المؤلفون: Kaufmann D; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., West PJ; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Smith MD; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA., Yagen B; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; David R. Bloom Center for Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Bialer M; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; David R. Bloom Center for Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Devor M; Department of Cell and Animal Biology, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., White HS; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA. Electronic address: hswhite@uw.edu., Brennan KC; Department of Neurology, University of Utah, Salt Lake City, UT, USA. Electronic address: K.C.Brennan@hsc.utah.edu.

المصدر: Pharmacological research [Pharmacol Res] 2017 Mar; Vol. 117, pp. 129-139. Date of Electronic Publication: 2016 Nov 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacology , Neuralgia/*drug therapy , Pain/*drug therapy , Valproic Acid/*analogs & derivatives , Valproic Acid/*pharmacology, Amines/pharmacology ; Analgesics/pharmacology ; Animals ; Cyclohexanecarboxylic Acids/pharmacology ; Disease Models, Animal ; Gabapentin ; Inflammation/complications ; Male ; Mice ; Pain/etiology ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/drug effects ; gamma-Aminobutyric Acid/pharmacology

المؤلفون: Kaufmann D; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, USA Department of Neurology, University of Utah, USA., Bates EA; Department of Pediatrics, University of Colorado Denver School of Medicine, USA., Yagen B; Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Israel David R. Bloom Center for Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Bialer M; Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Israel David R. Bloom Center for Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Saunders GH; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, USA., Wilcox K; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, USA., White HS; Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, USA., Brennan KC; Department of Neurology, University of Utah, USA K.C.Brennan@hsc.utah.edu.

المصدر: Cephalalgia : an international journal of headache [Cephalalgia] 2016 Sep; Vol. 36 (10), pp. 924-35. Date of Electronic Publication: 2015 Nov 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*therapeutic use , Anticonvulsants/*therapeutic use , Migraine Disorders/*physiopathology , Migraine Disorders/*prevention & control , Valproic Acid/*analogs & derivatives, Amides/pharmacology ; Animals ; Anticonvulsants/pharmacology ; Cell Line, Tumor ; Cells, Cultured ; Cerebral Cortex/cytology ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiology ; Cortical Spreading Depression/drug effects ; Cortical Spreading Depression/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Valproic Acid/pharmacology ; Valproic Acid/therapeutic use

المؤلفون: McComsey DF; Research & Development, Janssen Pharmaceutical Companies of Johnson & Johnson , Spring House, Pennsylvania 19477-0776, United States., Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, Maryanoff BE

المصدر: Journal of medicinal chemistry [J Med Chem] 2013 Nov 27; Vol. 56 (22), pp. 9019-30. Date of Electronic Publication: 2013 Nov 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*chemistry , Amides/*pharmacology , Anticonvulsants/*chemistry , Anticonvulsants/*pharmacology , Dioxanes/*chemistry , Dioxanes/*pharmacology , Sulfonamides/*chemistry , Sulfonamides/*pharmacology, Absorption ; Amides/pharmacokinetics ; Amides/therapeutic use ; Animals ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/therapeutic use ; Dioxanes/pharmacokinetics ; Dioxanes/therapeutic use ; Dogs ; Drug Evaluation, Preclinical ; Drug Resistance ; Epilepsy/drug therapy ; Female ; Humans ; Male ; Mice ; Rats ; Sulfonamides/pharmacokinetics ; Sulfonamides/therapeutic use

المؤلفون: Parker MH; Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania 19477-0776, USA., Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE

المصدر: Journal of medicinal chemistry [J Med Chem] 2009 Dec 10; Vol. 52 (23), pp. 7528-36.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*chemistry , Amides/*pharmacology , Anticonvulsants/*chemistry , Anticonvulsants/*pharmacology , Sulfonamides/*chemistry , Sulfonamides/*pharmacology , Thiophenes/*chemistry , Thiophenes/*pharmacology, Amides/metabolism ; Amides/pharmacokinetics ; Animals ; Anticonvulsants/metabolism ; Anticonvulsants/pharmacokinetics ; Carbonic Anhydrase II/antagonists & inhibitors ; Cell Line ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Female ; Humans ; Male ; Mice ; Rats ; Sulfonamides/metabolism ; Sulfonamides/pharmacokinetics ; Thiophenes/metabolism ; Thiophenes/pharmacokinetics

