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المؤلفون: Kathryn Crouch, Fiona Achcar, Federica Giordani, Annette MacLeod, Isabel M. Vincent, Pieter C. Steketee, Michael P. Barrett, Liam J. Morrison, Nicholas J. Dickens
المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Steketee, P, Giordani, F, Vincent, I M, Crouch, K, Achcar, F, Dickens, N J, Morrison, L, MacLeod, A & Barrett, M P 2021, ' 'Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole ', PLoS Neglected Tropical Diseases, vol. 15, no. 11, e0009939 . https://doi.org/10.1371/journal.pntd.0009939مصطلحات موضوعية: RC955-962, Drug Resistance, Protozoan Proteins, Transcriptome, 0302 clinical medicine, Medical Conditions, Drug Metabolism, Arctic medicine. Tropical medicine, Zoonoses, Medicine and Health Sciences, African trypanosomiasis, Procyclin, Protozoans, 0303 health sciences, biology, Eukaryota, Gene Expression Regulation, Developmental, Genomics, Phenotype, Trypanocidal Agents, 3. Good health, Cell biology, Infectious Diseases, Public aspects of medicine, RA1-1270, Transcriptome Analysis, Research Article, Neglected Tropical Diseases, Trypanosoma, Cell Physiology, Trypanosoma brucei brucei, Trypanosoma brucei, Research and Analysis Methods, African Trypanosomiasis, 03 medical and health sciences, Sinefungin, Trypanosomiasis, medicine, Trypanosoma Brucei, Genetics, Parasitic Diseases, Humans, Pharmacokinetics, Molecular Biology Techniques, Gene, Molecular Biology, 030304 developmental biology, Pharmacology, Life Cycle Stages, Protozoan Infections, Gene Expression Profiling, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, Computational Biology, Cell Biology, biology.organism_classification, medicine.disease, Genome Analysis, Tropical Diseases, Parasitic Protozoans, Cell Metabolism, Trypanosomiasis, African, 030217 neurology & neurosurgery, Trypanosoma Brucei Gambiense, Cloning
وصف الملف: application/pdf
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المؤلفون: Franziska Hentzschel, Paul Garside, Matthias Marti, Juan F. Quintana, Barbara Bradley, Lauren E. Jamieson, Karen Faulds, Matthew P. Gibbins, Paul Capewell, Alexandre Girard, Duncan Graham, Caroline Clucas, Samuel Mabbott, Francesco Marchesi, Anneli Cooper, Annette MacLeod, Steven Asiala
المصدر: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 11, p e1010060 (2021)مصطلحات موضوعية: Trypanosoma brucei gambiense, Skin infection, Spectrum Analysis, Raman, Mice, 0302 clinical medicine, Medical Conditions, Spectrum Analysis Techniques, Mathematical and Statistical Techniques, Medicine and Health Sciences, African trypanosomiasis, QD, Biology (General), Skin, 2. Zero hunger, Protozoans, 0303 health sciences, Principal Component Analysis, Mice, Inbred BALB C, biology, Statistics, Eukaryota, Animal Models, 3. Good health, Infectious Diseases, Experimental Organism Systems, Physical Sciences, symbols, Female, Research Article, Skin Infections, Medical diagnostic, Trypanosoma, Raman Spectroscopy, QH301-705.5, 030231 tropical medicine, Immunology, Trypanosoma brucei brucei, Mouse Models, Dermatology, Trypanosoma brucei, Research and Analysis Methods, Microbiology, Skin Diseases, 03 medical and health sciences, symbols.namesake, Model Organisms, Virology, parasitic diseases, Genetics, medicine, Parasitic Diseases, Trypanosoma Brucei, Animals, Statistical Methods, Molecular Biology, 030304 developmental biology, Organisms, Biology and Life Sciences, RC581-607, biology.organism_classification, medicine.disease, Parasitic Protozoans, Mice, Inbred C57BL, Trypanosomiasis, African, Multivariate Analysis, Animal Studies, Parasitology, Raman microscope, Immunologic diseases. Allergy, Raman spectroscopy, Ex vivo, Mathematics
وصف الملف: application/pdf
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المؤلفون: Enock Matovu, Christine Clayton, Julius Mulindwa, John Enyaru
