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المؤلفون: Lijuan Pang, Hong Zou, Wei Jia, Wen-hao Hu, Chao Wang, Xiaoli Diao, Feng Li, Xiao Niu, Meili Ding, Teng Jiang, Yan Qi
المصدر: Journal of Molecular Histology
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Histology, Physiology, Ovary, Biology, Sensitivity and Specificity, Diagnosis, Differential, SR-B1, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Clear cell carcinoma of the ovary, Clear cell renal carcinoma, Carcinoma, Renal Cell, Aged, Ovarian Neoplasms, Original Paper, Cell Biology, General Medicine, Middle Aged, Scavenger Receptors, Class B, medicine.disease, Immunohistochemistry, Kidney Neoplasms, Staining, Clear cell renal cell carcinoma, 030104 developmental biology, medicine.anatomical_structure, Cytoplasm, 030220 oncology & carcinogenesis, Clear cell carcinoma, CD10, Female, Neprilysin, Differential diagnosis, Ovarian cancer
الوصف: Both clear cell renal carcinoma (ccRCC) and clear cell carcinoma of the ovary (CCOC) have a clear cytoplasmic morphological feature, hence it is difficult to identify metastatic ccRCC and CCOC by morphology alone. At present, there are no effective immunohistochemical markers to distinguish between these two tumors. Studies have shown that the clear cytoplasm of ccRCC is mainly caused by cholesterol-rich lipids in the cytoplasm, while that of CCOC is due to the accumulation of cytoplasmic glycogen. Objective: to hypothesize that the scavenger receptor class B-type 1 (SR-B1) protein responsible for HDL cholesterol uptake may be differentially expressed in ccRCC and CCOC, and high CD10 expression in the renal tubular epithelium may assist in distinguishing between ccRCC and CCOC. Methods: effective immunohistochemical markers were applied in 90 cases of renal clear cell carcinoma and 31 cases of ovarian cancer to distinguish between the two types of tumors.Result: SR-B1 and CD10 expression is significantly higher in ccRCC than CCOC. Both SR-B1 and CD10 exhibited focal weak-medium intensity staining in CCOC, and their staining extent and intensity were significantly lower than ccRCC. The sensitivity and specificity of SR-B1 for identifying ccRCC were 74.4% and 83.9%, respectively. The sensitivity and specificity of CD10 for identifying CCOC were 93.3% and 80.6%, respectively. The combined SR-B1( +) CD10( +) immunoprofile supports the diagnosis of ccRCC with a specificity of 93.5%. The combined SR-B1(-) CD10(-) immunoprofile supports the diagnosis of CCOC with a specificity of 93.3%. Conclusions: our findings demonstrate that the combination of SR-B1 and CD10 immunoprofiling is a valuable tool for differential diagnosis of ccRCC and CCOC.
