المؤلفون: Palmer MJ; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Deng X; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., Watts S; Schrodinger, Inc., 120 West 45th St, 17th Floor, New York, New York 100036-4041, United States., Krilov G; Schrodinger, Inc., 120 West 45th St, 17th Floor, New York, New York 100036-4041, United States., Gerasyuto A; Schrodinger, Inc., 120 West 45th St, 17th Floor, New York, New York 100036-4041, United States., Kokkonda S; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., El Mazouni F; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., White J; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Striepen J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States., Bath J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States., Schindler KA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States., Deni I; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States., Lawong A; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., Huang A; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Wang W; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Jayaseelan J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Katneni K; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Patil R; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Saunders J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Shahi SP; Syngene International Ltd, Bangalore 560099, India., Chittimalla R; Syngene International Ltd, Bangalore 560099, India., Angulo-Barturen I; TAD, Biscay Science and Technology Park, Astondo Bidea, BIC Bizkaia Bd 612, Derio, 48160 Bizkaia, Basque Country, Spain., Jiménez-Díaz MB; TAD, Biscay Science and Technology Park, Astondo Bidea, BIC Bizkaia Bd 612, Derio, 48160 Bizkaia, Basque Country, Spain., Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.; University of Basel, 4002 Basel, Switzerland., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Rosenthal PJ; Department of Medicine, University of California, San Francisco, California 94143, United States., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States., Aguiar ACC; University of Sao Paulo, Sao Carlos Institute of Physics, Sáo Carlos, SP 13560-970, Brazil., Guido RVC; University of Sao Paulo, Sao Carlos Institute of Physics, Sáo Carlos, SP 13560-970, Brazil., Pereira DB; Tropical Medicine Research Center of Rondonia, Av. Guaporé, 215, Porto Velho, RO 76812-329, Brazil., Mittal N; Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States., Winzeler EA; Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States., Tomchick DR; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., Laleu B; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Rathod PK; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6085-6136. Date of Electronic Publication: 2021 Apr 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antimalarials/*pharmacology , Enzyme Inhibitors/*pharmacology , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Pyrroles/*pharmacology, Animals ; Antimalarials/chemistry ; Dihydroorotate Dehydrogenase ; Enzyme Inhibitors/chemistry ; Mice ; Plasmodium falciparum/drug effects ; Pyrroles/chemistry ; Structure-Activity Relationship

المؤلفون: White J; Departments of Chemistry and Global Health , University of Washington , 36 Bagley Hall, 400 15th Avenue NE , Seattle , Washington 98195 , United States., Dhingra SK; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Deng X; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., El Mazouni F; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Lee MCS; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States.; Parasites and Microbes Programme , Wellcome Sanger Institute , Hinxton, Cambridgeshire CB10 1SA , U.K., Afanador GA; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Lawong A; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Tomchick DR; Department of Biophysics , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Ng CL; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Bath J; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Rathod PK; Departments of Chemistry and Global Health , University of Washington , 36 Bagley Hall, 400 15th Avenue NE , Seattle , Washington 98195 , United States., Fidock DA; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States.; Division of Infectious Diseases, Department of Medicine , Columbia University Irving Medical Center , PH8-W, 630 West 168th Street, PH 8-West , New York , New York 10032 , United States., Phillips MA; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2019 Jan 11; Vol. 5 (1), pp. 90-101. Date of Electronic Publication: 2018 Nov 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Point Mutation*, Antimalarials/*pharmacology , Drug Resistance/*genetics , Oxidoreductases Acting on CH-CH Group Donors/*genetics , Plasmodium falciparum/*drug effects , Plasmodium falciparum/*genetics , Pyrimidines/*pharmacology , Triazoles/*pharmacology, Amino Acid Sequence ; Animals ; Binding Sites ; CRISPR-Cas Systems ; Crystallography, X-Ray ; Dihydroorotate Dehydrogenase ; Gene Editing ; Humans ; Malaria, Falciparum ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors ; Plasmodium falciparum/enzymology

