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المؤلفون: Kathryn Crouch, Fiona Achcar, Federica Giordani, Annette MacLeod, Isabel M. Vincent, Pieter C. Steketee, Michael P. Barrett, Liam J. Morrison, Nicholas J. Dickens
المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Steketee, P, Giordani, F, Vincent, I M, Crouch, K, Achcar, F, Dickens, N J, Morrison, L, MacLeod, A & Barrett, M P 2021, ' 'Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole ', PLoS Neglected Tropical Diseases, vol. 15, no. 11, e0009939 . https://doi.org/10.1371/journal.pntd.0009939مصطلحات موضوعية: RC955-962, Drug Resistance, Protozoan Proteins, Transcriptome, 0302 clinical medicine, Medical Conditions, Drug Metabolism, Arctic medicine. Tropical medicine, Zoonoses, Medicine and Health Sciences, African trypanosomiasis, Procyclin, Protozoans, 0303 health sciences, biology, Eukaryota, Gene Expression Regulation, Developmental, Genomics, Phenotype, Trypanocidal Agents, 3. Good health, Cell biology, Infectious Diseases, Public aspects of medicine, RA1-1270, Transcriptome Analysis, Research Article, Neglected Tropical Diseases, Trypanosoma, Cell Physiology, Trypanosoma brucei brucei, Trypanosoma brucei, Research and Analysis Methods, African Trypanosomiasis, 03 medical and health sciences, Sinefungin, Trypanosomiasis, medicine, Trypanosoma Brucei, Genetics, Parasitic Diseases, Humans, Pharmacokinetics, Molecular Biology Techniques, Gene, Molecular Biology, 030304 developmental biology, Pharmacology, Life Cycle Stages, Protozoan Infections, Gene Expression Profiling, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, Computational Biology, Cell Biology, biology.organism_classification, medicine.disease, Genome Analysis, Tropical Diseases, Parasitic Protozoans, Cell Metabolism, Trypanosomiasis, African, 030217 neurology & neurosurgery, Trypanosoma Brucei Gambiense, Cloning
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المؤلفون: Franziska Hentzschel, Paul Garside, Matthias Marti, Juan F. Quintana, Barbara Bradley, Lauren E. Jamieson, Karen Faulds, Matthew P. Gibbins, Paul Capewell, Alexandre Girard, Duncan Graham, Caroline Clucas, Samuel Mabbott, Francesco Marchesi, Anneli Cooper, Annette MacLeod, Steven Asiala
المصدر: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 11, p e1010060 (2021)مصطلحات موضوعية: Trypanosoma brucei gambiense, Skin infection, Spectrum Analysis, Raman, Mice, 0302 clinical medicine, Medical Conditions, Spectrum Analysis Techniques, Mathematical and Statistical Techniques, Medicine and Health Sciences, African trypanosomiasis, QD, Biology (General), Skin, 2. Zero hunger, Protozoans, 0303 health sciences, Principal Component Analysis, Mice, Inbred BALB C, biology, Statistics, Eukaryota, Animal Models, 3. Good health, Infectious Diseases, Experimental Organism Systems, Physical Sciences, symbols, Female, Research Article, Skin Infections, Medical diagnostic, Trypanosoma, Raman Spectroscopy, QH301-705.5, 030231 tropical medicine, Immunology, Trypanosoma brucei brucei, Mouse Models, Dermatology, Trypanosoma brucei, Research and Analysis Methods, Microbiology, Skin Diseases, 03 medical and health sciences, symbols.namesake, Model Organisms, Virology, parasitic diseases, Genetics, medicine, Parasitic Diseases, Trypanosoma Brucei, Animals, Statistical Methods, Molecular Biology, 030304 developmental biology, Organisms, Biology and Life Sciences, RC581-607, biology.organism_classification, medicine.disease, Parasitic Protozoans, Mice, Inbred C57BL, Trypanosomiasis, African, Multivariate Analysis, Animal Studies, Parasitology, Raman microscope, Immunologic diseases. Allergy, Raman spectroscopy, Ex vivo, Mathematics
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المؤلفون: Siddharth Jayaraman, Edith Paxton, Harry P. de Koning, Kathryn Crouch, Omar A. Alfituri, Pieter C. Steketee, Catarina Gadelha, Ryan Ritchie, Emily A. Dickie, Michael P. Barrett, Achim Schnaufer, Bill Wickstead, T.G Rowan, Liam J. Morrison, Georgina Awuah-Mensah, James Iremonger
المصدر: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1009734 (2021)
