المؤلفون: T. L. Kravchuk, Roman Zelchan, A. A. Medvedeva, Ye. A. Dudnikova, Ye. L. Simolina, A. V. Goldberg, N. O. Popova, V. I. Chernov, O. V. Shpileva, N. M. Lukina, V. A. Shatalova, V. Ye. Goldberg, A. V. Muravleva, O. D. Bragina, V. V. Vysockaja

المصدر: Sibirskij Onkologičeskij Žurnal, Vol 19, Iss 5, Pp 145-153 (2020)

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, positron emission tomography, medicine.medical_treatment, Treatment outcome, Single-photon emission computed tomography, radiopharmaceutical, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Primary Breast Lymphoma, 0302 clinical medicine, medicine, RC254-282, primary breast lymphoma, medicine.diagnostic_test, single-photon emission computed tomography, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Lymphoma, Radiation therapy, Left breast, Oncology, Positron emission tomography, 030220 oncology & carcinogenesis, 99mtc-1-thio-d-glucose, Radiology, business, Emission computed tomography

الوصف: The article shows the feasibility of detecting and monitoring primary breast diffuse large B-cell lymphoma using single-photon emission computed tomography (SPECT) with 99mTc-1-thio-D-glucose (99mТс-TG), a new radiopharmaceutical. The innovative radiopharmaceutical makes it possible to evaluate the metabolism of tumor tissue without using positron emission tomography. The findings of 99mTc-TG SPECT obtained during diagnosis and monitoring of the patient were confirmed by the results of computed tomography. A comprehensive examination of the patient, including 99mTc-TG SPECT, made it possible to diagnose a rare case of primary breast lymphoma. Primary breast lymphoma accounts for 1.7–2.2 % of all extranodal nonHodgkin lymphomas. Diffuse large B-cell lymphoma is the most common histological type occurring usually as a unilateral palpable tumor in middle-aged women. Extranodal lymphomas account for less than 0.5 % of all malignant neoplasms of the breast. After 6 courses of immunochemotherapy, the patient underwent 99mTc-TG SPECT, which demonstrated persistent hypermetabolic activity in the breast. The patient received radiation therapy to the remaining tumor of the left breast. The patient is in remission and followed up at the Cancer Research Institute of Tomsk National Research Medical Center. Thus, 99mTc-TG SPECT is believed to be a promising method for visualizing primary breast lymphomas and assessing their treatment outcomes. It is an alternative to the standard approach using 18F-FDG positron emission tomography. The method compares favorably with positron emission tomography with its wide availability and low cost of study.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c855a109e49b38c81ed1bb94d9c46c80
https://doi.org/10.21294/1814-4861-2020-19-5-145-153

المؤلفون: Matvey M. Tsyganov, I.V. Deryusheva, N.V. Litviakov, V A Bychkov, L. A. Kolomiets, O. V. Shpileva, O. N. Churuksaeva, M.K. Ibragimova

المصدر: Sibirskij Onkologičeskij Žurnal, Vol 17, Iss 6, Pp 70-77 (2019)

مصطلحات موضوعية: 0301 basic medicine, oncogenic viruses, Cancer Research, medicine.medical_specialty, survival, Gastroenterology, integrated and episomal forms of hpv, 03 medical and health sciences, 0302 clinical medicine, cervix, Internal medicine, Medicine, In patient, Human papillomavirus, human papillomavirus, prognostic factor, Genotyping, Cervix, RC254-282, Colposcopy, physical status of the virus, medicine.diagnostic_test, business.industry, Significant difference, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, viral load, 030104 developmental biology, medicine.anatomical_structure, Oncology, hsil, 030220 oncology & carcinogenesis, lsil, cin, business, Viral load, Oncovirus

الوصف: The study included 168 patients with precancerous cervical lesions 37 with low-grade squamous intraepithelial lesions (LSIL), 131 with high-grade squamous intraepithelial lesions (HSIL), and 150 women, who had not abnormal cervical cell changes. All patients underwent full colposcopy assessment, cytological/histological examination, molecular detection and genotyping of high-risk human papillomavirus. Viral load and physical status of HPV-16 DNA was evaluated in cases of mono-infection (n=208). The prevalence of virus-positive cases among the patients with LSIL/NSIL and healthy women was 78.5 and 50.7 %, respectively. The frequency of recurrence in patients with LSIL and HSIL was found to be determined by the physical status of HPV-16. A significant difference in episomal, mixed and integrated forms of HPV-16 between patients with LSIL/HSIL and patients without abnormal cervical cell changes was found (p=0.0002).

