المؤلفون: Paffenholz SV; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Salvagno C; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065., Ho YJ; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Limjoco M; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Baslan T; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Tian S; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Kulick A; Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10065., de Stanchina E; Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Wilkinson JE; Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109., Barriga FM; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Zamarin D; Department of Medicine, Gynecologic Medical Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065.; Weill Cornell Graduate School of Biomedical Sciences, Cornell University, New York, NY 10065., Leibold J; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065; lowes@mskcc.org Josef.Leibold@med.uni-tuebingen.de.; Department of Medical Oncology & Pneumology (Internal Medicine VIII), University Hospital Tuebingen, Tuebingen 72076, Germany.; DFG Cluster of Excellence 2180 'Image-Guided and Functional Instructed Tumor Therapy' (iFIT), University of Tuebingen, 72076 Tuebingen, Germany., Lowe SW; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065; lowes@mskcc.org Josef.Leibold@med.uni-tuebingen.de.; Howard Hughes Medical Institute (HHMI), Memorial Sloan Kettering Cancer Center, New York, NY 10065.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Feb 01; Vol. 119 (5).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Immune Checkpoint Inhibitors/*pharmacology , Ovarian Neoplasms/*drug therapy, Animals ; Carcinoma, Ovarian Epithelial/diet therapy ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Humans ; Immunotherapy/methods ; Mice ; Mice, Inbred C57BL

المؤلفون: Rudalska R; 1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2]., Dauch D; 1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2]., Longerich T; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., McJunkin K; The Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Wuestefeld T; Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany., Kang TW; 1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2] Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Hohmeyer A; 1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2] Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Pesic M; Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany., Leibold J; Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany., von Thun A; 1] Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany. [2] Theodor Boveri Institute, Biocenter, University of Wuerzburg, Wuerzburg, Germany., Schirmacher P; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Zuber J; Research Institute of Molecular Pathology, Vienna, Austria., Weiss KH; Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany., Powers S; Cancer Genome Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA., Malek NP; Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany., Eilers M; 1] Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany. [2] Theodor Boveri Institute, Biocenter, University of Wuerzburg, Wuerzburg, Germany., Sipos B; Institute of Pathology, University of Tuebingen, Tuebingen, Germany., Lowe SW; 1] Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Howard Hughes Medical Institute, New York, New York, USA., Geffers R; Helmholtz Centre for Infection Research, Braunschweig, Germany., Laufer S; Department of Pharmaceutical and Medicinal Chemistry, University of Tuebingen, Tuebingen, Germany., Zender L; 1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2] Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

المصدر: Nature medicine [Nat Med] 2014 Oct; Vol. 20 (10), pp. 1138-46. Date of Electronic Publication: 2014 Sep 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Liver Neoplasms, Experimental/*drug therapy , Liver Neoplasms, Experimental/*genetics , Mitogen-Activated Protein Kinase 14/*antagonists & inhibitors , Mitogen-Activated Protein Kinase 14/*genetics , Niacinamide/*analogs & derivatives , Phenylurea Compounds/*pharmacology, Activating Transcription Factor 2/metabolism ; Animals ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Drug Resistance, Neoplasm/genetics ; Female ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms, Experimental/metabolism ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase 14/metabolism ; Niacinamide/pharmacology ; Protein Kinase Inhibitors/pharmacology ; RNA Interference ; RNA, Small Interfering/genetics ; Signal Transduction ; Sorafenib ; Xenograft Model Antitumor Assays