المؤلفون: Leuti A; Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.; European Center for Brain Research/Institute for Research and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy., Fava M; European Center for Brain Research/Institute for Research and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy., Forte G; Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy., Pellegrini N; Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy., Oddi S; European Center for Brain Research/Institute for Research and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy.; Department of Veterinary Medicine, University of Teramo, Teramo, Italy., Scipioni L; European Center for Brain Research/Institute for Research and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Gomez EA; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK., Dalli J; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK.; William Harvey Research Institute, Queen Mary University of London, London, UK., Maccarrone M; European Center for Brain Research/Institute for Research and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 May 31; Vol. 38 (10), pp. e23675.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids*/metabolism , Endocannabinoids*/pharmacology , Receptor, Cannabinoid, CB2*/metabolism , Receptor, Cannabinoid, CB2*/genetics , Polyunsaturated Alkamides*/pharmacology , Polyunsaturated Alkamides*/metabolism , Arachidonic Acids*/pharmacology , Arachidonic Acids*/metabolism , Macrophages*/metabolism , Macrophages*/drug effects , Receptors, G-Protein-Coupled*/metabolism, Humans ; Inflammation/metabolism ; Cells, Cultured ; Signal Transduction/drug effects ; Docosahexaenoic Acids/pharmacology ; Docosahexaenoic Acids/metabolism ; Arachidonate 5-Lipoxygenase/metabolism

المؤلفون: Gamble MC; Molecular and Translational Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Miracle S; Graduate Program in Neuroscience, Boston University, Boston, MA, USA., Williams BR; Department of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA, USA., Logan RW; Department of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: ryan.logan@umassmed.edu.

المصدر: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2024 Jul; Vol. 240, pp. 173791. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5177 (Electronic) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids* , Arachidonic Acids*/pharmacology , Glycerides*/pharmacology , Mice, Inbred C57BL* , Substance Withdrawal Syndrome* , Fentanyl*/pharmacology , Fentanyl*/administration & dosage , Circadian Rhythm*/drug effects , Sleep*/drug effects, Animals ; Female ; Male ; Mice ; Wakefulness/drug effects ; Analgesics, Opioid/pharmacology ; Analgesics, Opioid/administration & dosage

المؤلفون: Guadalupi L; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Synaptic Immunopathology Lab, IRCCS San Raffaele Roma, Rome, Italy., Mandolesi G; Synaptic Immunopathology Lab, IRCCS San Raffaele Roma, Rome, Italy; Department of Human Sciences and Quality of Life Promotion University of Rome San Raffaele, Italy., Vanni V; Synaptic Immunopathology Lab, IRCCS San Raffaele Roma, Rome, Italy., Balletta S; IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli (IS), Italy., Caioli S; IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli (IS), Italy., Pavlovic A; Laboratory of Flow Cytometry, IRCCS San Raffaele Roma, Rome, Italy., De Vito F; IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli (IS), Italy., Fresegna D; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Synaptic Immunopathology Lab, IRCCS San Raffaele Roma, Rome, Italy., Sanna K; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Vitiello L; Department of Human Sciences and Quality of Life Promotion University of Rome San Raffaele, Italy; Laboratory of Flow Cytometry, IRCCS San Raffaele Roma, Rome, Italy., Nencini M; Synaptic Immunopathology Lab, IRCCS San Raffaele Roma, Rome, Italy., Tartacca A; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Mariani F; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Rovella V; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Schippling S; F. Hoffmann -La Roche Ltd. Roche. Innovation Center Basel, Switzerland by Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, 4070 Basel, Switzerland., Ruf I; F. Hoffmann -La Roche Ltd. Roche. Innovation Center Basel, Switzerland by Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, 4070 Basel, Switzerland., Collin L; F. Hoffmann -La Roche Ltd. Roche. Innovation Center Basel, Switzerland by Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, 4070 Basel, Switzerland., Centonze D; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli (IS), Italy. Electronic address: centonze@uniroma2.it., Musella A; Synaptic Immunopathology Lab, IRCCS San Raffaele Roma, Rome, Italy; Department of Human Sciences and Quality of Life Promotion University of Rome San Raffaele, Italy.

