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المؤلفون: Si Yang, Xi He, Qing Wu, Juan Deng, Wei-Jin Zang
المصدر: Laboratory Investigation. 101:878-896
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Choline, Pathology and Forensic Medicine, TRPC6, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Renin–angiotensin system, Animals, Medicine, Myocytes, Cardiac, Aorta, Abdominal, Calcium Signaling, Circadian rhythm, Molecular Biology, Cells, Cultured, Heart Failure, Calcium metabolism, Ventricular Remodeling, business.industry, Heart, Cell Biology, medicine.disease, Angiotensin II, Circadian Rhythm, Rats, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Heart failure, Calcium, business, PER1
الوصف: The key pathophysiological process leading to heart failure is cardiac remodeling, a term referring to cardiac hypertrophy, fibrosis, and apoptosis. We explored circadian rhythm disruption and calcium dyshomeostasis in cardiac remodeling and investigated the cardioprotective effect of choline. The experiments were conducted using a model of cardiac remodeling by abdominal aorta coarctation (AAC) in Sprague–Dawley rats. In vitro cardiomyocyte remodeling was induced by exposing neonatal rat cardiomyocytes to angiotensin II. The circadian rhythms of the transcript levels of the seven major components of the mammalian clock (Bmal1, Clock, Rev-erbα, Per1/2, and Cry1/2) were altered in AAC rat hearts during a normal 24 h light/dark cycle. AAC also upregulated the levels of proteins that mediate store-operated Ca2+ entry/receptor-operated Ca2+ entry (stromal interaction molecule 1 [STIM1], Orai1, and transient receptor potential canonical 6 [TRPC6]) in rat hearts. Moreover, choline ameliorated circadian rhythm disruption, reduced the upregulated protein levels of STIM1, Orai1, and TRPC6, and alleviated cardiac dysfunction and remodeling (evidenced by attenuated cardiac hypertrophy, fibrosis, and apoptosis) in AAC rats. In vitro analyses showed that choline ameliorated calcium overload, downregulated STIM1, Orai1, and TRPC6, and inhibited thapsigargin-induced store-operated Ca2+ entry and 1-oleoyl-2-acetyl-sn-glycerol-induced receptor-operated Ca2+ entry in angiotensin II-treated cardiomyocytes. In conclusion, choline attenuated AAC-induced cardiac remodeling and cardiac dysfunction, which was related to amelioration of circadian rhythm disruption and attenuation of calcium-handling protein defects. Modulation of vagal activity by choline targeting the circadian rhythm and calcium homeostasis may have therapeutic potential for cardiac remodeling and heart failure. Choline attenuates abdominal aortic coarctation-induced cardiac remodeling and cardiac dysfunction, by amelioration of circadian rhythm disruption and attenuation of calcium-handling protein defects. Modulation of vagal activity by choline may have therapeutic potential for cardiac remodeling and heart failure.
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المؤلفون: Yang Liu, Yifeng Hou, He-Fen Sun, Qiqi Liu, Xuan Li, Wei Jin
المصدر: Cancer Medicine, Vol 10, Iss 13, Pp 4658-4674 (2021)
Cancer Medicineمصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Anthracycline, Receptor, ErbB-2, Bioinformatics, medicine.medical_treatment, Antineoplastic Agents, Breast Neoplasms, Kaplan-Meier Estimate, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, Humans, Anthracyclines, HER2‐negative breast cancer, Radiology, Nuclear Medicine and imaging, Propensity Score, RC254-282, Original Research, Chemotherapy, Taxane, pharmacophore, business.industry, HER2 negative, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell cycle, medicine.disease, Neoadjuvant Therapy, Nomograms, 030104 developmental biology, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, gene expression, Female, Taxoids, prognosis, Pharmacophore, business, Adjuvant, neoadjuvant chemotherapy
