المؤلفون: Abdulkareem SJ; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Jafari-Gharabaghlou D; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Farhoudi-Sefidan-Jadid M; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Salmani-Javan E; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Toroghi F; Research Center for Molecular Medicine, Hamedan University of Medical Science, Hamedan, Iran., Zarghami N; Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. zarghamin@gmail.com.; Department of Medical Biochemistry, Faculty of Medicine, Istanbul Aydin University, Istanbul, Turkey. zarghamin@gmail.com.

المصدر: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Daru] 2024 Jun; Vol. 32 (1), pp. 133-144. Date of Electronic Publication: 2024 Jan 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101125969 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2008-2231 (Electronic) Linking ISSN: 15608115 NLM ISO Abbreviation: Daru Subsets: MEDLINE

مواضيع طبية MeSH: Artemisinins*/pharmacology , Artemisinins*/chemistry , Artemisinins*/administration & dosage , Metformin*/pharmacology , Metformin*/chemistry , Metformin*/administration & dosage , Lung Neoplasms*/drug therapy , Apoptosis*/drug effects , Nanoparticles*/chemistry, Humans ; A549 Cells ; Nickel/chemistry ; Polyethylene Glycols/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/administration & dosage ; Cell Survival/drug effects ; Liposomes/chemistry ; Cell Proliferation/drug effects

المؤلفون: Zhang D; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China., He X; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China., Wang T; Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang 050004, China., Xing Y; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China., Xiu Z; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China., Bao Y; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.; School of Ocean Science and Technology, Dalian University of Technology, Panjin 124221, China., Dong Y; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 May 14; Vol. 29 (10). Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Metformin*/pharmacology , Metformin*/chemistry , Pyruvaldehyde* , Flavonoids*/pharmacology , Flavonoids*/chemistry , Drug Synergism* , Apoptosis*/drug effects , Reactive Oxygen Species*/metabolism, Rats ; PC12 Cells ; Animals ; Structure-Activity Relationship ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Neuroblastoma/drug therapy ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/chemistry ; Signal Transduction/drug effects

المؤلفون: Salim EI; Zoology Department, Research Lab. of Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta, Egypt., Elsebakhy S; Molecular Cell Biology Unit, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt., Hessien M; Molecular Cell Biology Unit, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt.

المصدر: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2024 Jun; Vol. 38 (3), pp. 550-560. Date of Electronic Publication: 2024 Jan 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 8710411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-8206 (Electronic) Linking ISSN: 07673981 NLM ISO Abbreviation: Fundam Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Metformin*/pharmacology , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Atorvastatin*/pharmacology , Cell Proliferation*/drug effects , Drug Repositioning* , Drug Synergism* , Apoptosis*/drug effects, Humans ; A549 Cells ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Gemcitabine ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hypoglycemic Agents/pharmacology

المؤلفون: Salim EI; Department of Zoology, Research Lab of Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta, 31527, Egypt. elsayed.salim@science.tanta.edu.eg., Alabasy MM; Department of Zoology, Research Lab of Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta, 31527, Egypt., Nashar EME; Department of Anatomy, College of Medicine, King Khalid University, Abha, 62529, Saudi Arabia., Al-Zahrani NS; Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, 62529, Saudi Arabia., Alzahrani MA; Internal Medicine Department, College of Medicine, King Khalid University, Abha, 62529, Saudi Arabia., Guo Z; College of Life Science, Center of Bioinformatics, Northwest A and F University, Yangling, Shaanxi, 712100, China., Beltagy DM; Biochemistry Department, Faculty of Science, Damanhour University, Damanhour, Egypt., Shahen M; Department of Zoology, Research Lab of Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta, 31527, Egypt. Mshahen@science.tanta.edu.eg.

المصدر: BMC complementary medicine and therapies [BMC Complement Med Ther] 2024 May 06; Vol. 24 (1), pp. 185. Date of Electronic Publication: 2024 May 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE

مواضيع طبية MeSH: Metformin*/pharmacology , Limonene*/pharmacology , Apoptosis*/drug effects , Breast Neoplasms*/drug therapy , Liver Neoplasms*/drug therapy , Cell Proliferation*/drug effects, Humans ; Hep G2 Cells ; MCF-7 Cells ; Terpenes/pharmacology ; Female ; Antineoplastic Agents/pharmacology ; Cyclohexenes/pharmacology

المؤلفون: Alotaibi HF; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia., Khafagy ES; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., Abu Lila AS; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., Alotaibe HF; Department of Family Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia., Elbehairi SE; Faculty of science, Biology Department, King Khalid University, Abha, Saudi Arabia., Alanazi AS; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia., Alfaifi MY; Faculty of science, Biology Department, King Khalid University, Abha, Saudi Arabia., Alamoudi JA; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia., Alamrani SS; College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Mokhtar FA; Department of pharmacognosy, El Saleheya El Gadida University, El Saleheya El Gadida, Sharkia, Egypt.; Department of Pharmacognosy, Al Salam University, Kafr Alzayat, Egypt.

