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1Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
المؤلفون: Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
المصدر: Redox Biology. 60:102611
مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Biochemistry
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2
المؤلفون: Matthew D. Hall, Xin Xu, Pranav Shah, Olivia W. Lee, Min Shen, Hu Zhu, Samarjit Patnaik, Ajit Jadhav
المصدر: SLAS Discov
مصطلحات موضوعية: 0301 basic medicine, Pyrimidine, High-throughput screening, Enzyme Activators, Biochemistry, Malate dehydrogenase, Article, Fumarate Hydratase, Analytical Chemistry, chemistry.chemical_compound, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Enzyme kinetics, Gene, Dose-Response Relationship, Drug, biology, Chemistry, Microscale thermophoresis, Small molecule, Enzyme assay, High-Throughput Screening Assays, Kinetics, 030104 developmental biology, Metabolic enzymes, 030220 oncology & carcinogenesis, Fumarase, biology.protein, Molecular Medicine, Cell cancer, Oxidation-Reduction, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa439d9b9bbe84f73acc652d7ef0982b
https://doi.org/10.1177/2472555219873559 -
3
المؤلفون: Noel Southall, Jordan Williams, Ewy Mathé, Jorge Neyra, Vishal B. Siramshetty, Xin Xu, Ðắc-Trung Nguyễn, Pranav Shah
المصدر: SLAS discovery : advancing life sciences RD. 26(10)
مصطلحات موضوعية: Drug, Quantitative structure–activity relationship, media_common.quotation_subject, Quantitative Structure-Activity Relationship, Computational biology, 01 natural sciences, Biochemistry, Models, Biological, Analytical Chemistry, 03 medical and health sciences, Drug Discovery, Animals, Translational Science, Biomedical, 030304 developmental biology, media_common, ADME, 0303 health sciences, Chemistry, National Center for Advancing Translational Sciences (U.S.), United States, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pharmaceutical Preparations, Molecular Medicine, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892d5bc7a8a64d598d79f3528e2d53be
https://pubmed.ncbi.nlm.nih.gov/34176369 -
4
المؤلفون: Jordan Williams, Vishal Siramshetty, Ðắc-Trung Nguyễn, Elias Carvalho Padilha, Md. Kabir, Kyeong-Ri Yu, Amy Q. Wang, Tongan Zhao, Misha Itkin, Paul Shinn, Ewy A. Mathé, Xin Xu, Pranav Shah
المصدر: Bioorg Med Chem
مصطلحات موضوعية: Cell Membrane Permeability, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Ranitidine, Betamethasone, Biochemistry, Dexamethasone, Article, Madin Darby Canine Kidney Cells, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, Molecular Biology, Cells, Cultured, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Hydrogen-Ion Concentration, Rats, Verapamil, Molecular Medicine, Neural Networks, Computer, Caco-2 Cells
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5
المؤلفون: Matthew D. Hall, David J. Maloney, Amy Wang, Jeffrey W. Strovel, Makoto Yoshioka, Daniel J. Urban, Xin Xu, Shyh-Ming Yang, Pranav Shah, Ajit Jadhav, Steven Fletcher, Xin Hu
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: 0301 basic medicine, BRD4, Clinical Biochemistry, Lysine, Pharmaceutical Science, Cell Cycle Proteins, 01 natural sciences, Biochemistry, Article, BET inhibitor, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Quinazoline, Animals, Humans, Molecular Biology, Binding Sites, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Nuclear Proteins, Combinatorial chemistry, 0104 chemical sciences, Bromodomain, 030104 developmental biology, Acetylation, Microsomes, Liver, Quinazolines, Molecular Medicine, Transcription Factors
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6
المؤلفون: Douglas R. Davies, Gloria A. Benavides, Xin Hu, Jeffrey P. Norenberg, Somnath Jana, Ganesha Rai, Pavan Muttil, Larry A. Sklar, Katherine Pohida, Daniel J. Urban, Kabir, David M. Dranow, Andrew J. Flint, Leonard M. Neckers, Giuseppe L. Squadrito, David J. Maloney, William J. Moore, Victor M. Darley-Usmar, Elias C. Padilha, Ajit Jadhav, Matthew D. Hall, Kyle R. Brimacombe, Dorian M. Cheff, Anton Simeonov, Nitesh K. Kunda, Plamen P. Christov, Pranav Shah, Tamara Anderson, Dingyin Tao, Hu Zhu, Murali Cherukuri, Yuhong Fang, Shyh-Ming Yang, Gary A. Sulikowski, Gordon M. Stott, Donna F. Kusewitt, Tobie D. Lee, Chi V. Dang, Alex G. Waterson, Mark J. Henderson, Bryan T. Mott, Kwangho Kim, Michelle S. Johnson, Helen J. Hathaway, Nobu Oshima
المصدر: J Med Chem