الوصف: Aims Prognosis of patients for human epidermal growth factor receptor 2 (HER2)‐negative breast cancer post neoadjuvant chemotherapy is not well understood. The aim of this study was to develop a novel pharmacophore‐based signature to better classify and predict the risk of HER2‐negative patients after anthracycline‐and/or taxane‐based neoadjuvant chemotherapy (NACT). Main methods Anthracycline and taxane pharmacophore‐based genes were obtained from PharmMapper. Drug‐targeted genes (DTG) related clinical and bioinformatic analyses were undertaken in four GEO datasets. Key findings We used 12 genes from the pharmacophore to develop a DTG score (DTG‐S). The DTG‐S classification exhibited significant prognostic ability with respect to disease free survival (DFS) for HER2‐negative patients who receive at least one type of neoadjuvant chemotherapy that included anthracycline and/or taxane. DTG‐S associated with a high predictive ability for pathological complete response (pCR) as well as for prognosis of breast cancer. Using the DTG‐S classification in other prediction models may improve the reclassification accuracy for DFS. Combining the DTG‐S with other clinicopathological factors may further improve its predictive ability of patients’ outcomes. Gene ontology and KEGG pathway analysis showed that the biological processes of DTG‐S high group were associated with the cell cycle, cell migration, and cell signal transduction pathways. Targeted drug analysis shows that some CDK inhibitors and PI3K‐AKT pathway inhibitors may be useful for high DTG‐S patients. Significance The DTG‐S classification adds prognostic and predictive information to classical parameters for HER2‐negative patients who receive anthracycline‐and/or taxane‐based NACT, which could improve the patients’ risk stratification and may help guide adjuvant treatment.
Our pharmacophore‐based 12‐gene drug‐targeted genes score (DTG‐S) displays better predictive values for DFS and for pathological response to anthracycline‐and/or taxane‐based chemotherapy in human epidermal growth factor receptor 2 negative breast cancer. The biological relevance of the signature were cell cycle and cell signal transduction. The targeted drug analysis shows that some CDK inhibitors which can block the cell cycle and PI3K‐AKT pathway inhibitors may useful for high DTG‐S patients. -
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المؤلفون: Ya-Fei Liu, Jing-Liang Wu, Xiao-Yu Xu, Gui-Fan Li, Hongxing Pan, Wenling Wang, Jingxin Li, Jian-Kai Liu, Meng Wang, Baoying Huang, Kai Chu, Li Zhang, Wenjie Tan, Fengcai Zhu, Xian-Yun Chang, Dan-Dan Zhu, Wei-Jin Huang, Jialei Hu
المصدر: Chinese Medical Journal, Vol 134, Iss 11, Pp 1289-1298 (2021)
Chinese Medical Journalمصطلحات موضوعية: Adult, medicine.medical_specialty, COVID-19 Vaccines, Phases of clinical research, Placebo, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, Internal medicine, medicine, Humans, Seroconversion, Adverse effect, Inactivated vaccine, business.industry, SARS-CoV-2, COVID-19, General Medicine, Original Articles, Neutralizing antibody, Immunogenicity, Clinical trial, Regimen, Vaccines, Inactivated, 030220 oncology & carcinogenesis, Medicine, Safety, business, 030217 neurology & neurosurgery
الوصف: BACKGROUND: The significant morbidity and mortality resulted from the infection of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) call for urgent development of effective and safe vaccines. We report the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine, KCONVAC, in healthy adults. METHODS: Phase 1 and phase 2 randomized, double-blind, and placebo-controlled trials of KCONVAC were conducted in healthy Chinese adults aged 18 to 59 years. The participants in the phase 1 trial were randomized to receive two doses, one each on Days 0 and 14, of either KCONVAC (5 or 10 µg/dose) or placebo. The participants in the phase 2 trial were randomized to receive either KCONVAC (at 5 or 10 µg/dose) or placebo on Days 0 and 14 (0/14 regimen) or Days 