Steketee, P, Dickie, E A, Iremonger, J, Crouch, K, Paxton, E, Jayaraman, S, Alfituri, O, Awuah-Mensah, G, Ritchie, R, Schnaufer, A, Rowan, T, De Koning, H P, Gadelha, C, Wickstead, B, Barrett, M P & Morrison, L 2021, ' Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition ', PLoS Pathogens, vol. 17, no. 7, e1009734 . https://doi.org/10.1371/journal.ppat.1009734مصطلحات موضوعية: Trypanosoma congolense, Mitochondrial pyruvate dehydrogenase complex, Biochemistry, chemistry.chemical_compound, Mice, Glucose Metabolism, Metabolites, Glycolysis, African trypanosomiasis, Biology (General), Protozoans, 0303 health sciences, biology, Organic Compounds, Monosaccharides, Fatty Acids, Eukaryota, Genomics, Ketones, Lipids, 3. Good health, Chemistry, Saturated fatty acid, Physical Sciences, Carbohydrate Metabolism, Metabolic Labeling, Transcriptome Analysis, Research Article, Pyruvate, Trypanosoma, QH301-705.5, Immunology, Trypanosoma brucei brucei, Carbohydrates, Trypanosoma brucei, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Virology, parasitic diseases, medicine, Trypanosoma Brucei, Genetics, Animals, Molecular Biology Techniques, Molecular Biology, Fatty acid synthesis, 030304 developmental biology, Lipid Regulating Agents, 030306 microbiology, Organic Chemistry, Organisms, Chemical Compounds, Biology and Life Sciences, Computational Biology, Metabolism, RC581-607, biology.organism_classification, medicine.disease, Genome Analysis, Parasitic Protozoans, Glucose, Trypanosomiasis, African, chemistry, Cell Labeling, Parasitology, Immunologic diseases. Allergy, Acids, Trypanosoma Brucei Gambiense
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المؤلفون: Lucy J. Cornell, Youssef Madbouly, Michele Tinti, Zhihao Lai, Calvin Tiengwe, Phillip A. Yates, Carla Gilabert Carbajo
المساهمون: Wellcome Trust
المصدر: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009696 (2021)مصطلحات موضوعية: Protozoan Proteins, RNA-binding protein, Artificial Gene Amplification and Extension, Biochemistry, Polymerase Chain Reaction, Transcriptome, RNA interference, 1108 Medical Microbiology, Antibiotics, Medicine and Health Sciences, Homeostasis, Biology (General), Cells, Cultured, chemistry.chemical_classification, Protozoans, 0303 health sciences, Secretory Pathway, biology, Chemistry, Antimicrobials, Messenger RNA, 030302 biochemistry & molecular biology, RNA-Binding Proteins, Eukaryota, Drugs, Adaptation, Physiological, Endocytosis, Cell biology, Nucleic acids, RNA silencing, Genetic interference, 1107 Immunology, Tetracyclines, Cell Processes, Epigenetics, 0605 Microbiology, Research Article, Trypanosoma, QH301-705.5, Iron, Immunology, Trypanosoma brucei brucei, Transferrin receptor, Trypanosoma brucei, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Downregulation and upregulation, Virology, Microbial Control, Receptors, Transferrin, Genetics, Trypanosoma Brucei, Molecular Biology Techniques, Molecular Biology, 030304 developmental biology, Pharmacology, Organisms, Biology and Life Sciences, Cell Biology, RC581-607, biology.organism_classification, Parasitic Protozoans, Trypanosomiasis, African, Transferrin, RNA, Parasitology, Gene expression, Immunologic diseases. Allergy, Trypanosoma Brucei Gambiense
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المؤلفون: Brice Rotureau, Oriana Villafraz, Marc Biran, Loïc Rivière, Nicolas Plazolles, Marion Wargnies, Erika Pineda, Pauline Morand, Emmanuel Tetaud, Corinne Asencio, Frédéric Bringaud, Hanna Kulyk, Edern Cahoreau, Stefan Allmann, Arnaud Mourier, Jean-Charles Portais
