المؤلفون: Ewa Wysocka, Edyta Fatyga, Karolina Wyszomirska, Sylwia Dzięgielewska-Gęsiak, Małgorzata Muc-Wierzgoń

المصدر: Science progress. 104(2)

مصطلحات موضوعية: medicine.medical_specialty, Adipose tissue, 030204 cardiovascular system & hematology, medicine.disease_cause, Antioxidants, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Resistin, 030304 developmental biology, Aged, Metabolic Syndrome, 0303 health sciences, Multidisciplinary, business.industry, Superoxide Dismutase, Oxidant antioxidant, medicine.disease, Oxidants, Endocrinology, Glucose, Metabolic syndrome, business, Oxidative stress, Biomarkers, Hormone

الوصف: In elderly, hormones and oxidant-antioxidant interplay are suggested to mediate biochemical balance between adipose tissue to other tissues. Thus the study attempts to explore metabolic traits, plasma resistin, and oxidant-antioxidant markers in metabolic syndrome (MetS) in comparison to non-metabolic syndrome (non-MetS) elderly individuals. A total of 541 healthy elderly Caucasians, with no acute and/or chronic disorders were invited. After taking into account inclusion/exclusion criteria’s the MetS was defined as the presence of three out of five abnormal findings and allowed to divided groups into: non-metabolic syndrome, non-MetS ( n = 25, median age 69.0 years), and newly diagnosed MetS ( n = 29; median age 70.5 years) individuals. Glucose, plasma lipids, resistin (Res), thiobarbituric acid-reacting substances (TBARS), total antioxidant status (TAS), and Cu,Zn-superoxide dismutase (SOD-1) were measured. The MetS had higher resistin than non-MetS ( p 2 = 0.23; p 2 = 0.53; p = 0.0004) moreover in that group TAS correlated negatively with HDL-C (β = −0.71; R = 0.72; R 2 = 0.37; p = 0.01). While age correlated negatively with systolic blood pressure (β = −0.60; R = 0.62; R 2 = 0.14; p = 0.03) independently from other factors in the non-MetS group. Various metabolic factors contribute to maintain serum resistin and oxidant-antioxidant balance in the elderly people in the presence or absence of MetS. Resistin may serve as a predictor of MetS in the elderly, while strong antioxidant defense interactions in older individuals may indicate good health.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadfab171d57ae2bbbf7b2a244a5ff46
https://pubmed.ncbi.nlm.nih.gov/33913390