0 and 28 (0/28 regimen). In the phase 1 trial, the primary safety endpoint was the proportion of participants experiencing adverse reactions/events within 28 days following the administration of each dose. In the phase 2 trial, the primary immunogenicity endpoints were neutralization antibody seroconversion and titer and anti-receptor-binding domain immunoglobulin G seroconversion at 28 days after the second dose. RESULTS: In the phase 1 trial, 60 participants were enrolled and received at least one dose of 5-µg vaccine (nâ=â24), 10-µg vaccine (nâ=â24), or placebo (nâ=â12). In the phase 2 trial, 500 participants were enrolled and received at least one dose of 5-µg vaccine (nâ=â100 for 0/14 or 0/28 regimens), 10-µg vaccine (nâ=â100 for each regimen), or placebo (nâ=â50 for each regimen). In the phase 1 trial, 13 (54%), 11 (46%), and seven (7/12) participants reported at least one adverse event (AE) after receiving 5-, 10-µg vaccine, or placebo, respectively. In the phase 2 trial, 16 (16%), 19 (19%), and nine (18%) 0/14-regimen participants reported at least one AE after receiving 5-, 10-µg vaccine, or placebo, respectively. Similar AE incidences were observed in the three 0/28-regimen treatment groups. No AEs with an intensity of grade 3+ were reported, expect for one vaccine-unrelated serious AE (foot fracture) reported in the phase 1 trial. KCONVAC induced significant antibody responses; 0/28 regimen showed a higher immune responses than that did 0/14 regimen after receiving two vaccine doses. CONCLUSIONS: Both doses of KCONVAC are well tolerated and able to induce robust immune responses in healthy adults. These results support testing 5-µg vaccine in the 0/28 regimen in an upcoming phase 3 efficacy trial. TRIAL REGISTRATION: http://www.chictr.org.cn/index.aspx (No. ChiCTR2000038804, http://www.chictr.org.cn/showproj.aspx?proj=62350; No. ChiCTR2000039462, http://www.chictr.org.cn/showproj.aspx?proj=63353).
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المؤلفون: Xianjun Yu, Liang Liu, Hua-Xiang Xu, Wei Jin, Huijing Yin, Hao Li
المصدر: Journal of Cellular and Molecular Medicine
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Pancreatic ductal adenocarcinoma, Neutrophils, IL‐1β, Mice, Nude, Apoptosis, Biology, Extracellular Traps, 03 medical and health sciences, Pancreatic Cancer, Mice, 0302 clinical medicine, Cell Movement, Pancreatic cancer, medicine, Tumor Cells, Cultured, Animals, Humans, In patient, Neoplasm Invasiveness, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation, Mice, Inbred BALB C, EMT, Cancer, NETs, Cell Biology, Original Articles, medicine.disease, Extracellular dna, Xenograft Model Antitumor Assays, ErbB Receptors, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Molecular Medicine, Original Article, Female, Antibody
الوصف: Neutrophil extracellular DNA traps (NETs) are newly discovered forms of activated neutrophils. Increasing researches have shown that NETs play important roles in cancer progression. Our previous study has proved that tumour‐infiltrating NETs could predict postsurgical survival in patients with pancreatic ductal adenocarcinoma (PDAC). However, the roles of NETs on the progression of pancreatic cancer are unknown. Here, we investigated the effects of NETs on pancreatic cancer cells. Results showed that both PDAC patients’ and normal individuals’ neutrophils‐derived NETs could promote migration and invasion of pancreatic cancer cells with epithelial‐mesenchymal transition. Further, study confirmed that EGFR/ERK pathway played an important role in this progression. The addition of neutralizing antibodies for IL‐1β could effectively block the activation of EGFR/ERK companied with reduction of EMT, migration and invasion. Taken together, NETs facilitated EMT, migration and invasion via IL‐1β/EGFR/ERK pathway in pancreatic cancer cells. Our study suggests that NETs may provide promising therapeutic targets for pancreatic cancer.