مصطلحات موضوعية: Pyrazole, 01 natural sciences, Article, Cell activity, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Lactate dehydrogenase, Drug Discovery, Animals, Humans, Glycolysis, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, L-Lactate Dehydrogenase, Xenograft Model Antitumor Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Biochemistry, chemistry, Molecular Medicine, Pyrazoles, Half-Life
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7
المؤلفون: Gregory J. Tawa, Richard Stone, Amy Wang, Gurmit Grewal, Ashish Thakur, Suiyang Liu, Xin Xu, Carina Danchik, Elias C. Padilha, Pranav Shah, Anton Simeonov, Surender Kharbanda, Kabir, Garrett Dunn, Mark J. Henderson
المصدر: J Med Chem
مصطلحات موضوعية: Thermal shift assay, Drug Evaluation, Preclinical, Hydroxamic Acids, 01 natural sciences, Article, 03 medical and health sciences, Mice, Phosphatidylinositol 3-Kinases, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Cytotoxicity, IC50, 030304 developmental biology, Phosphoinositide-3 Kinase Inhibitors, Quinazolinones, chemistry.chemical_classification, 0303 health sciences, Mice, Inbred BALB C, Chemistry, In vitro, 0104 chemical sciences, Protein Structure, Tertiary, Rats, Histone Deacetylase Inhibitors, 010404 medicinal & biomolecular chemistry, Enzyme, HEK293 Cells, Biochemistry, Cell culture, Drug Design, Molecular Medicine, Female, Pharmacophore
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9ffbdc8bfa071c84860ca39d9c7e49
https://europepmc.org/articles/PMC7238858/ -
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المؤلفون: Ganesha Rai, Elias C. Padilha, Xin Xu, Pranav Shah
المصدر: J Pharm Biomed Anal
مصطلحات موضوعية: Metabolite, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, 01 natural sciences, Article, Analytical Chemistry, Mice, chemistry.chemical_compound, Drug Discovery, Animals, Aldehyde oxidase, Spectroscopy, chemistry.chemical_classification, Sulfonamides, Reactive oxygen species, NADPH oxidase, biology, 010405 organic chemistry, Superoxide, 010401 analytical chemistry, NADPH Oxidases, Metabolism, Rats, 0104 chemical sciences, Cytosol, Enzyme, Pharmaceutical Preparations, chemistry, Biochemistry, biology.protein, Reactive Oxygen Species
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9
المؤلفون: Zina Itkin, Paul Shinn, Wei Zheng, Miao Xu, Catherine Z. Chen, Carleen Klumpp-Thomas, Sam Michael, Guo Li Ming, Pranav Shah, Hui Guo, Wenwei Huang, Lu Chen, Min Shen, Emily M. Lee, Xin Hu, Xiao Lu, Richard T. Eastman, Ruili Huang, Donald C. Lo, Hengli Tang, Xin Xu, Anton Simeonov, Khalida Shamim, Hongjun Song
المصدر: Bioorganic & Medicinal Chemistry Letters
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Pharmacology, ZIKV, Zika virus, PAMPA, parallel artificial membrane permeability assay, 01 natural sciences, Biochemistry, Zika virus, NS-1 assay, chemistry.chemical_compound, Drug Stability, Chlorocebus aethiops, Drug Discovery, MOI, multiplicity of infection, Niclosamide, media_common, Molecular Structure, biology, Serine Endopeptidases, Small molecule, Molecular Docking Simulation, ADME, absorption, Salicylanilide, Drug repositioning, Flavivirus, distribution, metabolism and excretion, Microsomes, Liver, Molecular Medicine, Protein Binding, medicine.drug, Drug, media_common.quotation_subject, small molecule, Microbial Sensitivity Tests, Antiviral Agents, SAR, structure-activity relationship, Article, Structure-Activity Relationship, Viral Proteins, medicine, Animals, Humans, Structure–activity relationship, Vero Cells, Molecular Biology, ComputingMethodologies_COMPUTERGRAPHICS, Binding Sites, SARS-CoV-2, 010405 organic chemistry, Organic Chemistry, biology.organism_classification, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, RLM, rat liver microsomal stability, salicylanilide
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10
المؤلفون: Pranav Shah, Kyeong Ri Yu, Hongmao Sun, Zhengyin Yan, Edward H. Kerns, Kimloan Nguyen, Xin Xu, Ajit Jadhav
المصدر: Bioorganic & Medicinal Chemistry. 25:1266-1276
مصطلحات موضوعية: 0301 basic medicine, Cell Membrane Permeability, Support Vector Machine, Cell membrane permeability, In silico, Clinical Biochemistry, Pharmaceutical Science, Bioinformatics, Models, Biological, Biochemistry, Article, 03 medical and health sciences, Search engine, 0302 clinical medicine, Artificial Intelligence, Molecular descriptor, Drug Discovery, Humans, Organic Chemicals, Molecular Biology, Receiver operating characteristic, Chemistry, Drug discovery, Organic Chemistry, Support vector machine, Permeability (earth sciences), 030104 developmental biology, 030220 oncology & carcinogenesis, Regression Analysis, Molecular Medicine, Caco-2 Cells, Biological system