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المؤلفون: Donald B. Kimmel, E.J. Castillo, José Aguirre, J.M. Jiron, N. Bhattacharyya, C. Van Poznak, Jonathan G. Messer, J.L. Mendieta Calle
المصدر: Bone
مصطلحات موضوعية: medicine.medical_specialty, Histology, Physiology, Endocrinology, Diabetes and Metabolism, Dose dependence, Toxicology, Osteocytes, Zoledronic Acid, Gastroenterology, Article, Lesion, 03 medical and health sciences, 0302 clinical medicine, Localized periodontitis, Internal medicine, Prevalence, medicine, Animals, Femur, Sigmodontinae, Bone Resorption, Periodontitis, Oryzomys, 2. Zero hunger, Dose-Response Relationship, Drug, biology, business.industry, Body Weight, Anti-resorptives, 030206 dentistry, medicine.disease, biology.organism_classification, 3. Good health, Dose–response relationship, Duration, Treatment Outcome, Zoledronic acid, 030220 oncology & carcinogenesis, Bisphosphonate-Associated Osteonecrosis of the Jaw, Female, medicine.symptom, Osteonecrosis of the jaw, business, medicine.drug
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المؤلفون: Donald B. Kimmel
المصدر: Molecular and Integrative Toxicology ISBN: 9783319561905
مصطلحات موضوعية: 0301 basic medicine, Calcium metabolism, Bone growth, Osteoporosis, 030209 endocrinology & metabolism, Biology, medicine.disease, Osteopenia, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Bone cell, medicine, WHOLE ANIMAL, Neuroscience, Bone mass
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bb9058a14aeb4e032401d8ed9e685782
https://doi.org/10.1007/978-3-319-56192-9_4 -
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المؤلفون: Pascale V. Nantermet, Thomayant Prueksaritanont, William J. Ray, James J. Perkins, Chih-Tai Leu, Fang Chen, Azriel Schmidt, Mark E. Duggan, Viera Kasparcova, Sharon Adamski, Donald B. Kimmel, Leonard P. Freedman, SuJane Rutledge, T. Cusick, Brenda L Pennypacker, George D. Hartman, Jiabing Wang, P. Masarachia, Meissner Robert S, Shun-ichi Harada, Paul Hodor, Robert L. Vogel, Chang Bai, Hai-Zhuan Zhang, Sheila McElwee-Witmer, Helen J. Mitchell, Michael A. Gentile, Evan E. Opas, Angela Scafonas, Yuntae Kim
المصدر: Journal of Biological Chemistry. 285:17054-17064
مصطلحات موضوعية: Male, Transcriptional Activation, Agonist, medicine.medical_specialty, Transcription, Genetic, medicine.drug_class, Steroid hormone receptor, Chemistry, Pharmaceutical, Receptors, Cytoplasmic and Nuclear, Biology, Ligands, Models, Biological, Biochemistry, Hormone Antagonists, Cell Line, Tumor, Internal medicine, Chlorocebus aethiops, Coactivator, medicine, Animals, Humans, Gene Regulation, Receptor, Molecular Biology, Cell Biology, Androgen, Protein Structure, Tertiary, Rats, Cell biology, Androgen receptor, Endocrinology, Nuclear receptor, Selective androgen receptor modulator, Receptors, Androgen, Azasteroids, Drug Design, COS Cells, Androgens, Female, Steroids
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c9fd8a36b1708c44fd44519c66c7a
https://doi.org/10.1074/jbc.m109.099002 -
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المؤلفون: Soumya P. Sahoo, Donald B. Kimmel, P. Masarachia, Pascale V. Nantermet, Meissner Robert S, Fang Chen, William J. Ray, Dwight A. Towler, Shun Ichi Harada, Chang Bai, Angela Scafonas, Mark E. Duggan, Brenda L Pennypacker, Su Jane Rutledge, Azriel Schmidt, Gideon A. Rodan, Sheila McElwee-Witmer, Robert L. Vogel, Michael A. Gentile, George D. Hartman, Yuntae Kim
المصدر: Journal of Biological Chemistry. 284:36367-36376
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, Anabolism, medicine.drug_class, medicine.medical_treatment, Biology, Biochemistry, Partial agonist, Anabolic Agents, Rats, Sprague-Dawley, Internal medicine, medicine, Animals, Transcription, Chromatin, and Epigenetics, Antigens, Viral, Tumor, Promoter Regions, Genetic, Receptor, Testosterone Congeners, Molecular Biology, Viral Core Proteins, Prostate, Cell Biology, Rats, Androgen receptor, Endocrinology, Nuclear receptor, Receptors, Androgen, Androgens, Androgen replacement therapy
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3561e1ddd1ac61e3162e944e8e5b8d4e
https://doi.org/10.1074/jbc.m109.049734 -
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المؤلفون: Serge Leger, Denis Deschenes, Chun Sing Li, Donald B. Kimmel, M. David Percival, Michel Therien, Mary E. McGrath, Robert Zamboni, Daniel J. McKay, Sevgi B. Rodan, Gregg Wesolowski, Denis Riendeau, W. Cameron Black, Jean-Pierre Falgueyret, Sylvie Desmarais, Frédéric Massé, Jacques Yves Gauthier, Vouy-Linh Truong
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1985-1989
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Isostere, Ovariectomy, Cathepsin K, Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Amide, Drug Discovery, Animals, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Biological activity, Cathepsins, Macaca mulatta, Cysteine protease, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Female
