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المؤلفون: António Rego, Manuela Côrte-Real, Filipa Mendes, Vítor Costa, Susana R. Chaves
المساهمون: Instituto de Investigação e Inovação em Saúde
المصدر: Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevityمصطلحات موضوعية: Aging, Ceramide, Saccharomyces cerevisiae Proteins, Article Subject, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases, Cell fate determination, Mitochondrion, Biochemistry, chemistry.chemical_compound, Saccharomyces cerevisiae / metabolism, Acetic Acid, Saccharomyces cerevisiae Proteins / metabolism, QH573-671, Cell Death, biology, Chemistry, Endoplasmic reticulum, Cytochrome c, Mitochondria / metabolism, Cell Biology, General Medicine, Sphingolipid, Mitochondria, Acetic Acid / metabolism, Cell biology, Apoptosis, Protein Serine-Threonine Kinases / metabolism, biology.protein, Phosphorylation, Cytology, Research Article
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المؤلفون: Handoko, L., Kaczkowski, B., Hon, C. C., Lizio, M., Wakamori, M., Matsuda, T., Ito, T., Jeyamohan, P., Sato, Y., Sakamoto, K., Yokoyama, S., Kimura, Hiroshi, Minoda, A., Umehara, T.
المصدر: Epigenetics. 13(No. 4):410-431
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cage, Cancer Research, Lung Neoplasms, Histones, Mice, Lung Neoplasms/drug therapy/*genetics/metabolism, Carcinoma, Non-Small-Cell Lung, Transcriptional regulation, Histone code, Promoter Regions, Genetic, Azepines/*pharmacology, Triazoles/*pharmacology, Brd2, biology, Chemistry, Acetylation, Azepines, Chromatin, Cell biology, Jq1, Gene Expression Regulation, Neoplastic, Histone, Protein-Serine-Threonine Kinases/*metabolism, Transcription Initiation Site, Proto-Oncogene Proteins c-myc/genetics, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-myc, Histone H4, Chromatin/metabolism, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Enhancer, Molecular Biology, Transcription factor, Promoter Regions, Genetic/drug effects, Transcription Initiation Site/drug effects, Carcinoma, Non-Small-Cell Lung/drug therapy/*genetics/metabolism, Promoter, Triazoles, Acetylation/drug effects, Bromodomain, 030104 developmental biology, Histones/*chemistry/metabolism, Gene Expression Regulation, Neoplastic/drug effects, Bet, biology.protein, Cancer research, H4 hyperacetylation, Transcription Factors
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المؤلفون: Jennifer Röhrl, Zuzana Storchova, Stephan Gruber, Karolina Peplowska, Young-Min Soh, Frank Bürmann, Yehui Wu, Galal Yahya Metwaly
المصدر: PLoS genetics, vol. 16, no. 8, pp. e1008569
PLoS Genetics
PLoS Genetics, Vol 16, Iss 8, p e1008569 (2020)مصطلحات موضوعية: Cancer Research, Condensin, Amino Acid Motifs, Yeast and Fungal Models, QH426-470, Biochemistry, Spindle pole body, Chromosome segregation, 0302 clinical medicine, Medicine and Health Sciences, 570 Biowissenschaften, Biologie, Drug Interactions, Protein Phosphatase 2, Cell Cycle and Cell Division, Phosphorylation, Post-Translational Modification, Genetics (clinical), Adenosine Triphosphatases, Centromeres, 0303 health sciences, biology, Kinetochore, Chromosome Biology, Nuclear Proteins, Eukaryota, Cell biology, DNA-Binding Proteins, Spindle checkpoint, Experimental Organism Systems, Cell Processes, Protein Binding, Research Article, Chromosome Structure and Function, Saccharomyces cerevisiae Proteins, Biorientation, Centromere, Immunoblotting, Molecular Probe Techniques, Mitosis, Saccharomyces cerevisiae, macromolecular substances, Protein Serine-Threonine Kinases, Research and Analysis Methods, Chromosomes, 03 medical and health sciences, Condensin complex, Saccharomyces, Model Organisms, ddc:570, Genetics, Molecular Biology Techniques, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Adenosine Triphosphatases/metabolism, Centromere/metabolism, DNA-Binding Proteins/metabolism, Multiprotein Complexes/metabolism, Nuclear Proteins/chemistry, Nuclear Proteins/genetics, Nuclear Proteins/metabolism, Protein Phosphatase 2/metabolism, Protein Serine-Threonine Kinases/metabolism, Saccharomyces cerevisiae Proteins/chemistry, Saccharomyces cerevisiae Proteins/genetics, Saccharomyces cerevisiae Proteins/metabolism, Pharmacology, Cohesin, Organisms, Fungi, Biology and Life Sciences, Proteins, Cell Biology, Yeast, Spindle apparatus, Multiprotein Complexes, biology.protein, Animal Studies, 030217 neurology & neurosurgery