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المؤلفون: Dong-Fang Meng, Bi-Jun Huang, Chao Cheng, Li-Xia Peng, Chao-Nan Qian, Jing Wang, Si-Ting Lin, Xin‐Ke Zhang, Tie-Jun Huang, Fei-Fei Luo, Yu‐Jie Xie, Hao Hu, Zhan-Fei Zhang
المصدر: Journal of Cellular and Molecular Medicine
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.disease_cause, combination therapy, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Cell Movement, Gene knockdown, Mice, Inbred BALB C, AKR1C2, Middle Aged, Up-Regulation, Gene Expression Regulation, Neoplastic, oesophageal squamous cell carcinoma, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Molecular Medicine, Original Article, Female, Esophageal Squamous Cell Carcinoma, cisplatin resistance, medicine.drug, Signal Transduction, PI3K/AKT signalling pathway, Mice, Nude, Antineoplastic Agents, 03 medical and health sciences, In vivo, Cell Line, Tumor, medicine, Biomarkers, Tumor, Animals, Humans, PI3K/AKT/mTOR pathway, Cell Proliferation, Cisplatin, Oncogene, business.industry, Hydroxysteroid Dehydrogenases, Cell Biology, Original Articles, Oncogenes, In vitro, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer research, Ectopic expression, business, Carcinogenesis, Proto-Oncogene Proteins c-akt
الوصف: The aldo‐keto reductases family 1 member C2 (AKR1C2) has critical roles in the tumorigenesis and progression of malignant tumours. However, it was also discovered to have ambiguous functions in multiple cancers and till present, its clinical significance and molecular mechanism in oesophageal squamous cell carcinoma (ESCC) has been unclear. The aim of this study was to explore the role of AKR1C2 in the tumorigenesis of ESCC. Here, we showed that AKR1C2 expression was found to be up‐regulated in ESCC tissues and was significantly associated with pathological stage, lymph node metastasis and worse outcomes. Functional assays demonstrated that an ectopic expression of AKR1C2 in ESCC cells resulted in increased proliferation, migration and cisplatin resistance, while knockdown led to inversing effects. Bioinformation analyses and mechanistic studies demonstrated that AKR1C2 activated the PI3K/AKT signalling pathway, furthermore, the inhibitor of PI3K or the selective inhibitor of AKR1C2 enzyme activity could reverse the aggressiveness and showed synergistic antitumour effect when combined with cisplatin, both in vitro and in vivo. In conclusion, Our findings revealed that AKR1C2 could function as an oncogene by activating the PI3K/AKT pathway, as a novel prognostic biomarker and/or as a potential therapeutic target to ESCC.
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المؤلفون: Yao Yu, Chad D. Huff, Hao Hu, Paul Scheet, Fulan Hu, Jiun Sheng Chen
المصدر: Journal of Medical Genetics. 58:145-153
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Mutation, Missense, Biology, Germline, 03 medical and health sciences, 0302 clinical medicine, Molecular genetics, Exome Sequencing, Genetic variation, Genetics, medicine, Humans, Missense mutation, Exome, Genetic Predisposition to Disease, 1000 Genomes Project, Germ-Line Mutation, Genetics (clinical), Aged, Neurofibromin 1, Soft tissue sarcoma, Sarcoma, Middle Aged, medicine.disease, DNA-Binding Proteins, Germ Cells, MutS Homolog 2 Protein, 030104 developmental biology, MSH2, 030220 oncology & carcinogenesis, Medical genetics, Female, Tumor Suppressor Protein p53, Genome-Wide Association Study, Transcription Factors
الوصف: PurposeThe contribution of rare genetic variation in the development of soft-tissue sarcoma (STS) remains underexplored. To address this gap, we conducted a whole-exome case-control and somatic-germline interaction study to identify and characterise STS susceptible genes.MethodsThe study involved 219 STS cases from The Cancer Genome Atlas and 3507 controls. All cases and controls were matched genetically onEuropean ancestry based on the 1000 Genomes project. Cross-platform technological stratification was performed with XPAT and gene-based association tests with VAAST 2.ResultsNF1 exhibited the strongest genome-wide signal across the six subtypes, with p=1×10−5. We also observed nominally significant association signals for three additional genes of interest, TP53 (p=0.0025), RB1 (p=0.0281), and MSH2 (p=0.0085). BAG1, which has not previously been implicated in STS, exhibited the strongest genome-wide signal after NF1, with p=6×10−5. The association signals for NF1 and MSH2 were driven primarily by truncating variants, with ORs of 39 (95% CI: 7.1 to 220) for NF1 and 33 (95% CI: 2.4 to 460) for MSH2. In contrast, the association signals for RB1 and BAG1 were driven primarily by predicted damaging missense variants, with estimated ORs of 12 (95% CI: 2.4 to 59) for RB1 and 20 (95% CI: 1.4 to 300) for BAG1.ConclusionsOur results confirm that pathogenic variants in NF1, RB1 and TP53 confer large increases in the risk of developing multiple STS subtypes, provide support for the role of MSH2 in STS susceptibility and identify BAG1 as a novel candidate STS risk gene.