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المؤلفون: Peppi Prasit, James T. Palmer, Robert G. Strickley, M. David Percival, Liang Liu, Dan-Xiong Wang, Rohan Mendonca, Donald B. Kimmel, Leland C. Ii Burrill, Oballa Renata Marcella, Denis Riendeau, Colena Johnson, Tobee Chung, Young Robert N, Mary E. McGrath, John McCarter, Gregg Wesolowski, Michael C. Venuti, Eric B. Springman, Sevgi B. Rodan, Robert M. Rydzewski, James W. Janc, Bryant Clifford M, Z. Walter Yu, Harry Cheung, Eduardo L. Setti, Tian Zong-Qiang, Dana E. Davis, Jean-Pierre Falgueyret, Philip Enriquez, John R. Somoza, Gideon A. Rodan, Shankar Venkatraman
المصدر: Journal of Medicinal Chemistry. 48:7520-7534
مصطلحات موضوعية: Models, Molecular, Cathepsin K, Administration, Oral, Biological Availability, Crystallography, X-Ray, Bone resorption, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Nitriles, Drug Discovery, medicine, Animals, Humans, Bone Resorption, Benzamide, Bone Density Conservation Agents, Molecular Structure, biology, Chemistry, Cathepsins, Macaca mulatta, Rats, Resorption, Kinetics, Thiazoles, Mechanism of action, Biochemistry, Enzyme inhibitor, Drug Design, Benzamides, biology.protein, Ovariectomized rat, Molecular Medicine, Cattle, Collagen, Rabbits, medicine.symptom, Biomarkers
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المؤلفون: Azriel Schmidt, Shun Ichi Harada, William J. Ray, Donald B. Kimmel, P. Masarachia, Pascale V. Nantermet, Leonard P. Freedman, Daniel J. Holder, Michael A. Gentile, Dwight A. Towler, Brenda L Pennypacker, Jian Xu, David Gerhold
المصدر: Endocrinology. 146:564-578
مصطلحات موضوعية: Male, medicine.medical_specialty, Cell signaling, medicine.drug_class, Cellular differentiation, Gene Expression, Estrogen receptor, Biology, urologic and male genital diseases, Rats, Sprague-Dawley, Mice, Endocrinology, Internal medicine, Gene expression, medicine, Animals, Oligonucleotide Array Sequence Analysis, Estradiol, Uterus, Prostate, Cell Differentiation, Dihydrotestosterone, Genomics, Hypertrophy, Organ Size, Rats, Androgen receptor, Receptors, Androgen, Estrogen, Knockout mouse, Androgens, Female, Stromal Cells, Signal transduction, Cell Division, hormones, hormone substitutes, and hormone antagonists, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277aad9faf950575fc55d89351b722ce
https://doi.org/10.1210/en.2004-1132 -
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المؤلفون: Donald B. Kimmel, Steven L. Teitelbaum, Mary Beth Humphrey, Wei Yao, Xiaozhu Huang, Dean Sheppard, F. Patrick Ross, Mary C. Nakamura, Nancy E Lane
المصدر: Journal of Bone and Mineral Research. 20:58-66
مصطلحات موضوعية: medicine.medical_specialty, Integrin beta Chains, Endocrinology, Diabetes and Metabolism, Cathepsin K, Gene Expression, Osteoclasts, Biology, Bone resorption, Bone remodeling, Osteoclast maturation, Mice, Osteoclast, Internal medicine, medicine, Animals, Orthopedics and Sports Medicine, RNA, Messenger, Bone Resorption, Calcitonin receptor, Mice, Knockout, Cathepsin, Integrin alphaVbeta3, Integrin beta3, Cell Differentiation, Estrogens, Receptors, Calcitonin, Cathepsins, Endocrinology, medicine.anatomical_structure, Mutation, Female
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المؤلفون: Colena Johnson, James T. Palmer, Rohan Mendonca, Jean-Pierre Falgueyret, Renata Oballa, Gregg Wesolowski, M David Percival, Peppi Prasit, Cliff Bryant, Joël Robichaud, Eduardo South San Francisco Setti, Donald B. Kimmel, Shankar Venkatraman, Sevgi B. Rodan
المصدر: Journal of Medicinal Chemistry. 46:3709-3727
مصطلحات موضوعية: Time Factors, Nitrile, Stereochemistry, Cathepsin L, Ovariectomy, Cathepsin K, Osteoclasts, In Vitro Techniques, Bone and Bones, Collagen Type I, Piperazines, Cathepsin B, Structure-Activity Relationship, chemistry.chemical_compound, Cathepsin O, Osteoclast, Nitriles, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protease Inhibitors, Bone Resorption, Cathepsin, biology, Biphenyl Compounds, Stereoisomerism, Cathepsins, Macaca mulatta, Cysteine Endopeptidases, medicine.anatomical_structure, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Cattle, Collagen, Rabbits, Peptides, Biomarkers
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المؤلفون: Robert R. Recker, Donald B. Kimmel, Guodong Gong, Mark L. Johnson, William J. Kimberling, Susan M. Recker
المصدر: The American Journal of Human Genetics. 60(6):1326-1332
مصطلحات موضوعية: Adult, Genetic Markers, Male, Peak bone mass, Adolescent, Genotype, Bone density, Genetic Linkage, Biology, Polymerase Chain Reaction, Absorptiometry, Photon, Bone Density, Genetic linkage, Confidence Intervals, Genetics, Humans, Genetics(clinical), Allele, Genetics (clinical), Aged, Aged, 80 and over, Linkage (software), Chromosomes, Human, Pair 11, Chromosome Mapping, Chromosome, Syndrome, Middle Aged, Spine, Pedigree, Genetic marker, Osteoporosis, Female, Bone Diseases, Research Article