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المؤلفون: Marie D. Ralff, Benedito A. Carneiro, Lanlan Zhou, Wen-I Chang, Rohinton Tarapore, Varun V. Prabhu, Joshua N. Honeyman, Attila A. Seyhan, Isacco Ferrarini, Alexander G. Raufi, Lindsey Carlsen, Martin Stogniew, Lee Schalop, Robyn Borsuk, Joshua E. Allen, Aakash Jhaveri, Cassandra Parker, Sara Morrow, Young Lee, Fabio Tavora, Wolfgang Oster, Jocelyn E. Ray, Kelsey E. Huntington, Howard Safran, Anna D Louie, Abed Rahman Kawakibi, Yiqun Zhang, Wafik S. El-Deiry
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)مصطلحات موضوعية: DRD4, dopamine receptor D4, SCLC, small-cell lung cancer, Pyridines, medicine.medical_treatment, OXPHOS, oxidative phosphorylation, GIRK, G protein-coupled inwardly rectifying potassium channel, GnRH, gonadotropin-releasing hormone receptor, Receptors, G-Protein-Coupled, TNF-Related Apoptosis-Inducing Ligand, 0302 clinical medicine, NOAEL, no-observed-adverse-event-level, DSRCT, desmoplastic small round cell tumor, RECIST, Response Evaluation Criteria in Solid Tumors, Antineoplastic Combined Chemotherapy Protocols, ATRT, atypical teratoid rhabdoid tumor, AML, acute myeloid leukemia, DRD2, dopamine receptor D2, CLL, chronic lymphocytic leukemia, Clinical Studies as Topic, A2A, Adenosine 2A receptor, ONC201, RANO, Response Assessment in Neuro-Oncology, MTD, maximum tolerated dose, HGG, high-grade glioma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PFS, progression-free survival, DRD5, dopamine receptor D5, DRD3, dopamine receptor D3, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, CRC, colorectal cancer, Neoplastic Stem Cells, NK, natural killer, IHC, immunohistochemistry, cAMP, cyclic AMP, EC, endometrial cancer, Antineoplastic Agents, lcsh:RC254-282, TNBC, triple-negative breast cancer, WHO, World Health Organization, 03 medical and health sciences, DRD1, dopamine receptor D1, Review article, Cancer stem cell, Glioma, MCL, mantle cell lymphoma, SAR, structure–activity relationship, Humans, Protein kinase B, ISR, integrated stress response, Tumor microenvironment, TMZ, temozolomide, cCK18, caspase-cleaved cytokeratin 18, GDSC, Genomics of Drug Sensitivity in Cancer, medicine.disease, DNA-PKcs, DNA-activated protein kinase catalytic subunit, FLAIR, fluid-attenuated inversion recovery, 030104 developmental biology, DIPG, diffuse intrinsic pontine glioma, 0301 basic medicine, Cancer Research, ClpX, caseinolytic mitochondrial matrix peptidase chaperone subunit X, Drug Evaluation, Preclinical, CTCL, cutaneous T-cell lymphoma, NHL, non-Hodgkin’s lymphoma, Targeted therapy, Prostate cancer, AUC, area under the curve, Neoplasms, CML, chronic myelogenous leukemia, Clinical Trials as Topic, AMPK, AMP kinase, Chemistry, CK18, cytokeratin 18, MM, multiple myeloma, Imidazoles, TIC10, TRAIL-inducing compound 10, Endopeptidase Clp, TRAIL, TNF-associated apoptosis-inducing ligand, Mitochondria, Treatment Outcome, RP2D, recommended phase II dose, Disease Susceptibility, DLBCL, diffuse large B-cell lymphoma, PD, pharmacodynamic, Signal Transduction, imipridones, PC-PG, pheochromocytoma-paraganglioma, rhTRAIL, recombinant human TRAIL, ClpP, caseinolytic protease P, PK, pharmacokinetic, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, OS, overall survival, Immune system, PLC, phospholipase C, DR5, death receptor 5, NSCLC, non-small cell lung cancer, medicine, BRD, bromodomain, cancer, Animals, ALCL, anaplastic large cell lymphoma, PDX, patient-derived xenograft, Cancer, GBM, glioblastoma multiforme, ALL, acute lymphoblastic leukemia, CSC, cancer stem cell, GPCR, G protein coupled receptor, EGFR, epidermal growth factor receptor, Pyrimidines, Cancer research, 5-FU, 5-fluorouracil, HCC, hepatocellular carcinoma, ONC201, imipridones, cancer