المساهمون: Microbiologie cellulaire et moléculaire et pathogénicité (MCMP), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Centre de résonance magnétique des systèmes biologiques (CRMSB), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie cellulaire des Trypanosomes - Trypanosome Cell Biology, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biochimie et génétique cellulaires (IBGC), STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), FB's team is supported by the Centre National de la Recherche Scientifique (CNRS, https://www.cnrs.fr/) (financial support for consumables and salary of permanent positions), the Université de Bordeaux (https://www.u-bordeaux.fr/) (financial support for consumables and salary of permanent positions), the Agence National de Recherche (ANR, https://anr.fr/) through the grants GLYCONOV (grant number ANR-15-CE15-0025-01) and ADIPOTRYP (grant number ANR19-CE15-0004-01) (financial support for consumables and PM and EP salary) and the Laboratoire d’Excellence (https://www.enseignementsup-recherche.gouv.fr/cid51355/laboratoires-d-excellence.html) through the LabEx ParaFrap (grant number ANR-11-LABX-0024) (financial support for consumables and SA salary), the ParaMet PhD programme of Marie Curie Initial Training Network (https://ec.europa.eu/research/mariecurieactions/) (FP7-PEOPLE-2011-ITN-290080) (financial support for consumables and MW salary) and the 'Fondation pour le Recherche Médicale' (FRM, https://www.frm.org/) ('Equipe FRM', grant n°EQU201903007845) (financial support for consumables and EP salary). BR is supported by and the Institut Pasteur (financial support for consumables and salary of permanent positions). JCP's team from Metabolomics & Fluxomics facilities (Toulouse, France, http://www.metatoul.fr) is supported by the Agence National de Recherche (ANR, https://anr.fr/) (grant MetaboHUB-ANR-11-INBS-0010) (financial support for consumables and salary of permanent positions)., We thank Daniel Inaoka (University of Nagasaki, Japan) and Hiromi Imamura (University of Tokyo, Japan) for providing us with the ATeam construct, Paul A. Michels (Edinburgh, UK) for providing us with the anti-GK, anti-aldolase, and anti-enolase immune sera, as well as K. Ersfeld, (Hull University, UK) for the anti-Myc immune serum and Christel Pujol (Bordeaux Imaging Center, France) for her invaluable technical assistance for the FRET and FLIM experiments. The microscopy was done in the Bordeaux Imaging Center, a service unit of CNRS-INSERM and Bordeaux University, member of the national infrastructure France BioImaging., ANR-15-CE15-0025,GLYCONOV,Voies métaboliques glycosomales non glycolytiques: nouvelles fonctions pour le développement et la virulence des trypanosomes(2015), ANR-19-CE15-0004,AdipoTryp,Interactions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomoses(2019), Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), MetaToul FluxoMet (TBI-MetaToul), MetaboHUB-MetaToul, MetaboHUB-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), VIAUD, Karine, Voies métaboliques glycosomales non glycolytiques: nouvelles fonctions pour le développement et la virulence des trypanosomes - - GLYCONOV2015 - ANR-15-CE15-0025 - AAPG2015 - VALID, Interactions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomoses - - AdipoTryp2019 - ANR-19-CE15-0004 - AAPG2019 - VALID
المصدر: Plos Biology
Plos Biology, 2021, 19 (8), ⟨10.1371/journal.pbio.3001359⟩
PLoS Biology
PLoS Biology, 2021, 19 (8), ⟨10.1371/journal.pbio.3001359⟩
PLoS Biology, Vol 19, Iss 8, p e3001359 (2021)مصطلحات موضوعية: Glycerol, Glycerol kinase, Enzyme Metabolism, Catabolite repression, Biochemistry, Microbodies, Fluorophotometry, chemistry.chemical_compound, 0302 clinical medicine, Spectrum Analysis Techniques, Adenosine Triphosphate, Glucose Metabolism, Glycerol Kinase, Hexokinase, Fluorescence Resonance Energy Transfer, Biology (General), Enzyme Chemistry, 2. Zero hunger, chemistry.chemical_classification, Protozoans, 0303 health sciences, Organic Compounds, General Neuroscience, Monomers, Monosaccharides, Eukaryota, Chemistry, Spectrophotometry, Physical Sciences, Carbohydrate Metabolism, General Agricultural and Biological Sciences, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Research Article, Trypanosoma, Cell Physiology, QH301-705.5, Trypanosoma brucei brucei, Carbohydrates, Nutrient sensing, Biology, Carbohydrate metabolism, Research and Analysis Methods, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Trypanosoma Brucei, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, 030304 developmental biology, General Immunology and Microbiology, Organic Chemistry, Organisms, Chemical Compounds, Biology and Life Sciences, Cell Biology, Polymer Chemistry, Parasitic Protozoans, Cell Metabolism, Metabolic pathway, Enzyme, Metabolism, Glucose, chemistry, Enzymology, 030217 neurology & neurosurgery, Trypanosoma Brucei Gambiense
