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المؤلفون: Robert H. Collins, Deirdre Devine, Beth Wilmot, Justin Ramsdill, Erik Segerdell, Bruno C. Medeiros, Brian J. Druker, Dylan Nelson, Micaela E. Martinez, Ryan C. Johnson, Robert Schuff, Robert P. Searles, Scott Weir, James Dibb, Elie Traer, Pierrette Lo, Haijiao Zhang, Rachel Henson, Tara A. Macey, Isabel English, Cody Coblentz, Christopher A. Eide, Ceilidh Nichols, Aurora Blucher, Ryan M. Winters, David L. Wiest, Corinne Visser, Michael W. Deininger, Stephen E. Kurtz, Daniel A. Pollyea, Justin M. Watts, Amy S. Carlos, Denise C. Connolly, Andy Kaempf, Angela Rofelty, Samuel B. Luty, Rachel J. Cook, Jill Peters, Kristen Werth, Shannon K. McWeeney, Joseph Carroll, Samantha L. Savage, Ronan T. Swords, Uma Borate, Aashis Thapa, Abdusebur Jemal, Joelle Wolf, Patricia Kropf, Rebecca Smith, Tyler Sweeney, Russell T. Burke, Rachel R. Pallapati, Anna Reister Schultz, Kim Hien T. Dao, Daniel Bottomly, Cristina E. Tognon, Alexey V. Danilov, Jason M. Glover, Jason D. MacManiman, Michie Degnin, Amy Yates, Libbey White, David K. Edwards, Anupriya Agarwal, Christopher R. Cogle, Kevin Watanabe-Smith, Leylah Drusbosky, Nicola Long, Motomi Mori, Christopher S. Hourigan, Tara L. Lin, Chenwei Lin, Jacqueline Martinez, Bill H. Chang, Richie Carpenter, Stephen E. Spurgeon, Brian Junio, Marc M. Loriaux, Craig T. Jordan, Hibery Ho, Selina Qiuying Liu, Melissa L. Abel, Amanda d’Almeida, Jake Wagner, Jade Bryant, Jeffrey W. Tyner, Jessica Leonard, Kara Johnson
المصدر: Nature
مصطلحات موضوعية: Male, 0301 basic medicine, Myeloid, Gene regulatory network, Datasets as Topic, Genomics, Computational biology, Biology, Article, DNA Methyltransferase 3A, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins, hemic and lymphatic diseases, medicine, Humans, Exome, DNA (Cytosine-5-)-Methyltransferases, Molecular Targeted Therapy, Exome sequencing, Regulation of gene expression, Multidisciplinary, Serine-Arginine Splicing Factors, Genome, Human, Sequence Analysis, RNA, Nuclear Proteins, medicine.disease, Human genetics, 3. Good health, Gene Expression Regulation, Neoplastic, Repressor Proteins, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Core Binding Factor Alpha 2 Subunit, Female, Nucleophosmin
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المؤلفون: Patrice Lee, Hibery Ho, David K. Edwards, Selina Qiuying Liu, Angela Rofelty, David Sweeney, Shannon K. McWeeney, Alexey V. Danilov, David Chantry, Stephen E. Spurgeon, Jeffrey W. Tyner, Brian J. Druker, Christopher A. Eide, Marc M. Loriaux, Anupriya Agarwal
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Chronic lymphocytic leukemia, Colony stimulating factor 1 receptor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, colony-stimulating factor 1 receptor, medicine, tumor microenvironment, Tumor microenvironment, Hematology, tumor-associated macrophages, business.industry, Monocyte, medicine.disease, 3. Good health, small-molecule inhibitors, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, chemistry, 030220 oncology & carcinogenesis, Ibrutinib, Cancer research, chronic lymphocytic leukemia, Idelalisib, business, Priority Research Paper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86a0bbd548169c03c3a3266c4841fdd
https://doi.org/10.18632/oncotarget.25191 -
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المؤلفون: Claire Godbersen, Bhargava Sreekantham, Olga V. Danilova, Scott R Best, Alexey V. Danilov, Cody Paiva, Prabhjot Kaur, Stephen E. Spurgeon, Marc M. Loriaux, Taylor Rowland
المصدر: Haematologica
مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Chronic lymphocytic leukemia, B-cell receptor, Receptors, Antigen, B-Cell, Syk, CHO Cells, Biology, Models, Biological, Article, 03 medical and health sciences, Cricetulus, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, B-Cell Activating Factor, medicine, Animals, Cluster Analysis, Humans, Syk Kinase, Chronic Lymphocytic Leukemia, B-cell activating factor, TNF Receptor-Associated Factor 3, Gene Expression Profiling, NF-kappa B, Hematology, TNF Receptor-Associated Factor 2, medicine.disease, Immunohistochemistry, Leukemia, Lymphocytic, Chronic, B-Cell, Cell biology, Leukemia, Crosstalk (biology), 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, Signal transduction, Immunoglobulin Heavy Chains, Protein Binding, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a841e2e303a0a930f0398030f14d15f
https://doi.org/10.3324/haematol.2017.170571 -
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المؤلفون: Stephen E. Spurgeon, James Gajewski, Edward A. Stadtmauer, Marc M. Loriaux, Emma C. Scott, Ravi K. Amaravadi, Miranda Gordon, George Thomas, Jennifer Botelho, Jennifer Podolak, Eva Medvedova, Richard T. Maziarz, Michael J. Cascio, Shara Reasor-Heard, Anne Kratz, Dan T. Vogl, Byung Park
المصدر: Haematologica. 102:e261-e265
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_treatment, Stimulation, Pharmacology, 03 medical and health sciences, Bone Marrow, Recurrence, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Autophagy, medicine, Humans, Neoplasm, In patient, Online Only Articles, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Aged, Aged, 80 and over, Chemotherapy, business.industry, TOR Serine-Threonine Kinases, Refractory Multiple Myeloma, Hydroxychloroquine, Hematology, Middle Aged, medicine.disease, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer research, Female, Multiple Myeloma, business, Signal Transduction, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c8b7e55f26d75c19575c21d9fd7f74
https://doi.org/10.3324/haematol.2016.162321 -
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المؤلفون: Jason D. MacManiman, Jason Gotlib, Emily A. Stevens, Peter L. Greenberg, Melissa L. Abel, Samuel B. Luty, Marc M. Loriaux, Jason C. Paik, Swaleh Bahamadi, Jeffrey W. Tyner, Julia E. Maxson, Christopher A. Eide, Samantha L. Savage
المصدر: Clinical Cancer Research. 22:757-764
مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Glycosylation, DNA Mutational Analysis, Chronic neutrophilic leukemia, Mutant, Biology, Ligands, medicine.disease_cause, Article, Cell Line, Mice, 03 medical and health sciences, Bone Marrow, Receptors, Colony-Stimulating Factor, medicine, Animals, Humans, Codon, Protein Kinase Inhibitors, Bone Marrow Transplantation, Janus Kinases, Mutation, Leukemia, Point mutation, Middle Aged, medicine.disease, Molecular biology, Disease Models, Animal, Cell Transformation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Amino Acid Substitution, Oncology, Atypical chronic myeloid leukemia, Female, Bone marrow, Janus kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0f2116441cfd4006dc1506ba5d3860
https://doi.org/10.1158/1078-0432.ccr-14-3100 -
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المؤلفون: Eneida R. Nemecek, Beth Wilmot, Samuel B. Luty, Jeffrey W. Tyner, Christopher A. Eide, Julia E. Maxson, Melissa L. Abel, Daniel Bottomly, Chelsea Jenkins, Marc M. Loriaux, Bill H. Chang, Shannon K. McWeeney, Corinne Togiai
المصدر: Science Signaling. 11
مصطلحات موضوعية: Male, musculoskeletal diseases, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Dasatinib, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Biochemistry, Article, Mice, 03 medical and health sciences, hemic and lymphatic diseases, medicine, Animals, Humans, Child, skin and connective tissue diseases, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Tumor Stem Cell Assay, Juvenile myelomonocytic leukemia, Chemistry, Myeloid leukemia, Cell Biology, Protein-Tyrosine Kinases, Prognosis, medicine.disease, Survival Rate, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, Leukemia, Myelomonocytic, Juvenile, Cancer research, Phosphorylation, Signal transduction, Synthetic Lethal Mutations, Signal Transduction, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49e14961db54376fdbe3d1364641900
https://doi.org/10.1126/scisignal.aao5617 -
