, Dörr, M, Felix, S B, Völker, U, Weiss, S, Havulinna, A S, Jula, A, Sääksjärvi, K, Salomaa, V, Guo, X, Heckbert, S R, Lin, H J, Rotter, J I, Taylor, K D, Yao, J, de Mutsert, R, Maan, A C, Mook-Kanamori, D O, Noordam, R, Cucca, F, Ding, J, Lakatta, E G, Qian, Y, Tarasov, K V, Levy, D, Lin, H, Newton-Cheh, C H, Lunetta, K L, Murray, A D, Porteous, D J, Smith, B H, Stricker, B H, Uitterlinden, A, van den Berg, M E, Haessler, J, Jackson, R D, Kooperberg, C, Peters, U, Reiner, A P, Whitsel, E A, Alonso, A, Arking, D E, Boerwinkle, E, Ehret, G B, Soliman, E Z, Avery, C L, Gogarten, S M, Kerr, K F, Laurie, C C, Seyerle, A A, Stilp, A, Assa, S, Abdullah Said, M, Yldau van der Ende, M, Lambiase, P D, Orini, M, Ramirez, J, Van Duijvenboden, S, Arnar, D O, Gudbjartsson, D F, Holm, H, Sulem, P, Thorleifsson, G, Thorolfsdottir, R B, Thorsteinsdottir, U, Benjamin, E J, Tinker, A, Stefansson, K, Ellinor, P T, Jamshidi, Y, Lubitz, S A & Munroe, P B 2020, ' Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction ', Nature Communications, vol. 11, no. 1, pp. 2542 . https://doi.org/10.1038/s41467-020-15706-x
Ntalla, I, Weng, L C, Cartwright, J H, Hall, A W, Sveinbjornsson, G, Tucker, N R, Choi, S H, Chaffin, M D, Roselli, C, Barnes, M R, Mifsud, B, Warren, H R, Hayward, C, Marten, J, Cranley, J J, Concas, M P, Gasparini, P, Boutin, T, Kolcic, I, Polasek, O, Rudan, I, Araujo, N M, Lima-Costa, M F, Ribeiro, A L P, Souza, R P, Tarazona-Santos, E, Giedraitis, V, Ingelsson, E, Mahajan, A, Morris, A P, Del Greco M, F, Foco, L, Gögele, M, Hicks, A A, Cook, J P, Lind, L, Lindgren, C M, Sundström, J, Nelson, C P, Riaz, M B, Samani, N J, Sinagra, G, Ulivi, S, Kähönen, M, Mishra, P P, Mononen, N, Nikus, K, Caulfield, M J, Dominiczak, A, Padmanabhan, S, Montasser, M E, O’Connell, J R, Ryan, K, Shuldiner, A R, Aeschbacher, S, Conen, D, Risch, L, Thériault, S, Hutri-Kähönen, N, Lehtimäki, T, Lyytikäinen, L P, Raitakari, O T, Barnes, C L K, Campbell, H, Joshi, P K, Wilson, J F, Isaacs, A, Kors, J A, van Duijn, C M, Huang, P L, Gudnason, V, Harris, T B, Launer, L J, Smith, A V, Bottinger, E P, Loos, R J F, Nadkarni, G N, Preuss, M H, Correa, A, Mei, H, Wilson, J, Meitinger, T, Müller-Nurasyid, M, Peters, A, Waldenberger, M, Mangino, M, Spector, T D, Rienstra, M, van de Vegte, Y J, van der Harst, P, Verweij, N, Kääb, S, Schramm, K, Sinner, M F, Strauch, K, Cutler, M J, Fatkin, D, London, B, Olesen, M, Roden, D M, Benjamin Shoemaker, M, Gustav Smith, J, Biggs, M L, Bis, J C, Brody, J A, Psaty, B M, Rice, K, Sotoodehnia, N, De Grandi, A, Fuchsberger, C, Pattaro, C, Pramstaller, P P, Ford, I, Wouter Jukema, J, Macfarlane, P W, Trompet, S, Dörr, M, Felix, S B, Völker, U, Weiss, S, Havulinna, A S, Jula, A, Sääksjärvi, K, Salomaa, V, Guo, X, Heckbert, S R, Lin, H J, Rotter, J I, Taylor, K D, Yao, J, de Mutsert, R, Maan, A C, Mook-Kanamori, D O, Noordam, R, Cucca, F, Ding, J, Lakatta, E G, Qian, Y, Tarasov, K V, Levy, D, Lin, H, Newton-Cheh, C H, Lunetta, K L, Murray, A D, Porteous, D J, Smith, B H, Stricker, B H, Uitterlinden, A, van den Berg, M E, Haessler, J, Jackson, R D, Kooperberg, C, Peters, U, Reiner, A P, Whitsel, E A, Alonso, A, Arking, D E, Boerwinkle, E, Ehret, G B, Soliman, E Z, Avery, C L, Gogarten, S M, Kerr, K F, Laurie, C C, Seyerle, A A, Stilp, A, Assa, S, Abdullah Said, M, Yldau van der Ende, M, Lambiase, P D, Orini, M, Ramirez, J, Van Duijvenboden, S, Arnar, D O, Gudbjartsson, D F, Holm, H, Sulem, P, Thorleifsson, G, Thorolfsdottir, R B, Thorsteinsdottir, U, Benjamin, E J, Tinker, A, Stefansson, K, Ellinor, P T, Jamshidi, Y, Lubitz, S A & Munroe, P B 2020, ' Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction ', Nature Communications, vol. 11, no. 1, 2542 . https://doi.org/10.1038/s41467-020-15706-x
Ntalla, I, Weng, L-C, Cartwright, J H, Hall, A W, Sveinbjornsson, G, Tucker, N R, Choi, S H, Chaffin, M D, Roselli, C, Barnes, M R, Mifsud, B, Warren, H R, Hayward, C, Marten, J, Cranley, J J, Concas, M P, Gasparini, P, Boutin, T, Kolcic, I, Polasek, O, Rudan, I, Araujo, N M, Lima-Costa, M F, Ribeiro, A L P, Souza, R P, Tarazona-Santos, E, Giedraitis, V, Ingelsson, E, Mahajan, A, Morris, A P, Del Greco M, F, Foco, L, Gögele, M, Hicks, A A, Cook, J P, Lind, L, Lindgren, C M, Sundström, J, Nelson, C P, Riaz, M B, Samani, N J, Sinagra, G, Ulivi, S, Kähönen, M, Mishra, P P, Mononen, N, Nikus, K, Caulfield, M J, Dominiczak, A, Padmanabhan, S, Montasser, M E, O'Connell, J R, Ryan, K, Shuldiner, A R, Aeschbacher, S, Conen, D, Risch, L, Thériault, S, Hutri-Kähönen, N, Lehtimäki, T, Lyytikäinen, L-P, Raitakari, O T, Barnes, C L K, Campbell, H, Joshi, P K, Wilson, J F, Isaacs, A, Kors, J A, van Duijn, C M, Huang, P L, Gudnason, V, Harris, T B, Launer, L J, Smith, A V, Bottinger, E P, Loos, R J F, Nadkarni, G N, Preuss, M H, Correa, A, Mei, H, Wilson, J, Meitinger, T, Müller-Nurasyid, M, Peters, A, Waldenberger, M, Mangino, M, Spector, T D, Rienstra, M, van de Vegte, Y J, van der Harst, P, Verweij, N, Kääb, S, Schramm, K, Sinner, M F, Strauch, K, Cutler, M J, Fatkin, D, London, B, Olesen, M, Roden, D M, Benjamin Shoemaker, M, Gustav Smith, J, Biggs, M L, Bis, J C, Brody, J A, Psaty, B M, Rice, K, Sotoodehnia, N, De Grandi, A, Fuchsberger, C, Pattaro, C, Pramstaller, P P, Ford, I, Wouter Jukema, J, Macfarlane, P W, Trompet, S, Dörr, M, Felix, S B, Völker, U, Weiss, S, Havulinna, A S, Jula, A, Sääksjärvi, K, Salomaa, V, Guo, X, Heckbert, S R, Lin, H J, Rotter, J I, Taylor, K D, Yao, J, de Mutsert, R, Maan, A C, Mook-Kanamori, D O, Noordam, R, Cucca, F, Ding, J, Lakatta, E G, Qian, Y, Tarasov, K V, Levy, D, Lin, H, Newton-Cheh, C H, Lunetta, K L, Murray, A D, Porteous, D J, Smith, B H, Stricker, B H, Uitterlinden, A, van den Berg, M E, Haessler, J, Jackson, R D, Kooperberg, C, Peters, U, Reiner, A P, Whitsel, E A, Alonso, A, Arking, D E, Boerwinkle, E, Ehret, G B, Soliman, E Z, Avery, C L, Gogarten, S M, Kerr, K F, Laurie, C C, Seyerle, A A, Stilp, A, Assa, S, Abdullah Said, M, Yldau van der Ende, M, Lambiase, P D, Orini, M, Ramirez, J, Van Duijvenboden, S, Arnar, D O, Gudbjartsson, D F, Holm, H, Sulem, P, Thorleifsson, G, Thorolfsdottir, R B, Thorsteinsdottir, U, Benjamin, E J, Tinker, A, Stefansson, K, Ellinor, P T, Jamshidi, Y, Lubitz, S A & Munroe, P B 2020, ' Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction ', Nature Communications, vol. 11, no. 1, pp. 2542 . https://doi.org/10.1038/s41467-020-15706-x

