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المؤلفون: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers
المساهمون: Mécanismes de tumorigenèse et thérapies ciblées, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), Universitat Pompeu Fabra [Barcelona] (UPF), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Pôle de Biologie Pathologie Génétique [CHU Lille], This work was in part supported by the Centre national de la recherche scientifique (CNRS), Ligue nationale contre le Cancer (Comité du Pas-de-Calais), Institut national du cancer (INCa_4419), Institut Pasteur de Lille, Conseil Régional du Nord-Pas-de-Calais and Fondation pour la Recherche Médicale (FRM), Conseil Régional du Nord-Pas-de-Calais, Association pour la Recherche sur le Cancer (ARC), MINECO (Juan de la Cierva Postdoctoral Fellowship FJCI-2014-22946), ARTP (Association de Recherche sur les tumeurs de prostate)., Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161 (M3T), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Center for Genomic Regulation (CRG-UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Service d'urologie, Hôpital Huriez-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), We would like to thank M. Tardivel, A. Bongiovanni and E. Werkmeister from the BioImaging Center Lille Nord de France (BICeL) for their technical assistance, M. Canouil for his statistics advice, and M. Vernier for his bioinformatic advice and stimulating discussions. We would also like to thank the local Tumor Tissue Bank (Tumorothèque), Regional Reference Oncology Center (CRRC) (Head, Pr. M.C. Copin) in Lille, France.
المصدر: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Oncogene Proteins, Fusion, [SDV]Life Sciences [q-bio], MESH: Gene Expression Regulation, Neoplastic, Mice, SCID, urologic and male genital diseases, Fusion gene, MESH: Oncogene Proteins, Fusion/metabolism, Metastasis, Prostate cancer, 0302 clinical medicine, MESH: Animals, MESH: Mice, SCID, MESH: Osteoblasts/pathology, ComputingMilieux_MISCELLANEOUS, MESH: Prostatic Neoplasms/genetics, Endothelin-1, Bone metastasis, MESH: Prostatic Neoplasms/pathology, Tumor Burden, 3. Good health, Gene Expression Regulation, Neoplastic, Phenotype, Osteoblastic lesions, Oncology, 030220 oncology & carcinogenesis, PC-3 Cells, MESH: Bone Neoplasms/metabolism, MESH: Bone Neoplasms/secondary, MESH: PC-3 Cells, MESH: Endothelin-1/metabolism, Erg, MESH: Alkaline Phosphatase/metabolism, MESH: Cell Line, Tumor, Transplantation, Heterologous, MESH: Biomarkers, Tumor/genetics, MESH: Tumor Burden/genetics, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, MESH: Phenotype, TMPRSS2, MESH: Oncogene Proteins, Fusion/genetics, 03 medical and health sciences, Transcriptional regulation, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, MESH: Transplantation, Heterologous, MESH: Biomarkers, Tumor/metabolism, Osteoblasts, MESH: Alkaline Phosphatase/genetics, MESH: Humans, MESH: Prostatic Neoplasms/metabolism, Prostatic Neoplasms, Gene rearrangement, Alkaline Phosphatase, MESH: Bone Neoplasms/genetics, MESH: Osteoblasts/metabolism, medicine.disease, MESH: Male, Collagen Type I, alpha 1 Chain, TMPRSS2:ERG, 030104 developmental biology, MESH: Endothelin-1/genetics, Cancer research, Ectopic expression
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المؤلفون: Jane E. Aubin, Geoffrey Vargas, Edith Bonnelye, Sophie Vacher, Marie Brevet, Pascal Reboul, M Filipits, Ivan Bièche, C Boyault, W Jacot, Lamia Bouazza, Sandra Geraci, Keltouma Driouch, Francesco Pantano, Michael Gnant, Catherine Alix-Panabières, M Gervais, Laure Cayrefourcq, Philippe Clézardin, M Bouchet, M Mazel, Martine Croset, Claire Benetollo, C Kan, Martine Duterque-Coquillaud
