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المؤلفون: Manuel Pascual, Nicolas J. Mueller, Katia Boggian, Brian M. Lang, Laura N Walti, Adrian Egli, Matteo Mombelli, Lorena van den Bogaart, Christian van Delden, Dionysios Neofytos, Christoph Berger, Christian Garzoni, Oriol Manuel
المساهمون: University of Zurich, Mombelli, Matteo, Swiss Transplant Cohort Study
المصدر: van den Bogaart, Lorena; Lang, Brian M; Neofytos, Dionysios; Egli, Adrian; Walti, Laura N; Boggian, Katia; Garzoni, Christian; Berger, Christoph; Pascual, Manuel; van Delden, Christian; Mueller, Nicolas J; Manuel, Oriol; Mombelli, Matteo (2022). Epidemiology and outcomes of medically attended and microbiologically confirmed bacterial foodborne infections in solid organ transplant recipients. American journal of transplantation, 22(1), pp. 199-209. Wiley-Blackwell 10.1111/ajt.16831 <http://dx.doi.org/10.1111/ajt.16831>
American journal of transplantation, vol. 22, no. 1, pp. 199-209مصطلحات موضوعية: medicine.medical_specialty, Salmonella, 2747 Transplantation, 610 Medicine & health, 030230 surgery, medicine.disease_cause, 10234 Clinic for Infectious Diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, medicine, Immunology and Allergy, 2736 Pharmacology (medical), Humans, Pharmacology (medical), Cumulative incidence, 030212 general & internal medicine, Prospective Studies, Transplantation, business.industry, Campylobacter, Incidence, Bacterial Infections, Organ Transplantation, infectious, epidemiology, infection and infectious agents - bacterial, infectious disease, patient safety [Bacterial Infections/epidemiology, Bacterial Infections/etiology, Organ Transplantation/adverse effects, Transplant Recipients, clinical research/practice, complication], 3. Good health, Infectious disease (medical specialty), 10036 Medical Clinic, Cohort, 2723 Immunology and Allergy, business, Solid organ transplantation
الوصف: Food-safety measures are recommended to solid organ transplant (SOT) recipients. However, the burden of foodborne infections in SOT recipients has not been established. We describe the epidemiology and outcomes of bacterial foodborne infections in a nationwide cohort including 4405 SOT recipients in Switzerland between 2008 and 2018. Participants were prospectively followed for a median of 4.2 years with systematic collection of data on infections, and patient and graft-related outcomes. We identified 151 episodes of microbiologically confirmed bacterial foodborne infections occurring in median 1.6 years (IQR 0.58-3.40) after transplantation (131 [88%] Campylobacter spp. and 15 [10%] non-typhoidal Salmonella). The cumulative incidence of bacterial foodborne infections was 4% (95% CI 3.4-4.8). Standardized incidence rates were 7.4 (95% CI 6.2-8.7) and 4.6 (95% CI 2.6-7.5) for Campylobacter and Salmonella infections, respectively. Invasive infection was more common with Salmonella (33.3% [5/15]) compared to Campylobacter (3.2% [4/125]; p = .001). Hospital and ICU admission rates were 47.7% (69/145) and 4.1% (6/145), respectively. A composite endpoint of acute rejection, graft loss, or death occurred within 30 days in 3.3% (5/151) of cases. In conclusion, in our cohort bacterial foodborne infections were late post-transplant infections and were associated with significant morbidity, supporting the need for implementation of food-safety recommendations.
وصف الملف: application/pdf; American_J_Transplantation_-_2021_-_van_den_Bogaart_-_Epidemiology_and_outcomes_of_medically_attended_and_microbiologically.pdf - application/pdf
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المؤلفون: Lina Quteineh, Frederik Vandenberghe, Roger Lehmann, Nicolas J. Mueller, Pierre-Yves Bochud, Agnieszka Wójtowicz, Mike Recher, Paul Mohacsi, Jean-François Dufour, Manuel Pascual, Paola M. Soccal, Séverine Crettol, Zoltán Kutalik, Isabelle Binet, Jean-Pierre Venetz, Peter Vollenweider, Dela Golshayan, Christian van Delden, Oriol Manuel, Pedro Marques-Vidal, Jürg Steiger, Christoph Hess, Chin B. Eap
المساهمون: University of Zurich, Eap, Chin B, Swiss Transplant Cohort Study
المصدر: American journal of transplantation, vol. 19, no. 1, pp. 238-246
American Journal of Transplantation, Vol. 19, No 1 (2019) pp. 238-246مصطلحات موضوعية: Male, 2747 Transplantation, medicine.medical_treatment, 030230 surgery, Gastroenterology, Organ transplantation, 10234 Clinic for Infectious Diseases, Diabetes mellitus genetics, 0302 clinical medicine, 600 Technology, Odds Ratio, Immunology and Allergy, 2736 Pharmacology (medical), ddc:576.5, Pharmacology (medical), Prospective Studies, 610 Medicine & health, Prospective cohort study, ddc:615, education.field_of_study, ddc:617, Homozygote, Immunosuppression, Middle Aged, 2723 Immunology and Allergy, Female, Immunosuppressive Agents, Switzerland, Adult, medicine.medical_specialty, Heterozygote, Adolescent, Population, Polymorphism, Single Nucleotide, 03 medical and health sciences, Young Adult, Internal medicine, Diabetes mellitus, medicine, Aged, Diabetes Mellitus/etiology, Diabetes Mellitus/genetics, Diabetes Mellitus/immunology, Gene-Environment Interaction, Humans, Immunosuppressive Agents/therapeutic use, Inflammation/genetics, Inflammation/immunology, Organ Transplantation, Switzerland/epidemiology, Transplant Recipients, clinical research/practice, diabetes, genetics, new onset/posttransplant, Diabetes Mellitus, education, Immunosuppression Therapy, Inflammation, Transplantation, business.industry, Odds ratio, medicine.disease, business
الوصف: New-onset diabetes mellitus after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT was investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n 1 = 696). Positive results were tested in a first STCS replication sample (n 2 = 489) and SNPs remaining significant after multiple test corrections were tested in a second SOT replication sample (n 3 = 156). Associations with diabetic traits were further tested in several large general population-based samples (n > 480 000). Only SP110 rs2114592C>T remained associated with NODAT in the STCS replication sample. Carriers of rs2114592-TT had 9.9 times (95% confidence interval [CI]: 3.22-30.5, P = .00006) higher risk for NODAT in the combined STCS samples (n = 1184). rs2114592C>T was further associated with NODAT in the second SOT sample (odds ratio: 4.8, 95% CI: 1.55-14.6, P = .006). On the other hand, SP110 rs2114592C>T was not associated with diabetic traits in population-based samples, suggesting a specific gene-environment interaction, possibly due to the use of specific medications (ie, immunosuppressants) in transplant patients and/or to the illness that may unmask the gene effect.