المصدر: Neuropharmacology [Neuropharmacology] 2024 Jul 01; Vol. 252, pp. 109940. Date of Electronic Publication: 2024 Apr 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Encephalomyelitis, Autoimmune, Experimental*/drug therapy , Encephalomyelitis, Autoimmune, Experimental*/pathology , Encephalomyelitis, Autoimmune, Experimental*/metabolism , Glycerides*/metabolism , Endocannabinoids*/metabolism , Mice, Inbred C57BL* , Arachidonic Acids*/pharmacology , Arachidonic Acids*/metabolism, Animals ; Female ; Mice ; Neuroinflammatory Diseases/drug therapy ; Neuroinflammatory Diseases/metabolism ; Synapses/drug effects ; Synapses/pathology ; Synapses/metabolism ; Microglia/drug effects ; Microglia/metabolism ; Monoacylglycerol Lipases/antagonists & inhibitors ; Monoacylglycerol Lipases/metabolism

المؤلفون: Belali R; Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Persian Gulf Physiology Research Center, Basic Medical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Mard SA; Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Persian Gulf Physiology Research Center, Basic Medical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Khoshnam SE; Persian Gulf Physiology Research Center, Basic Medical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Bavarsad K; Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Persian Gulf Physiology Research Center, Basic Medical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Sarkaki A; Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. sarkaki_a@ajums.ac.ir.; Persian Gulf Physiology Research Center, Basic Medical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. sarkaki_a@ajums.ac.ir., Farbood Y; Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. farbood_y@ajums.ac.ir.; Persian Gulf Physiology Research Center, Basic Medical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. farbood_y@ajums.ac.ir.

المصدر: Neurochemical research [Neurochem Res] 2024 Jun; Vol. 49 (6), pp. 1541-1555. Date of Electronic Publication: 2023 Nov 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids*/metabolism , Sleep Deprivation*/complications , Sleep Deprivation*/metabolism , Sleep Deprivation*/drug therapy , Arachidonic Acids*/pharmacology , Rats, Wistar* , Polyunsaturated Alkamides*/pharmacology , Oxidative Stress*/drug effects , Electroencephalography*, Animals ; Male ; Rats ; Anxiety/drug therapy ; Neuroinflammatory Diseases/drug therapy ; Neuroinflammatory Diseases/metabolism ; Depression/drug therapy ; Depression/metabolism ; Receptor, Cannabinoid, CB1/metabolism ; Behavior, Animal/drug effects ; Anti-Anxiety Agents/pharmacology ; Anti-Anxiety Agents/therapeutic use

المؤلفون: Lopez-Cortes OD; Licenciatura en Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico.; Instituto de Nutrigenética y Nutrigenómica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico.; Canada Excellence Research Chair in Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Quebec, QC, G1V 4G5, Canada.; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval, Québec, QC, G1V 4G5, Canada.; Institut sur la Nutrition et les Aliments Fonctionnels, Centre NUTRISS, Université Laval, Québec, QC, G1V 4G5, Canada., Trujillo-Sánchez F; Licenciatura en Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico.; Instituto de Nutrigenética y Nutrigenómica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico., Sierra-Ruelas E; Instituto de Nutrigenética y Nutrigenómica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico.; Doctorado en Ciencias de la Nutrición Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico., Martinez-Lopez E; Instituto de Nutrigenética y Nutrigenómica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico.; Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico., Di Marzo V; Canada Excellence Research Chair in Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Quebec, QC, G1V 4G5, Canada.; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval, Québec, QC, G1V 4G5, Canada.; Institut sur la Nutrition et les Aliments Fonctionnels, Centre NUTRISS, Université Laval, Québec, QC, G1V 4G5, Canada.; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale Delle Ricerche (CNR), Pozzuoli, Italy., Vizmanos B; Instituto de Nutrigenética y Nutrigenómica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico. bvizmanos@yahoo.com.mx.; Doctorado en Ciencias de la Nutrición Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico. bvizmanos@yahoo.com.mx.; Departamento de Clínicas de Reproducción Humana, Crecimiento y Desarrollo Infantil, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico. bvizmanos@yahoo.com.mx.; Departamento de Disciplinas Filosófico, Metodológicas e Instrumentales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, 44320, Mexico. bvizmanos@yahoo.com.mx.

