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المؤلفون: Pedro H. P. R. Carvalho, Lucio H. Freitas-Junior, Carolina B. Moraes, Giovana Aparecida de Souza Cintra, Brenno A. D. Neto
المصدر: SLAS Discovery. 24:755-765
مصطلحات موضوعية: 0303 health sciences, Drug discovery, Phenotypic screening, In vitro toxicology, Computational biology, Biology, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, In vivo, parasitic diseases, Molecular Medicine, Bioassay, Propidium iodide, Caenorhabditis elegans, 030304 developmental biology, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad418ec953bdf09d5670bdd711058dd0
https://doi.org/10.1177/2472555219851130 -
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المؤلفون: Flavio Di Pisa, Elisa Uliassi, Lucio H. Freitas-Junior, Maria Laura Bolognesi, Antonio Quotadamo, Maria Paola Costi, Claudia Danielli Pereira Bertolacini, Joachim Clos, Joanna Panecka-Hofman, Chiara Borsari, María Jesús Corral, G. Landi, Maria Kuzikov, Deepa Karunakaran, Pasquale Linciano, Wolfgang Müller, Birte Behrens, Kyriakos C. Prousis, Carolina B. Moraes, Lucia Dello Iacono, Markus Wolf, Oliver Keminer, Cecilia Pozzi, Rebecca C. Wade, Bruno dos Santos Pascoalino, José María Alunda, Stefania Ferrari, Martina Fenske, Alberto Venturelli, Sheraz Gul, Jeanette Reinshagen, Nuno Santarém, Matteo Santucci, Jennifer Leu, Stephen Wrigley, Ina Pöhner, Bethlehem Kebede, Theodora Calogeropoulou, Bernhard Ellinger, Stefano Mangani, Anabela Cordeiro-da-Silva, Gesa Witt
المساهمون: Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul, Publica
المصدر: Slas Discovery
مصطلحات موضوعية: Chagas disease, cell-based assays, Antiparasitic, medicine.drug_class, cell-based assay, Computational biology, liquid handling, Trypanosoma brucei, 01 natural sciences, Biochemistry, Article, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Trypanosomiasis, anti-infective drugs, Drug Discovery, parasitic diseases, medicine, Humans, compound repositories, enzyme assays or enzyme kinetics, Biotechnology, Molecular Medicine, 030304 developmental biology, 0303 health sciences, Biological Products, Natural product, biology, Drug discovery, Leishmaniasis, biology.organism_classification, medicine.disease, Trypanocidal Agents, anti-infective drug, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, chemistry, compound repositorie, Neglected tropical diseases, enzyme assays or enzyme kinetic
وصف الملف: ELETTRONICO
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b64ff9e20812ab96c4f3ad8331d20
https://hdl.handle.net/11380/1175165 -
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المؤلفون: Thalita Camêlo da Silva Ferreira, Vanessa Fontana, Laura M. Alcântara, Carolina B. Moraes, Lucio H. Freitas-Junior, Eric Chatelain
المصدر: Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2551, p 2551 (2020)مصطلحات موضوعية: THP-1 Cells, Phenotypic screening, 030231 tropical medicine, Antiprotozoal Agents, Drug Evaluation, Preclinical, Pharmaceutical Science, Biology, Article, Leishmania, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Mice, 0302 clinical medicine, lcsh:Organic chemistry, Species Specificity, Leishmania species, Drug Discovery, Multi species, medicine, leishmaniasis drug discovery, Animals, Humans, Physical and Theoretical Chemistry, Protriptyline, Leishmaniasis, 030304 developmental biology, 0303 health sciences, Drug discovery, Organic Chemistry, phenotypic screening, medicine.disease, biology.organism_classification, Phenotype, Small molecule, Biochemistry, Maprotiline, Chemistry (miscellaneous), Molecular Medicine, Leishmaniasis, Visceral
وصف الملف: application/pdf
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المؤلفون: Fábio P. Sellera, Douglas Ferreira Sales-Medina, Martha S. Ribeiro, Caetano P. Sabino, Edison Luiz Durigon, Lucio H. Freitas-Junior, Rafael Rahal Guaragna Machado