المساهمون: Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases [LYOS], Institut de Génomique Fonctionnelle de Lyon [IGFL], Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB], The University of Sydney, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL], Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 [AIDMP], Institut Curie [Paris], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM], Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Institut de biologie de Lille - IBL [IBLI], Mécanismes de tumorigenèse et thérapies ciblées, Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut Curie, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biochemistry [University of Toronto], University of Toronto, Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, This work was supported by the National Center for Scientific Research (CNRS) to EB, the National Institute of Health and Medical Research (INSERM), the University of Lyon1, La Ligue Nationale (Drôme), Inserm-Transfert (EB). GV was supported by the Labex DEVweCAN, MG, MB by the French National Cancer Institute (INCa), CK by the Marie-Curie-Individual-Fellowship (655777-miR-OMeS). CAP, LC, and MM by CANCER-ID (FP7/2007-2013) and EFPIA., The authors thank Anne Flourens, Cyprien Tilmant, Tina Louadj, and both CeCIL and ALECS platforms (Faculté de Médecine Laennec, Lyon) for their assistance., Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biochimie Générale et Médicale, INSERM-CNRS U.189 Faculté de Médecine Lyon-Sud, Centre de Recherche en Géomatique [Laval] (CRG), Université Laval, Swiss Federal Office for the Environment FOEN, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de Génétique [Institut Curie, Paris] (Unité de Pharmacogénomique), Department of Surgery, Breast Health Center, Medical University Vienna, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de biologie et chimie des protéines [Lyon] (IBCP), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
المصدر: Oncogene
Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3 ⟩
Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩
Oncogene, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Breast Neoplasms/pathology, Bone Neoplasms/secondary, [SDV]Life Sciences [q-bio], MESH: Gene Expression Regulation, Neoplastic, Transcriptome, Mammary Neoplasms, Animal/genetics, Mice, 0302 clinical medicine, Circulating tumor cell, Neoplasm Proteins/genetics, MESH: Breast Neoplasms/genetics, MESH: Animals, MESH: Breast Neoplasms/metabolism, ComputingMilieux_MISCELLANEOUS, MESH: Breast Neoplasms/pathology, Mice, Inbred BALB C, Receptor Activator of Nuclear Factor-kappa B, Receptors, Estrogen/genetics, MESH: Receptor Activator of Nuclear Factor-kappa B/genetics, Metastatic breast cancer, Primary tumor, Neoplasm Proteins, 3. Good health, Gene Expression Regulation, Neoplastic, Receptors, Estrogen, RANKL, 030220 oncology & carcinogenesis, MESH: Bone Neoplasms/metabolism, Female, MESH: Bone Neoplasms/secondary, Breast Neoplasms/metabolism, MESH: Bone Neoplasms/genetics, Receptor Activator of Nuclear Factor-kappa B/biosynthesis, MESH: Mice, Inbred BALB C, Bone Neoplasms, Breast Neoplasms, Mammary Neoplasms, Animal, [SDV.CAN]Life Sciences [q-bio]/Cancer, Mammary Neoplasms, Animal/metabolism, Neoplasm Proteins/metabolism, Biology, Breast Neoplasms/genetics, 03 medical and health sciences, Breast cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Genetics, medicine, Animals, Humans, MESH: Neoplasm Proteins/genetics, MESH: Receptors, Estrogen/metabolism, MESH: Neoplasm Proteins/metabolism, MESH: Mammary Neoplasms, Animal/pathology, Mammary Neoplasms, Animal/pathology, Molecular Biology, MESH: Mice, PI3K/AKT/mTOR pathway, Receptor Activator of Nuclear Factor-kappa B/genetics, MESH: Humans, MESH: Receptors, Estrogen/genetics, Bone Neoplasms/genetics, medicine.disease, Receptors, Estrogen/metabolism, MESH: Mammary Neoplasms, Animal/genetics, 030104 developmental biology, Cancer cell, Bone Neoplasms/metabolism, Cancer research, biology.protein, MESH: Receptor Activator of Nuclear Factor-kappa B/biosynthesis, MESH: Female, Bone Neoplasms/pathology, MESH: Mammary Neoplasms, Animal/metabolism, MESH: Bone Neoplasms/pathology