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المؤلفون: Yanxia Wang, Wei Wang, Shiyu Chen, Longhui Zhong, Rong Wang, Sijie Ding, Hong Yang, Xiaoqing Luo, Yueyun Ma, Shunli Peng
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 9, Pp 365-375 (2020)مصطلحات موضوعية: Vascular Endothelial Growth Factor A, 0301 basic medicine, Cancer Research, Colorectal cancer, medicine.medical_treatment, Homologous-recombination repair, Poly (ADP-Ribose) Polymerase-1, Apoptosis, medicine.disease_cause, Piperazines, Mice, chemistry.chemical_compound, Olaparib, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Tumor Cells, Cultured, Medicine, BER, base excision repair, Mice, Inbred BALB C, VEGF-A, vascular endothelial growth factor A, Cell cycle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, HRR, homologous-recombination repair, PFS, progression-free survival, Bevacizumab, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, CRC, colorectal cancer, Female, KRAS, Colorectal Neoplasms, medicine.drug, Original article, congenital, hereditary, and neonatal diseases and abnormalities, Mice, Nude, SSB, single-strand break, lcsh:RC254-282, Proto-Oncogene Proteins p21(ras), OS, overall survival, mCRC, metastatic colorectal cancer, 03 medical and health sciences, Biomarkers, Tumor, Animals, Humans, DSB, double-strand break, neoplasms, Cell Proliferation, Chemotherapy, business.industry, Cancer, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, EGFR, epidermal growth factor receptor, CoCl2, cobalt chloride, 030104 developmental biology, PARP, poly (adenosine diphosphate [ADP]-ribose) polymerase, chemistry, Mutation, Cancer research, Phthalazines, HR, homologous recombination, business
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المؤلفون: Hui-Chuan Sun, Xiao-Dong Zhu, Zhao-You Tang
المصدر: Genes and Diseases, Vol 7, Iss 3, Pp 328-335 (2020)
Genes & Diseasesمصطلحات موضوعية: 0301 basic medicine, Sorafenib, Oncology, medicine.medical_specialty, PD-L1, program death-1 ligand, lcsh:QH426-470, Combination therapy, Cabozantinib, Hepatocellular carcinoma, ICI, immune checkpoint inhibitor, Pembrolizumab, TKI, tyrosine kinase inhibitor, Biochemistry, Article, Ramucirumab, OS, overall survival, ORR, objective response rate, Combinational therapy, 03 medical and health sciences, chemistry.chemical_compound, PR, partial response, 0302 clinical medicine, RECIST, Response Evaluation Criteria in Solid Tumors, PD-1, program death-1, Regorafenib, Internal medicine, medicine, Molecular targeted therapy, TACE, transcatheter chemoembolization, Molecular Biology, Genetics (clinical), lcsh:R5-920, Systemic therapy, business.industry, Anti-angiogenic therapy, Cell Biology, PFS, progression-free survival, lcsh:Genetics, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, CR, complete response, Nivolumab, HCC, hepatocellular carcinoma, lcsh:Medicine (General), business, Lenvatinib, medicine.drug
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المؤلفون: Junhua Wang, Xinyu Zhu, Yanping Du, Tao Zhang, Pengfei Chen, Junwen Ou, Clifford L.K. Pang, Xinting Zhang, Shuang Bao, Xiufan Peng, Yimin Lu
المصدر: Journal of Advanced Research, Vol 24, Iss, Pp 175-182 (2020)