المصدر: International journal of obesity (2005) [Int J Obes (Lond)] 2024 Feb; Vol. 48 (2), pp. 188-201. Date of Electronic Publication: 2023 Dec 19.

نوع المنشور: Systematic Review; Journal Article; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101256108 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5497 (Electronic) Linking ISSN: 03070565 NLM ISO Abbreviation: Int J Obes (Lond) Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids*/genetics , Endocannabinoids*/metabolism , Obesity*/genetics , Amidohydrolases* , Arachidonic Acids* , Polyunsaturated Alkamides*, Humans ; Phenotype

المؤلفون: Pontearso M; Laboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic., Slepicka J; Laboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic., Bhattacharyya A; Laboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic., Spicarova D; Laboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic., Palecek J; Laboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: Jiri.Palecek@fgu.cas.cz.

المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Apr; Vol. 173, pp. 116369. Date of Electronic Publication: 2024 Mar 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids*/pharmacology , Nociception* , Arachidonic Acids* , Benzamides* , Carbamates*, Humans ; Polyunsaturated Alkamides/pharmacology ; Spinal Cord Dorsal Horn ; Analgesics/pharmacology ; Inflammation/drug therapy ; Amidohydrolases

المؤلفون: Akimov MG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Gretskaya NM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Gorbacheva EI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Khadour N; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Chernavskaya VS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Sherstyanykh GD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Kovaleko TF; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Fomina-Ageeva EV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia., Bezuglov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 14; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids*/pharmacology , Breast Neoplasms*/drug therapy , Arachidonic Acids* , Lysophospholipids*, Humans ; Female ; Polyunsaturated Alkamides/pharmacology ; Cell Death ; Receptor, Cannabinoid, CB1 ; Tumor Microenvironment

المؤلفون: Ruhl T; Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. Electronic address: truhl@ukaachen.de., Nuptybayeva A; Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. Electronic address: aigul.nuptybayeva@rwth-aachen.de., Kim BS; Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany; Department of Plastic and Hand Surgery, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland. Electronic address: bong-sung.kim@usz.ch., Beier JP; Department of Plastic Surgery, Hand Surgery-Burn Center, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. Electronic address: jbeier@ukaachen.de.

المصدر: Experimental cell research [Exp Cell Res] 2024 Feb 01; Vol. 435 (1), pp. 113908. Date of Electronic Publication: 2023 Dec 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids*/pharmacology , Adipogenesis* , Arachidonic Acids*, Humans ; Receptors, Cannabinoid ; Polyunsaturated Alkamides/pharmacology ; Polyunsaturated Alkamides/metabolism ; Stromal Cells/metabolism

المؤلفون: O'Donohue MP; School of Psychology and Counselling, Queensland University of Technology, Australia., Amir Hamzah K; School of Psychology and Counselling, Queensland University of Technology, Australia., Nichols D; Central Science Laboratory, University of Tasmania, Australia., Ney LJ; School of Psychology and Counselling, Queensland University of Technology, Australia. Electronic address: luke.ney@qut.edu.au.

المصدر: Psychoneuroendocrinology [Psychoneuroendocrinology] 2024 Jun; Vol. 164, pp. 107007. Date of Electronic Publication: 2024 Mar 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Hydrocortisone* , Salivary alpha-Amylases* , Arachidonic Acids*, Humans ; Endocannabinoids ; Polyunsaturated Alkamides ; Saliva

المؤلفون: Tarasova E; Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russian Federation., Bogacheva P; Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russian Federation., Chernyshev K; Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russian Federation., Balezina O; Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russian Federation.

المصدر: Synapse (New York, N.Y.) [Synapse] 2024 Jan; Vol. 78 (1), pp. e22281. Date of Electronic Publication: 2023 Sep 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Country of Publication: United States NLM ID: 8806914 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2396 (Electronic) Linking ISSN: 08874476 NLM ISO Abbreviation: Synapse Subsets: MEDLINE

مواضيع طبية MeSH: Neuromuscular Junction*/metabolism , Endocannabinoids*/pharmacology , Endocannabinoids*/metabolism , Arachidonic Acids* , Glycerides*, Mice ; Animals ; Receptors, Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Gene-Related Peptide/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/pharmacology ; Synapses/metabolism