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المؤلفون: Qian Zhu, Ji-Hua Zheng, Xi Liu, Hao Hu, Zhi-Yong Xu, Sicong Jiang
المصدر: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunologyمصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, Time Factors, medicine.medical_treatment, efficacy, Immunology, Risk Assessment, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Risk Factors, law, brain metastases, Internal medicine, Humans, Medicine, Immunology and Allergy, Lung cancer, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Brain Neoplasms, business.industry, Hazard ratio, programmed cell death ligand 1, Immunotherapy, Middle Aged, RC581-607, medicine.disease, Progression-Free Survival, Confidence interval, Clinical trial, lung cancer, 030104 developmental biology, Systematic review, 030220 oncology & carcinogenesis, Meta-analysis, Female, Systematic Review, immunotherapy, Immunologic diseases. Allergy, business
الوصف: BackgroundBrain metastases (BMs) indicate poor outcomes and are commonly excluded in immunotherapy clinical trials in advanced lung cancer; moreover, the effect of BM status on immunotherapy efficacy is inconsistent and inconclusive. Therefore, we conducted a meta-analysis to assess the influence of BM status on immunotherapy efficacy in advanced lung cancer.MethodsElectronic databases and all major conference proceedings were searched without language restrictions according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. We extracted randomized clinical trials on lung cancer immunotherapy that had available overall survival (OS) and/or progression-free survival (PFS) data based on the BM status. All analyses were performed using random effects models.ResultsFourteen randomized clinical trials with 9,089 patients were identified. Immunotherapy conferred a survival advantage to BM patients [OS-hazard ratio (HR), 0.72; 95% confidence interval (CI), 0.58–0.90; P = 0.004; and PFS-HR, 0.68; 95% CI, 0.52–0.87, P = 0.003]. Non-BM patients could also derive a survival benefit from immunotherapy (OS-HR, 0.76; 95% CI, 0.71–0.80; P versus non-BM patients were 0.96 (95% CI, 0.78–1.18; P = 0.72) and 0.97 (95% CI, 0.79–1.20; P = 0.78), respectively, indicating no statistically significant difference between them. Subsequent sensitivity analyses did not alter the results. Subgroup analyses according to tumor type, line of therapy, immunotherapy type, study design, and representation of BM patients reconfirmed these findings.ConclusionWe demonstrated that BM status did not significantly influence the immunotherapy efficacy in lung cancer, suggesting that both BM and non-BM patients could obtain comparable benefits.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier (CRD42020207446).
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cde0d5c5663d38af51f8b730a0e915
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المؤلفون: Lan Tan, Qiang Dong, Jin-Tai Yu, Hao Hu, Wei Xu, Xue-Ning Shen, Jiu-Long Yang, Lin-Lin Li, Yan-Lin Bi, Ya-Hui Ma, Xiao-He Hou, Fu-Rong Sun
المصدر: Journal of Alzheimer's disease : JAD. 81(1)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Amyloid, tau Proteins, Disease, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Cognition, Alzheimer Disease, Internal medicine, medicine, Humans, Hyperuricemia, Phosphorylation, Aged, Amyloid beta-Peptides, business.industry, General Neuroscience, Amyloidosis, Neurodegeneration, General Medicine, Middle Aged, medicine.disease, Peptide Fragments, Uric Acid, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Endocrinology, Biomarker (medicine), Female, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Oxidative stress, Biomarkers
