نتائج البحث - "William J. Griffiths"

1

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

المؤلفون: Jonas Abdel-Khalik, Alison Dickson, Douglas F. Covey, Anu Goenka, Tom Hearn, Yuqin Wang, Simon Jones, Brian W. Bigger, Arunabha Ghosh, William J. Griffiths, Teresa Hoi-Yee Wu, Eylan Yutuc, Daniel S. Ory, Peter J. Crick

المصدر: Griffiths, W J, Yutuc, E, Abdel-Khalik, J, Crick, P J, Hearn, T, Dickson, A, Bigger, B W, Hoi-Yee Wu, T, Goenka, A, Ghosh, A, Jones, S A, Covey, D F, Ory, D S & Wang, Y 2019, ' Metabolism of Non-Enzymatically Derived Oxysterols : Clues from sterol metabolic disorders ', Free Radical Biology and Medicine . https://doi.org/10.1016/j.freeradbiomed.2019.04.020
Free Radical Biology & Medicine

مصطلحات موضوعية: 0301 basic medicine, Bile acid biosynthesis, Free Radicals, Lydia Becker Institute, Oxysterol, Inborn errors of metabolism, Lysosomal acid lipase deficiency, Hydroxylation, Biochemistry, Article, Cholesterol/metabolism, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Free radical, ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation, Physiology (medical), Lipidomics, medicine, Humans, Ketocholesterols, Biotransformation, Epoxide Hydrolases, Niemann-Pick Diseases, Mass spectrometry, Chemistry, Cholesterol, Bile acid and salts/biosynthesis, Wolman Disease, Cholic Acids, Metabolism, medicine.disease, Hydroxycholesterols, Sterol, 3. Good health, Lysosomal Storage Diseases, 030104 developmental biology, Niemann–Pick disease, Oxidation-Reduction, Niemann-Pick disease, Cholestanols, 030217 neurology & neurosurgery, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b27579309f9deacec8b4704193c0ba
https://doi.org/10.1016/j.freeradbiomed.2019.04.020

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2

Cholesterol metabolism pathways - are the intermediates more important than the products?

المؤلفون: William J. Griffiths, Eylan Yutuc, Yuqin Wang

المصدر: The Febs Journal

مصطلحات موضوعية: 0301 basic medicine, Cell, nuclear receptors, inborn errors of metabolism, sterols, Biochemistry, digestive system, Bile Acids and Salts, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, COVID‐19, G protein‐coupled receptors, medicine, State‐of‐the‐Art Review, Animals, Humans, Cholesterol metabolism, Receptor, Molecular Biology, G protein-coupled receptor, mass spectrometry, State‐of‐the‐Art Reviews, Primary (chemistry), Molecular Structure, Chemistry, Cholesterol, Cholestenes, Biological activity, Cell Biology, Oxysterols, 030104 developmental biology, medicine.anatomical_structure, Nuclear receptor, Models, Chemical, 030220 oncology & carcinogenesis, glutamate receptors, cholestenoic acids, Hepatocytes, Metabolic Networks and Pathways

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29357e41def241aa675c6c91ed00e52e
https://pubmed.ncbi.nlm.nih.gov/33506652

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3

Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

المؤلفون: Alfred H. Merrill, Christer S. Ejsing, Harald Köfeler, Ivo Feussner, Michael J.O. Wakelam, Robert C. Murphy, Junken Aoki, Eoin Fahy, Friedrich Spener, William J. Griffiths, Thierry Durand, Shankar Subramaniam, Maria Fedorova, Edward A. Dennis, Valerie B. O'Donnell, Olga Oskolkova, Gerhard Liebisch

المساهمون: University Hospital Regensburg, University of California [San Diego] (UC San Diego), University of California, The University of Tokyo (UTokyo), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), University of Southern Denmark (SDU), European Molecular Biology Laboratory [Heidelberg] (EMBL), Leipzig University, University of Göttingen - Georg-August-Universität Göttingen, Swansea University, Medical University Graz, Georgia Institute of Technology [Atlanta], University of Colorado [Denver], Cardiff University, Karl-Franzens-Universität [Graz, Autriche], The Babraham Institute [Cambridge, UK], University of Graz

المصدر: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (12), pp.1539-1555. ⟨10.1194/jlr.S120001025⟩
Liebisch, G, Fahy, E, Aoki, J, Dennis, E A, Durand, T, Ejsing, C S, Fedorova, M, Feussner, I, Griffiths, W J, Köfeler, H, Merrill, A H, Murphy, R C, O'Donnell, V B, Oskolkova, O, Subramaniam, S, Wakelam, M J O & Spener, F 2020, ' Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures ', Journal of Lipid Research, vol. 61, no. 12, pp. 1539-1555 . https://doi.org/10.1194/jlr.S120001025
Journal of Lipid Research, Vol 61, Iss 12, Pp 1539-1555 (2020)
Journal of lipid research, vol 61, iss 12

