المؤلفون: Radislav Sedlacek, Monika Burocziova, Vladimir Korinek, Libor Macurek, Ludmila Vodickova, Gabriela Jenikova, Ivana Tichá, Pavel Vodicka, Michaela Schneiderova, Katerina Jiraskova, Lucie Janeckova, Ragnhild A. Lothe, Jozef Pavel, Lucie Schwarzova, Marianna Borecka, Petr Kasparek, Stine A. Danielsen, Xiao-Feng Sun, Andra S. Martinikova, Kamila Burdova, Petra Zemankova, Petra Kleiblova, Zdenek Kleibl, Vaclav Liska

المصدر: Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 11, Pp 1-15 (2019)

مصطلحات موضوعية: Checkpoints, Cancer Research, DNA Repair, Carcinogenesis, Colorectal cancer, DNA repair, DNA damage, Somatic cell, Adenomatous Polyposis Coli Protein, Immunology, Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy), Genotoxic Stress, Biology, medicine.disease_cause, Article, Mice, Cellular and Molecular Neuroscience, medicine, Animals, Humans, lcsh:QH573-671, Cancer models, Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci), Cell Proliferation, lcsh:Cytology, Cell Cycle Checkpoints, Exons, Cell Biology, Cell cycle, medicine.disease, Chromatin, Gene Expression Regulation, Neoplastic, Protein Phosphatase 2C, Colonic Neoplasms, Mutation, Cancer research, Fluorouracil, Tumor Suppressor Protein p53, Stem cell, DNA Damage

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e95266b010fd3356c39aab8fedb61eb
https://doi.org/10.1038/s41419-019-2057-4

المؤلفون: Marketa Janatova, Hana Hartmannová, Katerina Hodanova, Petra Kleiblova, Jan Hojny, Michal Vocka, Petra Zemankova, Filip Lhota, Ondrej Mestak, Viktor Stranecky, Jana Soukupova, Jan Sevcik, Zdenek Kleibl, D. Pavlista

المصدر: Gene. 637:41-49

مصطلحات موضوعية: 0301 basic medicine, animal structures, Breast Neoplasms, Biology, Germline, Transcriptome, 03 medical and health sciences, Multiplex polymerase chain reaction, RNA Isoforms, Genetics, Humans, Gene, BRCA1 Protein, Alternative splicing, Computational Biology, High-Throughput Nucleotide Sequencing, General Medicine, Alternative Splicing, 030104 developmental biology, Cell culture, Mutation, embryonic structures, RNA splicing, Female, Identification (biology), Multiplex Polymerase Chain Reaction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79cb59f73a27210fc4c1fb99738dc12
https://doi.org/10.1016/j.gene.2017.09.025

المؤلفون: Vessela N. Kristensen, Zdenek Kleibl

المصدر: The Breast. 28:136-144

مصطلحات موضوعية: 0301 basic medicine, Proband, Oncology, medicine.medical_specialty, PALB2, Genes, BRCA2, Genes, BRCA1, Breast Neoplasms, Penetrance, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, AMP-Activated Protein Kinase Kinases, Antigens, CD, Risk Factors, Internal medicine, medicine, Humans, PTEN, Genetic Predisposition to Disease, skin and connective tissue diseases, CHEK2, biology, business.industry, Tumor Suppressor Proteins, PTEN Phosphohydrolase, Nuclear Proteins, Cancer, General Medicine, Cadherins, medicine.disease, FANCA, Checkpoint Kinase 2, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, biology.protein, Female, Surgery, Tumor Suppressor Protein p53, Fanconi Anemia Complementation Group N Protein, business, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e129520e08b30d07b2accc052e6f2c
https://doi.org/10.1016/j.breast.2016.05.006

المؤلفون: Lenka Stolarova, Libor Macurek, Aleš Panczak, Klara Lhotova, Marta Cerna, Stanislav Kmoch, Monika Burocziova, Jana Soukupova, Katerina Krizova, Jaroslav Kotlas, Viktor Stranecky, Petra Kleiblova, Kamila Burdova, Marketa Janatova, Jan Hojny, Michal Vocka, Petra Zemankova, Kamila Vesela, Jana Červenková, Jan Sevcik, Ondrej Havranek, Filip Lhota, Zdenek Kleibl, Eva Machackova, Spiros Tavandzis, Martina Zimovjanova, Lenka Foretova, Michaela Schneiderova, Marianna Borecka