المصدر: BMC Medical Genomics, Vol 13, Iss 1, Pp 1-12 (2020)
BMC Medical Genomicsمصطلحات موضوعية: Adult, Male, lcsh:Internal medicine, Adolescent, lcsh:QH426-470, Trypanosoma brucei gambiense, CSF, Disease, Biology, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Immune system, Genetics, medicine, Humans, African trypanosomiasis, RNA-Seq, Child, Human host transcriptome, lcsh:RC31-1245, Genetics (clinical), 030304 developmental biology, T. b rhodesiense, 0303 health sciences, Innate immune system, medicine.diagnostic_test, Lumbar puncture, Human African Trypanosomiasis, medicine.disease, Human genetics, Up-Regulation, 3. Good health, lcsh:Genetics, Trypanosomiasis, African, Blood, Immunology, Female, DNA microarray, 030217 neurology & neurosurgery, Biomarkers, Research Article
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المؤلفون: Adriana Temporão, Terry K. Smith, Rafael Luis, Miguel Prudêncio, Margarida Sanches-Vaz, Luisa M. Figueiredo, Helena Nunes-Cabaço
المساهمون: Repositório da Universidade de Lisboa, The Wellcome Trust, University of St Andrews. School of Biology, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Biomedical Sciences Research Complex
المصدر: PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009912 (2021)
PLoS Neglected Tropical Diseasesمصطلحات موضوعية: Male, Plasmodium, Physiology, RC955-962, Defence mechanisms, Protozoan Proteins, Disease, Mice, 0302 clinical medicine, Medical Conditions, Arctic medicine. Tropical medicine, Medicine and Health Sciences, chemistry.chemical_classification, Protozoans, 0303 health sciences, Liver infection, biology, Coinfection, Malarial Parasites, Eukaryota, QR Microbiology, 3. Good health, Infectious Diseases, Liver, RB Pathology, Sporozoites, Public aspects of medicine, RA1-1270, Research Article, Trypanosoma, education, Trypanosoma brucei brucei, NDAS, Excretion, Trypanosoma brucei, Microbiology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Parasite Groups, parasitic diseases, medicine, Trypanosoma Brucei, Parasitic Diseases, Animals, Humans, 030304 developmental biology, Host (biology), Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, biology.organism_classification, medicine.disease, Parasitic Protozoans, QR, Malaria, Mice, Inbred C57BL, Trypanosomiasis, African, chemistry, Parasitology, Glycoprotein, RB, Physiological Processes, Apicomplexa, 030215 immunology, Trypanosoma Brucei Gambiense
وصف الملف: application/pdf
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المؤلفون: Siddharth Jayaraman, Edith Paxton, Harry P. de Koning, Kathryn Crouch, Omar A. Alfituri, Pieter C. Steketee, Catarina Gadelha, Ryan Ritchie, Emily A. Dickie, Michael P. Barrett, Achim Schnaufer, Bill Wickstead, T.G Rowan, Liam J. Morrison, Georgina Awuah-Mensah, James Iremonger
المصدر: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1009734 (2021)
Steketee, P, Dickie, E A, Iremonger, J, Crouch, K, Paxton, E, Jayaraman, S, Alfituri, O, Awuah-Mensah, G, Ritchie, R, Schnaufer, A, Rowan, T, De Koning, H P, Gadelha, C, Wickstead, B, Barrett, M P & Morrison, L 2021, ' Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition ', PLoS Pathogens, vol. 17, no. 7, e1009734 . https://doi.org/10.1371/journal.ppat.1009734مصطلحات موضوعية: Trypanosoma congolense, Mitochondrial pyruvate dehydrogenase complex, Biochemistry, chemistry.chemical_compound, Mice, Glucose Metabolism, Metabolites, Glycolysis, African trypanosomiasis, Biology (General), Protozoans, 0303 health sciences, biology, Organic Compounds, Monosaccharides, Fatty Acids, Eukaryota, Genomics, Ketones, Lipids, 3. Good health, Chemistry, Saturated fatty acid, Physical Sciences, Carbohydrate Metabolism, Metabolic Labeling, Transcriptome Analysis, Research Article, Pyruvate, Trypanosoma, QH301-705.5, Immunology, Trypanosoma brucei brucei, Carbohydrates, Trypanosoma brucei, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Virology, parasitic diseases, medicine, Trypanosoma Brucei, Genetics, Animals, Molecular Biology Techniques, Molecular Biology, Fatty acid synthesis, 030304 developmental biology, Lipid Regulating Agents, 030306 microbiology, Organic Chemistry, Organisms, Chemical Compounds, Biology and Life Sciences, Computational Biology, Metabolism, RC581-607, biology.organism_classification, medicine.disease, Genome Analysis, Parasitic Protozoans, Glucose, Trypanosomiasis, African, chemistry, Cell Labeling, Parasitology, Immunologic diseases. Allergy, Acids, Trypanosoma Brucei Gambiense