وصف الملف: application/octet-stream; application/pdf
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المؤلفون: Roberta Mazzone, Piero Picci, Katia Scotlandi, Michela Pasello, Patrizia Nanni, Giordano Nicoletti, Maria Cristina Manara, Antonello Mai, Clara Guerzoni, Camilla Cristalli, Pier Luigi Lollini, Lorena Landuzzi, Sergio Valente, Giulia Stazi, Paola B. Arimondo, Clemens Zwergel
المساهمون: Istituto Ortopedico Rizzoli [Bologna, Italy], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de la Recherche Scientifique (CNRS), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], This work was funded by AIRC (IG 18451 to K. Scotlandi, IG 19162 to A. Mai), the Italian Ministry of Health (TRANSCAN_ project TORPEDO_ER-2015-23604059 to K. Scotlandi), Progetto Ateneo Sapienza (to A. Mai), PRIN 2016 (prot 20152TE5PK to A. Mai), and the NIH (R01GM114306 to A. Mai)., The authors thank Cristina Ghinelli for editing the manuscript., Manara, Maria Cristina, Valente, Sergio, Cristalli, Camilla, Nicoletti, Giordano, Landuzzi, Lorena, Zwergel, Clemen, Mazzone, Roberta, Stazi, Giulia, Arimondo, Paola B, Pasello, Michela, Guerzoni, Clara, Picci, Piero, Nanni, Patrizia, Lollini, Pier-Luigi, Mai, Antonello, Scotlandi, Katia
المصدر: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩مصطلحات موضوعية: 0301 basic medicine, Male, patient-derived xenograft (PDX), MESH: Osteosarcoma/genetics, MESH: Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cellular differentiation, DNA Methyltransferase Inhibitor, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, chemotherapy, MESH: Mice, Knockout, 0302 clinical medicine, MESH: Osteosarcoma/drug therapy, Antineoplastic Combined Chemotherapy Protocols, MESH: Aminoquinolines/administration & dosage, MESH: Animals, MESH: Quinolines/chemistry, Enzyme Inhibitors, MESH: DNA (Cytosine-5-)-Methyltransferase 1/metabolism, Mice, Knockout, DNA methylation, Chemistry, 3. Good health, Tumor Burden, MESH: Benzamides/pharmacology, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Benzamides, oncology, Aminoquinolines, Quinolines, MESH: Cisplatin/administration & dosage, MESH: Bone Neoplasms/metabolism, Osteosarcoma, MESH: Doxorubicin/administration & dosage, epigenetic, MESH: Bone Neoplasms/genetics, medicine.drug, DNA (Cytosine-5-)-Methyltransferase 1, musculoskeletal diseases, MESH: Aminoquinolines/pharmacology, MESH: Cell Line, Tumor, DNA damage, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Tumor Burden/genetics, MESH: Xenograft Model Antitumor Assays, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Cell Line, Tumor, osteosarcoma, medicine, Animals, Humans, Doxorubicin, MESH: DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, MESH: Enzyme Inhibitors/chemistry, Cisplatin, MESH: Humans, Nucleoside inhibitor, medicine.disease, MESH: Enzyme Inhibitors/pharmacology, Xenograft Model Antitumor Assays, MESH: Male, MESH: Enzyme Inhibitors/administration & dosage, MESH: Bone Neoplasms/drug therapy, 030104 developmental biology, MESH: Osteosarcoma/metabolism, Cancer research, cancer research, MESH: DNA (Cytosine-5-)-Methyltransferase 1/genetics, MESH: Benzamides/administration & dosage, MESH: Tumor Burden/drug effects
وصف الملف: STAMPA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d5482d55dc2ed43ad6818ec4cbf60
https://hal.archives-ouvertes.fr/hal-02383680 -
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المؤلفون: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu
المساهمون: Dev, Harveer [0000-0003-2874-6894], Yang, Fengtang [0000-0002-3573-2354], Balmus, Gabriel [0000-0003-2872-4468], Serra, Violeta [0000-0001-6620-1065], Beli, Petra [0000-0001-9507-9820], Pellegrini, Luca [0000-0002-9300-497X], Deriano, Ludovic [0000-0002-9673-9525], Jacobs, Jacqueline JL [0000-0002-7704-4795], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge [UK] (CAM), Department of Biochemistry [Cambridge], Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), Institute of Molecular Biology (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute [Hinxton, UK], AstraZeneca US [Waltham, USA], AstraZeneca [Cambridge, UK], The Wellcome Trust Sanger Institute [Cambridge], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance, Institut Pasteur [Paris], Johannes Gutenberg - Universität Mainz (JGU)
المصدر: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, RAD51, Cell Cycle Proteins, Poly (ADP-Ribose) Polymerase Inhibitor, MESH: Recombinational DNA Repair, Mice, MESH: Animals, DNA Breaks, Double-Stranded, skin and connective tissue diseases, Cancer, Telomere-binding protein, Ovarian Neoplasms, MESH: Breast Neoplasms / metabolism, MESH: Telomere-Binding Proteins / metabolism, 3. Good health, Cell biology, MESH: HEK293 Cells, MESH: Proteins / genetics, MESH: Telomere-Binding Proteins / genetics, MESH: Tumor Suppressor p53-Binding Protein 1 / metabolism, MESH: Xenograft Model Antitumor Assays, Telomere-Binding Proteins, MESH: Ovarian Neoplasms / drug therapy, Bone Neoplasms, MESH: Ovarian Neoplasms / metabolism, Article, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Bone Neoplasms / metabolism, Humans, MESH: Osteosarcoma / metabolism, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Tumor Suppressor p53-Binding Protein 1 / genetics, Dose-Response Relationship, Drug, HEK 293 cells, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, MESH: BRCA1 Protein / deficiency, 030104 developmental biology, Multiprotein Complexes, MESH: Mad2 Proteins / metabolism, MESH: Breast Neoplasms / genetics, MESH: Bone Neoplasms / drug therapy, Cisplatin, Homologous recombination, MESH: Osteosarcoma / genetics, MESH: Female, 0301 basic medicine, DNA End-Joining Repair, MESH: Proteins / metabolism, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Osteosarcoma / pathology, MESH: Breast Neoplasms / pathology, Homologous Recombination, Polymerase, MESH: Breast Neoplasms / drug therapy, Osteosarcoma, biology, Chemistry, BRCA1 Protein, DNA damage and repair, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Bone Neoplasms / genetics, DNA-Binding Proteins, MESH: Bone Neoplasms / pathology, Mad2 Proteins, Female, MESH: Ovarian Neoplasms / genetics, Tumor Suppressor p53-Binding Protein 1, MESH: Cisplatin / pharmacology, MESH: Cell Line, Tumor, Lymphocytes, Null, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: BRCA1 Protein / genetics, Poly(ADP-ribose) Polymerase Inhibitors, Cell Line, Tumor, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Mad2 Proteins / genetics, MESH: Ovarian Neoplasms / pathology, Animals, MESH: Mice, MESH: Osteosarcoma / drug therapy, Oligonucleotide, Protective Devices, Recombinational DNA Repair, Cell Biology, MESH: Multiprotein Complexes, Xenograft Model Antitumor Assays, HEK293 Cells, Drug Resistance, Neoplasm, biology.protein, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins
وصف الملف: application/pdf
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المؤلفون: Anne Flourens, Carine Delliaux, Yvan de Launoit, Xavier Leroy, Rachel Deplus, Martine Duterque-Coquillaud, Nathalie Marchand, Nathalie Vanpouille
المساهمون: Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This work was supported by grants from the Centre national de la recherche scientifique (CNRS), La Ligue contre le Cancer (Comité du Pas-de-Calais) and the Institut national du cancer (INCa_4419). CD is a recipient of Ph.D. fellowships from the Institut Pasteur of Lille/Nord-Pas-de-Calais Regional Council (Région Nord-Pas-de Calais) and the FRM (Fondation pour la Recheche Médicale)., We thank Tian V. Tian, Edith Bonnelye and Olivier Morales for help and advices in mouse experiments. We thank the Microscopy-Imaging-Cytometry Facility of the BioImaging Center Lille Nord-de-France for access to instruments and technical advice. We thank also Francois Fuks for his helpful advices in manuscript redaction., de Launoit, Yvan