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المؤلفون: Elie Traer, Paul Tardi, Tibor Kovacsovics, Stephen E. Spurgeon, Marc M. Loriaux, Max J. Gordon, Lawrence D. Mayer, Jeffrey W. Tyner
المصدر: Leukemia research. 53
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Antimetabolites, Antineoplastic, Daunorubicin, Chronic lymphocytic leukemia, Pharmacology, Biology, 03 medical and health sciences, Inhibitory Concentration 50, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Tumor Cells, Cultured, Cytotoxic T cell, Humans, Antibiotics, Antineoplastic, Cytarabine, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Lymphoma, Leukemia, 030104 developmental biology, Oncology, fms-Like Tyrosine Kinase 3, 030220 oncology & carcinogenesis, Fms-Like Tyrosine Kinase 3, Liposomes, Mutation, Blast Crisis, Ex vivo, medicine.drug
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المؤلفون: Jeffrey W. Tyner, Joelle Rowley, Jessica Leonard, Bill H. Chang, Brian J. Druker, Elie Traer, Brandon Hayes-Lattin, Stephen E. Spurgeon, Marc M. Loriaux, Christopher A. Eide
المصدر: Science Translational Medicine. 8
مصطلحات موضوعية: 0301 basic medicine, Dasatinib, Mice, SCID, Pharmacology, Philadelphia chromosome, Translational Research, Biomedical, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Mice, Inbred NOD, LYN, Cell Line, Tumor, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, STAT5 Transcription Factor, medicine, Animals, Humans, Philadelphia Chromosome, Proto-Oncogene Proteins c-abl, Protein Kinase Inhibitors, Mice, Knockout, Sulfonamides, ABL, business.industry, Venetoclax, Ponatinib, Imidazoles, General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Xenograft Model Antitumor Assays, Pyridazines, Leukemia, src-Family Kinases, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, chemistry, 030220 oncology & carcinogenesis, Myeloid Cell Leukemia Sequence 1 Protein, business, Tyrosine kinase, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cf6935e3f9381bbe61ea5e17a006b1
https://doi.org/10.1126/scitranslmed.aaf5309 -
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المؤلفون: Shelton Viola, Marc M. Loriaux, Elie Traer, Jianya Huan, Anupriya Agarwal, Noah I. Hornick, Peter Kurre, Brian Johnstone, Jeffrey W. Tyner
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Stromal cell, Adolescent, Cellular differentiation, medicine.medical_treatment, Population, Antineoplastic Agents, Biology, Exosomes, Exosome, Article, 03 medical and health sciences, Young Adult, hemic and lymphatic diseases, medicine, Humans, education, Child, Protein Kinase Inhibitors, Aged, education.field_of_study, Mesenchymal stem cell, Mesenchymal Stem Cells, Hematology, Middle Aged, Protein-Tyrosine Kinases, Molecular biology, Microvesicles, Leukemia, Myeloid, Acute, 030104 developmental biology, Cytokine, Drug Resistance, Neoplasm, Hepatocyte growth factor, Female, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae2c960ea095239cc7d865b710f856b
https://europepmc.org/articles/PMC4755922/ -
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المؤلفون: Srinivas K. Tantravahi, Beth Wilmot, Richard D. Press, Daniel Bottomly, Marc M. Loriaux, Elie Traer, Samantha L. Savage, Jerald P. Radich, Olga Sala-Torra, Garrett Eickelberg, Brian J. Druker, Lan Beppu, Anna Reister Schultz, Kimberly A. Uchida, Matthew S. Zabriskie, Thomas O'Hare, Libbey White, Shannon K. McWeeney, Michael W. Deininger, Anthony D. Pomicter, Cristina E. Tognon, Anupriya Agarwal, Jeffrey W. Tyner, Christopher A. Eide
المصدر: Blood. 128:1119-1119
مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Myeloid, Immunology, MAP3K1, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, medicine, Kinase activity, Exome sequencing, ABL, business.industry, Myeloid leukemia, Cancer, Imatinib, Cell Biology, Hematology, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b09ddf43e86cfba4d47936e428d36242
https://doi.org/10.1182/blood.v128.22.1119.1119