الوصف: Background: Serum uric acid (SUA) affects the reaction of oxidative stress and free radicals in the neurodegenerative processes. However, whether SUA impacts Alzheimer’s disease (AD) pathology remains unclear. Objective: We aimed to explore whether high SUA levels can aggravate the neurobiological changes of AD in preclinical AD. Methods: We analyzed cognitively intact participants (n = 839, age 62.16 years) who received SUA and cerebrospinal fluid (CSF) biomarkers (amyloid-β [Aβ], total tau [t-Tau], and phosphorylated tau [p-Tau]) measurements from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) database using multivariable-adjusted linear models. Results: Levels of SUA in the preclinical AD elevated compared with the healthy controls (p = 0.007) and subjects with amyloid pathology had higher concentration of SUA than controls (p = 0.017). Roughly, equivalent levels of SUA displayed among cognitively intact individuals with or without tau pathology and neurodegeneration. CSF Aβ1 - 42 (p = 0.019) and Aβ1 - 42/Aβ1 - 40 (p = 0.027) were decreased and CSF p-Tau/Aβ1 - 42 (p = 0.009) and t-Tau/Aβ1 - 42 (p = 0.043) were increased with the highest (> 75th percentile) SUA when compared to lowest SUA, implying a high burden of cerebral amyloidosis in individuals with high SUA. Sensitivity analyses using the usual threshold to define hyperuricemia and precluding drug effects yielded robust associations. Nevertheless, the quadratic model did not show any U-shaped relationships between them. Conclusion: SUA may aggravate brain amyloid deposition in preclinical AD, which corroborated the detrimental role of SUA.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a361bb26f5697e4214ac6c52c11eedd1
https://pubmed.ncbi.nlm.nih.gov/33814427 -
6
المؤلفون: Zuo-Teng Wang, Hao Hu, Yu Guo, Lan Tan, Lin Tan, Ya-Nan Ou, Ting Zhang, Alzheimer’s Disease Neuroimaging Initiative, Jin-Tai Yu, Guang-Xiang Yu, Xiao-He Hou, Wei Xu
المصدر: Journal of Alzheimer's disease : JAD. 80(1)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Databases, Factual, Neuroimaging, Kaplan-Meier Estimate, Prevention of dementia, 03 medical and health sciences, Amyloid beta-Protein Precursor, Executive Function, 0302 clinical medicine, Framingham Heart Study, Risk Factors, Bayesian multivariate linear regression, Internal medicine, medicine, Dementia, Humans, Cognitive Dysfunction, Longitudinal Studies, Vascular Diseases, Cognitive decline, Survival analysis, Aged, Brain Chemistry, Framingham Risk Score, business.industry, General Neuroscience, Cognition, General Medicine, Middle Aged, medicine.disease, Mental Status and Dementia Tests, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Cross-Sectional Studies, Glucose, Positron-Emission Tomography, Disease Progression, Female, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
الوصف: Background: Increasing evidence supports an important role of vascular risk in cognitive decline and dementia. Objective: This study aimed to examine whether vascular risk was associated with cognitive decline, cerebral hypometabolism, and clinical progression in cognitively intact elders. Methods: Vascular risk was assessed by the Framingham Heart Study general Cardiovascular disease (FHS-CVD) risk score. The cross-sectional and longitudinal associations of FHS-CVD risk score with cognition and brain glucose metabolism were explored using multivariate linear regression and linear mixed effects models, respectively. The risk of clinical progression conversion was assessed using Kaplan-Meier survival curves and multivariate Cox proportional hazard models. Results: A total of 491 cognitively intact elders were included from Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Participants with high FHS-CVD risk scores had lower baseline Mini-Mental State Examination (MMSE) (p = 0.009), executive function (EF) (p