المؤلفون: Kokkonda S; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Deng X, White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Coteron JM; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Marco M; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., de Las Heras L; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., White J; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., El Mazouni F, Tomchick DR, Manjalanagara K; Syngene International Ltd. , Bangalore 560 099, India., Rudra KR; Syngene International Ltd. , Bangalore 560 099, India., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Morizzi J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Ryan E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Kaminsky W; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Leroy D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Martínez-Martínez MS; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Jimenez-Diaz MB; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Bazaga SF; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Angulo-Barturen I; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Waterson D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Matthews D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Phillips MA, Rathod PK; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2016 Jun 09; Vol. 59 (11), pp. 5416-31. Date of Electronic Publication: 2016 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*pharmacology , Enzyme Inhibitors/*pharmacology , Malaria, Falciparum/*drug therapy , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Plasmodium falciparum/*drug effects , Pyrimidines/*pharmacology , Triazoles/*pharmacology, Animals ; Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Dihydroorotate Dehydrogenase ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Mice ; Mice, SCID ; Molecular Structure ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Parasitic Sensitivity Tests ; Plasmodium falciparum/enzymology ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Rats ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry

المؤلفون: Phillips MA; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, TX 75390-9041, USA. margaret.phillips@utsouthwestern.edu susan.charman@monash.edu., Lotharius J; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Marsh K; Abbvie, 1 North Waukegan Road, North Chicago, IL 60064-6104, USA., White J; Departments of Chemistry and Global Health, University of Washington, Seattle, WA 98195, USA., Dayan A; Medicines for Malaria Venture, 1215 Geneva, Switzerland., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Njoroge JW; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, TX 75390-9041, USA., El Mazouni F; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, TX 75390-9041, USA., Lao Y; Abbvie, 1 North Waukegan Road, North Chicago, IL 60064-6104, USA., Kokkonda S; Departments of Chemistry and Global Health, University of Washington, Seattle, WA 98195, USA., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA., Deng X; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, TX 75390-9041, USA., Laird T; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Bhatia SN; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., March S; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ng CL; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA., Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland. University of Basel, 4003 Basel, Switzerland., Lafuente-Monasterio M; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Benito FJ; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Alonso LM; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Martinez MS; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Jimenez-Diaz MB; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Bazaga SF; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Angulo-Barturen I; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Haselden JN; GlaxoSmithKline (GSK), Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Louttit J; GSK, Park Road, Ware, Hertfordshire SG12 0DP, UK., Cui Y; GSK, Park Road, Ware, Hertfordshire SG12 0DP, UK., Sridhar A; GSK, Park Road, Ware, Hertfordshire SG12 0DP, UK., Zeeman AM; Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, Netherlands., Kocken C; Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, Netherlands., Sauerwein R; TropIQ Health Sciences, 6525 GA Nijmegen, Netherlands., Dechering K; TropIQ Health Sciences, 6525 GA Nijmegen, Netherlands., Avery VM; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia., Duffy S; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia., Delves M; Imperial College of Science Technology and Medicine, London SW7 2AY, UK., Sinden R; Imperial College of Science Technology and Medicine, London SW7 2AY, UK., Ruecker A; Imperial College of Science Technology and Medicine, London SW7 2AY, UK., Wickham KS; State University of New York Upstate Medical University, Syracuse, NY 13210, USA., Rochford R; State University of New York Upstate Medical University, Syracuse, NY 13210, USA., Gahagen J; SRI International, Menlo Park, CA 94025, USA., Iyer L; SRI International, Menlo Park, CA 94025, USA., Riccio E; SRI International, Menlo Park, CA 94025, USA., Mirsalis J; SRI International, Menlo Park, CA 94025, USA., Bathhurst I; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Rueckle T; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Ding X; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Campo B; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Leroy D; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Rogers MJ; National Institutes for Allergy and Infectious Diseases, 6610 Rockledge Drive, Bethesda, MD 20892, USA., Rathod PK; Departments of Chemistry and Global Health, University of Washington, Seattle, WA 98195, USA., Burrows JN; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. margaret.phillips@utsouthwestern.edu susan.charman@monash.edu.

المصدر: Science translational medicine [Sci Transl Med] 2015 Jul 15; Vol. 7 (296), pp. 296ra111.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*chemistry , Enzyme Inhibitors/*chemistry , Malaria, Falciparum/*drug therapy , Malaria, Falciparum/*prevention & control , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Pyrimidines/*chemistry , Triazoles/*chemistry, Administration, Oral ; Animals ; Antimalarials/pharmacokinetics ; Area Under Curve ; Caco-2 Cells ; Crystallography, X-Ray ; Dihydroorotate Dehydrogenase ; Dogs ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/pharmacokinetics ; Haplorhini ; Humans ; Inhibitory Concentration 50 ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Molecular Sequence Data ; Oxidoreductases Acting on CH-CH Group Donors/chemistry ; Plasmodium falciparum ; Pyrimidines/pharmacokinetics ; Rabbits ; Substrate Specificity ; Triazoles/pharmacokinetics