المؤلفون: Amos Norman, Keisuke S. Iwamoto, Myron Wollin, A.R. Kagan

المصدر: Radiotherapy and Oncology. 23:196-197

مصطلحات موضوعية: Adult, Oncology, Aging, Heterozygote, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Esthetics, Buccal swab, Breast Neoplasms, Radiation Tolerance, Indirect evidence, Ataxia Telangiectasia, Radiation sensitivity, Breast cancer, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, skin and connective tissue diseases, Micronuclei, Chromosome-Defective, Aged, business.industry, Mouth Mucosa, Cosmesis, Hematology, Middle Aged, medicine.disease, Ataxia-telangiectasia, Micronucleus test, Female, business

الوصف: The age dependence of poor cosmesis from breast irradiation and the frequency of micronuclei (MN) in buccal cells provide indirect evidence for the presence of a relatively radiosensitive subpopulation of ataxia telangiectasia (AT) heterozygotes in breast cancer patients

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861449ef2908a3ce5997179055465ebf
https://doi.org/10.1016/0167-8140(92)90331-n

المؤلفون: Myron Wollin, Herman Nussbaum, Aroor R. Rao, A.R. Kagan, B. L. Hintz, Paul Y. M. Chan, Harvey A. Gilbert

المصدر: International Journal of Radiation Oncology*Biology*Physics. 6:711-716

مصطلحات موضوعية: Adult, Cancer Research, medicine.medical_specialty, Vaginal Neoplasms, Necrosis, medicine.medical_treatment, Brachytherapy, Physiology, Radiation Tolerance, Radiation tolerance, medicine, Humans, Radiology, Nuclear Medicine and imaging, Cobalt Radioisotopes, Radiation Injuries, Aged, Mucous Membrane, Radiation, business.industry, Vaginal mucosa, Cancer, Dose-Response Relationship, Radiation, Middle Aged, Vaginal Cylinder, medicine.disease, Surgery, Vaginal necrosis, medicine.anatomical_structure, Oncology, Vagina, Female, Radioisotope Teletherapy, medicine.symptom, business

الوصف: Sixteen patients with cancer of the vagina that were controlled locally for a minimum of eighteen months after teletherapy (T) or brachytherapy (B) or both (T & B), were analyzed for radiation tolerance of the vaginal mucosa. The site of vaginal necrosis did not always coincide with the site of the tumor. The posterior wall appeared more vulnerable than the anterior or lateral walls. For the distal vaginal mucosa, necrosis requiring surgical intervention occurred following combined T & B, if summated rad exceeded 9800. The upper vagina tolerated higher dosages. No patient required surgery for upper vaginal necrosis even though summated (T & B) dosage up to 14,000 rad was applied. Placing radioactive needles on the surface of the vaginal cylinder with or without interstitial perinea) needles should be avoided. Further accumulation of data is needed to define these vaginal mucosa tolerance limits more closely.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bef5d1234534918d4984524d1ab482
https://doi.org/10.1016/0360-3016(80)90227-8

المؤلفون: Herman Nussbaum, A.R. Kagan, Katsumi Tawa, Myron Wollin, Philip J. Disaia

المصدر: Gynecologic Oncology. 4:291-298

مصطلحات موضوعية: medicine.medical_specialty, Urinary Bladder, Vaginal Diseases, Uterine Cervical Neoplasms, Rectum, Radiation Dosage, Humans, Medicine, Radiation Injuries, Elderly patient, Aged, Pelvic organ, business.industry, Radiation Therapist, Age Factors, Obstetrics and Gynecology, Radiotherapy Dosage, Surgery, Antecedent (behavioral psychology), medicine.anatomical_structure, Oncology, Vagina, Female, Spatial relationship, business, Gynecologic Oncologist, Radium

الوصف: The narrow vagina may result in an overirradiation of the normal pelvic organs. This inadequate spatial relationship cannot be avoided by packing or choosing another applicator. Since this problem often occurs in the elderly patient, surgery is not seriously considered as an alternative. The prediction of radionecrotic complications is important for both the radiation therapist and the gynecologic oncologist. The narrow vagina can be defined in terms of the ratio of Point A dose to that of the bladder and/or rectum. It is important that a poor therapeutic ratio be recognized in order to prevent excessive radiation to the normal structures. Alternates to the "routine" intracavity Curie therapy will be presented. The role of the colpostats, the protruding source, and the tandem will be discussed in a manner which will yield better communication between the radiation therapist and the gynecologic oncologist. The deliverance of overtolerance radiation in order to gain cancer cure in select patients must be a combined radiotherapeutic surgical decision. Guidelines for management will be presented.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc2ede1b90f6ff7c9fd27f69d5b76f7
https://doi.org/10.1016/0090-8258(76)90034-2

المؤلفون: M. Wollin, B. L. Hintz, D Potyk, M. C. Ryoo, A.R. Kagan, Aroor R. Rao, Herman Nussbaum, Paul K.S. Chan

المصدر: American journal of clinical oncology. 7(3)

مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, Lymphoma, medicine.medical_treatment, Biopsy, Perforation (oil well), Gastroenterology, Neoplasms, Multiple Primary, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Stage (cooking), Child, Aged, Gastrointestinal Neoplasms, Neoplasm Staging, Chemotherapy, medicine.diagnostic_test, business.industry, Stomach, Age Factors, Middle Aged, medicine.disease, Prognosis, Combined Modality Therapy, Surgery, Radiation therapy, medicine.anatomical_structure, Oncology, Lymphatic Metastasis, Abdomen, Female, business, Follow-Up Studies

الوصف: A study was made of 65 patients with primary gastrointestinal (GI) lymphoma. The occurrence was 40 (62%) in stomach, 15 (23%) in the small intestine, and 10 (15%) in colorectum. The majority of patients had their histology classified according to Rappaport's classification. Diffuse histiocytic type had the worst prognosis (median survival 13.8 months), and nodular histology had the best prognosis. A modified staging system proposed by Blackledge et al. was used. Patients who had their disease confined to one viscus (Stage I) or with spread to regional lymph nodes (Stage II) had an excellent prognosis, with a 5-year survival of 87 and 67%, respectively. However, those who had distant nodal involvement (Stage III, e.g., para-aortic nodes) or spread to adjacent organs within the abdomen (Stage IV) had worse prognosis, with 5-year survival of 40 and 13%, respectively. In Stage I, radiotherapy alone was as effective as surgical resection. None of the 11 patients treated by radiotherapy alone had perforation or bleeding. The 5-year disease-free survival was 51%.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4107a2179b92c3d3866127cd39a1c22b
https://pubmed.ncbi.nlm.nih.gov/6731344