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5c1836a69091431c807a715b7af139
https://serval.unil.ch/resource/serval:BIB_D23C2314CE14.P001/REF.pdf -
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المؤلفون: Jawahar Kopparam, Mauro Delorenzi, Etienne Meylan, Paolo Angelino, Nadine Zangger, Alessandra Piersigilli, Johanna Chiffelle
المصدر: Cell death and differentiation, vol. 24, no. 10, pp. 1761-1771
Cell Death and Differentiationمصطلحات موضوعية: STAT3 Transcription Factor, 0301 basic medicine, Original Paper, Gene knockdown, biology, Adenocarcinoma/metabolism, Cell Differentiation/physiology, Genes, ras/genetics, Humans, Lung Neoplasms/metabolism, Phosphorylation, Protein-Serine-Threonine Kinases/metabolism, Signal Transduction/physiology, Cancer, Lysyl oxidase, Cell Biology, medicine.disease, Proto-Oncogene Proteins p21(ras), Extracellular matrix, 03 medical and health sciences, 030104 developmental biology, HMGA2, Neoplasms, Extracellular, medicine, biology.protein, Cancer research, Adenocarcinoma, Lung cancer, Molecular Biology
وصف الملف: application/pdf
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المؤلفون: Florence Cordier, Nicolas Wolff, Henri Buc, Bertrand Raynal, Elouan Terrien, Muriel Delepierre, Alain Chaffotte, Florent Delhommel
المساهمون: Résonance Magnétique Nucléaire des Biomolécules, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Cellule Pasteur UPMC, Institut Pasteur [Paris]-Sorbonne Université (SU), Biophysique Moléculaire (Plate-forme), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris], This work was supported by the Institut Pasteur and Institut Carnot Pasteur Maladies Infectieuses [grant number 13/10/120], and the Ministère de l’Enseignement Supérieur [grant number 883/2013 (to F.D.)]., We thank Jane Hardy and Terence Strick for careful proofreading of the manuscript and Patrick England for valuable discussions., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Sorbonne Université (SU), Institut Pasteur [Paris] (IP)
المصدر: Biochemical Journal
Biochemical Journal, Portland Press, 2015, 469 (1), pp.159-168. ⟨10.1042/BJ20141198⟩
Biochemical Journal, 2015, 469 (1), pp.159-168. ⟨10.1042/BJ20141198⟩مصطلحات موضوعية: Scaffold protein, MESH: Protein Structure, Quaternary, [SDV]Life Sciences [q-bio], Peptide binding, MESH: Protein Multimerization, Biochemistry, MESH: Protein Structure, Tertiary, MESH: Protein-Serine-Threonine Kinases / metabolism, 0302 clinical medicine, MESH: Nuclear Magnetic Resonance, Biomolecular, Tensin, MESH: Rabies virus / metabolism, MESH: Viral Proteins / chemistry, pre-steady-state kinetics, 0303 health sciences, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], biology, MESH: Molecular Dynamics Simulation, Cell biology, DLG1, Microtubule-Associated Proteins, Protein Binding, PDZ domain, MESH: Rabies virus / chemistry, protein–protein interactions, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, MESH: Protein-Serine-Threonine Kinases / chemistry, Viral Proteins, 03 medical and health sciences, MESH: Microtubule-Associated Proteins / chemistry, Humans, MESH: Protein Binding, PTEN, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein Structure, Quaternary, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, Protein kinase B, 030304 developmental biology, Serine/threonine-specific protein kinase, MESH: Humans, PDZ domains, Cell Biology, MESH: Viral Proteins / metabolism, Protein Structure, Tertiary, MESH: Microtubule-Associated Proteins / metabolism, Rabies virus, intradomain energetic connectivity, biology.protein, sense organs, Protein Multimerization, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4686c21e9c3b7509080eb7a4c0a244