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c317fa46e020b4d14d08aac7ed78bb5
https://doi.org/10.21294/1814-4861-2018-17-6-70-77

المؤلفون: L. A. Kolomiets, O. N. Churuksaeva, Nikolai V. Litviakov, Matvey M. Tsyganov, M.K. Ibragimova, O. V. Shpileva

المصدر: Current problems in cancer. 44(5)

مصطلحات موضوعية: 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, Cancer Research, Microarray, Squamous Intraepithelial Lesions, Uterine Cervical Neoplasms, medicine.disease_cause, Malignant transformation, 03 medical and health sciences, 0302 clinical medicine, medicine, Biomarkers, Tumor, Humans, Papillomaviridae, Cervical cancer, business.industry, Gene Expression Profiling, Papillomavirus Infections, Cancer, medicine.disease, Prognosis, Uterine Cervical Dysplasia, Gene Expression Regulation, Neoplastic, Survival Rate, Squamous intraepithelial lesion, 030104 developmental biology, Oncology, Dysplasia, 030220 oncology & carcinogenesis, Mutation, Cancer research, Female, KRAS, business, Follow-Up Studies

الوصف: In 5 patients, a change in the genetic landscape from HPV16 positive high-grade squamous intraepithelial lesion (HSIL) to squamous cervical cancer was traced, which occurred in these patients within the period from 7 months to 5 years after diagnosing HSIL. Materials and Methods: The DNA from paraffin blocks of dysplasia tissue and the tumor that emerged afterwards was used for the study, which was analyzed using the OncoScan FFPE microarray Assay Kit Affymetrix (USA) for genome-wide determination of gene abundance and 65 key somatic driver mutations of oncogenes and tumor suppressor genes. Results: In the study of HSIL material, somatic mutations were observed in 4/5 cases, 18 different somatic driver mutations of the NRAS, EGFR, BRAF, KRAS, IDH2 oncogenes and TP53 suppressor genes were found and almost no CNA-Copy Number Aberration was identified. HSIL malignization is associated with the appearance of secondary driver mutations in oncogenes and tumor suppressor genes and a large number of structural and numerical CNA, the frequency of which correlates with the time of dysplasia malignization into cancer with a very high correlation coefficient r = 0.98, P = 0.004. The trees of dysplasia evolution into tumor were constructed for each patient. Conclusion: According to the results of the work, it is assumed that the initiation of the development of mucosa dysplastic changes is due to primary driver mutations. The formation of secondary driver mutations and CNA are genetic mechanisms of malignant transformation, while the scenarios of the evolution of dysplasia into a tumor are individual and very diverse.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791a316e6c686a19ab80b47097daac70
https://pubmed.ncbi.nlm.nih.gov/32201051

المؤلفون: M.K. Ibragimova, Nikolai V. Litviakov, L. A. Kolomiets, O. V. Shpileva, Matvey M. Tsyganov, O. N. Churuksaeva, V A Bychkov

المصدر: Neoplasma. 65(3)

مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Virus Integration, Uterine Cervical Neoplasms, Affect (psychology), Virus, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Text mining, Internal medicine, Medicine, Humans, Hpv status, Cervical cancer, Human papillomavirus 16, business.industry, Papillomavirus Infections, virus diseases, Cancer, Genomics, medicine.disease, Predictive value, female genital diseases and pregnancy complications, Predictive factor, Survival Rate, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, Neoplasm Recurrence, Local, business

الوصف: To evaluate the relapse-free and overall survival of HPV-positive patients with regard to the physical status of type 16 HPV and of HPV-negative patients with primary CC. As a main result of the study the predictive value of the physical status of type 16 HPV was determined for relapse-free and overall survival of patients with CC. Episomal form of the virus is a favorable predictive factor. Integrated form of the virus is a severely unfavorable predictive factor and survival of such patients is significantly lower, than for HPV- patients and patients with mixed form of the virus. The results of the research are data on survival of patients with CC depending on the physical status of the virus (for HPV+ patients) and of patients with HPV-negative cancer.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b315a1a24082ad2869432b1ddf02f0c1
https://pubmed.ncbi.nlm.nih.gov/29788735