المصدر: Oncotarget
Oncotarget, Impact journals, 2017, 8 (7), pp.11827-11840. ⟨10.18632/oncotarget.14399⟩
Oncotarget, 2017, 8 (7), pp.11827-11840. ⟨10.18632/oncotarget.14399⟩
Oncotarget, 8 (7مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, Oncogene Proteins, Fusion, TMPRSS2-ERG, MESH: Cell Movement/physiology, [SDV]Life Sciences [q-bio], Mice, SCID, urologic and male genital diseases, Metastasis, Transcriptome, Cell Proliferation -- physiology, Prostate cancer, Cell Movement -- physiology, Mice, 0302 clinical medicine, Cell Movement, MESH: Animals, MESH: Oncogene Proteins, Fusion/genetics, Neoplasm Metastasis, MESH: Mice, SCID, bone metastasis, Prostatic Neoplasms -- genetics -- metabolism -- pathology, Bone metastasis, Cell migration, Sciences bio-médicales et agricoles, MESH: Prostatic Neoplasms/pathology, prostate cancer, bone tropism, [SDV] Life Sciences [q-bio], Oncogene Proteins, Fusion -- biosynthesis -- genetics, Oncology, 030220 oncology & carcinogenesis, MESH: Bone Neoplasms/metabolism, Heterografts, MESH: Bone Neoplasms/secondary, MESH: Bone Neoplasms/genetics, Research Paper, medicine.medical_specialty, MESH: Cell Line, Tumor, Bone Neoplasms, Transfection, TMPRSS2, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, MESH: Mice, Tropism, Cell Proliferation, MESH: Prostatic Neoplasms/genetics, Bone Neoplasms -- genetics -- metabolism -- secondary, MESH: Humans, MESH: Oncogene Proteins, Fusion/biosynthesis, business.industry, MESH: Transfection, MESH: Prostatic Neoplasms/metabolism, Prostatic Neoplasms, MESH: Cell Proliferation/physiology, medicine.disease, MESH: Neoplasm Metastasis, MESH: Male, 030104 developmental biology, Cancer cell, MESH: Heterografts, business
وصف الملف: application/pdf; 1 full-text file(s): application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6842a4a21bd05145fce04e57a3617d
https://hal.archives-ouvertes.fr/hal-02391621/file/TMPRSS2-ERG_fusion_promotes_prostate.pdf -
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المؤلفون: Ivan Stamenkovic, Miguel Rivera, Angela Volorio, Sowmya Iyer, Liliane C. Broye, Nicolo Riggi, Gaylor Boulay
المصدر: Genes & development, vol. 32, no. 15-16, pp. 1008-1019
مصطلحات موضوعية: 0301 basic medicine, Animals, Bone Neoplasms/genetics, Bone Neoplasms/metabolism, Bone Neoplasms/pathology, Cells, Cultured, Chromatin/metabolism, Enhancer Elements, Genetic, Gene Expression Regulation, Neoplastic, Gene Silencing, Homeodomain Proteins/biosynthesis, Homeodomain Proteins/genetics, Humans, Mesenchymal Stromal Cells/metabolism, Mice, Microsatellite Repeats, Oncogene Proteins, Fusion/metabolism, Proto-Oncogene Protein c-fli-1/metabolism, RNA, Untranslated/biosynthesis, RNA-Binding Protein EWS/metabolism, Sarcoma, Ewing/genetics, Sarcoma, Ewing/metabolism, Sarcoma, Ewing/pathology, Transcription Factors/biosynthesis, Transcription Factors/genetics, Transcription, Genetic, Tumor Cells, Cultured, EWS-FLI1, Ewing sarcoma, enhancer therapy, epigenetics, epigenome editing, pediatric cancer, RNA, Untranslated, Oncogene Proteins, Fusion, Bone Neoplasms, Computational biology, Sarcoma, Ewing, Biology, 03 medical and health sciences, Gene expression, Genetics, Epigenome editing, Gene silencing, Enhancer, Gene, Regulation of gene expression, Homeodomain Proteins, Proto-Oncogene Protein c-fli-1, Mesenchymal Stem Cells, Epigenome, Zebrafish Proteins, Chromatin, 030104 developmental biology, Homeobox Protein Nkx-2.2, RNA-Binding Protein EWS, Outlook, Developmental Biology, Transcription Factors
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5970a5a72d1ba8518ad231ed454cdb0
https://pubmed.ncbi.nlm.nih.gov/30068701 -