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Photodiagnosis and Photodynamic Therapyمصطلحات موضوعية: 0303 health sciences, 2019-20 coronavirus outbreak, Chemistry, viruses, Inactivation kinetics, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), fungi, 030303 biophysics, Kinetics, Biophysics, Dermatology, Photosensitizing Agent, Virology, Article, Virus, In vitro, RNA VIRAL, body regions, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Oncology, Pharmacology (medical), skin and connective tissue diseases, Anti-Infective Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef4dde24829c09d99a1842a2a510e4b
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5Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening
المؤلفون: Lucio H. Freitas-Junior, Cleber C. Melo-Filho, Carolina Horta Andrade, Caio Haddad Franco, Eugene N. Muratov, Carolina B. Moraes, Rodolpho C. Braga
المصدر: European journal of medicinal chemistry. 163
مصطلحات موضوعية: Chagas disease, Quantitative structure–activity relationship, Trypanosoma cruzi, Drug Evaluation, Preclinical, Quantitative Structure-Activity Relationship, Disease, Pharmacology, 01 natural sciences, 03 medical and health sciences, Drug Discovery, medicine, Humans, Chagas Disease, Triatominae, 030304 developmental biology, 0303 health sciences, Virtual screening, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Tropical disease, General Medicine, medicine.disease, biology.organism_classification, Trypanocidal Agents, 0104 chemical sciences, Benznidazole, medicine.drug
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المؤلفون: Lici A. Schurig-Briccio, Kai Li, Benoit Lechartier, Lucio H. Freitas-Junior, Feifei Ren, Venugopal Pujari, Rey-Ting Guo, Douglas A. Mitchell, Tong Jiang, Eric Oldfield, Hong Sun, Peter Orlean, Shannon Bogue, Dean C. Crick, Xinxin Feng, Wei Zhu, Katie J. Molohon, Guodong Rao, Yi Liang Liu, Stewart T. Cole, Anmol Gulati, Hongliang Yang, Ashutosh Upadhyay, Fabio L. Fontes, Giovana Aparecida de Souza Cintra, Robert B. Gennis, Joo Hwan No, Yujie Li
المصدر: Journal of Medicinal Chemistry; Vol 57
Journal of Medicinal Chemistryمصطلحات موضوعية: Models, Molecular, Tuberculosis, Plasmodium falciparum, SQ109, Antitubercular Agents, Antineoplastic Agents, Breast Neoplasms, Drug resistance, Article, Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Anti-Infective Agents, Drug Discovery, medicine, Tumor Cells, Cultured, Humans, Malaria, Falciparum, 030304 developmental biology, Cell Proliferation, 0303 health sciences, biology, Bacteria, Molecular Structure, 030306 microbiology, Drug discovery, Membrane transport protein, Fungi, Membrane Transport Proteins, biology.organism_classification, medicine.disease, 3. Good health, chemistry, Drug Design, biology.protein, MCF-7 Cells, Molecular Medicine, Female
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المؤلفون: Camila T. da Silva, Joo Hwan No, Michael Adsetts Edberg Hansen, Olivier Schwartz, Deu John M. Cruz, Rafaela Milan Bonotto, Lucio H. Freitas-Junior, Juliana B. Taniguchi, Rafael G. B. Gomes, Benoit Lombardot
المساهمون: Inst Pasteur Korea, Univ Feevale, Universidade Federal de Uberlândia (UFU), Univ Estadual Rio Grande do Sul, Universidade Estadual Paulista (Unesp), Inst Pasteur, Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Universidade Federal de Uberlândia, Universidade Estadual do Rio Grande do Sul, Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Virus et Immunité - Virus and immunity, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), The authors would like to acknowledge Katja Fink for the gift of HuH-7 cells and Claudia N. D. dos-Santos for the gift of C6/36 cells., Universidade Estadual do Rio Grande do Sul (UERGS), Virus et Immunité - Virus and immunity (CNRS-UMR3569), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2012, 7 (10), pp.e2471. ⟨10.1371/journal.pntd.0002471⟩
