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1
المؤلفون: Kelly Bleasby, Dwight Macdonald, Bruce Mackay, Richard Tschirret-Guth, Robert Houle, Sebastien Laliberte, Patrick Lacombe, Robert Papp, Erich L. Grimm, Amandine Chefson, Jean-François Lévesque, Michael J. Hafey, Pierre-André Fournier, Sébastien Gagné, Yongxin Han, Yves Ducharme, Michel Gallant, Austin Chen, Daniel Dube
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5547-5551
مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Cell Membrane Permeability, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, ATP-binding cassette transporter, Absorption (skin), Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Piperidines, Renin, Drug Discovery, Renin–angiotensin system, Animals, Structure–activity relationship, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Biological Transport, Stereoisomerism, Transporter, Rats, Bioavailability, Permeability (electromagnetism), Molecular Medicine, Efflux
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2
المؤلفون: Stephen M. Soisson, Tom Y.-H. Wu, Michel Gallant, Austin Chen, Dwight Macdonald, Daniel Dube, Robert Houle, Jean-Pierre Falgueyret, Renee Aspiotis, Dan McKay, Jean-François Lévesque, Patrick Roy, Helene Juteau, Sébastien Gagné, M. David Percival, Erich L. Grimm, Sebastien Laliberte, Patrick Lacombe, Elizabeth Cauchon
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2430-2436
مصطلحات موضوعية: Stereochemistry, Carboxylic acid, Clinical Biochemistry, hERG, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Catalytic Domain, Renin, Drug Discovery, Animals, Humans, Structure–activity relationship, Computer Simulation, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Prodrug, Rats, Enzyme, chemistry, Enzyme inhibitor, Zwitterion, biology.protein, Molecular Medicine
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3
المؤلفون: Renee Aspiotis, Amadine Chefson, Jean-François Lévesque, Yongxin Han, Louis-Charles Campeau, Dan McKay, Guillaume Larouche, Jean-Pierre Falgueyret, Robert Houle, Elizabeth Cauchon, David Percival, Austin Chen, Sébastien Gagné, Yves Ducharme, Sebastien Laliberte
المصدر: Bioorganicmedicinal chemistry letters. 21(24)
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Biochemistry, Renin inhibitor, Structure-Activity Relationship, Dogs, Piperidines, Catalytic Domain, Drug Discovery, Renin–angiotensin system, Renin, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Computer Simulation, Protease Inhibitors, Spiro Compounds, Molecular Biology, Antihypertensive Agents, Binding Sites, biology, CYP3A4, Chemistry, Organic Chemistry, Macaca mulatta, Rats, Drug Design, Hypertension, biology.protein, Molecular Medicine, Cytochrome P-450 CYP3A Inhibitors
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4
المؤلفون: Paul Krolikowski, Kevin P. Bateman, Cheri M Maciolek, Sebastien Laliberte, Bennett Ma, Karsten Menzel, Christopher R. Gibson
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 39(5)
مصطلحات موضوعية: Male, Cytochrome, Stereochemistry, Metabolite, Pharmaceutical Science, Oxidative phosphorylation, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Coumarins, Animals, Lipoxygenase Inhibitors, Pharmacology, chemistry.chemical_classification, Oxadiazoles, Trifluoromethyl, Arachidonate 5-Lipoxygenase, biology, CYP1A2, Cytochrome P450, Atherosclerosis, Asthma, Rats, Enzyme, chemistry, Biochemistry, biology.protein, Microsome, Microsomes, Liver
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cd61695a744d622d67d650ef50e2d3
https://pubmed.ncbi.nlm.nih.gov/21325431 -
5
المؤلفون: Christopher P. Regan, Elizabeth Cauchon, Bruce Mackay, Yves Ducharme, Sylvie Toulmond, Sebastien Laliberte, Patrick Lacombe, Sébastien Gagné, M. David Percival, Daniel Dube, Jean-Pierre Falgueyret, JingQi Huang, Jean-François Lévesque, Dan McKay, Yongxin Han, René St-Jacques, Louis-Charles Campeau, Austin Chen, Hillary K. Regan, Pierre-André Fournier, Amandine Chefson, Erich L. Grimm, Robert Houle, Dwight Macdonald, Susana Liu
المصدر: Bioorganicmedicinal chemistry letters. 21(13)
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Renin inhibitor, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Piperidines, In vivo, Drug Discovery, Renin–angiotensin system, Renin, medicine, Structure–activity relationship, Animals, Enzyme Inhibitors, Molecular Biology, biology, Molecular Structure, Organic Chemistry, Rats, chemistry, Enzyme inhibitor, Drug Design, Lipophilicity, Hypertension, Lactam, biology.protein, Molecular Medicine
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6
المؤلفون: Laurence Dube, Richard Friesen, Karen Townson, Daniel Dube, Jean-François Lévesque, Susana Liu, Michel Gallant, Dwight Macdonald, Donald W. Nicholson, Zheng Huang, Renee Aspiotis, Rebecca Dias, Sebastien Laliberte, Patrick Lacombe, Pierre Hamel, Daniel Guay, Kerry A. Waters, Mario Girard, Joseph A. Mancini, Stephen Day, Robert N. Young, Angela Styhler, Yves Girard
المصدر: Bioorganicmedicinal chemistry letters. 20(22)
مصطلحات موضوعية: Cyclopropanes, Male, Memory, Long-Term, Phosphodiesterase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Heterocyclic Compounds, 2-Ring, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, Structure–activity relationship, Animals, Humans, PDE4 Inhibitors, Adverse effect, Cognitive impairment, Molecular Biology, Whole blood, Chemistry, Organic Chemistry, Phosphodiesterase, Long-term memory loss, Macaca mulatta, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, Molecular Medicine, Female, Cognition Disorders