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8358c71b509e1edcbc7d290fd538de36
https://pubmed.ncbi.nlm.nih.gov/33523005 -
7
المؤلفون: Hao Hu, Qian Zhu, Yu-Kang Kuang, Chang-Ying Guo, Xiao-Ming Wen, Fang-Fang Tou
المصدر: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Cancerمصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Lung adenocarcinoma, Cancer Research, Lung Neoplasms, B7-H1 Antigen, 0302 clinical medicine, Surgical oncology, Programmed death ligand 1, Pyruvate kinase M2, Prognostic factor, medicine.diagnostic_test, biology, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, Research Article, Adult, medicine.medical_specialty, Thyroid Hormones, Subgroup analysis, Adenocarcinoma of Lung, lcsh:RC254-282, Disease-Free Survival, Flow cytometry, 03 medical and health sciences, Internal medicine, PD-L1, Cell Line, Tumor, Genetics, medicine, Biomarkers, Tumor, Humans, Survival analysis, Aged, Proportional Hazards Models, Lung, business.industry, Proportional hazards model, Membrane Proteins, medicine.disease, 030104 developmental biology, biology.protein, business, Carrier Proteins
الوصف: Background The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma (LUAD) is unclear. Methods A total of 506 lung adenocarcinoma samples from The Cancer Genome Atlas (TCGA) dataset and 173 LUAD tumour tissues from Jiangxi Cancer Hospital were used to analyse the correlation between PKM2 and PD-L1 expression. We further established a stable LUAD cell line with PKM2 knockdown and confirmed the association via Western blotting and flow cytometry analysis. Moreover, the prognostic values of PKM2 and PD-L1 were evaluated by the Kaplan-Meier method and Cox proportional hazards models. Results Based on the above two large cohorts, we found that PKM2 was significantly positively associated with PD-L1 expression (r = 0.132, P = 0.003 and r = 0.287, P
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المؤلفون: Kees E. P. van Roozendaal, Molka Kammoun, Michael Field, Andreas Dufke, Joris Vermeesch, Annick Toutain, Hao Hu, Theresa Mihalic Mosher, Joep P.M. Geraedts, Hans-Hilger Ropers, Peter White, Jan Liebelt, Sungjin Moon, Vera M. Kalscheuer, Joost Gribnau, Bas de Hoon, Germán Rodríguez Criado, Marie Shaw, Ute Grasshoff, Stefan A. Haas, Benjamin J. Kelly, Lynne Hobson, Marjan De Rademaeker, Christelle Golzio, Suzanna G.M. Frints, Olaf Riess, Claudia S. Bauer, Eric Haan, Nicholas Katsanis, Peter Bauer, Karen W. Gripp, Renee Carroll, Jozef Gecz, Jean Pierre Fryns, Cristina Gontan, Aysegul Ozanturk, Eveline Rentmeester, Martine Raynaud, Scott E. Hickey, Daniel C. Koboldt, Sylvie Manouvrier-Hanu, Lucinda Murray, Koen Devriendt, Christopher Schroeder, Kathryn Friend