https://doi.org/10.1042/bj20141198 -
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المؤلفون: David G. Schatz, Iannis Aifantis, Panagiotis Ntziachristos, Mariann Micsinai, Joy M. H. Wang, Ludovic Deriano, Yuval Kluger, Jeffrey A. Jeddeloh, Elphège P. Nora, Matthew Rodesch, Julie Chaumeil, Yanhong Ji, Jane A. Skok
المساهمون: New York University School of Medicine (NYU), New York University School of Medicine, NYU System (NYU)-NYU System (NYU), Développement lymphocytaire et Oncogénèse, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Génétique et Biologie du Développement, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Roche NimbleGen Inc., Yale Cancer Center, Yale School of Medicine [New Haven, Connecticut] (YSM), Yale University [New Haven], Howard Hughes Medical Institute (HHMI), This work is supported by the National Institute ofHealth: R01GM086852 (to J.A.S.), R37AI32524 (to D.G.S.), RO1CA133379,RO1CA105129, RO1CA149655, and RO1GM088847 (to I.A.). J.A.S. is aLeukemia & Lymphoma Society (LLS) scholar. J.C. is an Irvington Institute Fellow of the Cancer Research Institute. M.M. was supported by an NSFIGERT 0333389. L.D. was an LLS Fellow. E.P.N. was supported by the FrenchMinistry of Research and the Association pour la Recherche sur le Cancer(France). I.A. is also supported by the Leukemia & Lymphoma Society (TRPgrant), The V Foundation for Cancer Research, and the Dana Foundation.D.G.S. is an Investigator, and I.A. is an Early Career Scientist of the HowardHughes Medical Institute. The authors from Roche NimbleGen, Inc. (M.J.R.and J.A.J.) recognize a competing interest in this publication as employeesof the company., Lassailly-Bondaz, Anne, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Yale University School of Medicine
المصدر: Cell Reports
Cell Reports, 2013, 3 (2), pp.359-70. ⟨10.1016/j.celrep.2013.01.024⟩
CELL REPORTS
Cell Reports, Vol 3, Iss 2, Pp 359-370 (2013)
Cell Reports, Elsevier Inc, 2013, 3 (2), pp.359-70. ⟨10.1016/j.celrep.2013.01.024⟩مصطلحات موضوعية: Genome instability, MESH: V(D)J Recombination, Ataxia Telangiectasia Mutated Proteins, Inbred C57BL, MESH: Mice, Knockout, Tumor Suppressor Proteins/metabolism, Mice, 0302 clinical medicine, Transcription (biology), Receptors, Recombinase, Medicine and Health Sciences, MESH: Animals, MESH: Ataxia Telangiectasia Mutated Proteins, lcsh:QH301-705.5, DNA-Binding Proteins/genetics/*metabolism, Genetics, MESH: Histones, 0303 health sciences, MESH: Mice, Inbred CBA, MESH: Receptors, Antigen, T-Cell, alpha-beta, biology, MESH: Genomic Instability, V(D)J recombination, Protein-Serine-Threonine Kinases/metabolism, Chromatin, alpha-beta/genetics/*metabolism, Histone, Antigen, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Cell Nucleus, [SDV.IMM] Life Sciences [q-bio]/Immunology, Knockout, Cleavage (embryo), DNA-binding protein, MESH: Genetic Loci, General Biochemistry, Genetics and Molecular Biology, Genomic Instability, MESH: Protein-Serine-Threonine Kinases, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Mice, Inbred C57BL, MESH: Homeodomain Proteins, Homeodomain Proteins/genetics/*metabolism, Animals, MESH: Tumor Suppressor Proteins, MESH: Mice, Alleles, 030304 developmental biology, MESH: DNA Damage, Histones/genetics, Cell Cycle Proteins/metabolism, MESH: Alleles, Inbred CBA, Biology and Life Sciences, T-Cell, lcsh:Biology (General), Genetic Loci, Cell Nucleus/metabolism, biology.protein, 030217 neurology & neurosurgery, MESH: DNA-Binding Proteins, V(D)J Recombination, DNA Damage
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المؤلفون: Kelly, A. E., Ghenoiu, C., Xue, J. Z., Zierhut, C., Kimura, Hiroshi, Funabiki, H.