مصطلحات موضوعية: 0301 basic medicine, Biochemistry & Molecular Biology, Fatty acyls, [SDV]Life Sciences [q-bio], Computational biology, QD415-436, Glycerophospholipids, sterols, 030204 cardiovascular system & hematology, Medical Biochemistry and Metabolomics, Notation, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Terminology as Topic, fatty acyls, Lipidomics, Special Report, Nomenclature, mass spectrometry, glycerophospholipids, Sphingolipids, sphingolipids, Mass spectrometry, Chemistry, glycerolipids, Glycerolipids, Cell Biology, Lipids, Mass spectrometric, Sterols, 030104 developmental biology, Metabolic labeling, Data presentation, lipidomics, lipids (amino acids, peptides, and proteins), Biochemistry and Cell Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079a7ca95a873a94dd9935eae3165e66
https://hal.umontpellier.fr/hal-03377984

4

The Biosynthesis of Enzymatically Oxidized Lipids

المؤلفون: Valerie B. O'Donnell, Ali A Hajeyah, William J. Griffiths, Yuqin Wang, Andrew J. Finch

المصدر: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 11 (2020)

مصطلحات موضوعية: 0301 basic medicine, cyclooxygenase (COX), cytochrome P450, oxylipins, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Lipoxygenase, Aldo-Keto Reductases, biosynthesis of oxidized lipids, Review, lcsh:Diseases of the endocrine glands. Clinical endocrinology, digestive system, Steroid, 03 medical and health sciences, chemistry.chemical_compound, Endocrinology, Cytochrome P-450 Enzyme System, Biosynthesis, medicine, Animals, Humans, sterols and steroid hormones, aldo-keto reductase (AKR), chemistry.chemical_classification, lcsh:RC648-665, 030102 biochemistry & molecular biology, biology, Chemistry, Cytochrome P450, Metabolism, Lipids, Endocannabinoid system, lipoxygenase (LOX), 3. Good health, 030104 developmental biology, Enzyme, Biochemistry, Prostaglandin-Endoperoxide Synthases, biology.protein, oxidized phospholipids, lipids (amino acids, peptides, and proteins), Oxidation-Reduction, Polyunsaturated fatty acid, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032c5a7a584d056b740d19395542ff85
https://doi.org/10.3389/fendo.2020.591819

5

Standardizing and increasing the utility of lipidomics: a look to the next decade

المؤلفون: Yuqin Wang, Eylan Yutuc, William J. Griffiths

المصدر: Expert review of proteomics. 17(10)

مصطلحات موضوعية: 0301 basic medicine, 030102 biochemistry & molecular biology, Computer science, Steroid biosynthesis, Lipid Metabolism, Biochemistry, Data science, Mass Spectrometry, 03 medical and health sciences, 030104 developmental biology, Expert opinion, Metabolite profiling, Lipidomics, Animals, Humans, Metabolomics, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a28489301056213234419290358c472
https://pubmed.ncbi.nlm.nih.gov/33191815

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6

Neuro-oxysterols and neuro-sterols as ligands to nuclear receptors, GPCRs, ligand-gated ion channels and other protein receptors

المؤلفون: Eylan Yutuc, Yuqin Wang, William J. Griffiths

المصدر: British journal of pharmacologyREFERENCES. 178(16)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d99bba49f6f95111a138f395dc526c
https://pubmed.ncbi.nlm.nih.gov/32621622

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7

Unravelling new pathways of sterol metabolism: lessons learned from in-born errors and cancer

المؤلفون: Yuqin Wang, William J. Griffiths

المصدر: Current Opinion in Clinical Nutrition and Metabolic Care

مصطلحات موضوعية: 0301 basic medicine, Metabolite, Medicine (miscellaneous), Breast Neoplasms, Biology, Cerebrotendinous Xanthomatosis, 03 medical and health sciences, chemistry.chemical_compound, medicine, bile acid, Humans, Ketocholesterols, Nutrition and Dietetics, Niemann–Pick disease, type C, Cholesterol, Imidazoles, LIPID METABOLISM AND THERAPY: Edited by Philip Calder and Richard J. Deckelbaum, cholesterol, Lipid metabolism, Niemann-Pick Disease, Type C, Niemann-Pick Disease, Type B, Xanthomatosis, Cerebrotendinous, medicine.disease, Lipid Metabolism, Sterol, 3. Good health, Smith-Lemli-Opitz Syndrome, Metabolic pathway, Sterols, 030104 developmental biology, chemistry, Biochemistry, Smith–Lemli–Opitz syndrome, oxysterol, Biomarkers, Cholestanols