المساهمون: Developmental Biology, Obstetrics & Gynecology, MUMC+: DA KG Bedrijfsbureau (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, Klinische Genetica, MUMC+: DA KG Lab Centraal Lab (9), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Duke University [Durham], Hospital Universitario Virgen del Rocío [Sevilla], University of Tübingen, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Hunter Genetics, Clinique de Génétique médicale Guy Fontaine [CHRU LIlle], Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 (RADEME), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nationwide Children's Hospital, Ohio State University [Columbus] (OSU), University Hospitals Leuven [Leuven], Nemours/Alfred I. du Pont Hospital for Children, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Max Planck Institute for Molecular Genetics (MPIMG), Max-Planck-Gesellschaft, University of Adelaide, Women’s and Children’s Hospital [Adelaide], SA Pathology [Adelaide, SA, Australia], Vrije Universiteit Brussel (VUB), South Australian Health and Medical Research Institute [ Adelaide] (SAHMRI), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte, Reproduction and Genetics, Clinical sciences, Medical Genetics
المصدر: Molecular Psychiatry, 24(11), 1748-1768. Nature Publishing Group
Molecular Psychiatry
Mol Psychiatry
Mol Psychiatry, 2019, 24 (11), pp.1748-1768. ⟨10.1038/s41380-018-0065-x⟩مصطلحات موضوعية: Male, 0301 basic medicine, X-linked intellectual disability, PROTEIN, [SDV.GEN] Life Sciences [q-bio]/Genetics, FUNCTIONAL-ACTIVITY, Mice, 0302 clinical medicine, Genes, X-Linked, X Chromosome Inactivation, RNF12, Missense mutation, TRANSCRIPTION, Child, Zebrafish, Genetics, Middle Aged, Phenotype, Pedigree, Ubiquitin ligase, Psychiatry and Mental health, medicine.anatomical_structure, Child, Preschool, Female, Adult, Conduct Disorder, Adolescent, Ubiquitin-Protein Ligases, NPAS3, Biology, 03 medical and health sciences, Cellular and Molecular Neuroscience, Intellectual Disability, medicine, Ring finger, Animals, Humans, Molecular Biology, Transcription factor, RLIM, [SDV.GEN]Life Sciences [q-bio]/Genetics, CHROMOSOME INACTIVATION, MUTATIONS, Infant, Newborn, Ubiquitination, Wild type, Zebrafish Proteins, medicine.disease, biology.organism_classification, HEK293 Cells, 030104 developmental biology, Mutation, Mental Retardation, X-Linked, biology.protein, LIM COFACTORS, 030217 neurology & neurosurgery, Transcription Factors, GENE UBE2A CAUSE
الوصف: RLIM, also known as RNF12, is an X-linked E3 ubiquitin ligase acting as a negative regulator of LIM-domain containing transcription factors and participates in X-chromosome inactivation (XCI) in mice. We report the genetic and clinical findings of 84 individuals from nine unrelated families, eight of whom who have pathogenic variants in RLIM (RING finger LIM domain-interacting protein). A total of 40 affected males have X-linked intellectual disability (XLID) and variable behavioral anomalies with or without congenital malformations. In contrast, 44 heterozygous female carriers have normal cognition and behavior, but eight showed mild physical features. All RLIM variants identified are missense changes co-segregating with the phenotype and predicted to affect protein function. Eight of the nine altered amino acids are conserved and lie either within a domain essential for binding interacting proteins or in the C-terminal RING finger catalytic domain. In vitro experiments revealed that these amino acid changes in the RLIM RING finger impaired RLIM ubiquitin ligase activity. In vivo experiments in rlim mutant zebrafish showed that wild type RLIM rescued the zebrafish rlim phenotype, whereas the patient-specific missense RLIM variants failed to rescue the phenotype and thus represent likely severe loss-of-function mutations. In summary, we identified a spectrum of RLIM missense variants causing syndromic XLID and affecting the ubiquitin ligase activity of RLIM, suggesting that enzymatic activity of RLIM is required for normal development, cognition and behavior.
