المؤلفون: Frank Seeliger, Carla P. Martins, Emily James, Sandra Wimberger, Camilla Johansson, Mohammad Bohlooly-Y, Emma J. Davies, Maryam Clausen, Lukas Badertscher, Michelle J. Porritt, Simon T. Barry, Xiufeng Xu, Anna Schantz, Roberto Nitsch, Amir Taheri-Ghahfarokhi, Marcello Maresca, Himjyot Jaiswal, Elizabeth Hardaker, Jenna Bradley, Babak Alaeimahabadi, Lorenz M. Mayr, Abdel Wahad Bidar, Therese Admyre, Anders Lundin

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Male, Lung Neoplasms, Somatic cell, Molecular biology, General Physics and Astronomy, Gene Expression, Mice, 0302 clinical medicine, Genome editing, CRISPR-Associated Protein 9, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Transgenes, lcsh:Science, Cancer, Doxycycline, Gene Editing, Recombination, Genetic, Multidisciplinary, 3. Good health, Gene Expression Regulation, Neoplastic, Drug development, 030220 oncology & carcinogenesis, Female, medicine.drug, RNA, Guide, Kinetoplastida, Transcriptional Activation, Transgene, Science, Genetic Vectors, Antineoplastic Agents, Mice, Transgenic, Computational biology, Biology, Transfection, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, In vivo, Cell Line, Tumor, medicine, Genetics, Animals, Humans, Cas9, HEK 293 cells, Reproducibility of Results, General Chemistry, High-Throughput Screening Assays, 030104 developmental biology, HEK293 Cells, lcsh:Q, CRISPR-Cas Systems, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be35d27a5ad372f5e73cee5b16a0b91e
http://link.springer.com/article/10.1038/s41467-020-18548-9

المؤلفون: Frank Seeliger, Jimmy A. Guo, Luca Pinello, Mohammad Bohlooly-Y, Roberto Nitsch, Lorenz M. Mayr, Shengdar Q. Tsai, Mick D. Fellows, Pinar Akcakaya, Marcello Maresca, Jose Malagon-Lopez, Alba Carreras, Mikael Bjursell, J. Keith Joung, Nhu T. Nguyen, Mike Firth, Sara P. Garcia, Kendell Clement, Martin J. Aryee, Michelle J. Porritt, Tania Baccega, Maggie L. Bobbin

المصدر: Nature

مصطلحات موضوعية: Male, 0301 basic medicine, CRISPR-Associated Proteins, Computational biology, Biology, Genome, Article, Substrate Specificity, Mice, 03 medical and health sciences, PCSK9 Gene, INDEL Mutation, Genome editing, In vivo, Animals, Humans, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Transgenes, Guide RNA, Gene Editing, Multidisciplinary, Highly sensitive, Mice, Inbred C57BL, 030104 developmental biology, Mutation, Female, Proprotein Convertase 9, CRISPR-Cas Systems

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af450eb5d0a837ac895b4df97292f10b
http://europepmc.org/articles/PMC6194229

المؤلفون: Mohammad Bohlooly-Y, Nina Akrap, Benjamin J. M. Taylor, Euan Gordon, Grzegorz Sienski, Mike Firth, Giovanni Ciotta, Anders Lundin, Matthew A. Coelho, Silvia Cerboni, Aleksandra Sieńska, Marcella Sini, Marcello Maresca, Luna Simona Pane, Giovanni Pellegrini, Xiufeng Xu, Songyuan Li, Suman Mitra, Bojana Lazovic, Sandra Wimberger, Carl Möller, Michelle J. Porritt

المساهمون: University of Zurich, Li, Songyuan, Sienski, Grzegorz, Maresca, Marcello

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: 0301 basic medicine, Science, Population, 10184 Institute of Veterinary Pathology, General Physics and Astronomy, 1600 General Chemistry, Genetics and Molecular Biology, Computational biology, Gene delivery, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Genome engineering, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Genome editing, 1300 General Biochemistry, Genetics and Molecular Biology, Recombinase, education, Gene, education.field_of_study, Multidisciplinary, Biological techniques, General Chemistry, 3100 General Physics and Astronomy, 030104 developmental biology, chemistry, General Biochemistry, Genetic engineering, 570 Life sciences, biology, Stem cell, Genetic techniques, 030217 neurology & neurosurgery, DNA, Biotechnology

وصف الملف: application/pdf; 41467_2020_Article_20810.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798fdfd73b6144e3164b3a68db2768da
https://doi.org/10.1038/s41467-020-20810-z

المؤلفون: Jan Borén, Mario Ruiz, Ranjan Devkota, Marcus Henricsson, Mohammad Bohlooly-Y, Marc Pilon, Marcello Maresca, Himjyot Jaiswal, Xiao-Rong Peng, Henrik Palmgren

