المؤلفون: Hiromi Nishioka, Shoya Yamada, Tomoharu Motoyama, Hiroki Kakuta, Makoto Makishima, Sohei Ito, Yuta Takamura, Mayu Kawasaki, Yasuo Takeuchi, Shogo Nakano, Michiko Fujihara, Maho Takioku, Hiroaki Tokiwa, Masaki Watanabe

المصدر: Journal of Medicinal Chemistry. 62:8809-8818

مصطلحات موضوعية: Agonist, Tetrahydronaphthalenes, medicine.drug_class, Retinoid X receptor, Ligands, Umbelliferone, Binding, Competitive, 01 natural sciences, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, Genes, Reporter, Competitive binding, Drug Discovery, medicine, Humans, Umbelliferones, Retinoid, Receptor, Fluorescent Dyes, 030304 developmental biology, 0303 health sciences, Chemistry, Ligand, Fluorescence, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Retinoid X Receptors, Biochemistry, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f0b88f01a1c1e065c93add4b81e6f3
https://doi.org/10.1021/acs.jmedchem.9b00995

المؤلفون: Peter B. Senese, Eric Zanelli, Kristian Agmund Haanes, Joseph Kovalchin, Ad J.J.C. Bogers, Antoinette MaassenVanDenBrink, Carlos M. Villalón, Alejandro Labastida-Ramírez, Antoon J. van den Bogaerdt, Kirk W. Johnson, Laurent Meeus, Eloísa Rubio-Beltrán, Michael R Gralinski, A.H. Jan Danser

المساهمون: Internal Medicine, Cardiothoracic Surgery

المصدر: British Journal of Pharmacology
British Journal of Pharmacology, 176(24), 4681-4695. Wiley-Blackwell

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.drug_class, Pyridines, Triptans, CHO Cells, Pharmacology, In Vitro Techniques, Binding, Competitive, 03 medical and health sciences, chemistry.chemical_compound, Radioligand Assay, 0302 clinical medicine, Cricetulus, Dogs, Piperidines, In vivo, medicine, Potency, Animals, Humans, Receptor, Dose-Response Relationship, Drug, business.industry, Sumatriptan, Cell Membrane, 5-HT1F receptor, Research Papers, Coronary Vessels, Meningeal Arteries, Lasmiditan, Serotonin Receptor Agonists, 030104 developmental biology, chemistry, Vasoconstriction, Receptors, Serotonin, Benzamides, cardiovascular system, Female, business, 030217 neurology & neurosurgery, medicine.drug, Research Paper, Muscle Contraction, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45db3763c959ce78f9ceaf2dbf6f5759
https://doi.org/10.1111/bph.14832

المؤلفون: Yasuyuki Shimohigashi, Miki Shimohigashi, Keitaro Suyama, Takeru Nose, Xiaohui Liu

المصدر: PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246583 (2021)

مصطلحات موضوعية: Composite Particles, Bisphenol, Reporter Gene Assay, Estrogen receptor, Ligands, Physical Chemistry, Biochemistry, Bisphenol AF, chemistry.chemical_compound, Binding Analysis, 0302 clinical medicine, Halogens, Genes, Reporter, London Dispersion Forces, Luciferases, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, Halogen bond, Molecular Structure, Physics, Enzymes, Chemistry, 030220 oncology & carcinogenesis, Physical Sciences, Medicine, Oxidoreductases, Luciferase, Research Article, Agonist, Transcriptional Activation, Atoms, Double bond, medicine.drug_class, Stereochemistry, Science, DNA transcription, Research and Analysis Methods, Binding, Competitive, 03 medical and health sciences, Phenols, medicine, Genetics, Estrogen Receptor beta, Humans, Benzhydryl Compounds, Bifunctional, Particle Physics, Molecular Biology Techniques, Molecular Biology, Receptor Binding Assays, Chemical Characterization, 030304 developmental biology, Intermolecular Forces, Molecular Biology Assays and Analysis Techniques, Chemical Physics, Antagonist, Estrogen Receptor alpha, Biology and Life Sciences, Proteins, chemistry, Chemical Properties, Enzymology, Gene expression, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747e50aa0893ee36b37254eff9edc5c7
https://pubmed.ncbi.nlm.nih.gov/33561155