المؤلفون: Jones PJ; Department of Chemistry, University of Virginia, Charlottesville, VA 22908, USA., Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2007 Feb; Vol. 320 (2), pp. 828-36. Date of Electronic Publication: 2006 Nov 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacology , Anticonvulsants/*pharmacology , Hippocampus/*drug effects , Propofol/*analogs & derivatives , Sodium Channel Blockers/*pharmacology, Action Potentials/drug effects ; Animals ; Cells, Cultured ; Hippocampus/physiology ; Propofol/pharmacology ; Rats ; Structure-Activity Relationship

المؤلفون: Isoherranen N; Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel., Levy RH, Yagen B, Woodhead JH, White HS, Bialer M

المصدر: Epilepsy research [Epilepsy Res] 2004 Jan; Vol. 58 (1), pp. 1-12.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8703089 Publication Model: Print Cited Medium: Print ISSN: 0920-1211 (Print) Linking ISSN: 09201211 NLM ISO Abbreviation: Epilepsy Res Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*metabolism , Anticonvulsants/*metabolism , Cyclopropanes/*metabolism , Valproic Acid/*analogs & derivatives, Amides/chemistry ; Amides/therapeutic use ; Animals ; Anticonvulsants/chemistry ; Anticonvulsants/therapeutic use ; Aryl Hydrocarbon Hydroxylases ; Behavior, Animal/drug effects ; Biotransformation ; Brain/drug effects ; Brain Chemistry/physiology ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid/methods ; Cyclopropanes/chemistry ; Cyclopropanes/therapeutic use ; Cytochrome P-450 CYP2A6 ; Cytochrome P-450 CYP2C19 ; Dose-Response Relationship, Drug ; Electroshock/adverse effects ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; Hydroxylation/drug effects ; In Vitro Techniques ; Male ; Mice ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Mixed Function Oxygenases ; Pentylenetetrazole ; Seizures/chemically induced ; Seizures/drug therapy ; Valproic Acid/therapeutic use

المؤلفون: Isoherranen N; Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel., White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M

المصدر: Pharmaceutical research [Pharm Res] 2003 Aug; Vol. 20 (8), pp. 1293-301.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print Cited Medium: Print ISSN: 0724-8741 (Print) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacokinetics , Amides/*pharmacology , Anticonvulsants/*pharmacokinetics , Anticonvulsants/*pharmacology , Epilepsy/*drug therapy, Amides/chemistry ; Animals ; Anticonvulsants/chemistry ; Area Under Curve ; Brain/metabolism ; Epilepsy/metabolism ; Half-Life ; Injections, Intraperitoneal ; Kindling, Neurologic ; Male ; Mice ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism ; Structure-Activity Relationship ; Time Factors

المؤلفون: Isoherranen N; Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., White HS, Finnell RH, Yagen B, Woodhead JH, Bennett GD, Wilcox KS, Barton ME, Bialer M

المصدر: Epilepsia [Epilepsia] 2002 Feb; Vol. 43 (2), pp. 115-26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print Cited Medium: Print ISSN: 0013-9580 (Print) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

مواضيع طبية MeSH: Mutagenicity Tests*, Amides/*therapeutic use , Anticonvulsants/*therapeutic use , Cyclopropanes/*therapeutic use , Epilepsy/*drug therapy, Acoustic Stimulation ; Administration, Oral ; Amides/administration & dosage ; Amides/adverse effects ; Animals ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Behavior, Animal/drug effects ; Bicuculline ; Convulsants ; Cyclopropanes/administration & dosage ; Cyclopropanes/adverse effects ; Electrophysiology ; Electroshock ; Epilepsy/psychology ; Injections, Intraperitoneal ; Mice ; Mice, Inbred Strains ; Neural Tube Defects/chemically induced ; Pentylenetetrazole ; Rats ; Rats, Sprague-Dawley ; Seizures/chemically induced ; Seizures/etiology ; Seizures/prevention & control