المصدر: International journal of cancer. 145(7)

مصطلحات موضوعية: Adult, Male, Cancer Research, Mutation, Missense, Breast Neoplasms, Biology, medicine.disease_cause, Germline, Breast Neoplasms, Male, Cell Line, 03 medical and health sciences, Gene Knockout Techniques, Young Adult, 0302 clinical medicine, Germline mutation, Breast cancer, medicine, Missense mutation, Humans, Genetic Predisposition to Disease, CHEK2, Gene, Germ-Line Mutation, Aged, Czech Republic, Sequence Deletion, Aged, 80 and over, Ovarian Neoplasms, Mutation, Middle Aged, medicine.disease, Checkpoint Kinase 2, Oncology, 030220 oncology & carcinogenesis, Case-Control Studies, Cancer research, Female, Ovarian cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e562181451ed0efce90310e998849c5
https://pubmed.ncbi.nlm.nih.gov/31050813

المؤلفون: Marianna Borecka, Jan Sevcik, Zdenek Kleibl, Petra Kleiblova, Marketa Janatova, Jana Soukupova, Pavel Soucek, Michal Vocka, Petra Zemankova

المصدر: Cancer Genetics. 209:199-204

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Genotype, endocrine system diseases, Family Cancer History, PALB2, DNA Mutational Analysis, Population, Biology, Bioinformatics, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, Pancreatic cancer, Genetics, medicine, Humans, Genetic Predisposition to Disease, education, Molecular Biology, Genotyping, Czech Republic, education.field_of_study, Mutation, Tumor Suppressor Proteins, Nuclear Proteins, Middle Aged, medicine.disease, digestive system diseases, Pancreatic Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, Fanconi Anemia Complementation Group N Protein, Carcinoma, Pancreatic Ductal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05506fe3bde4d4484536aebd76e83ff5
https://doi.org/10.1016/j.cancergen.2016.03.003

المؤلفون: Filip Lhota, Petra Kleiblova, Michal Vocka, Hana Hartmannová, Petra Zemankova, Marketa Janatova, Jana Soukupova, Zdenek Kleibl, Katerina Hodanova, Stanislav Kmoch, Viktor Stranecky

المصدر: Clinical Genetics. 90:324-333

مصطلحات موضوعية: 0301 basic medicine, Genetics, Mutation, DNA repair, PALB2, Biology, medicine.disease_cause, medicine.disease, BRCA2 Protein, Frameshift mutation, 03 medical and health sciences, 030104 developmental biology, Breast cancer, medicine, FANCL, Gene, Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d7e3ebe051e527d2d31939da7742526d
https://doi.org/10.1111/cge.12748

المؤلفون: René H. Medema, Jan Benada, Zdenek Kleibl, Jiri Bartek, Soňa Pecháčková, Libor Macurek, Indra A. Shaltiel, Jan evčík, Pavel Dundr, Petr Pohlreich, Emile E. Voest, Petra Kleiblova

المصدر: The Journal of Cell Biology

مصطلحات موضوعية: Cell cycle checkpoint, DNA damage, Biology, medicine.disease_cause, Germline, 03 medical and health sciences, 0302 clinical medicine, Report, Cell Line, Tumor, Neoplasms, Phosphoprotein Phosphatases, medicine, Humans, Genetic Predisposition to Disease, Research Articles, 030304 developmental biology, 0303 health sciences, Mutation, Oncogene, Cell Cycle, G1 Phase, Cancer, Cell Biology, Cell cycle, medicine.disease, 3. Good health, Gene Expression Regulation, Neoplastic, Protein Phosphatase 2C, 030220 oncology & carcinogenesis, MCF-7 Cells, Cancer research, Tumor Suppressor Protein p53, Carcinogenesis, DNA Damage, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7469f6ecf3104d7bee39c28c98128d6
https://doi.org/10.1083/jcb.201210031

