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المؤلفون: Keith A. Houck, Nicole Kleinstreuer, Ruili Huang, Kamel Mansouri, Alexandre Borrel, Anton Simeonov, Srilatha Sakamuru, Menghang Xia, Richard S. Judson
المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Quantitative structure–activity relationship, Bioinformatics, Computer science, Chemical structure, High-throughput screening, Quantitative Structure-Activity Relationship, lcsh:Medicine, Computational biology, 01 natural sciences, Article, Assay interference, 03 medical and health sciences, Interference (communication), Computational platforms and environments, Molecular descriptor, Toxicity Tests, High-Throughput Screening Assays, Cluster Analysis, Luciferase, lcsh:Science, Internet, Multidisciplinary, 010405 organic chemistry, lcsh:R, Assay, In vitro, 0104 chemical sciences, 030104 developmental biology, Screening, lcsh:Q, Databases, Chemical
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المؤلفون: Hongmin Li, Cheri A. Koetzner, Zhong Li, Menghang Xia, Anil Mathew Tharappel, Laura D. Kramer, Nicole Trudeau, Lili Kuo, Lianna D'Brant, Saiyang Hu, Subodh Kumar Samrat, David Butler, Yuekun Lang, Natasha Rugenstein, Jing Zhang, Srilatha Sakamuru, Ruili Huang
المصدر: Emerging Microbes & Infections. 9:2404-2416
مصطلحات موضوعية: 0301 basic medicine, Epidemiology, viruses, 030106 microbiology, Immunology, Biology, Dengue virus, medicine.disease_cause, Microbiology, Virus, Zika virus, 03 medical and health sciences, Virology, Drug Discovery, medicine, Protease inhibitor (pharmacology), NS3, Yellow fever, virus diseases, General Medicine, Japanese encephalitis, medicine.disease, biology.organism_classification, Flavivirus, 030104 developmental biology, Infectious Diseases, Parasitology
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المؤلفون: Rajarshi Guha, Anton Simeonov, Jesus Moreno, Min Shen, Yi Tang, James Inglese, Jared T. Shaw, Jimmy Ming-Tai Wu, Samir A. Ross, Tobie D. Lee, Surendra Karavadhi, Dorian M. Cheff, Susruta Majumdar, Adam Yasgar, Richard E. Taylor, Sam Michael, Zhengren Xu, Wei Sun, Lucas A. Morrill, David A. Vosburg, Wei Zheng, Corey R. J. Stephenson, Noah Z. Burns, Michael J. Iannotti, Carleen Klumpp-Thomas, Richard T. Eastman, Ohyun Kwon, Armen Zakarian, Yufeng Zhang, Matthew D. Hall, Sara E. Kearney, Ya Qin Zhang, Tongan Zhao, Ken Cheng, Indrajeet Sharma, Nathan P. Coussens, Ruili Huang, Derek S. Tan, Paul Shinn, Michael J. Krische, Caitlin Lynch, Jon Clardy, Larry E. Overman, Kanny K. Wan, Chambers C. Hughes, Madeleine M. Joullié, Thomas J. Maimone, Matthew B. Boxer, Jason A. Clement, A. Douglas Kinghorn, Peter A. Crooks, Brian C. Goess, Robert B. Susick, Gergely Zahoránszky-Kőhalmi, Alyssa L. Verano, Danielle Bougie, Jacob S. Roth, Ben Shen, Dorjbal Dorjsuren, Elias Picazo, Jinghua Zhao, John K. Snyder, Rodrigo B. Andrade, Wei Shi, Jin K. Cha, Brian T. Murphy, Fatima Rivas, William M. Wuest, Jake Ganor, Robert B. Grossman, Pavel Nagorny, Emily Mevers, Enas I. Mohamed, David E. Olson, John A. Porco, Neil K. Garg, Srilatha Sakamuru, Jason M. Rohde, M. Kevin Brown, Menghang Xia, Tianjing Ren, Steve Titus, Christopher Dillon, Mark J. Henderson, Zhong Zuo, Regan J. Thomson, David G. I. Kingston, Lauren E. Brown, Jeffrey N. Johnston, Katherine N. Maloney, Richmond Sarpong, Zina Itkin, Gregory D. Cuny, Ajit Jadhav, Kyle R. Brimacombe
المصدر: ACS Central Science
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)مصطلحات موضوعية: 0301 basic medicine, Natural product, General Chemical Engineering, General Chemistry, Biological potential, Space (commercial competition), Data science, Chemical library, Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Workflow, chemistry, Identification (biology), Cluster analysis, QD1-999, Limited resources, Research Article
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المؤلفون: Anton Simeonov, Caitlin Lynch, Christopher P. Austin, Menghang Xia, Srilatha Sakamuru, Jinghua Zhao, Tongan Zhao, Ruili Huang, Hu Zhu
المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Human toxicity, Drug, Quantitative structure–activity relationship, Drug-Related Side Effects and Adverse Reactions, In Vitro Techniques, media_common.quotation_subject, Quantitative Structure-Activity Relationship, lcsh:Medicine, Computational biology, Biology, Article, 03 medical and health sciences, Toxicity Tests, Animals, Humans, Adverse effect, lcsh:Science, media_common, Multidisciplinary, Toxicity data, Incidence, lcsh:R, United States, In vitro, High-Throughput Screening Assays, 030104 developmental biology, Pharmaceutical Preparations, Toxicity, lcsh:Q
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المؤلفون: Ruili Huang, Chaozhong Zou, Srilatha Sakamuru, Shuaizhang Li, Menghang Xia, Chia-Wen Hsu
المصدر: Slas Technology