وصف الملف: application/pdf
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المؤلفون: C. Martin-Gandul, Oriol Manuel, Manuel Pascual, Nicolas J. Mueller
المساهمون: University of Zurich, Manuel, O
مصطلحات موضوعية: Graft Rejection, medicine.medical_specialty, 2747 Transplantation, Urinary system, Hepatitis C virus, 610 Medicine & health, medicine.disease_cause, Infections, Organ transplantation, 10234 Clinic for Infectious Diseases, Anti-Infective Agents, Chronic allograft nephropathy, medicine, BK Virus Infection, Immunology and Allergy, Humans, 2736 Pharmacology (medical), Pharmacology (medical), Transplantation, Kidney, Lung, business.industry, Graft Survival, Organ Transplantation, medicine.disease, Allografts, Prognosis, surgical procedures, operative, medicine.anatomical_structure, Immunology, 2723 Immunology and Allergy, business, Respiratory tract
الوصف: Infectious diseases after solid organ transplantation (SOT) are a significant cause of morbidity and reduced allograft and patient survival; however, the influence of infection on the development of chronic allograft dysfunction has not been completely delineated. Some viral infections appear to affect allograft function by both inducing direct tissue damage and immunologically related injury, including acute rejection. In particular, this has been observed for cytomegalovirus (CMV) infection in all SOT recipients and for BK virus infection in kidney transplant recipients, for community-acquired respiratory viruses in lung transplant recipients, and for hepatitis C virus in liver transplant recipients. The impact of bacterial and fungal infections is less clear, but bacterial urinary tract infections and respiratory tract colonization by Pseudomonas aeruginosa and Aspergillus spp appear to be correlated with higher rates of chronic allograft dysfunction in kidney and lung transplant recipients, respectively. Evidence supports the beneficial effects of the use of antiviral prophylaxis for CMV in improving allograft function and survival in SOT recipients. Nevertheless, there is still a need for prospective interventional trials assessing the potential effects of preventive and therapeutic strategies against bacterial and fungal infection for reducing or delaying the development of chronic allograft dysfunction.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0369453ace140e48142dc161ce0007c
https://www.zora.uzh.ch/id/eprint/120071/ -
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المؤلفون: Katia Boggian, Oriol Manuel, Nicolas J. Mueller, Christian Garzoni, C. van Delden, Hans H. Hirsch, G. Kralidis, Pascal Meylan, Maja Weisser, Manuel Pascual, Christoph Berger, Alexia Cusini, Michael T. Koller
المساهمون: University of Zurich, Manuel, O
المصدر: American Journal of Transplantation, Vol. 13, No 9 (2013) pp. 2402-10
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, 2747 Transplantation, Cytomegalovirus, 610 Medicine & health, Disease, Antiviral Agents, 10234 Clinic for Infectious Diseases, Risk Factors, Internal medicine, Humans, Valganciclovir, 2736 Pharmacology (medical), Immunology and Allergy, Medicine, Pharmacology (medical), Prospective Studies, Prospective cohort study, Ganciclovir, Aged, ddc:616, Transplantation, business.industry, Proportional hazards model, Incidence, Incidence (epidemiology), Graft Survival, Hazard ratio, Organ Transplantation, Middle Aged, Surgery, 10036 Medical Clinic, Cytomegalovirus Infections, Cohort, 2723 Immunology and Allergy, Female, business, Serostatus, medicine.drug
الوصف: We assessed the impact of antiviral prophylaxis and preemptive therapy on the incidence and outcomes of cytomegalovirus (CMV) disease in a nationwide prospective cohort of solid organ transplant recipients. Risk factors associated with CMV disease and graft failure-free survival were analyzed using Cox regression models. One thousand two hundred thirty-nine patients transplanted from May 2008 until March 2011 were included; 466 (38%) patients received CMV prophylaxis and 522 (42%) patients were managed preemptively. Overall incidence of CMV disease was 6.05% and was linked to CMV serostatus (D+/R− vs. R+, hazard ratio [HR] 5.36 [95% CI 3.14–9.14], p
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