المصدر: Science. 330:235-239
مصطلحات موضوعية: Histones/*metabolism, Mitosis, Xenopus Proteins/chemistry/*metabolism, Molecular Sequence Data, Aurora B kinase, Chromosomal Proteins, Non-Histone/metabolism, macromolecular substances, Biology, Article, Chromatin/metabolism, Xenopus laevis, Histone H3, Aurora Kinases, Animals, Protein Interaction Domains and Motifs, Phosphorylation, Kinase activity, Chromosomes/*metabolism, Spindle Apparatus/metabolism, Multidisciplinary, Molecular biology, Spindle apparatus, Enzyme Activation, enzymes and coenzymes (carbohydrates), Histone, Histone phosphorylation, Chromosome passenger complex, Centromere/metabolism, biology.protein, Protein-Serine-Threonine Kinases/*metabolism, Aurora Kinase B, Threonine/metabolism, Cell Division, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85bfa8fb568dc0ce377e4f2b6610b5f
https://doi.org/10.1126/science.1189505 -
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المؤلفون: Yin Xu, Ivan Stamenkovic, Qin Yu
المصدر: Cancer Research, vol. 70, no. 6, pp. 2455-2464
مصطلحات موضوعية: Cancer Research, Recombinant Fusion Proteins, medicine.medical_treatment, Apoptosis, Cell Growth Processes, Protein Serine-Threonine Kinases, Article, Targeted therapy, Mice, Downregulation and upregulation, Cancer stem cell, Glioma, Chlorocebus aethiops, medicine, Animals, Humans, RNA, Small Interfering, Hippo signaling pathway, biology, Brain Neoplasms, CD44, Antigens, CD44/biosynthesis, Antigens, CD44/genetics, Apoptosis/physiology, Brain Neoplasms/drug therapy, Brain Neoplasms/genetics, COS Cells, Cell Growth Processes/physiology, Cercopithecus aethiops, Glioblastoma/drug therapy, Glioblastoma/genetics, Immunoglobulin Fc Fragments/genetics, Immunoglobulin Fc Fragments/pharmacology, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins c-met/metabolism, RNA, Small Interfering/genetics, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/isolation & purification, Signal Transduction, Up-Regulation, Proto-Oncogene Proteins c-met, medicine.disease, nervous system diseases, Immunoglobulin Fc Fragments, Hyaluronan Receptors, Oncology, Cancer cell, biology.protein, Cancer research, Signal transduction, Glioblastoma
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a24c9cee259d8d91ac4f279cecd33b
https://doi.org/10.1158/0008-5472.can-09-2505 -
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المؤلفون: Marcel Mettlen, Costin N. Antonescu, Miriam Carolin Stoeber, Gaudenz Danuser, Dinah Loerke, Sandra L. Schmid
المصدر: Molecular Biology of the Cell, Vol. 20, No 14 (2009) pp. 3251-3260
مصطلحات موضوعية: Small Interfering/metabolism, Green Fluorescent Proteins, Endocytic cycle, Monomeric Clathrin Assembly Proteins/metabolism, Monomeric Clathrin Assembly Proteins, Protein Serine-Threonine Kinases, Endocytosis, Clathrin, Cell Line, Vesicular Transport/metabolism, Calcium-Binding Proteins/metabolism, Calcium-binding protein, Animals, RNA, Small Interfering, Molecular Biology, Green Fluorescent Proteins/metabolism, Dynamin, biology, Calcium-Binding Proteins, Clathrin/metabolism, Adaptor Proteins, Signal transducing adaptor protein, Coated Pits, Cell-Membrane, Cell-Membrane/enzymology/metabolism, Articles, Protein-Serine-Threonine Kinases/metabolism, Cell Biology, Rats, Cell biology, Adaptor Proteins, Vesicular Transport, Phenotype, Coated Pits, Membrane curvature, biology.protein, RNA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5450b49444cc1069c8fa74f5782228
https://doi.org/10.1091/mbc.e09-03-0256 -
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المؤلفون: Peter Huypens, Erik Quartier, Daniel Pipeleers, Mark Van de Casteele
المساهمون: Medical Biochemistry, Pathologic Biochemistry and Physiology
المصدر: European Journal of Pharmacology. 518:90-95
مصطلحات موضوعية: RNA, Messenger/genetics, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Gene Expression, AMP-Activated Protein Kinases, Phenformin, Chromans/pharmacology, chemistry.chemical_compound, AMP-activated protein kinase, Metformin/pharmacology, Adipocyte, Adipocytes, Ribonucleotides/pharmacology, Multienzyme Complexes/metabolism, Phenformin/pharmacology, Thiazolidinediones/pharmacology, biology, Adipocytes/cytology, Protein-Serine-Threonine Kinases/metabolism, Culture Media, Conditioned/metabolism, Glucose/pharmacology, Metformin, Tumor Necrosis Factor-alpha/pharmacology, Intercellular Signaling Peptides and Proteins, Enzyme Activation/drug effects, medicine.drug, medicine.medical_specialty, Intercellular Signaling Peptides and Proteins/genetics, mice, Blotting, Western, Gene Expression/drug effects, Protein Serine-Threonine Kinases, Hypoglycemic Agents/pharmacology, Troglitazone, Multienzyme Complexes, 3T3-L1 Cells, Aminoimidazole Carboxamide/analogs & derivatives, Internal medicine, medicine, Hypoglycemic Agents, Animals, RNA, Messenger, Chromans, Protein kinase A, Pharmacology, adiponectin, Dose-Response Relationship, Drug, Adiponectin, Tumor Necrosis Factor-alpha, nutritional and metabolic diseases, AMPK, Ribonucleotides, Aminoimidazole Carboxamide, Blotting, Northern, Enzyme Activation, Glucose, Endocrinology, chemistry, Culture Media, Conditioned, biology.protein, Thiazolidinediones
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