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المؤلفون: Michele Tinti, Michael A. J. Ferguson, Zhe Ji
المصدر: PLoS ONE, Vol 16, Iss 3, p e0244699 (2021)
PLoS ONEمصطلحات موضوعية: Proteomics, Proteomes, Glycosylphosphatidylinositols, Surfactants, Protozoan Proteins, Biochemistry, Epitope, 0302 clinical medicine, Materials, Protozoans, 0303 health sciences, Multidisciplinary, biology, medicine.diagnostic_test, Chemistry, Eukaryota, Precipitation Techniques, Native Polyacrylamide Gel Electrophoresis, Physical Sciences, Proteome, Medicine, Research Article, Trypanosoma, Immunoprecipitation, Recombinant Fusion Proteins, Protein subunit, Science, Materials Science, Detergents, Trypanosoma brucei brucei, Quantitative proteomics, Trypanosoma brucei, Research and Analysis Methods, Biosynthesis, N-Acetylglucosaminyltransferases, 03 medical and health sciences, Western blot, Trypanosoma Brucei, medicine, Molecular Biology Techniques, Molecular Biology, 030304 developmental biology, Organisms, Fungi, Biology and Life Sciences, Proteins, biology.organism_classification, Yeast, Parasitic Protozoans, carbohydrates (lipids), Protein Subunits, 030217 neurology & neurosurgery, Trypanosoma Brucei Gambiense, Cloning
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المؤلفون: Yiran Li, Rodrigo P. Baptista, Duo Peng, Jessica C. Kissinger, Rick L. Tarleton, Wei Wang
المصدر: PLoS Pathogens, Vol 17, Iss 1, p e1009254 (2021)
PLoS Pathogensمصطلحات موضوعية: Genome, Biochemistry, Geographical locations, Database and Informatics Methods, 0302 clinical medicine, Gene duplication, Medicine and Health Sciences, Copy-number variation, Biology (General), Immune Response, Genetics, Protozoans, 0303 health sciences, Eukaryota, Genomics, Sequence Analysis, Brazil, Research Article, Genome evolution, Trypanosoma, DNA Copy Number Variations, Bioinformatics, QH301-705.5, Trypanosoma cruzi, 030231 tropical medicine, Immunology, Biology, Research and Analysis Methods, Microbiology, Evolution, Molecular, 03 medical and health sciences, Virology, parasitic diseases, Trypanosoma Brucei, Gene family, Humans, Chagas Disease, Molecular Biology, Gene, 030304 developmental biology, Organisms, Biology and Life Sciences, Proteins, Computational Biology, Genetic Variation, South America, RC581-607, biology.organism_classification, Genome Analysis, Parasitic Protozoans, Mucin, Parasitology, People and places, Immunologic diseases. Allergy, Sequence Alignment, Genome, Protozoan, Trypanosoma Brucei Gambiense
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المؤلفون: Eva Rico, Andrew W. Pountain, Isabel M. Vincent, Michael J. Witty, Michael P. Barrett, Fernando Fernandez-Cortes, Ning Zhang, Mark C. Field, David Horn, Jonathan M. Wilkes, Justin J. J. van der Hooft, Yvonne Freund, Darren Y. Edwards, Daniel Paape, Liam J. Morrison, Rosemary Peter, Clément Regnault, Federica Giordani, Kevin D. Read
المصدر: PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
PLoS Pathogens
PLoS Pathogens, 16(11)
PLoS Pathogens 16 (2020) 11
Giordani, F, Paape, D, Vincent, I M, Pountain, A W, Fernandez-Cortes, F, Rico, E, Zhang, N, Morrison, L, Freund, Y, Witty, M J, Peter, R, Edwards, D, Wilkes, J, van der Hooft, J J J, Regnault, C, Read, K D, Horn, D, Field, M C & Barrett, M P 2020, ' Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs ', PLoS Pathogens, vol. 16, no. 11, e1008932 . https://doi.org/10.1371/journal.ppat.1008932مصطلحات موضوعية: Benzoxaborole, Veterinary medicine, Trypanosoma congolense, Carboxylic Acids, Drug Resistance, Protozoan Proteins, Drug resistance, Carboxypeptidases, Parasitemia, Biochemistry, Serine, Mice, RNA interference, Prodrugs, Trypanosoma brucei, Amino Acids, Biology (General), 2. Zero hunger, Protozoans, 0303 health sciences, biology, Chemistry, Organic Compounds, Eukaryota, Valine, Genomics, Prodrug, Trypanocidal Agents, 3. Good