مصطلحات موضوعية: 0301 basic medicine, Male, Multifactorial Inheritance, General Physics and Astronomy, Gene Expression, Genome-wide association study, 030204 cardiovascular system & hematology, Arrhythmias, Genome-wide association studies, CALCINEURIN, Electrocardiography, 0302 clinical medicine, Cardiovascular Disease, Multi-ancestry GWAS, ELEMENTS, Medicine, Cardiac and Cardiovascular Systems, Blóðrásarsjúkdómar, lcsh:Science, RISK, DECREASE, education.field_of_study, Multidisciplinary, Kardiologi, medicine.diagnostic_test, 1184 Genetics, developmental biology, physiology, Atrial fibrillation, 3142 Public health care science, environmental and occupational health, 3. Good health, Endophenotype, Arrhythmias, Cardiac, Cardiovascular Diseases, Endophenotypes, Female, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Quantitative Trait Loci, cardiovascular system, Cardiology, medicine.symptom, Erfðarannsóknir, Cardiac, Medical Genetics, Human, Bradycardia, medicine.medical_specialty, Science, GENOME-WIDE ASSOCIATION, ATRIAL-FIBRILLATION, MUTATIONS, DURATION, CARDIOMYOPATHY, BRADYCARDIA, Population, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Internal medicine, Cardiac conduction, PR interval, education, Medicinsk genetik, business.industry, Cardiovascular genetics, General Chemistry, Arfgengi, medicine.disease, 030104 developmental biology, lcsh:Q, business

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https://doi.org/10.1038/s41467-020-15706-x

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5

Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment

المؤلفون: Niek Verweij, Chris H. L. Thio, Hilde E. Groot, M. Abdullah Said, Harold Snieder, Peter J. van der Most, Yordi J. van de Vegte, Pim van der Harst, Siqi Wang

المساهمون: Life Course Epidemiology (LCE), Cardiovascular Centre (CVC)

المصدر: Genes
Genes, Vol 12, Iss 1174, p 1174 (2021)
Volume 12
Issue 8
Genes, 12(8):1174, 1-13. MDPI AG

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Untranslated region, UK Biobank, Quantitative Trait Loci, heart failure, Single-nucleotide polymorphism, QH426-470, 030204 cardiovascular system & hematology, Biology, Polymorphism, Single Nucleotide, CARDIOVASCULAR OUTCOMES, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, HBA1C, Genetics, Humans, Missense mutation, Sodium-Glucose Transporter 2 Inhibitors, Gene, Genetics (clinical), Glycated Hemoglobin, RISK, genetic variants, EMPAGLIFLOZIN, Genetic Variation, SGLT2 inhibitor, ASSOCIATION, Middle Aged, POTASSIUM, Renal glucose reabsorption, SODIUM, Minor allele frequency, 030104 developmental biology, chemistry, Female, Glycated hemoglobin, SGLT2 Inhibitor

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https://doi.org/10.3390/genes12081174

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6

Lipidomics, Atrial Conduction, and Body Mass Index Evidence From Association, Mediation, and Mendelian Randomization Models

المساهمون: Erasmus MC other, Epidemiology, Del Greco M, F, Foco, L, Teumer, A, Verweij, N, Paglia, G, Meraviglia, V, Melotti, R, Vukovic, V, Rauhe, W, Joshi, P, Demirkan, A, Felix, S, Pietzner, M, Said, M, van de Vegte, Y, van der Harst, P, Wright, A, Hicks, A, Campbell, H, Dorr, M, Snieder, H, Wilson, J, Pramstaller, P, Rossini, A, Pattaro, C

المصدر: Circulation-Genomic and Precision Medicine, 12(7). Lippincott Williams & Wilkins
Del Greco, F M, Foco, L, Teumer, A, Verweij, N, Paglia, G, Meraviglia, V, Melotti, R, Vukovic, V, Rauhe, W, Joshi, P, Demirkan, A, Campbell, H & Wilson, J 2019, ' Lipidomics, atrial conduction, and body mass index: evidence from association, mediation, and Mendelian randomization models ', Circulation: Genomic and Precision Medicine, vol. 12, no. 7 . https://doi.org/10.1161/CIRCGEN.118.002384

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https://pure.eur.nl/en/publications/1ef78bde-9650-45f9-be48-0ec4286a08b8

7

Genetically Determined Physical Activity and Its Association with Circulating Blood Cells

المؤلفون: Niek Verweij, Yordi J. van de Vegte, Femke M. Prins, Pim van der Harst, Hilde E. Groot, M. Abdullah Said

المساهمون: Cardiovascular Centre (CVC)

المصدر: Genes
Volume 10
Issue 11
Genes, 10(11):908. MDPI AG
Genes, Vol 10, Iss 11, p 908 (2019)

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, lcsh:QH426-470, Physical activity, physical activity, Inflammation, Single-nucleotide polymorphism, Disease, Systemic inflammation, Polymorphism, Single Nucleotide, Article, single nucleotide polymorphisms, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Eosinophilia, Mendelian randomization, Genetics, medicine, Humans, Exercise, Genetics (clinical), Aged, business.industry, Mendelian Randomization Analysis, Middle Aged, Blood Cell Count, blood cell counts, lcsh:Genetics, 030104 developmental biology, Increased risk, Endocrinology, inflammation, Female, medicine.symptom, business, 030217 neurology & neurosurgery

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https://doi.org/10.3390/genes10110908

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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

المؤلفون: Rico Rueedi, Yuri Milaneschi, Brenda W.J.H. Penninx, Neil Poulter, Karen Schwander, Marco Brumat, Kenneth Rice, Yize Li, Veronique Vitart, Ioanna Ntalla, Michele K. Evans, Jeffrey R. O'Connell, Nilesh J. Samani, Colleen M. Sitlani, W. James Gauderman, Xuan Deng, Paul M. Ridker, Yun J. Sung, Yukihide Momozawa, Archie Campbell, Tin Louie, Nona Sotoodehnia, Yii-Der Ida Chen, Cornelia M. van Duijn, Tanika N. Kelly, Peter S. Sever, André G. Uitterlinden, Brigitte Kühnel, John M. Starr, Lawrence F. Bielak, Christopher P. Nelson, Wanqing Wen, Stephan B. Felix, Stefan Weiss, Daniel Levy, Nicholette D. Palmer, Alisa K. Manning, Salman M. Tajuddin, Jill M. Norris, Marie Loh, M. Abdullah Said, Alena Stančáková, Anuradhani Kasturiratne, John M. C. Connell, Jian'an Luan, Tuomas O. Kilpeläinen, Amy R. Bentley, Stephen Sidney, Alan B. Zonderman, Karin Leander, David J. Porteous, Jianjun Liu, Tin Aung, Charles B. Eaton, Sharon L.R. Kardia, Rajkumar Dorajoo, Stephen Turner, Michael Boehnke, Diane M. Becker, Cora E. Lewis, Ozren Polasek, Mickaël Canouil, Kurt Lohman, Georg Ehret, Sarah E. Harris, Robert A. Scott, Claude Bouchard, Lynne E. Wagenknecht, Mohsen Ghanbari, Stephen B. Kritchevsky, Jin-Fang Chai, Gregory L. Burke, Jiang He, Federica Laguzzi, Michael R. Brown, Walter Palmas, Lili Milani, Thomas T. Perls, Tibor V. Varga, José Eduardo Krieger, Erin B. Ware, Tamara B. Harris, Tomohiro Katsuya, Nicole Schupf, Mika Kähönen, Nana Matoba, Hugues Aschard, Ilaria Gandin, Jennifer A. Smith, Traci M. Bartz, James Scott, Tuomo Rankinen, Yuan Shi, Meian He, Timo A. Lakka, Helen R. Warren, Mike A. Nalls, Kent D. Taylor, Woon-Puay Koh, Ya Xing Wang, Muhammad Riaz, Sandosh Padmanabhan, Mary F. Feitosa, Jost B. Jonas, Paul Elliott, Christian Gieger, Terho Lehtimäki, Kaare Christensen, Maris Alver, Pirjo Komulainen, Pamela J. Schreiner, M. Arfan Ikram, David R. Weir, Charles Kooperberg, Oscar H. Franco, Yongmei Liu, Lisa de las Fuentes, Nancy L. Pedersen, Thomas W. Winkler, Bruna Gigante, Göran Hallmans, Ingrid B. Borecki, Shiow Lin, Ian J. Deary, Wei Zheng, Yajuan Wang, Bernardo L. Horta, Heather M. Stringham, Bruce M. Psaty, Paul W. Franks, Weihua Zhang, Nora Franceschini, Adolfo Correa, Nita G. Forouhi, Xiuqing Guo, Fumihiko Takeuchi, L. Adrienne Cupples, William R. Scott, Zoltán Kutalik, He Gao, Nicholas J. Wareham, E. Shyong Tai, Aravinda Chakravarti, C. Charles Gu, Paolo Gasparini, Albertine J. Oldehinkel, Xueling Sim, Norihiro Kato, Evangelos Evangelou, Philippe Froguel, Colin A. McKenzie, Qing Duan, Aldi T. Kraja, Carsten Oliver Schmidt, Bamidele O. Tayo, Xiaofeng Zhu, Thomas Meitinger, Mary K. Wojczynski, Markku Laakso, Mark J. Caulfield, Carl D. Langefeld, Jingzhong Ding, Yechiel Friedlander, Tien Yin Wong, Virginia Fisher, Raymond Noordam, Caizheng Yu, Pim van der Harst, Yik Ying Teo, Ervin R. Fox, Sabanayagam Charumathi, Jonathan Marten, Nicholas Y.Q. Tan, Jerome I. Rotter, Harold Snieder, Karen L. Mohlke, Christine Williams, Olli T. Raitakari, Renée de Mutsert, Lihua Wang, Kathryn Roll, Jingmin Liu, Dongfeng Gu, Wei Zhao, Lynda M. Rose, Michael A. Province, Fernando Pires Hartwig, Rob M. van Dam, Barry I. Freedman, Andres Metspalu, Donald W. Bowden, Andrea R. V. R. Horimoto, Martin Farrall, Frits R. Rosendaal, Rainer Rauramaa, Konstantin Strauch, Albert V. Smith, Yanick Hagemeijer, Michiaki Kubo, Ilja M. Nolte, Tõnu Esko, Yih Chung Tham, Cathy C. Laurie, Antonietta Robino, Anne U. Jackson, Chuan Gao, Dabeeru C. Rao, Xiao-Ou Shu, H. Janaka de Silva, Morris J. Brown, Alanna C. Morrison, Peter J. van der Most, Jian-Min Yuan, Melanie Waldenberger, Leslie J. Raffel, Ulrich John, Fang-Chi Hsu, Reedik Mägi, Solomon K. Musani, Chiea Chuen Khor, Mario Sims, Ruben N. Eppinga, Melissa A. Richard, Yoichiro Kamatani, Changwei Li, Qiuyin Cai, Daniel I. Chasman, Mathilde Boissel, Claudia Langenberg, Sami Heikkinen, Jasmin Divers, Saima Afaq, Wen Bin Wei, Jaspal S. Kooner, Terrence Forrester, Hua Tang, Charles N. Rotimi, Anuj Goel, Annette Peters, Tangchun Wu, Dennis O. Mook-Kanamori, Caroline Hayward, Ching-Yu Cheng, Lisa R. Yanek, Ananda R. Wickremasinghe, Chew-Kiat Heng, Myriam Fornage, Dina Vojinovic, Najaf Amin, Lenore J. Launer, Hugh Watkins, Johanna Kuusisto, Jing Hua Zhao, Barbara V. Howard, Vilmundur Gudnason, Ulrich Broeckel, Eric Boerwinkle, Saskia P. Hagenaars, Dan E. Arking, Peter Vollenweider, Alexandre C. Pereira, Jie Yao, Makoto Hirata, Patricia B. Munroe, Patricia A. Peyser, Jessica D. Faul, Xu Chen, Patrik K. E. Magnusson, John C. Chambers, Tamar Sofer, Marzyeh Amini, Benjamin Lehne

المساهمون: Epidemiology, Erasmus MC other, Neurology, Radiology & Nuclear Medicine, Internal Medicine, Læknadeild (HÍ), Faculty of Medicine (UI), School of Health Sciences (UI), Heilbrigðisvísindasvið (HÍ), Háskóli Íslands (HÍ), University of Iceland (UI), Life Course Epidemiology (LCE), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Cardiovascular Centre (CVC), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Brigham and Women's Hospital [Boston], Harvard Medical School [Boston] (HMS), University of Regensburg, Queen Mary University of London (QMUL), Harbor UCLA Medical Center [Torrance, Ca.], Department of Epidemiology, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC)-UNC Gillings School of Global Public Health-Carolina Center for Genome Sciences, Northwestern Polytechnical University [Xi'an] (NPU), Centre for Molecular Epidemiology, National University of Singapore (NUS), Harvard School of Public Health, Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), European Genomic Institute for Diabetes - FR 3508 (EGID), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), National Institutes of Health [Bethesda] (NIH), The following authors declare commercial private and/or governmental affiliations: Bruce M. Psaty (BMP) serves on the DSMB of a clinical trial funded by Zoll Lifecor and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. Barbara V. Howard (BVH) has a contract from National Heart, Lung, and Blood Institute (NHLBI). Brenda W.J.H. Penninx (BWJHP) has received research funding (non-related to the work reported here) from Jansen Research and Boehringer Ingelheim. Mike A. Nalls (MAN) is supported by a consulting contract between Data Tecnica International LLC and the National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD, USA. MAN also consults for Illumina Inc., the Michael J. Fox Foundation, and the University of California Healthcare. MAN also has commercial affiliation with Data Tecnica International, Glen Echo, MD, USA. Mark J. Caulfield (MJC) has commercial affiliation and is Chief Scientist for Genomics England, a UK government company. Oscar H Franco (OHF) is supported by grants from Metagenics (on women's health and epigenetics) and from Nestlé (on child health). Peter S. Sever (PSS) is financial supported from several pharmaceutical companies which manufacture either blood pressure lowering or lipid lowering agents, or both, and consultancy fees. Paul W. Franks (PWF) has been a paid consultant in the design of a personalized nutrition trial (PREDICT) as part of a private-public partnership at Kings College London, UK, and has received research support from several pharmaceutical companies as part of European Union Innovative Medicines Initiative (IMI) projects. Fimlab LTD provided support in the form of salaries for author Terho Lehtimäki (TL) but did not have any additional role in the study design to publish, or preparation of the manuscript. Gen‐info Ltd provided support in the form of salaries for author Ozren Polašek (OP) but did not have any additional role in the study design to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. There are no patents, products in development, or marked products to declare. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., AGES (Age Gene/Environment Susceptibility Reykjavik Study) is approved by the Icelandic National Bioethics Committee, VSN: 00–063. The researchers are indebted to the participants for their willingness to participate in the study. ARIC (Atherosclerosis Risk in Communities): The authors thank the staff and participants of the ARIC study for their important contributions. CARDIA (Coronary Artery Risk Development in Young Adults): This manuscript has been reviewed and approved by CARDIA for scientific content. CHS (Cardiovascular Health Study): A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. IGMM (Institute of Genetics and Molecular Medicine): CROATIA-Korcula: We would like to acknowledge the staff of several institutions in Croatia that supported the field work, including but not limited to The University of Split and Zagreb Medical Schools and the Croatian Institute for Public Health. We would like to acknowledge the invaluable contributions of the recruitment team in Korcula, the administrative teams in Croatia and Edinburgh and the participants. The SNP genotyping for the CROATIA-Korcula cohort was performed in Helmholtz Zentrum München, Neuherberg, Germany. CROATIA-Vis: We would like to acknowledge the staff of several institutions in Croatia that supported the field work, including but not limited to The University of Split and Zagreb Medical Schools, the Institute for Anthropological Research in Zagreb and Croatian Institute for Public Health. The SNP genotyping for the CROATIA-Vis cohort was performed in the core genotyping laboratory of the Wellcome Trust Clinical Research Facility at the Western General Hospital, Edinburgh, Scotland. GS:SFHS: Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland. ERF (Erasmus Rucphen Family study): We are grateful to all study participants and their relatives, general practitioners and neurologists for their contributions and to P. Veraart for her help in genealogy, J. Vergeer for the supervision of the laboratory work, P. Snijders for his help in data collection and E.M. van Leeuwen for genetic imputation. GENOA (Genetic Epidemiology Network of Arteriopathy): Genotyping was performed at the Mayo Clinic (Stephen T. Turner, MD, Mariza de Andrade PhD, Julie Cunningham, PhD). We thank Eric Boerwinkle, PhD and Megan L. Grove from the Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, Texas, USA for their help with genotyping. We would also like to thank the families that participated in the GENOA study. HANDLS (Healthy Aging in Neighborhoods of Diversity across the Life Span): Data analyses for the HANDLS study utilized the high-performance computational resources of the Biowulf Linux cluster at the National Institutes of Health, Bethesda, MD. http://hpc.nih.gov HUFS (Howard University Family Study): We thank the participants of the study. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official view of the National Institutes of Health. HyperGEN (Hypertension Genetic Epidemiology Network): The study involves: University of Utah: (Network Coordinating Center, Field Center, and Molecular Genetics Lab), Univ. of Alabama at Birmingham: (Field Center and Echo Coordinating and Analysis Center), Medical College of Wisconsin: (Echo Genotyping Lab), Boston University: (Field Center), University of Minnesota: (Field Center and Biochemistry Lab), University of North Carolina: (Field Center), Washington University: (Data Coordinating Center), Weil Cornell Medical College: (Echo Reading Center), National Heart, Lung, & Blood Institute. For a complete list of HyperGEN Investigators: http://www.biostat.wustl.edu/hypergen/Acknowledge.html JHS (Jackson Heart Study): The authors wish to thank the staffs and participants of the JHS. MESA (Multi-Ethnic Study of Atherosclerosis): MESA and the MESA SHARe project are conducted in collaboration with MESA investigators. Genotyping was performed at Affymetrix (Santa Clara, California, USA) and the Broad Institute of Harvard and MIT (Boston, Massachusetts, USA) using the Affymetrix Genome-Wide Human SNP Array 6.0. NEO (The Netherlands Epidemiology of Obesity study): The authors of the NEO study thank all individuals who participated in the Netherlands Epidemiology in Obesity