المصدر: Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(4)

مصطلحات موضوعية: 0301 basic medicine, Transcriptional Activation, Membrane Fluidity, Membrane lipids, Cell, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, medicine, Membrane fluidity, Humans, Molecular Biology, biology, Chemistry, Cell Membrane, Fatty Acids, Endothelial Cells, Lipid metabolism, Cell Biology, Cell biology, 030104 developmental biology, Fatty acid desaturase, medicine.anatomical_structure, HEK293 Cells, Lipotoxicity, biology.protein, Receptors, Adiponectin, 030217 neurology & neurosurgery, Homeostasis, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f848e7ea3c4a61da9b0a06516ba612
https://pubmed.ncbi.nlm.nih.gov/33444759

المؤلفون: Andrea M. Zuhl, Jerome Robert, Iva Kulic, Cameron Parro, Nicholas J. Brandon, Michael W. Wood, Dean G. Brown, Qi Wang, Samantha Barichievy, Ryan Hicks, Hsien-Ya Chou, Ola Engkvist, Wenchen Zhao, Johan Meuller, Amanda Clark, Cheryl L. Wellington, Carina Raynoschek, Marcello Maresca, Cheryl M. Koh, Jianjia Fan, Alvin Lok

المصدر: Molecular Brain, Vol 13, Iss 1, Pp 1-13 (2020)
Molecular Brain

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, Cell Survival, Astrocytoma, lcsh:RC346-429, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, Apolipoproteins E, 0302 clinical medicine, Downregulation and upregulation, Alzheimer Disease, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Animals, Humans, Kinase activity, Liver X receptor, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, biology, Microglia, AXL receptor tyrosine kinase, Chemistry, Research, Receptor Protein-Tyrosine Kinases, AXL, Axl Receptor Tyrosine Kinase, High-Throughput Screening Assays, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Astrocytes, Gene Knockdown Techniques, ABCA1, biology.protein, lipids (amino acids, peptides, and proteins), Astrocyte, Alzheimer’s disease, 030217 neurology & neurosurgery, ATP Binding Cassette Transporter 1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e716cd41a33c1c054d351d225258866

المؤلفون: Anna-Lina Cavallo, Mohammad Bohlooly-Y, Lorenz M. Mayr, Maryam Clausen, Ryan Hicks, Amir Taheri-Ghahfarokhi, Fredrik Karlsson, Katja Madeyski-Bengtson, Roberto Nitsch, Marcello Maresca, Anders Lundin, Benjamin J. M. Taylor

المصدر: Nucleic Acids Research. 46:8417-8434

مصطلحات موضوعية: 0301 basic medicine, DNA End-Joining Repair, Streptococcus pyogenes, Datasets as Topic, DNA-Directed DNA Polymerase, Computational biology, medicine.disease_cause, Polymorphism, Single Nucleotide, Genome, Cell Line, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, INDEL Mutation, Genome editing, CRISPR-Associated Protein 9, Genetics, medicine, Humans, Francisella, Nucleotide Motifs, Indel, Nuclease, Mutation, Base Sequence, biology, Cas9, Recombinant Proteins, Protospacer adjacent motif, 030104 developmental biology, chemistry, A549 Cells, biology.protein, Algorithms, Software, 030217 neurology & neurosurgery, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ca3e43364230a7efc4736438d44a9c
https://doi.org/10.1093/nar/gky653

المؤلفون: Alvaro Avivar-Valderas, Marcello Maresca, Larissa S. Carnevalli, Francisco Cruzalegui, Elizabeth Hardaker, Elizabeth A. Harrington, Kevin Hudson, Amir Taheri-Ghahfarokhi, Robert McEwen

المصدر: Oncotarget

مصطلحات موضوعية: CRISPR gene editing, 0301 basic medicine, Mutation, Tumor suppressor gene, luminal A, PIK3CA, Biology, medicine.disease_cause, IRS1, 03 medical and health sciences, breast cancer, 030104 developmental biology, MAP3K1, Oncology, Cancer research, medicine, biology.protein, PTEN, Signal transduction, Carcinogenesis, Protein kinase B, PI3K/AKT/mTOR pathway, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc050d299bc13265291befbd0245088e
https://doi.org/10.18632/oncotarget.25118

المؤلفون: Leif Aasehaug, Lisa U. Magnusson, Amir Taheri-Ghahfarokhi, Roberto Nitsch, Frank Seeliger, Mohammad Bohlooly-Y, Marcello Maresca, Lorenz M. Mayr, Elke Ericson, Therese Admyre, Maryam Clausen, Michelle J. Porritt, John Wiseman, Mikael Bjursell