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المؤلفون: Michele Iuliani, Bruno Vincenzi, Alice Zoccoli, Martine Croset, Giuseppe Tonini, Daniele Santini, Marco Fioramonti, Francesco Pantano
المصدر: Molecules
Molecules, Vol 19, Iss 7, Pp 10115-10128 (2014)
Molecules, 19 (7مصطلحات موضوعية: epithelial-mesenchymal transition, Pharmaceutical Science, Bone Neoplasms, Review, Biology, Analytical Chemistry, lcsh:QD241-441, RNA, Neoplasm -- genetics -- metabolism, lcsh:Organic chemistry, bone metastases, Drug Discovery, microRNA, Bone cell, medicine, Tumor Microenvironment, Animals, Humans, RNA, Neoplasm, Physical and Theoretical Chemistry, Neoplasm Metastasis, Bone Neoplasms -- genetics -- metabolism -- pathology -- secondary, Tumor microenvironment, osteomimicry, Organic Chemistry, Intravasation, Bone metastasis, Sciences bio-médicales et agricoles, medicine.disease, MicroRNAs, medicine.anatomical_structure, MicroRNAs -- genetics -- metabolism, Chemistry (miscellaneous), Immunology, Cancer cell, Cancer research, Molecular Medicine, Bone marrow, Homing (hematopoietic)
وصف الملف: 1 full-text file(s): application/pdf
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المؤلفون: Claire Benetollo, Edith Bonnelye, Vincenzo Castronovo, Jennifer Rieusset, Thomas J. Rosol, Mathilde Bouchet, Anais Fradet, Akeila Bellahcene, Lamia Bouazza, Carine Delliaux, Philippe Clézardin, Martine Duterque-Coquillaud, Martine Croset, Casina Kan, Francesco Pantano, Xavier Leroy, Manon Gervais, Jane E. Aubin, Geoffrey Vargas, Yohann Bala
المساهمون: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), College of Veterinary Medicine [Colombus], Ohio State University [Columbus] (OSU), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Liège, University of Toronto, This work was supported by the Association pour la recherche sur les tumeurs de la prostate (ARTP), the National Center for Scientific Research (CNRS) to EB and by the National Institute of Health and Medical Research (INSERM) and the University of Lyon1. AF was supported by the Ligue nationale contre le cancer and the Fondation pour la recherche médicale (FRM), MB, MG by the French National Cancer Institute (INCa), CD by the Institut Pasteur/Région Nord-Pas-de-Calais, GV by the Labex DEVweCAN and AB from the Belgian National Fund for Scientific Research. CK is a recipient of the H2020 Marie Sklodowska-Curie Individual Fellowship under agreement number (655777-miROMeS)., We are grateful to the Animalerie Lyon Est Conventionnelle (ALECS) and to D. Sahay for discussion., Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Oncotarget
Oncotarget, Impact journals, 2016, 7 (47), pp.77071-77086. ⟨10.18632/oncotarget.12787⟩
Oncotarget, 2016, 7 (47), pp.77071-77086. ⟨10.18632/oncotarget.12787⟩مصطلحات موضوعية: 0301 basic medicine, MESH: Signal Transduction, MESH: Wnt-5a Protein/metabolism, Male, Vascular Endothelial Growth Factor A, Pathology, MESH: Cell Adhesion Molecules/metabolism, [SDV]Life Sciences [q-bio], Cell, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, bone, Prostate cancer, Estrogen-related receptor alpha, Mice, 0302 clinical medicine, MESH: Prostatic Neoplasms, Castration-Resistant/genetics, MESH: Tumor Microenvironment, Tumor Microenvironment, Medicine, MESH: Animals, MESH: Transforming Growth Factor beta1/metabolism, MESH: Gene Expression Regulation, Neoplastic, prostate cancer, 3. Good health, Gene Expression Regulation, Neoplastic, Prostatic Neoplasms, Castration-Resistant, medicine.anatomical_structure, Oncology, Receptors, Estrogen, 030220 oncology & carcinogenesis, MESH: Bone Neoplasms/metabolism, Disease Progression, MESH: Disease Progression, MESH: Bone Neoplasms/genetics, Research Paper, Signal Transduction, medicine.medical_specialty, Stromal cell, MESH: Cell Line, Tumor, medicine.drug_class, MESH: Vascular Endothelial Growth Factor A/metabolism, [SDV.CAN]Life