study, all participating general practitioners for inviting eligible participants and all research nurses for collection of the data. We thank the NEO study group, Petra Noordijk, Pat van Beelen and Ingeborg de Jonge for the coordination, lab and data management of the NEO study. RS (Rotterdam Study) was funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. The authors are grateful to the study participants, the staff from the Rotterdam Study and the participating general practitioners and pharmacists. The generation and management of GWAS genotype data for the Rotterdam Study was executed by the Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. We thank Pascal Arp, Mila Jhamai, Marijn Verkerk, Lizbeth Herrera, Marjolein Peters and Carolina Medina-Gomez for their help in creating the GWAS database, and Karol Estrada, Yurii Aulchenko and Carolina Medina-Gomez for the creation and analysis of imputed data. WHI (Women’s Health Initiative): The authors thank the WHI investigators and staff for their dedication, and the study participants for making the program possible. A full listing of WHI investigators can be found at: http://www.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Short%20List.pdf Replication: AA-DHS (African American Diabetes Heart Study): The investigators acknowledge the cooperation of our Diabetes Heart Study (DHS) and AA-DHS participants. ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial): We thank all ASCOT trial participants, physicians, nurses, and practices in the participating countries for their important contribution to the study. In particular, we thank Clare Muckian and David Toomey for their help in DNA extraction, storage, and handling. We would also like to acknowledge the Barts and The London Genome Centre staff for genotyping the Exome chip array. P.B.M, M.J.C and H.R.W wish to acknowledge the support of the NIHR Cardiovascular Biomedical Research Centre at Barts and Queen Mary University of London, UK. BBJ (Biobank Japan Project): We thank all the participants, medical coordinators of the cooperating hospitals for collecting samples and clinical information in the project. BRIGHT (British Genetics of Hypertension): The BRIGHT study is extremely grateful to all the patients who participated in the study and the BRIGHT nursing team. P.B.M, M.J.C and H.R.W wish to acknowledge the support of the NIHR Cardiovascular Biomedical Research Centre at Barts and Queen Mary University of London, UK. CoLaus (Cohorte Lausannoise Study): The authors would like to thank all the people who participated in the recruitment of the participants, data collection and validation, particularly Nicole Bonvin, Yolande Barreau, Mathieu Firmann, François Bastardot, Julien Vaucher, Panagiotis Antiochos and Cédric Gubelmann. DESIR (Data from an Epidemiological Study on the Insulin Resistance): The DESIR Study Group is composed of Inserm-U1018 (Paris: B. Balkau, P. Ducimetière, E. Eschwège), Inserm-U367 (Paris: F. Alhenc-Gelas), CHU d’Angers (A. Girault), Bichat Hospital (Paris: F. Fumeron, M. Marre, R. Roussel), CHU de Rennes (F. Bonnet), CNRS UMR-8199 (Lille: A. Bonnefond, P. Froguel), Medical Examination Services (Alençon, Angers, Blois, Caen, Chartres, Chateauroux, Cholet, LeMans, Orléans and Tours), Research Institute for General Medicine (J. Cogneau), the general practitioners of the region and the Cross- Regional Institute for Health (C. Born, E. Caces, M. Cailleau, N. Copin, J.G. Moreau, F. Rakotozafy, J. Tichet, S. Vol). DHS (Diabetes Heart Study): The authors thank the investigators, staff, and participants of the DHS for their valuable contributions. EGCUT Estonian Genome Center—University of Tartu (Estonian Biobank): Data analyzes were carried out in part in the High Performance Computing Center of University of Tartu. EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk: We thank all EPIC participants and staff for their contribution to the study. FENLAND (The Fenland Study): We are grateful to all the volunteers for their time and help, and to the General Practitioners and practice staff for assistance with recruitment. We thank the Fenland Study Investigators, Fenland Study Co-ordination team and the Epidemiology Field, Data and Laboratory teams. We further acknowledge support from the Medical research council (MC_UU_12015/1). GeneSTAR (Genetic Studies of Atherosclerosis Risk): We are very grateful to all of our participants for their long-term involvement. GLACIER (Gene x Lifestyle Interactions and Complex Traits Involved in Elevated Disease Risk): We thank the participants, health professionals and data managers involved in the Västerbottens Intervention Project. We are also grateful to the staff of the Northern Sweden Biobank for preparing materials and to K Enqvist and T Johansson (Västerbottens County Council, Umeå, Sweden) for DNA preparation. HCHS/SOL (Hispanic Community Health Study/Study of Latinos): We thank the participants and staff of the HCHS/SOL study for their contributions to this study. HRS (Health & Retirement Study): Our genotyping was conducted by the NIH Center for Inherited Disease Research (CIDR) at Johns Hopkins University. Genotyping quality control and final preparation of the data were performed by the Genetics Coordinating Center at the University of Washington. HyperGEN-AXIOM (Hypertension Genetic Epidemiology Network—Axiom Chip GWAS): We thank the study investigators, staff and participants for their value contributions. INGI (Italian Network Genetic Isolate): We thank all the inhabitants who participated to the projects. InterAct (The EPIC-InterAct Case-Cohort Study): We thank all EPIC participants and staff for their contribution to the study. IRAS (Insulin Resistance Atherosclerosis Study): The authors thank study investigators, staff, and participants for their valuable contributions. KORA (Cooperative Health Research in the Augsburg Region): We thank all KORA participants and staff for their contribution to the study. LBC1921 (Lothian Birth Cohort 1921): We thank the LBC1921 cohort participants and team members who contributed to these studies. Funding from the Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) is gratefully acknowledged. LBC1936 (Lothian Birth Cohort 1936): We thank the LBC1936 cohort participants and team members who contributed to these studies. Funding from the Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC) is gratefully acknowledged. LifeLines (Lifelines Cohort Study): The authors wish to acknowledge the services of the Lifelines, the contributing research centers delivering data to Lifelines, and all the study participants. The authors wish to acknowledge the services of the Lifelines, the contributing research centers delivering data to Lifelines, and all the study participants. Also, Lifelines acknowledges the contributions from Behrooz Z Alizadeh (Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands), H Marike Boezen (Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands), Lude Franke (Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands), Pim van der Harst (Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands), Gerjan Navis (Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands), Marianne Rots (Department of Medical Biology, University of Groningen, University Medical Center Groningen, The Netherlands), Harold Snieder (Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands), Morris Swertz (Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands), Bruce