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المؤلفون: Guo-Liang Lu, Xiao-Jin Wang, Bao-Xing Huang, Yang Zhao, Wei-Chao Tu, Xing-Wei Jin, Yuan Shao, Da-Wei Wang, Yuan-Yuan Ji
المصدر: Chinese Medical Journal
Chinese Medical Journal, Vol 134, Iss 10, Pp 1209-1214 (2021)مصطلحات موضوعية: medicine.medical_specialty, Ureteral Calculi, Stone clearance, Nephrolithotomy, Percutaneous, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Complication rate, Retroperitoneal Space, Laparoscopic ureterolithotomy, Percutaneous, Nephrostomy, business.industry, Optimal treatment, Significant difference, Original Articles, General Medicine, Length of Stay, Surgery, Treatment Outcome, 030220 oncology & carcinogenesis, Medicine, Operative time, Laparoscopy, Mini percutaneous nephrolithotomy, business, Hospital stay, 030217 neurology & neurosurgery
الوصف: Background:. The optimal treatment for large impacted proximal ureteral stones remains controversial. The aim of this study was to evaluate the efficacy, safety, and potential complications of mini-percutaneous nephrolithotomy (MPCNL) and retroperitoneal laparoscopic ureterolithotomy (RPLU) in the treatment of impacted proximal ureteral stones with size greater than 15 mm. Methods:. A total of 268 patients with impacted proximal ureteral stones greater than 15 mm who received MPCNL or RPLU procedures were enrolled consecutively between January 2014 and January 2019. Data on surgical outcomes and complications were collected and analyzed. Results:. Demographic and ureteral stone characteristics found between these two groups were not significantly different. The surgical success rate (139/142, 97.9% vs. 121/126, 96.0%, P = 0.595) and stone-free rate after 1 month (139/142, 97.9% vs. 119/126, 94.4%, P = 0.245) of RPLU group were marginally higher than that of the MPCNL group, but there was no significant difference. There was no significant difference in the drop of hemoglobin between the two groups (0.8 ± 0.6 vs. 0.4 ± 0. 2 g/dL, P = 0.621). The mean operative time (68.2 ± 12.5 vs. 87.2 ± 16.8 min, P = 0.041), post-operative analgesics usage (2/121, 1.7% vs. 13/139, 9.4%, P = 0.017), length of hospital stay after surgery (2.2 ± 0.6 vs. 4.8 ± 0.9 days, P
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المؤلفون: Shuyi Wang, Subat Turdi, Xing Qin, Zhaohui Pei, Yan Gong, Yandong Liu, Wen-Liang Zha, Elena Topchiy, Zhi-Yun Zhu, Wei Jin, Yue-Feng Gao, Wei Ge, Jun Ren, Bruce Culver
المصدر: Acta Pharmacol Sin
مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Cardiac function curve, medicine.medical_specialty, Transgene, Mice, Transgenic, GPX4, medicine.disease_cause, Article, Lipid peroxidation, Amyloid beta-Protein Precursor, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Alzheimer Disease, Internal medicine, Coenzyme A Ligases, Presenilin-1, medicine, Animals, Ferroptosis, Pharmacology (medical), ALDH2, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Aldehyde Dehydrogenase, Mitochondrial, General Medicine, Myocardial Contraction, Triacsin C, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Oxidative stress
الوصف: Alzheimer’s disease (AD) is associated with high incidence of cardiovascular events but the mechanism remains elusive. Our previous study reveals a tight correlation between cardiac dysfunction and low mitochondrial aldehyde dehydrogenase (ALDH2) activity in elderly AD patients. In the present study we investigated the effect of ALDH2 overexpression on cardiac function in APP/PS1 mouse model of AD. Global ALDH2 transgenic mice were crossed with APP/PS1 mutant mice to generate the ALDH2-APP/PS1 mutant mice. Cognitive function, cardiac contractile, and morphological properties were assessed. We showed that APP/PS1 mice displayed significant cognitive deficit in Morris water maze test, myocardial ultrastructural, geometric (cardiac atrophy, interstitial fibrosis) and functional (reduced fractional shortening and cardiomyocyte contraction) anomalies along with oxidative stress, apoptosis, and inflammation in myocardium. ALDH2 transgene significantly attenuated or mitigated these anomalies. We also noted the markedly elevated levels of lipid peroxidation, the essential lipid peroxidation enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4), the transcriptional regulator for ACLS4 special protein 1 (SP1) and ferroptosis, evidenced by elevated NCOA4, decreased GPx4, and SLC7A11 in myocardium of APP/PS1 mutant mice; these effects were nullified by ALDH2 transgene. In cardiomyocytes isolated from WT mice and in H9C2 myoblasts in vitro, application of Aβ (20 μM) decreased cell survival, compromised cardiomyocyte contractile function, and induced lipid peroxidation; ALDH2 transgene or activator Alda-1 rescued Aβ-induced deteriorating effects. ALDH2-induced protection against Aβ-induced lipid peroxidation was mimicked by the SP1 inhibitor tolfenamic acid (TA) or the ACSL4 inhibitor triacsin C (TC), and mitigated by the lipid peroxidation inducer 5-hydroxyeicosatetraenoic acid (5-HETE) or the ferroptosis inducer erastin. These results demonstrate an essential role for ALDH2 in AD-induced cardiac anomalies through regulation of lipid peroxidation and ferroptosis.