المؤلفون: Wanglong Zheng, Rongyun Zhou, Shuangjie Li, Shan He, Jia Luo, Meiqin Zhu, Nanhua Chen, Hongjun Chen, François Meurens, Jianzhong Zhu

المساهمون: Yangzhou University, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety, Partenaires INRAE, Chinese Academy of Agricultural Sciences (CAAS), Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work was partly supported by the National Key Research and Development Program of China (2017YFD0502301), the National Natural Science Foundation of China (31672523 and 31872450), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

المصدر: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2020, 11, ⟨10.3389/fimmu.2020.01669⟩
Frontiers in Immunology, Vol 11 (2020)

مصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Agonist, Transcription, Genetic, Porcine, medicine.drug_class, [SDV]Life Sciences [q-bio], Immunology, DNA sensor, Stimulation, Herpesvirus 1, Human, Kidney, Binding, Competitive, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Mutual relationship, medicine, Humans, Immunology and Allergy, Protein Interaction Domains and Motifs, Original Research, Innate immunity, Binding Sites, Innate immune system, IFI16, Intracellular parasite, Nuclear Proteins, DNA, Transfection, Phosphoproteins, Nucleotidyltransferases, Signaling, Cell biology, HEK293 Cells, 030104 developmental biology, chemistry, Second messenger system, lcsh:RC581-607, Protein Binding, Signal Transduction, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c3294221bb968c3f23a9a5d2de0df0
https://doi.org/10.3389/fimmu.2020.01669

المؤلفون: Philip Seeman, Sivan Subburaju, Anna W. Sromek, John L. Neumeyer

المصدر: ACS Chem Neurosci

مصطلحات موضوعية: 0301 basic medicine, Agonist, Apomorphine, Physiology, medicine.drug_class, Dopamine, Cognitive Neuroscience, Binding, Competitive, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dopamine receptor D2, medicine, Animals, Aporphine, Receptor, Raclopride, Receptors, Dopamine D2, Chemistry, Antagonist, Cell Biology, General Medicine, Ligand (biochemistry), Corpus Striatum, 030104 developmental biology, Dopamine Agonists, Schizophrenia, Biophysics, Dopamine Antagonists, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac8ae3a2d925a203e60932a1dfd9de6
https://doi.org/10.1021/acschemneuro.8b00096

المؤلفون: Lorella Pasquinucci, Orazio Prezzavento, Giuseppina Cantarella, Giuseppina Aricò, Emanuela Arena, Rita Turnaturi, Zafiroula Georgoussi, Carmela Parenti, Rosalba Parenti

المصدر: Bioorganic & Medicinal Chemistry. 25:4745-4752

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Receptors, Opioid, mu, Substituent, Pain, Pharmaceutical Science, Tritium, Binding, Competitive, Biochemistry, δ-opioid receptor, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Mu opioid receptor, Delta opioid receptor, 6,7-Benzomorhan scaffold, Radioligand competition-binding, GPI and MVD, Receptors, Opioid, delta, Drug Discovery, medicine, Animals, 7-Benzomorhan scaffold, Receptor, Molecular Biology, Analgesics, Receptors, Opioid, kappa, Organic Chemistry, Antagonist, Benzomorphans, Kinetics, 030104 developmental biology, chemistry, Opioid, Molecular Medicine, μ-opioid receptor, 030217 neurology & neurosurgery, Tail flick test, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db9f3f84388eb99af019edd0197a980
https://doi.org/10.1016/j.bmc.2017.07.021

المؤلفون: Neha Kanojia, Chitra Rawat, Ajay Jajodia, Samiksha Kukal, Karthikeyan Muthusamy, Selvaraman Nagamani, Richa Misra, Anshika Singhal, Ritushree Kukreti, Khuraijam Dhanachandra Singh, Gurpreet Kaur Grewal