HR Wolffenbuttel (Department of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands), Cisca Wijmenga (Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands). LLFS (Long Life Family Study): The LLFS would like to thank the participants and research staff who make the study possible. LOLIPOP (London Life Sciences Prospective Population Study): We acknowledge support of the MRC-PHE Centre for Environment and Health, and the NIHR Health Protection Research Unit on Health Impact of Environmental Hazards. The work was carried out in part at the NIHR/Wellcome Trust Imperial Clinical Research Facility. The views expressed are those of the author(s) and not necessarily those of the Imperial College Healthcare NHS Trust, the NHS, the NIHR or the Department of Health. We thank the participants and research staff who made the study possible. PROCARDIS (Precocious Coronary Artery Disease): The PROCARDIS researchers thank the patients for their selfless participation in this project. RHS (Ragama Health Study): The RHS was supported by the Grant of National Center for Global Health and Medicine (NCGM), Japan. SWHS/SMHS (Shanghai Women's Health Study/ Shanghai Men's Health Study): We thank all the individuals who took part in these studies and all the researchers who have enabled this work to be carried out. TRAILS (TRacking Adolescents’ Individual Lives Survey): TRAILS is a collaborative project involving various departments of the University Medical Center and University of Groningen, the Erasmus University Medical Center Rotterdam, the University of Utrecht, the Radboud Medical Center Nijmegen, and the Parnassia Bavo group, all in the Netherlands. We are grateful to all adolescents who participated in this research and to everyone who worked on this project and made it possible. UKB (United Kingdom Biobank, www.ukbiobank.ac.uk): This research has been conducted using the UK Biobank Resource. The UK Biobank data were analyzed from the data set corresponding to UK Biobank access application no. 236, application title 'Genome-wide association study of blood pressure', with Paul Elliott as the PI/applicant. This work was supported by the UK-CMC and the BP working group., InterAct Consortium, Marten, Jonathan [0000-0001-6916-2014], Luan, Jian'an [0000-0003-3137-6337], Zhao, Jing Hua [0000-0003-4930-3582], Forouhi, Nita [0000-0002-5041-248X], Langenberg, Claudia [0000-0002-5017-7344], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Lee Kong Chian School of Medicine (LKCMedicine), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 (EGID), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Feitosa, Mary F., Kraja, Aldi T., Chasman, Daniel I., Sung, Yun J., Winkler, Thomas W., Ntalla, Ioanna, Guo, Xiuqing, Franceschini, Nora, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Marten, Jonathan, Musani, Solomon K., Li, Changwei, Bentley, Amy R., Brown, Michael R., Schwander, Karen, Richard, Melissa A., Noordam, Raymond, Aschard, Hugue, Bartz, Traci M., Bielak, Lawrence F., Dorajoo, Rajkumar, Fisher, Virginia, Hartwig, Fernando P., Horimoto, Andrea R. V. R., Lohman, Kurt K., Manning, Alisa K., Rankinen, Tuomo, Smith, Albert V., Tajuddin, Salman M., Wojczynski, Mary K., Alver, Mari, Boissel, Mathilde, Cai, Qiuyin, Campbell, Archie, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gao, Chuan, Goel, Anuj, Hagemeijer, Yanick, Harris, Sarah E., He, Meian, Hsu, Fang-Chi, Jackson, Anne U., Kähönen, Mika, Kasturiratne, Anuradhani, Komulainen, Pirjo, Kühnel, Brigitte, Laguzzi, Federica, Luan, Jian'An, Matoba, Nana, Nolte, Ilja M., Padmanabhan, Sandosh, Riaz, Muhammad, Rueedi, Rico, Robino, Antonietta, Said, M. Abdullah, Scott, Robert A., Sofer, Tamar, Stančáková, Alena, Takeuchi, Fumihiko, Tayo, Bamidele O., Van Der Most, Peter J., Varga, Tibor V., Vitart, Veronique, Wang, Yajuan, Ware, Erin B., Warren, Helen R., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Zhang, Weihua, Zhao, Jing Hua, Afaq, Saima, Amin, Najaf, Amini, Marzyeh, Arking, Dan E., Aung, Tin, Boerwinkle, Eric, Borecki, Ingrid, Broeckel, Ulrich, Brown, Morri, Brumat, Marco, Burke, Gregory L., Canouil, Mickaël, Chakravarti, Aravinda, Charumathi, Sabanayagam, Chen, Yii-Der Ida, Connell, John M., Correa, Adolfo, De Las Fuentes, Lisa, De Mutsert, Renée, De Silva, H. Janaka, Deng, Xuan, Ding, Jingzhong, Duan, Qing, Eaton, Charles B., Ehret, Georg, Eppinga, Ruben N., Evangelou, Evangelo, Faul, Jessica D., Felix, Stephan B., Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Friedlander, Yechiel, Gandin, Ilaria, Gao, He, Ghanbari, Mohsen, Gigante, Bruna, Gu, C. Charle, Gu, Dongfeng, Hagenaars, Saskia P., Hallmans, Göran, Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Howard, Barbara V., Ikram, M. Arfan, John, Ulrich, Katsuya, Tomohiro, Khor, Chiea Chuen, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Krieger, José E., Kritchevsky, Stephen B., Kubo, Michiaki, Kuusisto, Johanna, Lakka, Timo A., Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lehne, Benjamin, Lewis, Cora E., Li, Yize, Lin, Shiow, Liu, Jianjun, Liu, Jingmin, Loh, Marie, Louie, Tin, Mägi, Reedik, Mckenzie, Colin A., Meitinger, Thoma, Metspalu, Andre, Milaneschi, Yuri, Milani, Lili, Mohlke, Karen L., Momozawa, Yukihide, Nalls, Mike A., Nelson, Christopher P., Sotoodehnia, Nona, Norris, Jill M., O'Connell, Jeff R., Palmer, Nicholette D., Perls, Thoma, Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Poulter, Neil, Raffel, Leslie J., Raitakari, Olli T., Roll, Kathryn, Rose, Lynda M., Rosendaal, Frits R., Rotter, Jerome I., Schmidt, Carsten O., Schreiner, Pamela J., Schupf, Nicole, Scott, William R., Sever, Peter S., Shi, Yuan, Sidney, Stephen, Sims, Mario, Sitlani, Colleen M., Smith, Jennifer A., Snieder, Harold, Starr, John M., Strauch, Konstantin, Stringham, Heather M., Tan, Nicholas Y. Q., Tang, Hua, Taylor, Kent D., Teo, Yik Ying, Tham, Yih Chung, Turner, Stephen T., Uitterlinden, André G., Vollenweider, Peter, Waldenberger, Melanie, Wang, Lihua, Wang, Ya Xing, Wei, Wen Bin, Williams, Christine, Yao, Jie, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., Chambers, John C., Deary, Ian J., Esko, Tõnu, Farrall, Martin, Franks, Paul W., Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Jonas, Jost Bruno, Kamatani, Yoichiro, Kato, Norihiro, Kooner, Jaspal S., Kutalik, Zoltán, Laakso, Markku, Laurie, Cathy C., Leander, Karin, Lehtimäki, Terho, Magnusson, Patrik K. E., Oldehinkel, Albertine J., Penninx, Brenda W. J. H., Polasek, Ozren, Porteous, David J., Rauramaa, Rainer, Samani, Nilesh J., Scott, Jame, Shu, Xiao-Ou, Van Der Harst, Pim, Wagenknecht, Lynne E., Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wickremasinghe, Ananda R., Wu, Tangchun, Zheng, Wei, Bouchard, Claude, Christensen, Kaare, Evans, Michele K., Gudnason, Vilmundur, Horta, Bernardo L., Kardia, Sharon L. R., Liu, Yongmei, Pereira, Alexandre C., Psaty, Bruce M., Ridker, Paul M., Van Dam, Rob M., Gauderman, W. Jame, Zhu, Xiaofeng, Mook-Kanamori, Dennis O., Fornage, Myriam, Rotimi, Charles N., Cupples, L. Adrienne, Kelly, Tanika N., Fox, Ervin R., Hayward, Caroline, Van Duijn, Cornelia M., Tai, E. Shyong, Wong, Tien Yin, Kooperberg, Charle, Palmas, Walter, Rice, Kenneth, Morrison, Alanna C., Elliott, Paul, Caulfield, Mark J., Munroe, Patricia B., Rao, Dabeeru C., Province, Michael A., Levy, Daniel, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Surgery, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Ehret, Georg Benedikt