المصدر: EBioMedicine, Vol 29, Iss, Pp 104-111 (2018)
EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, Transgene, Liver fibrosis, Genetic Vectors, Gene Expression, lcsh:Medicine, Mice, Transgenic, α1-antitrypsin deficiency, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Adenoviridae, Mice, 03 medical and health sciences, Transduction, Genetic, Fibrosis, alpha 1-Antitrypsin Deficiency, Gene expression, medicine, Animals, Humans, Transgenes, Gene, Cell Proliferation, Gene Editing, Mutation, lcsh:R5-920, Alpha 1-antitrypsin deficiency, lcsh:R, General Medicine, medicine.disease, Phenotype, Disease Models, Animal, medicine.anatomical_structure, 030104 developmental biology, alpha 1-Antitrypsin, Hepatocyte, Neutrophil elastase, Humanized mouse, biology.protein, Cancer research, CRISPR/Cas9 gene editing, Protein aggregation, CRISPR-Cas Systems, lcsh:Medicine (General), Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf00afa857797ceb9b4f7d0d1278be6
http://www.sciencedirect.com/science/article/pii/S2352396418300690

المؤلفون: Wenchen Zhao, Johan Meuller, Jianjia Fan, Carina Raynoschek, Jerome Robert, Cheryl L. Wellington, Iva Kulic, Tarek Z. Deeb, Samantha Barichievy, Rui Qi Zhao, Cameron Parro, Hsien-Ya Chou, Ryan Hicks, Ola Engkvist, Nicholas J. Brandon, Marcello Maresca, Stephen J. Moss, Michael W. Wood

المصدر: Journal of Lipid Research, Vol 59, Iss 5, Pp 830-842 (2018)
J Lipid Res

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, Purinergic P2X Receptor Antagonists, brain, Aziridines, adenosine 5′-triphosphate-binding cassette transporter A1, Adamantane, QD415-436, Biochemistry, Small Molecule Libraries, Mice, 03 medical and health sciences, Apolipoproteins E, astrocyte, Endocrinology, Downregulation and upregulation, polycyclic compounds, Transcriptional regulation, medicine, Animals, Humans, Secretion, nuclear receptors/liver X receptor, Liver X receptor, Cells, Cultured, Research Articles, apolipoprotein E, Mice, Knockout, Sulfonamides, Molecular Structure, biology, Microglia, Chemistry, Purinergic receptor, Cell Biology, Alzheimer's disease, Up-Regulation, Cell biology, 030104 developmental biology, medicine.anatomical_structure, ABCA1, Benzamides, biology.protein, lipids (amino acids, peptides, and proteins), Receptors, Purinergic P2X7, Corrigendum, ATP Binding Cassette Transporter 1, Naphthoquinones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9cf9291f69614030989bdc48aae7ff
https://doi.org/10.1194/jlr.m081851

المؤلفون: Nadia Gaïa, Marcello Maresca, Nicolas Suárez-Zamorano, Doron Merkler, Jacques Schrenzel, Christelle Veyrat-Durebex, Andrew J. Macpherson, Silas Kieser, Mercedes Gomez de Agüero, Mirko Trajkovski, Vladimir Lazarevic, Stefano Leo, Claire Chevalier, Salvatore Fabbiano, Dorothée Rigo

المصدر: Fabbiano, Salvatore; Suárez-Zamorano, Nicolas; Chevalier, Claire; Lazarević, Vladimir; Kieser, Silas; Rigo, Dorothée; Leo, Stefano; Veyrat-Durebex, Christelle; Gaïa, Nadia; Maresca, Marcello; Merkler, Doron; Gomez de Agüero Tamargo, Maria de la Mercedes; Macpherson, Andrew; Schrenzel, Jacques; Trajkovski, Mirko (2018). Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements. Cell metabolism, 28(6), 907-921.e7. Cell Press 10.1016/j.cmet.2018.08.005 <http://dx.doi.org/10.1016/j.cmet.2018.08.005>
Cell Metabolism, Vol. 28, No 6 (2018) pp. 907-921.e7
Cell Metabolism

مصطلحات موضوعية: Male, 0301 basic medicine, Lipopolysaccharide, Physiology, Macrophage polarization, 610 Medicine & health, ddc:616.07, Gut flora, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, medicine, insulin sensitivity, Animals, TLR4, ddc:612, innate immunity, Molecular Biology, browning, Innate immune system, gut microbiota, biology, Macrophages, Fatty liver, Cell Biology, Adipose Tissue, Beige, medicine.disease, biology.organism_classification, Gastrointestinal Microbiome, Cell biology, Eosinophils, Fatty Liver, Gastrointestinal Tract, Mice, Inbred C57BL, Toll-Like Receptor 4, Transplantation, Haematopoiesis, Lipid A, 030104 developmental biology, chemistry, beige fat, caloric restriction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da353e205cbf70ba8e0ce0eb3c13e10b
https://boris.unibe.ch/122377/1/1-s2.0-S1550413118305060-main.pdf