المصدر: Pharmaceutical Research. 34:1444-1458

مصطلحات موضوعية: 0301 basic medicine, Agonist, Receptors, Steroid, medicine.drug_class, In silico, Active Transport, Cell Nucleus, Pharmaceutical Science, Molecular Dynamics Simulation, Phloroglucinol, Pharmacology, Ligands, Binding, Competitive, digestive system, 03 medical and health sciences, chemistry.chemical_compound, medicine, Humans, Computer Simulation, Pharmacology (medical), Cell Nucleus, Pregnane X receptor, Terpenes, Chemistry, Multidrug resistance-associated protein 2, Organic Chemistry, Pregnane X Receptor, Antagonist, Transporter, Hep G2 Cells, Multidrug Resistance-Associated Protein 2, digestive system diseases, In vitro, Molecular Docking Simulation, Hyperforin, Carbamazepine, Ketoconazole, 030104 developmental biology, Mutation, Molecular Medicine, Anticonvulsants, RNA Interference, Multidrug Resistance-Associated Proteins, Protein Binding, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e907bc969096a2754b8d30563dd307e6
https://doi.org/10.1007/s11095-017-2161-z

المؤلفون: Mine Yurtsever, Matthias Stein, Serdar Durdagi, Busecan Aksoydan, Philip Seeman, Ramin Ekhteiari Salmas

المصدر: ACS Chemical Neuroscience. 8:826-836

مصطلحات موضوعية: 0301 basic medicine, Agonist, Molecular model, Physiology, medicine.drug_class, Stereochemistry, Cognitive Neuroscience, Binding, Competitive, Biochemistry, Molecular Docking Simulation, 03 medical and health sciences, chemistry.chemical_compound, Molecular dynamics, 0302 clinical medicine, Piperidines, Dopamine receptor D2, medicine, Humans, Protein Structure, Quaternary, Receptors, Dopamine D2, Dopaminergic, Cell Biology, General Medicine, Ligand (biochemistry), 030104 developmental biology, Monomer, chemistry, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd04006c1776d4c03bb50fba8e4017ef
https://doi.org/10.1021/acschemneuro.6b00396

المؤلفون: Ramesh Neelamegam, Michael S. Placzek, Hsiao-Ying Wey, Jacob M. Hooker, Changning Wang, Tao Che, Bryan L. Roth, Frederick A. Schroeder

المصدر: ACS chemical neuroscience. 10(1)

مصطلحات موضوعية: Agonist, Male, Pyrrolidines, Physiology, medicine.drug_class, Cognitive Neuroscience, (+)-Naloxone, Pharmacology, Biochemistry, κ-opioid receptor, Binding, Competitive, Naltrexone, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Carbon Radioisotopes, 030304 developmental biology, 0303 health sciences, Dose-Response Relationship, Drug, business.industry, Receptors, Opioid, kappa, Binding potential, Cell Biology, General Medicine, Human brain, JDTic, Rats, Analgesics, Opioid, medicine.anatomical_structure, chemistry, Positron-Emission Tomography, Benzamides, business, 030217 neurology & neurosurgery, Kappa, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa86d9ed017bfe9a93e0f0aac593eaf
https://pubmed.ncbi.nlm.nih.gov/30212182

المؤلفون: Yan Zhang, Yi Zheng, William L. Dewey, Yunyun Yuan, Dana E. Selley, Hamid I. Akbarali, Saheem A. Zaidi, Dwight A. Williams, David Stevens, Bethany G. David, Krista L. Scoggins

المصدر: ACS Chemical Neuroscience. 7:1120-1129

مصطلحات موضوعية: Male, Agonist, Physiology, Stereochemistry, medicine.drug_class, Cognitive Neuroscience, Guinea Pigs, Receptors, Opioid, mu, CHO Cells, In Vitro Techniques, Pharmacology, Ligands, Binding, Competitive, Biochemistry, κ-opioid receptor, Partial agonist, Article, Naltrexone, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, 0302 clinical medicine, Ileum, medicine, Animals, Muscle, Skeletal, Neurons, Chemistry, Receptors, Opioid, kappa, Antagonist, Muscle, Smooth, Visceral pain, Cell Biology, General Medicine, Disease Models, Animal, DAMGO, Guanosine 5'-O-(3-Thiotriphosphate), 030211 gastroenterology & hepatology, medicine.symptom, μ-opioid receptor, Gastrointestinal Motility, 030217 neurology & neurosurgery, Muscle Contraction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea749a4131413dd01af1bb255747ab1
https://doi.org/10.1021/acschemneuro.6b00075