المصدر: Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C-Y, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F-C, Jackson, A U, Kähönen, M, Zhao, J H, Kilpeläinen, T O, Christensen, K & V Varga, T 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166, pp. 1-36 . https://doi.org/10.1371/journal.pone.0198166
Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C Y, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F C, Jackson, A U, Kähönen, M, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Luan, JA, Matoba, N, Nolte, I M, Padmanabhan, S, Riaz, M, Rueedi, R, Robino, A, Said, M A, Scott, R A, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, B O, Van Der Most, P J, Varga, T V, Vitart, V, Wang, Y, Ware, E B, Warren, H R, Weiss, S, Wen, W, Yanek, L R, Zhang, W, Zhao, J H, Afaq, S, Amin, N, Amini, M, Arking, D E, Aung, T, Boerwinkle, E, Borecki, I, Broeckel, U, Brown, M, Brumat, M, Burke, G L, Canouil, M, Chakravarti, A, Charumathi, S, Chen, Y D I, Connell, J M, Correa, A, De Las Fuentes, L, De Mutsert, R, De Silva, H J, Deng, X, Ding, J, Duan, Q, Eaton, C B, Ehret, G, Eppinga, R N, Evangelou, E, Faul, J D, Felix, S B, Forouhi, N G, Forrester, T, Franco, O H, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gigante, B, Gu, C C, Gu, D, Hagenaars, S P, Hallmans, G, Harris, T B, He, J, Heikkinen, S, Heng, C K, Hirata, M, Howard, B V, Ikram, M A, John, U, Katsuya, T, Khor, C C, Kilpeläinen, T O, Koh, W P, Krieger, J E, Kritchevsky, S B, Kubo, M, Kuusisto, J, Lakka, T A, Langefeld, C D, Langenberg, C, Launer, L J, Lehne, B, Lewis, C E, Li, Y, Lin, S, Liu, J, Liu, J, Loh, M, Louie, T, Mägi, R, McKenzie, C A, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, K L, Momozawa, Y, Nalls, M A, Nelson, C P, Sotoodehnia, N, Norris, J M, O'Connell, J R, Palmer, N D, Perls, T, Pedersen, N L, Peters, A, Peyser, P A, Poulter, N, Raffel, L J, Raitakari, O T, Roll, K, Rose, L M, Rosendaal, F R, Rotter, J I, Schmidt, C O, Schreiner, P J, Schupf, N, Scott, W R, Sever, P S, Shi, Y, Sidney, S, Sims, M, Sitlani, C M, Smith, J A, Snieder, H, Starr, J M, Strauch, K, Stringham, H M, Tan, N Y Q, Tang, H, Taylor, K D, Teo, Y Y, Tham, Y C, Turner, S T, Uitterlinden, A G, Vollenweider, P, Waldenberger, M, Wang, L, Wang, Y X, Wei, W B, Williams, C, Yao, J, Yu, C, Yuan, J M, Zhao, W, Zonderman, A B, Becker, D M, Boehnke, M, Bowden, D W, Chambers, J C, Deary, I J, Esko, T, Farrall, M, Franks, P W, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Jonas, J B, Kamatani, Y, Kato, N, Kooner, J S, Kutalik, Z, Laakso, M, Laurie, C C, Leander, K, Lehtimäki, T, Magnusson, P K E, Oldehinkel, A J, Penninx, B W J H, Polasek, O, Porteous, D J, Rauramaa, R, Samani, N J, Scott, J, Shu, X O, Van Der Harst, P, Wagenknecht, L E, Wareham, N J, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zheng, W, Bouchard, C, Christensen, K, Evans, M K, Gudnason, V, Horta, B L, Kardia, S L R, Liu, Y, Pereira, A C, Psaty, B M, Ridker, P M, Van Dam, R M, Gauderman, W J, Zhu, X, Mook-Kanamori, D O, Fornage, M, Rotimi, C N, Cupples, L A, Kelly, T N, Fox, E R, Hayward, C, Van Duijn, C M, Tai, E S, Wong, T Y, Kooperberg, C, Palmas, W, Rice, K, Morrison, A C, Elliott, P, Caulfield, M J, Munroe, P B, Rao, D C, Province, M A & Levy, D 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
Feitosa, M F, Kraja, A T, Chasman, D I, Sung, Y J, Winkler, T W, Ntalla, I, Guo, X, Franceschini, N, Cheng, C, Sim, X, Vojinovic, D, Marten, J, Musani, S K, Li, C, Bentley, A R, Brown, M R, Schwander, K, Richard, M A, Noordam, R, Aschard, H, Bartz, T M, Bielak, L F, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Lohman, K K, Manning, A K, Rankinen, T, Smith, A V, Tajuddin, S M, Wojczynski, M K, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, J F, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, S E, He, M, Hsu, F, Jackson, A U, Kähönen, M, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Luan, J, Matoba, N, Nolte, I M, Padmanabhan, S, Riaz, M, Rueedi, R, Robino, A, Said, M A, Scott, R A, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, B O, Van Der Most, P J, Varga, T V, Vitart, V, Wang, Y, Ware, E B, Warren, H R, Weiss, S, Wen, W, Yanek, L R, Zhang, W, Zhao, J H, Afaq, S, Amin, N, Amini, M, Arking, D E, Aung, T, Boerwinkle, E, Borecki, I, Broeckel, U, Brown, M, Brumat, M, Burke, G L, Canouil, M, Chakravarti, A, Charumathi, S, Ida Chen, Y, Connell, J M, Correa, A, De Las Fuentes, L, De Mutsert, R, De Silva, H J, Deng, X, Ding, J, Duan, Q, Eaton, C B, Ehret, G, Eppinga, R N, Evangelou, E, Faul, J D, Felix, S B, Forouhi, N G, Forrester, T, Franco, O H, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gigante, B, Gu, C C, Gu, D, Hagenaars, S P, Hallmans, G, Harris, T B, He, J, Heikkinen, S, Heng, C, Hirata, M, Howard, B V, Ikram, M A, John, U, Katsuya, T, Khor, C C, Kilpeläinen, T O, Koh, W, Krieger, J E, Kritchevsky, S B, Kubo, M, Kuusisto, J, Lakka, T A, Langefeld, C D, Langenberg, C, Launer, L J, Lehne, B, Lewis, C E, Li, Y, Lin, S, Liu, J, Liu, J, Loh, M, Louie, T, Mägi, R, Mckenzie, C A, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, K L, Momozawa, Y, Nalls, M A, Nelson, C P, Sotoodehnia, N, Norris, J M, O'connell, J R, Palmer, N D, Perls, T, Pedersen, N L, Peters, A, Peyser, P A, Poulter, N, Raffel, L J, Raitakari, O T, Roll, K, Rose, L M, Rosendaal, F R, Rotter, J I, Schmidt, C O, Schreiner, P J, Schupf, N, Scott, W R, Sever, P S, Shi, Y, Sidney, S, Sims, M, Sitlani, C M, Smith, J A, Snieder, H, Starr, J M, Strauch, K, Stringham, H M, Tan, N Y Q, Tang, H, Taylor, K D, Teo, Y Y, Tham, Y C, Turner, S T, Uitterlinden, A G, Vollenweider, P, Waldenberger, M, Wang, L, Wang, Y X, Wei, W B, Williams, C, Yao, J, Yu, C, Yuan, J, Zhao, W, Zonderman, A B, Becker, D M, Boehnke, M, Bowden, D W, Chambers, J C, Deary, I J, Esko, T, Farrall, M, Franks, P W, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Jonas, J B, Kamatani, Y, Kato, N, Kooner, J S, Kutalik, Z, Laakso, M, Laurie, C C, Leander, K, Lehtimäki, T, Study, L C, Magnusson, P K E, Oldehinkel, A J, Penninx, B W J H, Polasek, O, Porteous, D J, Rauramaa, R, Samani, N J, Scott, J, Shu, X, Van Der Harst, P, Wagenknecht, L E, Wareham, N J, Watkins, H, Weir, D R, Wickremasinghe, A R, Wu, T, Zheng, W, Bouchard, C, Christensen, K, Evans, M K, Gudnason, V, Horta, B L, Kardia, S L R, Liu, Y, Pereira, A C, Psaty, B M, Ridker, P M, Van Dam, R M, Gauderman, W J, Zhu, X, Mook-kanamori, D O, Fornage, M, Rotimi, C N, Cupples, L A, Kelly, T N, Fox, E R, Hayward, C, Van Duijn, C M, Tai, E S, Wong, T Y, Kooperberg, C, Palmas, W, Rice, K, Morrison, A C, Elliott, P, Caulfield, M J, Munroe, P B, Rao, D C, Province, M A, Levy, D & Kuivaniemi, H 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, pp. e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLoS One (online), 13(6):e0198166. Public Library of Science
PLoS ONE, 13(6):0198166. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, Public Library of Science, 2018, 13 (6), pp.e0198166. ⟨10.1371/journal.pone.0198166⟩
PloS one, vol. 13, no. 6, pp. e0198166
PLoS ONE, Vol 13, Iss 6, p e0198166 (2018)
InterAct Consortium 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLOS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLOS ONE
PLoS ONE 13:e0198166 (2018)
Feitosa, M F & Levy, D 2018, ' Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries ', PLoS ONE, vol. 13, no. 6, e0198166 . https://doi.org/10.1371/journal.pone.0198166
PLoS ONE, 2018, 13 (6), pp.e0198166. ⟨10.1371/journal.pone.0198166⟩
PLoS ONE, 13(6)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, 13(6):e0198166. Public Library of Science
PLOS ONE, Vol. 13, No 6 (2018) P. e0198166