وصف الملف: application/pdf
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المؤلفون: Violeta Kourbeli, Eleni Chontzopoulou, Kalliopi Moschovou, Dimitrios Pavlos, Ioannis Papanastasiou, Thomas Mavromoustakos
المصدر: Molecules
Molecules, Vol 26, Iss 4629, p 4629 (2021)مصطلحات موضوعية: Chagas disease, Trypanosoma brucei gambiense, Protozoan Proteins, Pharmaceutical Science, Review, kinetoplastid protozoan diseases, 01 natural sciences, Analytical Chemistry, QD241-441, Drug Discovery, African trypanosomiasis, Molecular Targeted Therapy, Leishmaniasis, media_common, Leishmania, 0303 health sciences, biology, Molecular Structure, Chemistry (miscellaneous), target-based drug design, Molecular Medicine, Metabolic Networks and Pathways, Drug, media_common.quotation_subject, Trypanosoma cruzi, Antiprotozoal Agents, Trypanosoma brucei, 03 medical and health sciences, leishmaniases, Structure-Activity Relationship, Protozoan infection, parasitic diseases, medicine, Animals, Humans, Physical and Theoretical Chemistry, 030304 developmental biology, Life Cycle Stages, 010405 organic chemistry, Organic Chemistry, Human African Trypanosomiasis, biology.organism_classification, medicine.disease, Virology, 0104 chemical sciences, Insect Vectors, Trypanosomiasis, African, Drug Design, Protozoa
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المؤلفون: Keneth Iceland Kasozi, Gerald Zirintunda, Fred Ssempijja, Bridget Buyinza, Khalid J. Alzahrani, Kevin Matama, Helen N. Nakimbugwe, Luay Alkazmi, David Onanyang, Paul Bogere, Juma John Ochieng, Saher Islam, Wycliff Matovu, David Paul Nalumenya, Gaber El-Saber Batiha, Lawrence Obado Osuwat, Mahmoud Abdelhamid, Tianren Shen, Leonard Omadang, Susan Christina Welburn
المصدر: Kasozi, K I, Zirintunda, G, Ssempijja, F, Buyinza, B, Alzahrani, K J, Matama, K, Nakimbugwe, H N, Alkazmi, L, Onanyang, D, Bogere, P, Ochieng, J J, Islam, S, Matovu, W, Nalumenya, D P, Batiha, G E, Osuwat, L O, Abdelhamid, M, Shen, T, Omadang, L & Welburn, S C 2021, ' Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa ', Frontiers in Veterinary Science, vol. 8 . https://doi.org/10.3389/fvets.2021.621699
Frontiers in Veterinary Science
Frontiers in Veterinary Science, Vol 8 (2021)مصطلحات موضوعية: Trypanosoma brucei rhodesiense, wildlife-livestock interactions, Veterinary medicine, human African trypanosomiasis, sleeping sickness, Trypanosoma brucei gambiense, 030231 tropical medicine, Zoology, Trypanosoma irwini, Review, Trypanosoma brucei, 03 medical and health sciences, 0302 clinical medicine, SF600-1100, parasitic diseases, medicine, Trypanosoma cruzi, human-wildlife interactions, 030304 developmental biology, 0303 health sciences, General Veterinary, biology, Trypanosoma evansi, biology.organism_classification, medicine.disease, Animal trypanosomiasis, Trypanosoma vivax, Trypanosoma, Veterinary Science, trypanosomes in wildlife
وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e715eb3297a12148142ba5f03f3af
https://www.pure.ed.ac.uk/ws/files/216361999/621699_Manuscript_vr3.docx -
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المؤلفون: Robert Bridger, Robert J. Schmitz, Yang Zhang, Alexandre P. Marand, Lance Wells, Jose Dagoberto Moran, Robert Sabatini, Rudo Kieft
المصدر: PLoS Genetics
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