PLoS Neglected Tropical Diseases, 2012, 7 (10), pp.e2471. ⟨10.1371/journal.pntd.0002471⟩
PLoS Neglected Tropical Diseases, Vol 7, Iss 10, p e2471 (2013)مصطلحات موضوعية: MESH: Oxidation-Reduction, MESH: Cell Death, Cell, MESH: Chikungunya virus/physiology, chemistry.chemical_compound, MESH: Optical Imaging/methods, Cytopathic effect, MESH: Inhibitory Concentration 50, MESH: Alphavirus Infections/virology, 0303 health sciences, Cell Death, lcsh:Public aspects of medicine, Optical Imaging, MESH: Protein Kinase Inhibitors/isolation & purification, virus diseases, 3. Good health, MESH: Hepatocytes/drug effects, medicine.anatomical_structure, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Antiviral Agents/isolation & purification, Chikungunya virus, Oxidation-Reduction, Research Article, Programmed cell death, lcsh:Arctic medicine. Tropical medicine, Cell Survival, lcsh:RC955-962, MESH: High-Throughput Screening Assays/methods, Biology, Antiviral Agents, Virus, Cell Line, MESH: Protein Kinase Inhibitors/pharmacology, 03 medical and health sciences, Inhibitory Concentration 50, Oxazines, medicine, Humans, Viability assay, Protein Kinase Inhibitors, 030304 developmental biology, MESH: Cell Survival/drug effectsm, MESH: Humans, Staining and Labeling, 030306 microbiology, Alphavirus Infections, Public Health, Environmental and Occupational Health, MESH: Hepatocytes/physiology, MESH: Xanthenes/metabolism, Resazurin, lcsh:RA1-1270, Virology, High-Throughput Screening Assays, MESH: Cell Line, chemistry, Xanthenes, Apoptosis, Cell culture, MESH: Alphavirus Infections/drug therapy, MESH: Hepatocytes/virology, Hepatocytes, MESH: Staining and Labeling/methods, MESH: Cell Survival/drug effects, MESH: Oxazines/metabolism
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المؤلفون: Lucio H. Freitas-Junior, Michael Adsetts Edberg Hansen, Monica Contreras-Dominguez, Carolina B. Moraes, Thierry Dorval, Auguste Genovesio, Fernando de M. Dossin
المساهمون: Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Interdisciplinary Nanoscience Centre (iNANO), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (2), pp.e55539. ⟨10.1371/journal.pone.0055539⟩
PLoS ONE, Vol 8, Iss 2, p e55539 (2013)مصطلحات موضوعية: Transcription, Genetic, [SDV]Life Sciences [q-bio], Fluorescent Antibody Technique, lcsh:Medicine, Molecular cell biology, 0302 clinical medicine, Transcription (biology), Gene expression, lcsh:Science, Genetics, Regulation of gene expression, 0303 health sciences, Multidisciplinary, Gene Expression Regulation, Developmental, Chromatin, Cellular Structures, 3. Good health, Infectious Diseases, medicine.anatomical_structure, Medicine, Epigenetics, Research Article, DNA transcription, Plasmodium falciparum, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Microbiology, 03 medical and health sciences, parasitic diseases, Parasitic Diseases, medicine, Animals, Gene, Transcription factor, 030304 developmental biology, Cell Nucleus, Nucleoplasm, lcsh:R, Parasite Physiology, Computational Biology, Malaria, Cell Compartmentation, Cell nucleus, Parasitology, lcsh:Q, 030217 neurology & neurosurgery
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المؤلفون: Heechang Kim, Lawrence Ayong, Sukjun Lee, Seunghyun Moon, Myungjoo Kang, Lucio H. Freitas-Junior, Michael Adsetts Edberg Hansen
المساهمون: Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Department of Mathematics, Seoul National University [Seoul] (SNU), This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST)(No. 2012-00011), Gyeonggi-do and KISTI. Myungjoo Kang was supported by the Basic Science Research Program (2012-001766) through the National Research Foundation of Korea.
المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (4), pp.e61812. ⟨10.1371/journal.pone.0061812⟩
PLoS ONE, Vol 8, Iss 4, p e61812 (2013)
PLOS ONE(8): 4مصطلحات موضوعية: Erythrocytes, Indoles, Spores, Protozoan, Population Modeling, lcsh:Medicine, 02 engineering and technology, Plasmodium, chemistry.chemical_compound, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Chloroquine, Image Processing, Computer-Assisted, 0202 electrical engineering, electronic engineering, information engineering, Parasite hosting, Organic Chemicals, Artemisinin, lcsh:Science, Cells, Cultured, 0303 health sciences, education.field_of_study, Multidisciplinary, Artemisinins, Mitochondria, 3. Good health, Infectious Diseases, Medical Microbiology, Medicine, 020201 artificial intelligence & image processing, Algorithm, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, Research Article, medicine.drug, Infectious Disease Control, Cell Survival, Plasmodium falciparum, Population, Biology, Microbiology, Antimalarials, Inhibitory Concentration 50, 03 medical and health sciences, parasitic diseases, Parasitic Diseases, medicine, Humans, education, Fluorescent Dyes, 030304 developmental biology, lcsh:R, Computational Biology, medicine.disease, biology.organism_classification, Malaria, Multiple drug resistance, Microscopy, Fluorescence, chemistry, Computer Science, SYBR Green I, lcsh:Q, Infectious Disease Modeling, Mathematics
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المؤلفون: Auguste Genovesio, Igor C. Almeida, Seo Yeon Choi, Yong-Jun Kwon, Neil Emans, Nam Youl Kim, Sung Yong Jung, Miriam A. Giardini, Sergio Schenkman, Hi Chul Kim, Fernando de M. Dossin, Lucio H. Freitas-Junior
المساهمون: Inst Pasteur Korea, Yonsei Univ, Universidade Federal de São Paulo (UNIFESP), Univ Texas El Paso, CSIR Biosci, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Yonsei University, Escola Paulista de Medicina [São Paulo] (EPM), Universidade de São Paulo (USP), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
PLoS ONE, Vol 6, Iss 5, p e19733 (2011)
PLoS ONE
PLoS ONE, Public Library of Science, 2011, 6 (5), pp.e19733. ⟨10.1371/journal.pone.0019733⟩مصطلحات موضوعية: Microarrays, [SDV]Life Sciences [q-bio], lcsh:Medicine, Protozoology, Kidney, Genome, [SPI]Engineering Sciences [physics], Transforming Growth Factor beta, RNA interference, RNA, Small Interfering, lcsh:Science, Cells, Cultured, Oligonucleotide Array Sequence Analysis, 0303 health sciences, Multidisciplinary, Reverse Transcriptase Polymerase Chain Reaction, Microbial Growth and Development, Haplorhini, Genomics, Functional Genomics, 3. Good health, Host-Pathogen Interaction, RNA Interference, Research Article, Chagas disease, Trypanosoma cruzi, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Microbiology, Host-Parasite Interactions, 03 medical and health sciences, Genetics, Genome-Wide Association Studies, medicine, Animals, Humans, Gene silencing, Chagas Disease, RNA, Messenger, 030304 developmental biology, Genome, Human, 030306 microbiology, Gene Expression Profiling, Intracellular parasite, lcsh:R, Computational Biology, biology.organism_classification, medicine.disease, Virology, High-Throughput Screening Assays, Gene expression profiling, Parastic Protozoans, Parasitology, lcsh:Q, Gene Function, Biomarkers, Genetic screen
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