مصطلحات موضوعية: Genetics and Molecular Biology (all), Male, Erfðagreining, Áfengissýki, LOCI, Social Sciences, Blood Pressure, Genome-wide association study, Biochemistry, Vascular Medicine, TRANSCRIPTION FACTOR GATA4, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), DEPENDENCE, HEPATOCELLULAR-CARCINOMA, 80 and over, Psychology, Public and Occupational Health, Alcohol consumption, Cardiac and Cardiovascular Systems, Gene–environment interaction, ddc:616, Aged, 80 and over, [STAT.AP]Statistics [stat]/Applications [stat.AP], MESH: Middle Aged, Kardiologi, MESH: Polymorphism, Single Nucleotide, Áfengisneysla, MESH: Gene-Environment Interaction, COMMON VARIANTS, Genomics, MESH: Blood Pressure, Pedigree, 3. Good health, Näringslära, MESH: Young Adult, Physical Sciences, Medicine, Medical genetics, Erfðarannsóknir, Statistics (Mathematics), medicine.medical_specialty, Blood Pressure/genetics, Alcohol Drinking, MESH: Pedigree, Science, Genetic loci, ta3111, Genome Complexity, 03 medical and health sciences, Gene mapping, Genetics, Humans, Polymorphism, Statistical Methods, GENOME-WIDE ASSOCIATION, Molecular Biology Techniques, Molecular Biology, Alleles, Aged, MESH: Adolescent, MESH: Humans, Adolescent, Adult, Alcohol Drinking/epidemiology, Alcohol Drinking/genetics, Cohort Studies, Continental Population Groups/genetics, Continental Population Groups/statistics & numerical data, Female, Gene-Environment Interaction, Genetic Predisposition to Disease/epidemiology, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Hypertension/epidemiology, Hypertension/genetics, Middle Aged, Polymorphism, Single Nucleotide, Young Adult, Gene Mapping, Racial Groups, ta1182, Biology and Life Sciences, Computational Biology, MESH: Adult, Meta-analysis, 030104 developmental biology, Genetic Loci, MESH: Genome-Wide Association Study, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], MESH: Female, Mathematics, MESH: Alcohol Drinking, Meta-Analysis, 0301 basic medicine, MESH: Continental Population Groups, MESH: Hypertension, Mathematical and Statistical Techniques, MESH: Aged, 80 and over, Polymorphism (computer science), Medicine and Health Sciences, FUNCTIONAL VARIATION, MESH: Cohort Studies, MESH: Aged, Alcohol Consumption, Multidisciplinary, Nutrition and Dietetics, MESH: Genetic Predisposition to Disease, Genetic Predisposition to Disease/epidemiology/genetics, Single Nucleotide, Blóðþrýstingur, ENVIRONMENT INTERACTION, PTP4A1-PHF3-EYS VARIANTS, Alcoholism, ANCESTRAIS, Háþrýstingur, Hypertension, Blood pressure, [STAT.ME]Statistics [stat]/Methodology [stat.ME], Medical Genetics, Research Article, Substance-Related Disorders, Addiction, RISK, METAANALYSIS, Research and Analysis Methods, Mental Health and Psychiatry, medicine, Medicine [Science], Genetic Predisposition to Disease, Allele, Hypertension/epidemiology/genetics, Nutrition, Medicinsk genetik, Continental Population Groups/genetics/statistics & numerical data, business.industry, Alcohol Drinking/epidemiology/genetics, Genetic architecture, MESH: Male, Introns, Diet, BODY-MASS INDEX, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business

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9

Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study

المؤلفون: Niek Verweij, M. Abdullah Said, Pim van der Harst

المساهمون: Cardiovascular Centre (CVC)

المصدر: Jama cardiology, 3(8), 693-702. AMER MEDICAL ASSOC

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Health Behavior, Population, Coronary Artery Disease, Type 2 diabetes, Disease, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Atrial Fibrillation, medicine, Humans, Genetic Predisposition to Disease, education, Exercise, Life Style, Aged, Biological Specimen Banks, Proportional Hazards Models, Original Investigation, education.field_of_study, Proportional hazards model, business.industry, Incidence, Smoking, Hazard ratio, Middle Aged, medicine.disease, United Kingdom, Diet, Stroke, 030104 developmental biology, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Hypertension, Female, Gene-Environment Interaction, Cardiology and Cardiovascular Medicine, business, Demography, Cohort study

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https://doi.org/10.1001/jamacardio.2018.1717

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