PLoS Genetics, 16(2):e1008390مصطلحات موضوعية: Cancer Research, Base J, Genes, Protozoan, Protozoan Proteins, RNA polymerase II, QH426-470, Biochemistry, Histones, chemistry.chemical_compound, 0302 clinical medicine, RNA interference, Glucosides, Transcription (biology), RNA polymerase, Gene expression, Transcriptional regulation, Transcriptional Termination, Genetics (clinical), Leishmania, Protozoans, 0303 health sciences, biology, DNA, Kinetoplast, Transcriptional Control, Messenger RNA, 030302 biochemistry & molecular biology, Eukaryota, Cell biology, Nucleic acids, Genetic interference, Glucosyltransferases, Epigenetics, RNA Polymerase II, DNA-binding proteins, Genomics, Transcriptional termination, Trypanosoma brucei gambiense, Transcriptional control, DNA transcription, Research Article, Trypanosoma, Trypanosoma brucei brucei, DNA-binding protein, 03 medical and health sciences, Trypanosoma Brucei, Genetics, Animals, Gene Regulation, Uracil, Molecular Biology, Gene, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, fungi, Organisms, Biology and Life Sciences, Proteins, Promoter, Parasitic Protozoans, chemistry, Transcription Termination, Genetic, Mutation, biology.protein, RNA, 030217 neurology & neurosurgery, DNA, Thymine, Trypanosoma Brucei Gambiense
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المؤلفون: Mathieu Cayla, Federico Rojas, Keith R. Matthews
المصدر: Rojas, F, Cayla, M & Matthews, K R 2021, ' Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro ', PLoS Neglected Tropical Diseases, vol. 15, no. 4 . https://doi.org/10.1371/journal.pntd.0009284
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009284 (2021)
PLoS Neglected Tropical Diseasesمصطلحات موضوعية: 0301 basic medicine, Life Cycles, Cellular differentiation, RC955-962, Protozoan Proteins, Matrix (biology), Biochemistry, Parasitic Cell Cycles, Basement Membrane, Extracellular matrix, 0302 clinical medicine, Arctic medicine. Tropical medicine, Protozoans, 0303 health sciences, biology, Chemistry, Cell Cycle, 030302 biochemistry & molecular biology, Eukaryota, Quorum Sensing, Cell Differentiation, Proteases, Cell cycle, Enzymes, Extracellular Matrix, Cell biology, Infectious Diseases, medicine.anatomical_structure, Cellular Structures and Organelles, Public aspects of medicine, RA1-1270, Research Article, Trypanosoma, Parasitic Life Cycles, Trypanosoma brucei brucei, Virulence, Trypanosoma brucei, 03 medical and health sciences, Trypanosoma Brucei, medicine, Animals, Secretion, 030304 developmental biology, Basement membrane, Life Cycle Stages, Organisms, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Proteins, Cell Biology, biology.organism_classification, Parasitic Protozoans, In vitro, Culture Media, 030104 developmental biology, Enzymology, Parasitology, Collagens, 030217 neurology & neurosurgery, Developmental Biology, Trypanosoma Brucei Gambiense
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44c5e74428dac6efd24020a69b1d0c0
https://www.pure.ed.ac.uk/ws/files/209116413/journal.pntd.0009284.pdf -
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المصدر: Drug research. 71(6)
مصطلحات موضوعية: Trypanosoma brucei rhodesiense, Cell Survival, Trypanosoma brucei gambiense, Drug Evaluation, Preclinical, Pharmacology, 01 natural sciences, Polar surface area, HeLa, 03 medical and health sciences, Pharmacokinetics, Parasitic Sensitivity Tests, Drug Discovery, Toxicity Tests, Acute, Humans, Cytotoxicity, IC50, 030304 developmental biology, Quinazolinones, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Low activity, General Medicine, biology.organism_classification, Trypanocidal Agents, In vitro, 0104 chemical sciences, Trypanosomiasis, African, Toxicity, HeLa Cells
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eda8581279a079049512170d0aea200
https://pubmed.ncbi.nlm.nih.gov/33607656
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