المؤلفون: Lei H; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Li C; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Yang Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Jia F; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Guo M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Zhu M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Jiang N; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Zhai X; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: zhaixin_syphu@126.com.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Sep 01; Vol. 201, pp. 112456. Date of Electronic Publication: 2020 Jun 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Hydrazones/*pharmacology , Indoles/*pharmacology , Phosphodiesterase Inhibitors/*pharmacology , Phosphoric Diester Hydrolases/*metabolism, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Catalytic Domain ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Hydrazones/chemical synthesis ; Hydrazones/metabolism ; Indoles/chemical synthesis ; Indoles/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/metabolism ; Phosphoric Diester Hydrolases/chemistry ; Protein Binding ; Structure-Activity Relationship ; Thermodynamics

المؤلفون: Guo J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Zhao F; Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China., Yin W; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Zhu M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Hao C; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Pang Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Wu T; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Wang J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Zhao D; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: dongmeiz-67@163.com., Li H; Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. Electronic address: lht@tsinghua.edu.cn., Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: mscheng@263.net.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2018 Jul 15; Vol. 155, pp. 197-209. Date of Electronic Publication: 2018 Jun 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*pharmacology , Enzyme Inhibitors/*pharmacology , Indoles/*pharmacology , p21-Activated Kinases/*antagonists & inhibitors, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Crystallography, X-Ray ; Cytochrome P-450 Enzyme System/metabolism ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; p21-Activated Kinases/isolation & purification ; p21-Activated Kinases/metabolism

المؤلفون: Wang Y; Guangxi Colleges and Universities Key Laboratory of Pharmacology, Guilin Medical University, 109 Huanchengbei Road Two, Guilin 541004, China. wangyuhuitg2017@163.com., Zhu M; Guangxi Colleges and Universities Key Laboratory of Pharmacology, Guilin Medical University, 109 Huanchengbei Road Two, Guilin 541004, China. zmlvarar123456@126.com., Yuan B; Guangxi Colleges and Universities Key Laboratory of Pharmacology, Guilin Medical University, 109 Huanchengbei Road Two, Guilin 541004, China. yuanbo3917@163.com., Zhang K; Guangxi Colleges and Universities Key Laboratory of Pharmacology, Guilin Medical University, 109 Huanchengbei Road Two, Guilin 541004, China. zkftg2017@163.com., Zhong M; Guangxi Colleges and Universities Key Laboratory of Pharmacology, Guilin Medical University, 109 Huanchengbei Road Two, Guilin 541004, China. zmltg2017@163.com., Yi W; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 18607739261@163.com., Xu X; Guangxi Colleges and Universities Key Laboratory of Pharmacology, Guilin Medical University, 109 Huanchengbei Road Two, Guilin 541004, China. mufeng_91@163.com., Duan X; Guangxi Colleges and Universities Key Laboratory of Pharmacology, Guilin Medical University, 109 Huanchengbei Road Two, Guilin 541004, China. robortduan@163.com.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2018 Jan 08; Vol. 23 (1). Date of Electronic Publication: 2018 Jan 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Cadherins/*genetics , Indoles/*chemical synthesis , Liver Neoplasms/*prevention & control , PPAR gamma/*agonists , Pyridines/*chemical synthesis , Triple Negative Breast Neoplasms/*prevention & control, Animals ; Antigens, CD ; Antineoplastic Agents/pharmacology ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Indoles/pharmacology ; Liver Neoplasms/secondary ; Mice, Nude ; PPAR gamma/metabolism ; Pyridines/pharmacology ; Triple Negative Breast Neoplasms/pathology ; Up-Regulation ; Xenograft Model Antitumor Assays

المؤلفون: Guo J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Zhu M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Wu T; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Hao C; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Wang K; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Yan Z; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Huang W; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Life Science and Bio-pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Wang J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Zhao D; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: dongmeiz-67@163.com., Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: mscheng@263.net.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Jul 01; Vol. 25 (13), pp. 3500-3511. Date of Electronic Publication: 2017 May 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Molecular Docking Simulation*, Antineoplastic Agents/*pharmacology , Indoles/*pharmacology , Protein Kinase Inhibitors/*pharmacology , p21-Activated Kinases/*antagonists & inhibitors, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; p21-Activated Kinases/metabolism

المؤلفون: Liegl B; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. bernadette.liegl-atzwanger@med.uni-gaz.at, Kepten I, Le C, Zhu M, Demetri GD, Heinrich MC, Fletcher CD, Corless CL, Fletcher JA

المصدر: The Journal of pathology [J Pathol] 2008 Sep; Vol. 216 (1), pp. 64-74.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print Cited Medium: Print ISSN: 0022-3417 (Print) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Drug Resistance, Neoplasm/*genetics , Gastrointestinal Stromal Tumors/*drug therapy , Indoles/*therapeutic use , Piperazines/*therapeutic use , Protein Kinase Inhibitors/*therapeutic use , Pyrimidines/*therapeutic use , Pyrroles/*therapeutic use, Aged ; Benzamides ; Drug Resistance, Neoplasm/drug effects ; Female ; Gastrointestinal Stromal Tumors/genetics ; Humans ; Imatinib Mesylate ; Male ; Middle Aged ; Sunitinib