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497c092f97f325777d6a98cf17b67a9b
http://europepmc.org/articles/PMC5808834

8

Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse

المؤلفون: Peter J. Crick, Eylan Yutuc, Jonas Abdel-Khalik, Ingemar Björkhem, Yuqin Wang, William J. Griffiths, Guillem Genové, Christer Betsholtz, Ahmed Saeed

المصدر: The Journal of Steroid Biochemistry and Molecular Biology

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Male, Bile acid biosynthesis, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Vascular permeability, Mice, Transgenic, Deuterium-isotope effect, Liquid chromatography–mass spectrometry, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, 24S-hydroxycholesterol, 0302 clinical medicine, Endocrinology, Human disease, Cholesterol 24-Hydroxylase, Animals, Molecular Biology, chemistry.chemical_classification, 24S,25-epoxycholesterol, Cholesterol, Cholestenes, Cell Biology, Metabolism, Oxysterols, Deuterium, Sterol, 3. Good health, Mice, Inbred C57BL, CYP46A1, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, lipids (amino acids, peptides, and proteins), Derivatisation, Deuterium-enrichment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd41a385d5e093f3c53268de111331d0
https://pubmed.ncbi.nlm.nih.gov/31541728

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9

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

المؤلفون: Shanzheng Yang, Eylan Yutuc, Jonas Abdel-Khalik, Angel Cedazo-Minguez, Ernest Arenas, Ahmed Saeed, Abbe Ullgren, Ingemar Björkhem, William J. Griffiths, Willy Antoni Abreu de Oliveira, Yuqin Wang, Spyridon Theofilopoulos

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9908c3d16a6842da8ea43195d8213b8
https://lirias.kuleuven.be/handle/123456789/636706

10

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis

المساهمون: University of Zurich, Misselwitz, Benjamin

المصدر: Journal of Lipid Research, Vol 60, Iss 7, Pp 1270-1283 (2019)
Raselli, Tina; Hearn, Tom; Wyss, Annika; Atrott, Kirstin; Peter, Alain; Frey-Wagner, Isabelle; Spalinger, Marianne R; Maggio, Ewerton M; Sailer, Andreas W; Schmitt, Johannes; Schreiner, Philipp; Moncsek, Anja; Mertens, Joachim; Scharl, Michael; Griffiths, William J; Bueter, Marco; Geier, Andreas; Rogler, Gerhard; Wang, Yuqin and Misselwitz, Benjamin (2019). Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis. Journal of lipid research, 60(7), pp. 1270-1283. American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.M093229 <http://dx.doi.org/10.1194/jlr.M093229>
Journal of Lipid Research

مصطلحات موضوعية: Male, nonalcoholic fatty liver disease, 0301 basic medicine, 1303 Biochemistry, Cirrhosis, 030204 cardiovascular system & hematology, Epstein-Barr virus-induced gene 2, Biochemistry, Mass Spectrometry, Mixed Function Oxygenases, 1307 Cell Biology, Pathogenesis, Mice, Liver disease, 0302 clinical medicine, Endocrinology, Non-alcoholic Fatty Liver Disease, Fibrosis, Nonalcoholic fatty liver disease, polycyclic compounds, Receptor, Research Articles, Mice, Knockout, Alanine Transaminase, Oxysterols, Middle Aged, Flow Cytometry, 1310 Endocrinology, 3. Good health, Cholesterol, 10219 Clinic for Gastroenterology and Hepatology, Liver, lipids (amino acids, peptides, and proteins), Adult, medicine.medical_specialty, Oxysterol, CYP7B1, 610 Medicine & health, 25-hydroxycholesterol 7α-hydroxylase, QD415-436, Biology, digestive system, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Aspartate Aminotransferases, ddc:610, 10217 Clinic for Visceral and Transplantation Surgery, cholesterol 25 hydroxylase, nutritional and metabolic diseases, Cell Biology, medicine.disease, Hydroxycholesterols, digestive system diseases, mouse feeding model, 030104 developmental biology, Steroid Hydroxylases, Chromatography, Liquid

وصف الملف: application/pdf; jlrM093229.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250afd769e85a1f81468461afd77ff23
https://doi.org/10.1194/jlr.M093229

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