Journal of Advanced Researchمصطلحات موضوعية: 0301 basic medicine, Oncology, G6PD, glucose 6-phosphate dehydrogenase, AUC, area under the curve, PR, partial response, 0302 clinical medicine, RECIST, Response Evaluation Criteria in Solid Tumors, Quality of life, Overall survival, CYFRA21-1, cytokeratin-19 fragments, Vitamin C, lcsh:R5-920, Multidisciplinary, mEHT, modulated electrohyperthermia, ECOG, Eastern Cooperative Oncology Group, QLQ-C30, Quality of Life Questionnaire, TKIs, tyrosine kinase inhibitors, PFS, progression-free survival, CT, computed tomography, 030220 oncology & carcinogenesis, CR, complete response, CRP, C-reactive protein, TNF-α, Tumor Necrosis Factor-α, Non small cell, CA15-3, carbohydrate antigen 15-3, lcsh:Medicine (General), IL-6, interleukin- 6, SCC, squamous cell carcinoma antigen, DCR, disease control rate, Hyperthermia, medicine.medical_specialty, PD, progressive disease, Modulated electrohyperthermia, Combination therapy, Remission rate, NSCLC, non-small-cell lung cancer, Article, OS, overall survival, 03 medical and health sciences, Refractory, Internal medicine, medicine, BSC, best supportive care, lcsh:Science (General), Lung cancer, ComputingMethodologies_COMPUTERGRAPHICS, IVC, intravenous vitamin C, business.industry, SD, stable disease, medicine.disease, QoL, quality of life, EGFR, epidermal growth factor receptor, CI, confidence interval, 030104 developmental biology, HT, hyperthermia, CEA, carcinoembryonic antigen, business, Non-small-cell lung cancer, lcsh:Q1-390
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المؤلفون: Min-Er Zhong, Huizhong Qiu, Wei Ge, Yanyu Chen, Guannan Zhang, Bin Wu, Lai Xu, Yi Xiao, Junyang Lu
المصدر: EBioMedicine
مصطلحات موضوعية: Proteomics, 0301 basic medicine, Research paper, Proteome, Colorectal cancer, HPLC, High performance liquid chromatography, Chemical Fractionation, urologic and male genital diseases, mCRC, metastatic CRC, Metastasis, 0302 clinical medicine, NTA, nanoparticle tracking analysis, Cell Movement, Tandem Mass Spectrometry, Osteonectin, Epidermal growth factor receptor, TMT, Tandem Mass Tagging, biology, LC, liquid chromatography, General Medicine, Extracellular vesicles, TOF, Time of Flight, PFS, progression-free survival, Colon cancer, ECM, extracellular matrix, DEPs, differentially expressed proteins, VCAM1, vascular cell adhesion molecule 1, LRG1, 030220 oncology & carcinogenesis, Colonic Neoplasms, CRC, colorectal cancer, ROC, receiver operating characteristic curve, EMT, epithelial–mesenchymal transition, FDR, false discovery rate, THBS1, thrombospondin 1, NCCN, National Comprehensive Cancer Network, Quantitative proteomics, Enzyme-Linked Immunosorbent Assay, VTN, vitronectin, Models, Biological, General Biochemistry, Genetics and Molecular Biology, OS, overall survival, 03 medical and health sciences, FBS, fetal bovine serum, GO, Gene Ontology, Biomarkers, Tumor, medicine, Humans, RCC, right-sided colon cancer, EV, extracellular vesicles, Epithelial–mesenchymal transition, Progression-free survival, Cell Proliferation, Glycoproteins, PCA, Principal component analysis, business.industry, SPARC, secreted protein acidic and cysteine rich, Computational Biology, LCC, left-sided colon cancer, medicine.disease, EGFR, epidermal growth factor receptor, FN1, fibronectin 1, 030104 developmental biology, ROC Curve, MS, mass spectrometry, LRG1, leucine rich alpha-2-glycoprotein 1, Cancer research, biology.protein, Tumour location, AUC, area under the receiver-operating characteristic curve, business
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المؤلفون: Iva Staniczková Zambo, Michal Mahdal, Jaroslav Štěrba, Michal Kýr, Peter Múdry, Tomáš Tomáš, Ondřej Rohleder, Marta Ježová
المصدر: Journal of Bone Oncology
Journal of Bone Oncology, Vol 28, Iss, Pp 100362-(2021)مصطلحات موضوعية: 0301 basic medicine, Oncology, AIC, Akaike information criterion, Survival, NEU, neutrophiles, medicine.medical_treatment, Diseases of the musculoskeletal system, chemistry.chemical_compound, 0302 clinical medicine, CTCAE, common terminology criteria for adverse events, A/AP, adriamycin (doxorubicin)/adriamycin (doxorubicin) and cisplatin, RC254-282, R0 and R1 resection, free margins and microscopic rest after resection respectively, Mifamurtide, Osteosarcoma, Comparative analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, BIC, Bayesian information criterion, 3. Good health, Single institution analysis, 030220 oncology & carcinogenesis, EFS, event free survival, Research Article, musculoskeletal diseases, medicine.medical_specialty, M/F, male/female, 03 medical and health sciences, LY, lymphocytes, Internal medicine, medicine, Progression-free survival, Adverse effect, neoplasms, MTX, methotrexate, Survival analysis, Chemotherapy, Proportional hazards model, business.industry, PLT, platelets, MFS, metastatic free survival, medicine.disease, FDA, Food and Drug Administration, HR, hazard ratio, MONO, monocytes, CI, confidence interval, 030104 developmental biology, RC925-935, chemistry, Localized disease, PFS, progression free survival, EMA, European Medicines Agency, business, SD, standard deviation
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المؤلفون: Ioan Dumitru Suciu, Paris Ionescu, Nicolae Bacalbasa, Olivia Ionescu, Lucian Pop
المصدر: Journal of Medicine and Life
مصطلحات موضوعية: 0301 basic medicine, Poly Adenosine Diphosphate Ribose, PARP – Poly (adenosine diphosphate-ribose) Polymerase, Receptor, ErbB-2, TNBC – Triple-Negative Breast Cancer, OS – Overall Survival, Breast Neoplasms, Synthetic lethality, Review, DSB – Double-Strand Break, Germline, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, HER-2/neu – Overexpression of the Herceptin Receptor, PARPi – Poly (adenosine diphosphate-ribose) Polymerase Inhibitors, Medicine, Talazoparib, Humans, cancer, Neoplasm Metastasis, Survival rate, PARP inhibitors, Germ-Line Mutation, breast, BRCA2 Protein, BC – Breast Cancer, HR – Homologous Recombination, business.industry, BRCA1 Protein, Cancer, General Medicine, PFS – Progression-Free Survival, medicine.disease, 030104 developmental biology, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Female, business
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المؤلفون: Yugang Wang, James Henderson, Udit Singhal, Ganesh S. Palapattu, Alexander Zaslavsky, Zachery R. Reichert, Jae Seung Chung, Daniel E. Spratt, Yuanyuan Qiao, Russell S. Taichman, Daniel H. Hovelson, Todd M. Morgan, Scott A. Tomlins
المصدر: Neoplasia (New York, N.Y.)
مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, LHRH, luteinizing hormone-releasing hormone, Kaplan-Meier Estimate, CTC, circulating tumor cell, Prostate cancer, chemistry.chemical_compound, ARSI, androgen receptor signaling inhibitors, AUC, area under the curve, 0302 clinical medicine, Circulating tumor cell, Prostate, Antineoplastic Combined Chemotherapy Protocols, Medicine, Neoplasm Metastasis, Aged, 80 and over, Area under the curve, Middle Aged, Neoplastic Cells, Circulating, Prognosis, 3. Good health, Prostatic Neoplasms, Castration-Resistant, medicine.anatomical_structure, Treatment Outcome, EpCAM, epithelial cell adhesion molecule, 030220 oncology & carcinogenesis, Benzamides, Androstenes, IRB, institutional review board, medicine.medical_specialty, Original article, EMT, epithelial mesenchymal transition, 03 medical and health sciences, Internal medicine, Nitriles, Phenylthiohydantoin, Biomarkers, Tumor, Enzalutamide, Humans, mCRPC, metastatic castrate-resistant prostate cancer, IQR, interquartile range, Aged, Neoplasm Staging, Proportional Hazards Models, business.industry, Gene Expression Profiling, TSPAN8, Computational Biology, medicine.disease, HR, hazard ratio, Gene expression profiling, Androgen receptor, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, PFS, progression free survival, Neoplasm Grading, business