health, Nucleic acids, Genetic interference, Physical Sciences, Epigenetics, Female, prodrug, Research Article, Boron Compounds, Trypanosoma, Livestock, Bioinformatics, QH301-705.5, Immunology, Trypanosoma brucei brucei, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Virology, Hydroxyl Amino Acids, Bioinformatica, parasitic diseases, Trypanosoma Brucei, Genetics, Life Science, Animals, nagana, Trypanosoma vivax, Molecular Biology Techniques, Gene, Molecular Biology, 030304 developmental biology, animal African trypanosomiasis, drug resistance, 030306 microbiology, veterinary trypanocide, Organic Chemistry, Organisms, Chemical Compounds, Biology and Life Sciences, Proteins, RC581-607, biology.organism_classification, Carboxypeptidase, Parasitic Protozoans, Trypanosomiasis, African, biology.protein, RNA, Parasitology, Gene expression, Immunologic diseases. Allergy, Trypanosoma Brucei Gambiense, Cloning
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المؤلفون: Harry P. de Koning, Fabio Zuccotto, Juan A. Bueren-Calabuig, Juan F. Quintana, Mark C. Field, David Horn
المصدر: PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008458 (2020)
PLoS Neglected Tropical Diseasesمصطلحات موضوعية: Glycerol, 0301 basic medicine, RC955-962, Drug Resistance, Drug resistance, Endoplasmic Reticulum, Biochemistry, 0302 clinical medicine, Ubiquitin, Arctic medicine. Tropical medicine, Amino Acids, Protozoans, 0303 health sciences, Secretory Pathway, biology, Protein Stability, Organic Compounds, Chemistry, Monomers, Eukaryota, ER retention, Trypanocidal Agents, Endocytosis, 3. Good health, Cell biology, Infectious Diseases, medicine.anatomical_structure, Drug development, Cell Processes, Physical Sciences, Cellular Structures and Organelles, Basic Amino Acids, Public aspects of medicine, RA1-1270, Aquaglyceroporins, Research Article, medicine.drug, Trypanosoma, Endosome, Trypanosoma brucei brucei, Immunoblotting, 030231 tropical medicine, Glycerol transport, Molecular Probe Techniques, Trypanosoma brucei, Research and Analysis Methods, 03 medical and health sciences, Lysosome, Trypanosoma Brucei, medicine, Animals, Amino Acid Sequence, Molecular Biology Techniques, Molecular Biology, 030304 developmental biology, 030306 microbiology, Lysine, Organic Chemistry, Organisms, Chemical Compounds, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Proteins, Cell Biology, Polymer Chemistry, biology.organism_classification, Parasitic Protozoans, Trypanosomiasis, African, 030104 developmental biology, biology.protein, Lysosomes, Trypanosoma Brucei Gambiense, Pentamidine
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المؤلفون: Petros Ligoxygakis, Karen Brooks, James Cotton, Thomas D. Otto, Megan A. Sloan, Mandy Sanders
المصدر: PLoS Genetics, Vol 15, Iss 11, p e1008452 (2019)
PLoS Geneticsمصطلحات موضوعية: Cancer Research, Physiology, Euglenozoa Infections, Insect, QH426-470, Biochemistry, Genome, 0302 clinical medicine, Invertebrate Genomics, Medicine and Health Sciences, Parasite hosting, Leishmania major, Leishmaniasis, Genetics (clinical), media_common, Protozoans, Leishmania, Genetics, 0303 health sciences, biology, Ingestion, Drosophila Melanogaster, Eukaryota, Animal Models, Genomics, 3. Good health, Insects, Experimental Organism Systems, Human parasite, Drosophila, Drosophila melanogaster, Transcriptome Analysis, Research Article, Trypanosoma, Arthropoda, media_common.quotation_subject, 030231 tropical medicine, Research and Analysis Methods, Host-Parasite Interactions, 03 medical and health sciences, Model Organisms, Protein Domains, parasitic diseases, Trypanosoma Brucei, medicine, Animals, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Host (biology), fungi, Organisms, Biology and Life Sciences, Proteins, Computational Biology, Genome Analysis, medicine.disease, biology.organism_classification, Invertebrates, Parasitic Protozoans, Insect Vectors, Animal Genomics, Animal Studies, Trypanosomatina, Psychodidae, Physiological Processes, 030217 neurology & neurosurgery, Trypanosoma Brucei Gambiense
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