المؤلفون: Steffen Emmert, Holger Thiele, Evelin Schröck, Eva Machackova, Karl Hackmann, Steffen Schubert, Filip Lhota, Luisa Mackenroth, Barbara Klink, Andreas Rump, Janin Lehmann, Romy Opitz, Karin Kast, Elitza Betcheva-Krajcir, Anna Benet-Pagès, Jan Dominik Kuhlmann, Petra Zemankova, Pauline Wimberger, Zdenek Kleibl, Nataliya DiDonato, Elke Holinski-Feder, Anke M. Nissen, Ramūnas Janavičius, Lenka Foretova

المساهمون: Eng, Charis

المصدر: PLoS Genetics
PLoS Genetics, Vol 12, Iss 8, p e1006248 (2016)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, DNA Repair, Breast cancer, Frameshift mutation, Mutation databases, Ovarian cancer, DNA transcription, DNA repair, Luciferase, Mutation, medicine.disease_cause, Biochemistry, Database and Informatics Methods, 0302 clinical medicine, Breast Tumors, Medicine and Health Sciences, Missense mutation, Frameshift Mutation, Genetics (clinical), Genetics, Ovarian Neoplasms, 3. Good health, Ovarian Cancer, Enzymes, Nucleic acids, Oncology, 030220 oncology & carcinogenesis, Female, Oxidoreductases, Research Article, Heterozygote, lcsh:QH426-470, Mutation, Missense, Breast Neoplasms, Biology, Research and Analysis Methods, 03 medical and health sciences, Germline mutation, Breast Cancer, medicine, Humans, Genetic Predisposition to Disease, Molecular Biology, Gene, Ecology, Evolution, Behavior and Systematics, Germ-Line Mutation, Xeroderma Pigmentosum Group D Protein, Biology and Life Sciences, Cancers and Neoplasms, Proteins, DNA, medicine.disease, lcsh:Genetics, 030104 developmental biology, Biological Databases, Mutation Databases, Enzymology, ERCC2, Gene expression, Gynecological Tumors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d68649e05d32f95dc4e1e4c86e62db
https://pubmed.ncbi.nlm.nih.gov/27504877

المؤلفون: Filip Lhota, Marketa Janatova, Michal Vocka, Ivana Tichá, Zdenek Kleibl, Marianna Borecka, Petra Kleiblova, Petra Zemankova, Jana Soukupova, Pavel Soucek

المصدر: Gene. 587(2)

مصطلحات موضوعية: 0301 basic medicine, Male, Poor prognosis, Pancreatic ductal adenocarcinoma, endocrine system diseases, medicine.medical_treatment, Cell Cycle Proteins, Biology, Adenocarcinoma, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, Genetics, medicine, Humans, Genetic Predisposition to Disease, Allele, Gene, Chemotherapy, Mutation, Nuclear Proteins, General Medicine, Middle Aged, medicine.disease, digestive system diseases, Pedigree, Czechoslovakia, Pancreatic Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Female, Deleterious mutation, Gene Deletion, Carcinoma, Pancreatic Ductal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76272c6d38d5007cec68a40ce4f03b94
https://pubmed.ncbi.nlm.nih.gov/27150568

المؤلفون: Eva Machackova, Marketa Janatova, Petr Pohlreich, Jan Novotny, Lenka Foretova, Jana Soukupova, Zdenek Kleibl, Spiros Tavandzis, Ondrej Havranek, Stanislav Kormunda

المصدر: Journal of Cancer Research and Clinical Oncology. 137:331-338

مصطلحات موضوعية: Adult, Heterozygote, Cancer Research, medicine.medical_specialty, Genotype, Genes, BRCA2, Genes, BRCA1, Breast Neoplasms, Biology, Risk Assessment, Nuclear Receptor Coactivator 3, Continuous variable, Exon, Breast cancer, Risk Factors, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, In patient, Gene, Aged, Czech Republic, Proportional Hazards Models, Aged, 80 and over, Genetics, Polymorphism, Genetic, Hematology, General Medicine, Middle Aged, medicine.disease, Survival Analysis, Oncology, Mutation, Female, Lifetime risk, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efba410b01730a4e1f786bb687fdff78
https://doi.org/10.1007/s00432-010-0889-5