Sciences [q-bio]/Cancer, Bone Neoplasms, Periostin, Wnt-5a Protein, Transforming Growth Factor beta1, 03 medical and health sciences, Stroma, MESH: Prostatic Neoplasms, Castration-Resistant/metabolism, Cell Line, Tumor, Animals, Humans, MESH: Receptors, Estrogen/metabolism, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Mice, MESH: Humans, MESH: Receptors, Estrogen/genetics, business.industry, ERRα, MESH: Bone Neoplasms/secondary, medicine.disease, microenvironment, MESH: Male, 030104 developmental biology, Tumor progression, Estrogen, Cancer research, business, Cell Adhesion Molecules, MESH: Neoplasm Transplantation, Neoplasm Transplantation
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c51bc67b6222c2f5b71c8a281298a9
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المؤلفون: Aleksandar Boro, Bruno Fuchs, Ram Mohan Ram Kumar
المساهمون: University of Zurich, Ram Kumar, Ram Mohan
المصدر: International Journal of Molecular Sciences, Vol 17, Iss 6, p 877 (2016)
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 17, no. 6, pp. E877مصطلحات موضوعية: 0301 basic medicine, 1607 Spectroscopy, Review, medicine.disease_cause, Bioinformatics, Metastasis, lcsh:Chemistry, 0302 clinical medicine, RNA interference, Genotype, Animals, Biomarkers, Bone Neoplasms/diagnosis, Bone Neoplasms/genetics, Bone Neoplasms/therapy, Cell Transformation, Neoplastic/genetics, Gene Expression Regulation, Neoplastic, Genetic Therapy, Humans, MicroRNAs/blood, MicroRNAs/genetics, MicroRNAs/therapeutic use, Osteosarcoma/diagnosis, Osteosarcoma/genetics, Osteosarcoma/therapy, RNA Interference, RNA, Messenger/genetics, 10266 Clinic for Reconstructive Surgery, lcsh:QH301-705.5, Spectroscopy, microRNA, General Medicine, Computer Science Applications, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Osteosarcoma, biomarker, 1606 Physical and Theoretical Chemistry, 1503 Catalysis, 610 Medicine & health, Bone Neoplasms, Biology, Catalysis, Inorganic Chemistry, 03 medical and health sciences, osteosarcoma, medicine, 1312 Molecular Biology, 1706 Computer Science Applications, metastasis, cancer, RNA, Messenger, Physical and Theoretical Chemistry, Molecular Biology, Gene, 1604 Inorganic Chemistry, Organic Chemistry, Cancer, medicine.disease, MicroRNAs, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Carcinogenesis, 1605 Organic Chemistry
وصف الملف: ijms-17-00877.pdf - application/pdf; application/pdf
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المؤلفون: Nicolo Riggi, Anoop P. Patel, Martin J. Aryee, Vishal Thapar, Gaylor Boulay, Aurélie Formey, G. Petur Nielsen, Ivan Stamenkovic, Shawn M. Gillespie, Edward B. Cook, Nikki E. Rossetti, Melissa Gymrek, Mario L. Suvà, Birgit Knoechel, David T. Ting, Francis J. Hornicek, Bradley E. Bernstein, Esther Rheinbay, Vikram Deshpande, Wannaporn E. Boonseng, Ozgur Oksuz, Miguel Rivera
المصدر: Cancer cell, vol. 26, no. 5, pp. 668-681
مصطلحات موضوعية: Cancer Research, Oncogene Proteins, Fusion, Enhancer RNAs, Bone Neoplasms, Mice, SCID, Sarcoma, Ewing, Biology, Chromatin remodeling, Article, Conserved sequence, Mice, Inbred NOD, Cell Line, Tumor, Animals, Humans, Enhancer, Transcription factor, Base Sequence, Bone Neoplasms/genetics, Bone Neoplasms/metabolism, Chromatin Assembly and Disassembly, Enhancer Elements, Genetic, Gene Expression Regulation, Neoplastic, Neoplasm Transplantation, Oncogene Proteins, Fusion/physiology, Protein Binding, Proto-Oncogene Protein c-fli-1/physiology, RNA-Binding Protein EWS/physiology, Sarcoma, Ewing/genetics, Sarcoma, Ewing/metabolism, Regulation of gene expression, Proto-Oncogene Protein c-fli-1, fungi, Promoter, Cell Biology, Chromatin, Oncology, Cancer research, RNA-Binding Protein EWS
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27644e8c251df925d6e8729c03419ab
https://europepmc.org/articles/PMC4492343/
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