وصف الملف: application/pdf
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المؤلفون: Qing-Hua Yu, Xing-Wang Wang, Ji-Hua Zheng, Zhi-Yong Xu, Hui-Lan Yang, Hao Hu, Gong-Kai Zhang
المصدر: Biology of Sex Differences
Biology of Sex Differences, Vol 12, Iss 1, Pp 1-8 (2021)مصطلحات موضوعية: 0301 basic medicine, Male, lcsh:Medicine, Comorbidity, Severity of Illness Index, lcsh:Physiology, 0302 clinical medicine, Endocrinology, Risk Factors, Medicine, 030212 general & internal medicine, Aged, 80 and over, lcsh:QP1-981, Medical record, Age Factors, Middle Aged, Hospitalization, Postmenopause, Treatment Outcome, Female, medicine.medical_specialty, China, Coronavirus disease 2019 (COVID-19), Gender Studies, 03 medical and health sciences, Sex Factors, Disease severity, Internal medicine, Propensity score matching, Severity of illness, Humans, Mortality, Propensity Score, Aged, Retrospective Studies, Postmenopausal women, Menopause status, business.industry, SARS-CoV-2, Research, lcsh:R, COVID-19, Retrospective cohort study, medicine.disease, 030104 developmental biology, Premenopause, business
الوصف: Background Despite the growing number of studies on the coronavirus disease-19 (COVID-19), little is known about the association of menopausal status with COVID-19 outcomes. Materials and methods In this retrospective study, we included 336 COVID-19 inpatients between February 15, 2020 and April 30, 2020 at the Taikang Tongji Hospital (Wuhan), China. Electronic medical records including patient demographics, laboratory results, and chest computed tomography (CT) images were reviewed. Results In total, 300 patients with complete clinical outcomes were included for analysis. The mean age was 65.3 years, and most patients were women (n = 167, 55.7%). Over 50% of patients presented with comorbidities, with hypertension (63.5%) being the most common comorbidity. After propensity score matching, results showed that men had significantly higher odds than premenopausal women for developing severe disease type (23.7% vs. 0%, OR 17.12, 95% CI 1.00–293.60; p = 0.003) and bilateral lung infiltration (86.1% vs. 64.7%, OR 3.39, 95% CI 1.08–10.64; p = 0.04), but not for mortality (2.0% vs. 0%, OR 0.88, 95% CI 0.04–19.12, p = 1.00). However, non-significant difference was observed among men and postmenopausal women in the percentage of severe disease type (32.7% vs. 41.7%, OR 0.68, 95% CI 0.37–1.24, p = 0.21), bilateral lung infiltration (86.1% vs. 91.7%, OR 0.56, 95% CI 0.22–1.47, p = 0.24), and mortality (2.0% vs. 6.0%, OR 0.32, 95% CI 0.06–1.69, p = 0.25). Conclusions Men had higher disease severity than premenopausal women, while the differences disappeared between postmenopausal women and men. These findings support aggressive treatment for the poor prognosis of postmenopausal women in clinical practice.
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المؤلفون: Hao Hu, Qiang Dong, Lan Tan, Ling-Zhi Ma, Jin-Tai Yu, Yan-Lin Bi, Xue-Ning Shen, Ya-Nan Ou, He-Ying Hu, Ya-Hui Ma
المصدر: Neurotoxicity research. 39(4)
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, China, Neurology, Toxicology, Bedtime, Pittsburgh Sleep Quality Index, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Cognition, Alzheimer Disease, Internal medicine, medicine, Humans, Neurochemistry, Receptors, Immunologic, Life Style, Aged, Aged, 80 and over, Membrane Glycoproteins, business.industry, General Neuroscience, Middle Aged, Sleep in non-human animals, 030104 developmental biology, Cross-Sectional Studies, Sleep Quality, Nocturnal sleep, Subjective sleep, Female, business, 030217 neurology & neurosurgery, Biomarkers, Follow-Up Studies
الوصف: As brain insults, sleep disorders could enhance microglial activation and aggravate neuroinflammation. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) serves as a readout for TREM2-associated microglial responses. We aimed to study the association of sleep characteristics with CSF sTREM2 in cognitively normal (CN) older adults. Linear and non-linear regression analyses were conducted in 830 participants with measurements of sleep characteristics and CSF sTREM2, after adjusting for age, sex, education, the Chinese-Modified Mini-Mental State Examination (CM-MMSE) scores, and APOE4 status. These analyses were also performed in amyloid-negative (A −) and amyloid-positive (A +) individuals. Linear relationships between sleep characteristics and CSF sTREM2 were found. In all the participants, sleep efficiency score in Pittsburgh Sleep Quality Index (PSQI) (p = 0.037) showed a positive linear association with CSF sTREM2. In A + individuals, the grade of PSQI total score (p = 0.011) as well as subjective sleep quality score (p = 0.048) and sleep efficiency score (p
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6fe995af04f2159cc7ce5176d2ee1a
https://pubmed.ncbi.nlm.nih.gov/34097185
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