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المؤلفون: Jeremiah W. Mooney, Daniel L. Riggsbee, Kirk E. Hevener, Tatsiana A. Verstak, Katie E. Lutat
المصدر: Acta Pharmaceutica Sinica B, Vol 8, Iss 6, Pp 844-861 (2018)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: 0301 basic medicine, ATP, adenosine triphosphate, Anthracycline, medicine.drug_class, Review, 03 medical and health sciences, chemistry.chemical_compound, Clinical, 0302 clinical medicine, DNA, deoxyribonucleic acid, NCI, National Cancer Institute, PD, pharmacodynamics, medicine, General Pharmacology, Toxicology and Pharmaceutics, Inhibition, Cancer, chemistry.chemical_classification, Topoisomerase, biology, lcsh:RM1-950, DNA replication, AQD, anti-cancer quinolone derivative, MTD, maximum tolerated dose, ADP, adenosine diphosphate, 3. Good health, NCT, national clinical trial, 030104 developmental biology, Enzyme, Podophyllotoxin, lcsh:Therapeutics. Pharmacology, chemistry, Oncology, 030220 oncology & carcinogenesis, PFS, progression free survival, Pre-clinical, biology.protein, Cancer research, DNA, Camptothecin, Topoisomerase inhibitor, medicine.drug
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المؤلفون: Yanqing Gong, Liqun Zhou, Jianrong Zheng, Shuyuan Guo, Anbang He, Jieshan Chi, Xinliang Zhong, Yonghao Zhan, Zhicong Chen, Xuesong Li
المصدر: EBioMedicine
مصطلحات موضوعية: 95%CI, 95% Confidence interval, 0301 basic medicine, Oncology, ROC curve, receiver operating characteristic curve, NMIBC, non-muscle-invasive bladder cancer, Urologic cancer, T, size or direct extent of the primary tumour, TRIPOD, Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis, TCGA-PRAD, prostate adenocarcinoma in TCGA chort, Metastasis, TCGA-BLCA, bladder cancer in TCGA chort, Prostate cancer, 0302 clinical medicine, miRNA, microRNA, FFPE, formalin fixed paraffin-embedded, Medicine, CHN, Chinese, GEO, Gene Expression Omnibus, TCGA-KICH, kidney chromophobe carcinoma in TCGA chort, DM, distant metastasis, TCGA-KIRP, kidney papillary cell carcinoma in TCGA chort, Hazard ratio, OR, odds ratios, qRT-PCR, quantitative real-time polymerase chain reaction, REMARK, Reporting Recommendations for Tumour Marker Prognostic Studies, General Medicine, G, histology grade, Prognosis, BRISQ, Biospecimen Reporting for Improved Study Quality, AT, advanced T-stage, Prostate-specific antigen, 030220 oncology & carcinogenesis, miRNAs, HG, higher histologic grade, qPCR, quantitative polymerase chain reaction, RFS, relapse free survival, Research Paper, LNM, lymph nodes metastasis, Stage, TNM stage, ISH, in-situ hybridization, miRNA panel, Urologic Neoplasms, medicine.medical_specialty, BCa, bladder cancer, PCa, prostate cancer, Gleason, gleason score, WHO, World Health Organization, General Biochemistry, Genetics and Molecular Biology, OS, overall survival, 03 medical and health sciences, Bioinformatics analysis, TCGA-KIRC, kidney clear cell carcinoma in TCGA chort, Internal medicine, Humans, Progression-free survival, IQR, interquartile range, non-CHN, Non-Chinese, Bladder cancer, BCR-FS, biochemical recurrence free survival, SE, standard error, CSS, cancer/disease specific survival, business.industry, AS, advanced TNM stage, KCa, kidney cancer, Biomarker, Odds ratio, medicine.disease, PRISMA, Preferred Reporting Items for Systematic Review and Meta-analysis, DFS, disease free survival, MicroRNAs, PSA, prostate specific antigen, 030104 developmental biology, NOS, Newcastle-Ottawa quality assessment scale, AUC, the area under the curve, HR, Hazard Ratio, PFS, progression free survival, RNA, ribonucleic acid, TCGA, The Cancer Genome Atlas, business, Kidney cancer
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