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المؤلفون: Wei-Jin Hong, Li-Yao Cong, Wei-Rui Zhao, Cheng-En Luo, Xiang-Xue Kong, Sheng-Kang Luo, Chun-Lin Chen
المصدر: Aesthetic Surgery Journal. 41:1306-1313
مصطلحات موضوعية: Computed tomography, Cosmetic Techniques, 030230 surgery, 030207 dermatology & venereal diseases, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Dermal Fillers, medicine.artery, Middle temporal artery, Cadaver, Humans, Medicine, Right lateral canthus, medicine.diagnostic_test, business.industry, General Medicine, Anatomy, Superficial temporal artery, Lateral margin, Carotid Arteries, medicine.anatomical_structure, Deep temporal arteries, Surgery, Tomography, X-Ray Computed, business, Cadaveric spasm, Artery
الوصف: Background Temple filler injection is one of the most common minimally invasive cosmetic procedures involving the face; however, vascular complications are not uncommon. Objectives This study aimed to investigate the anatomy of the temporal vessels and provide a more accurate protocol for temple filler injection. Methods Computed tomography (CT) scans of 56 cadaveric heads injected with lead oxide were obtained. We then used Mimics software to construct 3-dimensional (3D) images of the temporal vessels described by a coordinate system based on the bilateral tragus and right lateral canthus. Results In the XOY plane, the superficial temporal artery (STA), middle temporal artery (MTA), zygomatico-orbital artery (ZOA), posterior branch of the deep temporal artery (PDTA), and lateral margin of the orbital rim divide the temple into 4 parts (A, B, C, and D). The probabilities of the STA, MTA, ZOA, and PDTA appearing in parts A, B, C, and D were 30.73%, 37.06%, 39.48%, and 77.18%, respectively. In 3D images, these vessels together compose an arterial network that is anastomosed with other vessels, such as the external carotid, facial, and ocular arteries. Conclusions 3D CT images can digitally elucidate the exact positions of temporal vessels in a coordinate system, improving the safety of temple filler injections in a clinical setting.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575492bbdb3c52ec7a71aa3eddf3b5c6
https://doi.org/10.1093/asj/sjaa371 -
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المؤلفون: Chun-Lin Chen, Guo-Yi Zhang, Wei-Jin Hong, Haibin Wang, Fang-Wei Li
المصدر: Aesthetic Surgery Journal. 41:NP748-NP757
مصطلحات موضوعية: medicine.medical_specialty, Mammaplasty, medicine.medical_treatment, Breast Neoplasms, 030230 surgery, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Breast cancer, medicine, Adjuvant therapy, Humans, Mastectomy, business.industry, General Medicine, Capsular contracture, Odds ratio, medicine.disease, Surgery, 030220 oncology & carcinogenesis, Meta-analysis, Female, Radiotherapy, Adjuvant, business, Breast reconstruction
الوصف: Background Results regarding immediate prosthetic breast reconstruction after postmastectomy radiation therapy (PMRT) have been inconsistent. Objectives The authors aimed to assess the efficacy and safety of PMRT before immediate prosthetic breast reconstruction for patients with breast cancer. Methods Electronic databases (PubMed, EmBase, and the Cochrane Library) were systematically searched to identify eligible studies from their inception until March 2020. The pooled odds ratio (OR) with 95% confidence intervals (CIs) was applied as an effect estimate and calculated using the random-effects model. Results Nineteen studies including a total of 6757 patients were selected for final meta-analysis. The pooled OR showed that PMRT was associated with a higher incidence of reconstruction failure (OR = 2.57; 95% CI =1.55–4.26; P Conclusions Although PMRT is the standard adjuvant therapy for mastectomy patients treated with immediate implant-based breast reconstruction, PMRT for patients undergoing immediate implant-based breast reconstruction has been associated with high risks of reconstruction failure, capsular contracture, and overall complications as well as low incidences of patient satisfaction and good aesthetic results. Level of Evidence: 4
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be8a846b566bf0ebacf12f87a2628f8
https://doi.org/10.1093/asj/sjaa372 -
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المؤلفون: Wei Jin, Zhigang Zhou, Rui Tian, Ruilan Wang, Yijun Hou, Yun Xie, Tao Wang
المصدر: Annals of Palliative Medicine. 10:1610-1619
مصطلحات موضوعية: Adult, Diarrhea, 0301 basic medicine, medicine.medical_specialty, Critical Care, Critical Illness, Logistic regression, Gastroenterology, law.invention, 03 medical and health sciences, Enteral Nutrition, 0302 clinical medicine, law, Internal medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Advanced and Specialized Nursing, Receiver operating characteristic, business.industry, Area under the curve, Intensive care unit, Intensive Care Units, 030104 developmental biology, Anesthesiology and Pain Medicine, Parenteral nutrition, Defecation, medicine.symptom, Complication, business
الوصف: BACKGROUND Severe diarrhea is a common complication of enteral nutrition in intensive care unit (ICU) patients. CD55 not only plays a vital role in immune but also plays a crucial role in intestinal function. We intended to build a prediction model of enteral nutrition complicated with severe diarrhea in ICU patients based on CD55. METHODS This was a prospective, single-center, observational study. We collected 116 patients with enteral nutrition in the ICU. We collected blood samples from patients at the time of admission, tested blood biomarkers [CD55, interleukin-10 (IL-10), diamine oxidase, D-lactic acid and endotoxin], and recorded daily defecation and enteral nutrition. Finally, through multi-factor logistic regression model, a prediction model based on multiple prediction indicators was formed, and new joint predictive factors were calculated. The prediction model of enteral nutrition complicated with severe diarrhea in ICU patients was constructed through data processing analysis. RESULTS A total of 116 adult patients with enteral nutrition were divided into two groups: 77 patients without severe diarrhea and 39 with severe diarrhea. Compared with patients without severe diarrhea, CD55 on granulocyte membrane surface(gCD55) of patients with severe diarrhea was significantly reduced (P
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad9df209bb207f0bd1202df7afb6c08
https://doi.org/10.21037/apm-20-1050 -
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المؤلفون: Zhijie Wang, Jianchun Duan, Wei Jin, Hua Bai, Jie Wang, Lin Lin, Li Feng
المصدر: Cancer Management and Research. 12:11351-11358
مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Combination therapy, business.industry, Melanoma, medicine.medical_treatment, Cancer, Immunotherapy, medicine.disease, Head and neck squamous-cell carcinoma, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, business, Liver cancer, Thymic carcinoma, Thymic Squamous Cell Carcinoma
الوصف: Immunotherapy provided with checkpoint inhibitors such as the programmed cell death-1 (PD-1) receptor or its ligand-1 (PD-L1) protein has been shown to be effective for treating several types of cancer, and was recently approved for use in treating malignant melanoma, advanced non-small cell lung cancer (NSCLC), urothelial carcinoma, head and neck squamous cell carcinoma, liver cancer, and additional forms of cancer. However, there is little evidence concerning its effectiveness in treating thymic squamous cell carcinoma (TSCC). Here, we report two cases of refractory TSCC that were treated with PD-1 single/combination therapy in a clinical setting. The patients exhibited variable responses to therapy without any serious adverse events. In summary, our findings show that immunotherapy provided with an immuno-checkpoint inhibitor in combination with chemotherapy/anti-angiogenesis therapy can improve the treatment response of patients with refractory TSCC. Anti-PD-1 single/combination therapy may be used as a strategy for treating advanced refractory TC.
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