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المؤلفون: Gesa Meyer-Hamme, Henry Johannes Greten, Rosemarie Plaetke, Christian Gerloff, Sven Schroeder, Thomas Friedemann
المصدر: BMC Neurology
BMC Neurology, Vol 18, Iss 1, Pp 1-10 (2018)مصطلحات موضوعية: Acupuncture Therapy, Motor nerve, Neurography, Laser Acupuncture, Placebo, lcsh:RC346-429, law.invention, Study Protocol, 03 medical and health sciences, Laser acupuncture, 0302 clinical medicine, Diabetic Neuropathies, Randomized controlled trial, law, Acupuncture, medicine, Humans, 030212 general & internal medicine, lcsh:Neurology. Diseases of the nervous system, Randomized Controlled Trials as Topic, Placebo-control, business.industry, Magnetic resonance neurography, General Medicine, medicine.disease, Diabetic peripheral neuropathy, Clinical trial, Peripheral neuropathy, Diabetes Mellitus, Type 2, Anesthesia, Nerve conduction studies, Neurology (clinical), business, 030217 neurology & neurosurgery
الوصف: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus with significant clinical sequelae that can affect a patient’s quality of life. Metabolic and microvascular factors are responsible for nerve damage, causing loss of nerve function, numbness, painful sensory symptoms, and muscle weakness. Therapy is limited to anti-convulsant or anti-depressant drugs for neuropathic pain and paresthesia. However, reduced sensation, balance and gait problems are insufficiently covered by this treatment. Previous data suggests that acupuncture, which has been in use in Traditional Chinese Medicine for many years, may potentially complement the treatment options for peripheral neuropathy. Nevertheless, more objective data on clinical outcome is necessary to generally recommend acupuncture to the public. We developed a study design for a prospective, randomized (RCT), placebo-controlled, partially double-blinded trial for investigating the effect of acupuncture on DPN as determined by nerve conduction studies (NCS) with the sural sensory nerve action potential amplitude as the primary outcome. The sural sensory nerve conduction velocity, tibial motor nerve action potential amplitude, tibial motor nerve conduction velocity, the neuropathy deficit score, neuropathy symptom score, and numeric rating scale questionnaires are defined as secondary outcomes. One hundred and eighty patients with type 2 diabetes mellitus will be randomized into three groups (needle acupuncture, verum laser acupuncture, and placebo laser acupuncture). We hypothesize that needle and laser acupuncture have beneficial effects on electrophysiological parameters and clinical and subjective symptoms in relation to DPN in comparison with placebo. The ACUDIN trial aims at investigating whether classical needle acupuncture and/or laser acupuncture are efficacious in the treatment of DPN. For the purpose of an objective parameter, NCS were chosen as outcome measures. Acupuncture treatment may potentially improve patients’ quality of life and reduce the socio-economic burden caused by DPN. German Clinical Trial Register (DRKS), No. DRKS00008562 , trial search portal of the WHO ( http://apps.who.int/trialsearch/ ).
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المؤلفون: Daniel Briem, Thomas Friedemann, Gesa Meyer-Hamme, Sebastian Kirch, Sunja Friedrichs, Rosemarie Plaetke, Michael Hauck, Amit Gulati, Sven Schröder
المصدر: Pain medicine (Malden, Mass.). 18(11)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Double blinded, Pain relief, Acupuncture Therapy, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Bursitis, Shoulder Pain, Acupuncture, medicine, Severe pain, Humans, Pain Management, 030212 general & internal medicine, Aged, Pain Measurement, Aged, 80 and over, Dry needling, business.industry, Frozen shoulder, General Medicine, Recovery of Function, Acupuncture treatment, Middle Aged, medicine.disease, Surgery, Anesthesiology and Pain Medicine, Capsulitis, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
الوصف: Objective Primary adhesive capsulitis (AC), or frozen shoulder, is an insidious and idiopathic disease. Severe pain is predominant in the first two of the three stages of the condition, which can last up to 21 months. Design, Setting, and Subjects Sixty volunteers with primary AC were randomly assigned to acupuncture with press tack needles compared with press tack placebos in a patient- and observer-blinded placebo-controlled study. The participants were subsequently offered classical needle acupuncture in an open follow-up clinical application. Thirty-four volunteers received conservative therapy, including 10 classical needle acupuncture treatments over 10 weeks, 13 volunteers received conservative therapy without classical needle acupuncture. All subjects agreed to follow-up after one year. Methods Acupuncture treatment was performed using a specific distal needling concept, using reflex areas on distant extremities avoiding local treatment. Results An immediate improvement of 3.3 ± 3.2 points in Constant-Murley Shoulder Score (CMS) pain subscore was seen in the press tack needles group and of 1.6 ± 2.8 points in the press tack placebos group (P
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