مصطلحات موضوعية: 0301 basic medicine, Angiogenesis, High-throughput screening, Drug Evaluation, Preclinical, Angiogenesis Inhibitors, Docetaxel, high-content screening, 01 natural sciences, Metastasis, Bortezomib, 03 medical and health sciences, angiogenesis, co-culture cell model, Neoplasms, medicine, Humans, Telomerase reverse transcriptase, Telomerase, Cell Line, Transformed, Tube formation, Neovascularization, Pathologic, Chemistry, NF-kappa B, Mesenchymal Stem Cells, medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, In vitro, Coculture Techniques, 0104 chemical sciences, Computer Science Applications, 1536-well plate format, High-Throughput Screening Assays, 010404 medicinal & biomolecular chemistry, Medical Laboratory Technology, 030104 developmental biology, Special Issue: Quantitative Imaging in Medicine and the Life Sciences, Cell culture, High-content screening, Cancer research, Endothelium, Vascular, Topotecan, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0919cf9ba997bb7554a3deba94a49297
http://europepmc.org/articles/PMC6032403 -
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المؤلفون: Menghang Xia, Ruili Huang, Caitlin Lynch, Stephen S. Ferguson, Srilatha Sakamuru, Jake Niebler
المصدر: Biochem Pharmacol
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Pharmacology, digestive system, Biochemistry, Article, Small Molecule Libraries, Gene Knockout Techniques, 03 medical and health sciences, 0302 clinical medicine, medicine, Cytochrome P-450 CYP3A, Humans, chemistry.chemical_classification, Pregnane X receptor, CYP3A4, biology, Pregnane X Receptor, Cytochrome P-450 CYP3A Inducers, Reproducibility of Results, Cytochrome P450, Hep G2 Cells, digestive system diseases, High-Throughput Screening Assays, HEK293 Cells, 030104 developmental biology, Enzyme, chemistry, Nuclear receptor, 030220 oncology & carcinogenesis, biology.protein, Drug metabolism, Function (biology)
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المؤلفون: Warren Casey, Caitlin Lynch, Richard S. Paules, Ruili Huang, Anton Simeonov, Gordon L. Hager, Menghang Xia, Richard S. Judson, Lyuba Varticovski, Keith A. Houck, Diana A. Stavreva, Srilatha Sakamuru, Nicole Kleinstreuer
المصدر: Toxicology. 385:48-58
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, High-throughput screening, Biology, Toxicology, beta-Lactamases, Article, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Genes, Reporter, Internal medicine, Gene expression, medicine, Humans, Luciferases, Transcription factor, Testosterone, Reporter gene, High-Throughput Screening Assays, Cell biology, Androgen receptor, 030104 developmental biology, Endocrinology, Nuclear receptor, Receptors, Androgen, 030220 oncology & carcinogenesis, Androgens, Function (biology)
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المؤلفون: Patience Browne, Menghang Xia, Richard S. Judson, Srilatha Sakamuru, Matthew T. Martin, David J. Dix, Patricia Ceger, David Allen, Eric D. Watt, Keith A. Houck, Nicole Kleinstreuer, Russell S. Thomas, Ruili Huang, Warren Casey
المصدر: Chemical Research in Toxicology
مصطلحات موضوعية: Transcriptional Activation, 0301 basic medicine, Computational biology, Plasma protein binding, 010501 environmental sciences, Biology, Pharmacology, Toxicology, 01 natural sciences, Article, 03 medical and health sciences, High-Throughput Screening Assays, Androgen Receptor Antagonists, Humans, Cytotoxicity, Receptor, 0105 earth and related environmental sciences, In vitro toxicology, General Medicine, Models, Theoretical, In vitro, Androgen receptor, 030104 developmental biology, ROC Curve, Receptors, Androgen, Area Under Curve, Androgens, Androgen receptor activity, Protein Binding
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المؤلفون: Menghang Xia, Scott Heyward, Ruili Huang, Srilatha Sakamuru, Hongbing Wang, Caitlin Lynch, Linhao Li, Bryan Mackowiak
المصدر: Toxicological sciences : an official journal of the Society of Toxicology. 167(1)
مصطلحات موضوعية: 0301 basic medicine, Cytoplasm, Rimcazole, Cell Culture Techniques, Receptors, Cytoplasmic and Nuclear, Toxicology, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, CYP2B6 Gene, Tox21 SCREENING FOR CAR RECEPTOR ACTIVATION, Constitutive androstane receptor, Structure–activity relationship, Humans, Drug Interactions, Receptor, Cells, Cultured, Constitutive Androstane Receptor, Cell Nucleus, Pregnane X receptor, Molecular Structure, Chemistry, Cell biology, High-Throughput Screening Assays, Protein Transport, 030104 developmental biology, Nuclear receptor, Hepatocytes, 030217 neurology & neurosurgery, Drug metabolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493d20a1196b6e52757f695dc68f80ad
https://pubmed.ncbi.nlm.nih.gov/30247703 -
10Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening
المؤلفون: Helena T. Hogberg, Menghang Xia, Thomas Hartung, David Gerhold, Srilatha Sakamuru, Lena Smirnova, Zhi Bin Tong, David Kuo
المصدر: Journal of Applied Toxicology. 37:167-180
مصطلحات موضوعية: 0301 basic medicine, SH-SY5Y, Cellular differentiation, Biology, Toxicology, Neural stem cell, Cell biology, 03 medical and health sciences, 030104 developmental biology, nervous system, Cell culture, Survivin, Gene expression, Immunology, Cytotoxic T cell, Cytotoxicity