المصدر: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2023 Dec; Vol. 51 (1), pp. 419-427.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis* , Metformin*/pharmacology, Humans ; Coconut Oil/pharmacology ; HCT116 Cells ; MCF-7 Cells ; Cocos

المؤلفون: Hasan A; Molecular Cell Biology Laboratory, Integral Information and Research Centre-4 (IIRC-4), Integral University, Kursi Road, Lucknow, 226026, India.; Department of Bioengineering, Faculty of Engineering, Integral University, Kursi Road, Lucknow, 226026, India.; Current Address: Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA., Khamjan N; Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, 45142, Kingdom of Saudi Arabia., Lohani M; Medical Research Center, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia.; Emergency Medical Services, Faculty of Applied Medical Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia., Mir SS; Molecular Cell Biology Laboratory, Integral Information and Research Centre-4 (IIRC-4), Integral University, Kursi Road, Lucknow, 226026, India. smir@iul.ac.in.; Department of Biosciences, Faculty of Science, Integral University, Kursi Road, Lucknow, 226026, India. smir@iul.ac.in.

المصدر: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2023 Dec; Vol. 195 (12), pp. 7338-7378. Date of Electronic Publication: 2023 Mar 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Apoptosis*/drug effects , Autophagy* , Metformin*/pharmacology , Limonins*/pharmacology , Antineoplastic Agents*/pharmacology, Humans ; A549 Cells ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Lung/drug effects ; Cell Line ; Cytotoxins/pharmacology ; Drug Synergism ; Reactive Oxygen Species/metabolism ; Drug Combinations ; DNA Damage/drug effects ; AMP-Activated Protein Kinases/metabolism ; Cell Nucleus/metabolism ; Signal Transduction/drug effects ; Caspase 3/metabolism ; Caspase 9/metabolism

المؤلفون: Oscilowska I; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Rolkowski K; Department of Medicinal Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Baszanowska W; Department of Medicinal Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Huynh TYL; Department of Medicinal Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Lewoniewska S; Department of Medicinal Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Nizioł M; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Sawicka M; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Bielawska K; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Szoka P; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Miltyk W; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland., Palka J; Department of Medicinal Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 21; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis*, Melanoma/*drug therapy , Metformin/*pharmacology , Proline Oxidase/*metabolism, AMP-Activated Protein Kinases/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Humans ; Melanoma/enzymology ; Melanoma/physiopathology ; Metformin/therapeutic use ; Mitochondria/enzymology

المؤلفون: Wang G; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.; School of Pharmacy, Chongqing Medical University, Chongqing, China., Wang Y; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China., Yang Q; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China., Xu C; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China., Zheng Y; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China., Wang L; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China., Wu J; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China., Zeng M; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. zengminlz@163.com., Luo M; Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China. luomao20050908@163.com.; Laboratory for Cardiovascular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China. luomao20050908@163.com.; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. luomao20050908@163.com.

المصدر: Cell death & disease [Cell Death Dis] 2022 Jan 10; Vol. 13 (1), pp. 29. Date of Electronic Publication: 2022 Jan 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Metformin/*pharmacology , Oxidative Stress/*drug effects , Pyruvaldehyde/*toxicity, Animals ; Heme Oxygenase-1/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation ; Metformin/administration & dosage ; Mice ; Mitochondria/drug effects ; NF-E2-Related Factor 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Pyruvaldehyde/administration & dosage ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Vascular System Injuries/chemically induced ; Vascular System Injuries/drug therapy ; Vascular System Injuries/metabolism ; Vascular System Injuries/pathology

المؤلفون: Hu X; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.; Department of Animal Science, McGill University, Montréal, QC H3A 0G4, Canada., Luo H; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Dou C; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Chen X; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Huang Y; Department of Pharmacy, Suzhou Vocational Health College, Suzhou 215009, China., Wang L; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Xue S; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Sun Z; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Chen S; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Xu Q; Department of Animal Science, McGill University, Montréal, QC H3A 0G4, Canada., Geng T; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China., Zhao X; Department of Animal Science, McGill University, Montréal, QC H3A 0G4, Canada., Cui H; Institute of Epigenetics and Epigenomics, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.; Joint International Research Laboratory of Agricultural & Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.; Jiangsu Co-Innovation Center for Prevention & Control of Important Animal Infectious Diseases & Zoonoses, Yangzhou 225009, China.

المصدر: Genes [Genes (Basel)] 2021 Sep 17; Vol. 12 (9). Date of Electronic Publication: 2021 Sep 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Cell Cycle Proteins/*genetics , Gene Expression Regulation/*drug effects , Macrophages/*drug effects , Metformin/*pharmacology, Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Apoptosis/genetics ; Cell Line ; Chickens ; Dose-Response Relationship, Drug ; Macrophages/physiology ; Metformin/administration & dosage ; Mice ; RAW 264.7 Cells

المؤلفون: Cheki M; Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Ghasemi MS; Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Rezaei Rashnoudi A; Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Erfani Majd N; Department of Basic Sciences, Histology Section, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

المصدر: Drug and chemical toxicology [Drug Chem Toxicol] 2021 Jul; Vol. 44 (4), pp. 386-393. Date of Electronic Publication: 2019 May 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Bone Marrow Cells/*drug effects , Cisplatin/*toxicity , Metformin/*pharmacology, Animals ; Antineoplastic Agents/toxicity ; DNA Damage/drug effects ; Dose-Response Relationship, Drug ; Flow Cytometry ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology ; Male ; Metformin/administration & dosage ; Micronucleus Tests ; Protective Agents/administration & dosage ; Protective Agents/pharmacology ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism