نتائج البحث - "CHILDHOOD epilepsy"

1

Probability of Remission of the Main Epileptic Syndromes in Childhood

المؤلفون: Gema Martínez-Espinosa, Julio Ramos-Lizana, Patricia Aguilera-López, Javier Aguirre-Rodriguez

المصدر: Journal of Child Neurology. 37:89-97

الوصف: Aim To determine the long-term probability of remission without antiepileptic treatment of common epileptic syndromes and of children without a specific syndromic diagnosis. Patients and methods All children less than 14 years old with 2 or more unprovoked seizures seen at our hospital between June 1, 1994, and March 1, 2011 (n = 680), were included and prospectively followed up until August 15, 2020. Syndromic diagnosis was made retrospectively but blinded to subsequent evolution, employing the data available at 6 months after diagnosis and under predefined operational criteria. Results The Kaplan-Meier estimate of the probability of achieving a remission period of at least 5 years, with neither seizures nor antiepileptic treatment at 14 years was 97% for well-defined childhood epilepsy with centrotemporal spikes, 82% for uncertain childhood epilepsy with centrotemporal spikes, 85% for well-defined Panayiotopoulos syndrome, 88% for uncertain Panayiotopoulos syndrome, 93% for nonfamilial self-limited infantile epilepsy, 100% for familial self-limited infantile epilepsy, 86% for absence epilepsy, 6% for juvenile myoclonic epilepsy, 71% for cryptogenic West syndrome, 72% for patients with no associated neurologic deficits and no specific syndromic diagnosis, 65% for symptomatic West syndrome, and 40% for patients with associated neurologic deficits and no specific syndromic diagnosis. Conclusions The study results highlight the long-term outcomes of the main epileptic syndromes and also of the patients with no syndromic diagnosis.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b535f6bddd71a569212d311bafbd19
https://doi.org/10.1177/08830738211056780

2

دورية

New Epilepsy Study Findings Recently Were Reported by Researchers at Department of Molecular Genetics (Scn1a Gene Mutations In Indian Children With Epilepsy: Single Center Experience).

المصدر: Pain & Central Nervous System Week; 10/23/2023, p740-740, 1p

مصطلحات موضوعية: EPILEPSY, CHILDREN with epilepsy, MOLECULAR genetics, CHILDHOOD epilepsy, GENETIC mutation, CENTRAL nervous system diseases, MOLECULAR diagnosis

مصطلحات جغرافية: TAMIL Nadu (India)

مستخلص: Tamil Nadu, India, Asia, Brain Diseases and Conditions, Business, Central Nervous System Diseases and Conditions, Epilepsy, Genetics, Health and Medicine Keywords: Tamil Nadu; India; Asia; Brain Diseases and Conditions; Business; Central Nervous System Diseases and Conditions; Epilepsy; Genetics; Health and Medicine EN Tamil Nadu India Asia Brain Diseases and Conditions Business Central Nervous System Diseases and Conditions Epilepsy Genetics Health and Medicine 740 740 1 10/24/23 20231023 NES 231023 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Fresh data on Central Nervous System Diseases and Conditions - Epilepsy are presented in a new report. [Extracted from the article]

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3

A Review of the Selected and Newer Antiseizure Medications Used in Childhood Epilepsies

المؤلفون: Samata Singhi, Ajay Gupta

المصدر: Indian Journal of Pediatrics. 88:993-999

الوصف: There have been additions of newer antiseizure medications in the armamentarium of clinicians for the management of epilepsy. The newer antiseizure medications have advantages of better tolerability, lesser adverse effects, and minimal drug interactions in comparison with conventional antiseizure medications. However, high cost and availability are concerns. There are also peculiar pharmacokinetic and pharmacodynamic considerations for the pediatric age, particularly in the context of age-dependent electroclinical syndromes and precision-based medicine. This review attempts to provide a comprehensive and pragmatic update on newer antiseizure medications.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd250680b680c9e91e075129d92f2f2
https://doi.org/10.1007/s12098-021-03857-8

4

A Self-Limited Childhood Epilepsy as Co-Incidental in Cerebral Palsy

المؤلفون: An, Olga, Nagae, Lidia Mayumi, Winesett, Steven Parrish

المصدر: International Medical Case Reports Journal

الوصف: Olga An,1 Lidia Mayumi Nagae,2 Steven Parrish Winesett3 1Department of Childrenâs Diseases, Kazakhstanâs Medical University âKSPHâ - School of Public Health, Almaty, Kazakhstan; 2Department of Medical Imaging, Neuroradiology, Banner University Medical Center, Tucson, AZ, USA; 3Department of Pediatrics, Division of Pediatric Neurology, University of Florida, Gainesville, FL, USACorrespondence: Olga AnDepartment of Childrenâs Diseases, Kazakhstanâs Medical University âKSPHâ, 19 a, Utepov st., Almaty, KazakhstanTel +7 707 101-5023Email a.olga@ksph.kzBackground: Cerebral palsy is the most frequent motor disability in childhood and is associated with a higher incidence of seizure disorders. In many instances, it is recognized that motor difficulties, as well as seizures, are from the same underlying brain lesion. However, self-limited childhood epilepsies, being a common group of epilepsy syndromes, would be expected to occur in patients with cerebral palsy merely on chance association and be unrelated to the structural brain imaging abnormality causing the motor impairment. Differential diagnosis in this case is important determining the long-term prognosis and need for anticonvulsant treatment.Case Presentation: Here, we report two patients with cerebral palsy combined with epilepsy, whose age at onset, seizure semiology and electroclinical features were similar to children with self-limited childhood-specific seizure disorders (childhood epilepsy with centrotemporal spikes and Panayiotopoulos syndrome).Conclusion: These cases highlight the importance of comprehensive differential diagnosis of seizures in cerebral palsy. Co-existence of age-dependent focal epilepsies with an underlying brain pathology as white matter injury, not affecting the cerebral cortex, might take place in the case of children with impaired motor skills. With health systems increasingly utilizing clinical pathways, it is important to consider the possibility of a self-limited childhood epilepsy and avoid aggressive and unnecessary medication treatment in children with cerebral palsy.Keywords: childhood epilepsy with centrotemporal spikes, CECTS, Panayiotopoulos syndrome, cerebral palsy, white matter injury

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b3e62b178eb09b0378d6fc4a43c78b
https://doi.org/10.2147/imcrj.s315550

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5

High-frequency oscillations recorded with surface EEG in neonates with seizures

المؤلفون: Floor E. Jansen, Alexander C. van Huffelen, Lotte Noorlag, Nicole E.C. van Klink, Frans S. S. Leijten, Maryse A. van 't Klooster, Manon J.N.L. Benders, Kees P.J. Braun, Maeike Zijlmans, Linda S. de Vries

المصدر: Clinical Neurophysiology. 132:1452-1461

الوصف: Objective Neonatal seizures are often the first symptom of perinatal brain injury. High-frequency oscillations (HFOs) are promising new biomarkers for epileptogenic tissue and can be found in intracranial and surface EEG. To date, we cannot reliably predict which neonates with seizures will develop childhood epilepsy. We questioned whether epileptic HFOs can be generated by the neonatal brain and potentially predict epilepsy. Methods We selected 24 surface EEGs sampled at 2048 Hz with 175 seizures from 16 neonates and visually reviewed them for HFOs. Interictal epochs were also reviewed. Results We found HFOs in thirteen seizures (7%) from four neonates (25%). 5025 ictal ripples (rate 10 to 1311/min; mean frequency 135 Hz; mean duration 66 ms) and 1427 fast ripples (rate 8 to 356/min; mean frequency 298 Hz; mean duration 25 ms) were marked. Two neonates (13%) showed interictal HFOs (285 ripples and 25 fast ripples). Almost all HFOs co-occurred with sharp transients. We could not find a relationship between neonatal HFOs and outcome yet. Conclusions Neonatal HFOs co-occur with ictal and interictal sharp transients. Significance The neonatal brain can generate epileptic ripples and fast ripples, particularly during seizures, though their occurrence is not common and potential clinical value not evident yet.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267b67f26ac5f46c3a33844af692e72a
https://doi.org/10.1016/j.clinph.2021.02.400

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6

Effects of Ketogenic Diet on Some Immunological Parameters

المؤلفون: Fulla Kaydar Mohmad, Rojan G M Al-Allaff

المصدر: Pakistan Journal of Biological Sciences. 24:801-806

مصطلحات موضوعية: Adult, Male, Childhood epilepsy, Absolute number, Neutrophils, business.industry, medicine.medical_treatment, Significant difference, Healthy subjects, Physiology, Serum iga, medicine.disease, Weight range, Obesity, Case-Control Studies, Humans, Medicine, Female, Lymphocytes, Diet, Ketogenic, business, Agronomy and Crop Science, Ketogenic diet

الوصف: lt;bgt;Background and Objective:lt;/bgt; A well-established treatment for childhood epilepsy, the Ketogenic Diet (KD) is increasingly gaining acceptance as a preventative tool for obesity. The current study aims to compare the effects of a ketogenic diet on some of the immunological parameters among obese individuals and contrast them with non-obese individuals. This includes finding the absolute numbers of white blood cells and estimating the efficacy of phagocytic cells and serum IgA concentration.lt;bgt;Materials and Methods:lt;/bgt; Twenty healthy persons were chosen for the study, with an age range between 18-45 years, a weight range before the ketogenic diet of 80-115 kg and after the ketogenic diet 60-80 kg with a height range between 155-180 cm during a period between 8-16 weeks. Their daily food was composed of high fats (80%), moderate protein (15%) and small amounts of carbohydrates (5%). The control sample included twenty healthy subjects, their food consisted of different types of food carbohydrates (75-80%), proteins (10%) and fats (10%).lt;bgt;Results:lt;/bgt; The results showed a significant increase in the White Blood Cells (WBC) count in KD individuals. Additionally, no significant difference was noticed in the absolute number of neutrophils and lymphocytes. Conversely, a significant increase in the absolute number of monocytes was observed. Moreover, the study showed a significant decrease in IgA concentration in KD individuals compared with control.lt;bgt;Conclusion:lt;/bgt; In the ketogenic system users indicated a rise in the number of monocytes and a decrease in the concentration of IgA. This provides a strong sign that autoimmune disorders are emerging.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b379bd4f32607e6ecf0d4e5643053534
https://doi.org/10.3923/pjbs.2021.801.806

7

Hyperventilation maneuver during EEG in children with epilepsy after the COVID‐19 pandemic. Is a routine procedure necessary?

المؤلفون: Loreto Ríos-Pohl, Macarena Franco, Magdalena Gonzalez

المصدر: Epilepsia Open, Vol 6, Iss 2, Pp 437-442 (2021)
Epilepsia Open

مصطلحات موضوعية: Male, clinical seizure, generalized epileptiform discharges, Pediatrics, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), hyperventilation, Diagnostic Techniques, Neurological, Electroencephalography, Preliminary Report, Sensitivity and Specificity, absence childhood epilepsy, Epilepsy, Ambulatory care, Seizures, Hyperventilation, Ambulatory Care, medicine, Humans, Chile, COVID‐19, SARS‐CoV‐2, EEG activation, Child, RC346-429, Retrospective Studies, Ambulatory electroencephalogram, medicine.diagnostic_test, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, medicine.disease, Epilepsy, Absence, Neurology, Ambulatory, Female, Neurology (clinical), Neurology. Diseases of the nervous system, medicine.symptom, business

الوصف: Objective Hyperventilation (HV) is one of the main and basic activation methods during ambulatory electroencephalogram (EEG), unless medical reasons contraindicate it. During the COVID‐19 pandemic, with the high risk of human‐to‐human infection, local guidelines and recommendations have been developed that suggest not to perform the HV maneuver routinely. Our objective was to characterize patients who present positive HV in an epilepsy center. Methods We analyzed retrospectively all the ambulatory EEGs performed during one year in our specialized ambulatory child and adolescent epilepsy center, and describe patients with positive maneuver. Results A total of 305 EEGs were performed. Patients under 3 years and 11 months were excluded as well as all patients that did not fill up the criteria for epilepsy diagnosis. From the 252 EEGs that were included in the study, 194 EEGs (77%) were classified as abnormal and 58 (23%) as normal. From these same 252 EEGs, 150 EEG finished correctly the HV maneuver. Physiological slowing response was found in 54 EEGs (36%), no changes (negative) in 83 (55%), and abnormal response (positive) in 13 EEGs (9%). The 13 HV‐positive EEGs showed 4 patients with an increase of epileptiform activity, 3 patients experienced an increase of basal preregistered abnormal slowing, and 6 EEGs showed trigger of bilaterally synchronous and symmetric 2‐4 Hz spike‐and‐slow wave discharges and absences. None of these last 6 patients needed more than 3 minutes to elicit the paroxysmal discharge. Significance Based on these findings and according with other studies, the low positivity and high specificity of the HV maneuver support the idea that HV could be excluded during the COVID‐19 pandemic situation, and also reevaluate whether it could be changed to a complementary maneuver, restricted only for cases where absence epilepsy is suspected. Larger studies will be needed to reaffirm this proposal.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b516b602f2fd30053346da2bf321cb
https://doaj.org/article/c7cf5534a98b4debbc78e69723dde7d9

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8

Refractory status epilepticus – a major problem for the practitioners

المؤلفون: Cornelia Calcii, Svetlana Hadjiu, Mariana Sprincean, Ludmila Feghiu, Nadejda Lupusor, Ninel Revenco, Stanislav Groppa

المصدر: The Moldovan Medical Journal, Vol 64, Iss 2, Pp 12-15 (2021)

مصطلحات موضوعية: medicine.medical_specialty, Refractory, business.industry, refractory status epilepticus, childhood epilepsy, medicine, cns infection, Medicine, Status epilepticus, medicine.symptom, Intensive care medicine, business

الوصف: Introduction: Status epilepticus (SE) is a life-threatening neurological emergency requiring immediate medical intervention and is associated with high mortality and morbidity. The aim of this research was evaluation of clinical and etiological profile of refractory status epilepticus (RSE) among children aged between 1 month and 18 years. Material and methods: The study was done between January 1, 2017 and December 24, 2019. All children with the age limits mentioned above, who presented convulsive SE, subsequently with development in refractory status epileptic (RSE), were included in the study. Patients were investigated and evaluated according to a standard protocol. Subsequently, the characteristics of children with RSE and those without an evolution in RSE were compared. Results: 55 children, out of whom 32 boys with SE were enrolled in the study, of which 20 children (36%) developed RSE. Central nervous system (CNS) infections were the most common causes of SE and development of RSE (51% in SE and 53% in RSE, p > 0.05). Noncompliance of antiepileptic medication served as the second cause for evolution of RSE. The overall mortality rate was 10.9%, the chances of death in RSE (20%) being higher than in SE (5.7%). The unfavorable prognosis was seven times higher in children with RSE, compared to children who developed SE. Conclusions: In the management of CNS infections, pediatricians should be aware of the high risk of developing RSE. In addition, the possibility of developing RSE should be considered and promptly managed in an intensive care unit in order to reduce the risk of mortality and morbidity of this severe neurological condition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa679e1a8ef0e958ad540a7421d658c
https://doi.org/10.52418/moldovan-med-j.64-2.21.02

9

Evaluation of the Anxiety Level of Mothers of Children with Epilepsy during the COVID-19 Pandemic Period

المؤلفون: Deniz Yuksel, Ülkühan Öztoprak, Özge Kucur, Erhan Aksoy, Fatih Özdemir, Nesrin Ceylan, Sadettin Burak Acikel, Ergin Cucu, Halil Çelik

المصدر: European Neurology

الوصف: Background and Aim: Although anyone can be affected by the COVID-19 pandemic, it may cause additional concern for people with chronic conditions. Epilepsy is the most common neurological disease in childhood and adolescence. The aim of this study was to determine anxiety levels among the mothers of children under follow-up for epilepsy in our clinic during the COVID-19 pandemic. Methods: The study group consisted of the mothers of epilepsy patients who were under follow-up in the pediatric neurology outpatient clinic of the tertiary care center and were scheduled for a routine examination during the COVID-19 pandemic. The mothers’ anxiety levels according to the Beck Anxiety Inventory and their opinions about COVID-19 in relation to their child were assessed and compared based on whether the mother/patient attended their appointments in person and whether the child had frequent or infrequent seizures. Results: There was no statistically significant difference in anxiety level between the mothers of 64 children with epilepsy who attended their appointment during the pandemic and those of the mothers of 52 who did not attend their appointment. However, the mothers of children with frequent seizures had significantly higher anxiety levels. Conclusion: Anxiety level of mothers whose children have frequent seizures was significantly higher compared to mothers whose children have infrequent seizures. It is important to be aware about this point and using telemedicine approach in suitable population and postpone routine outpatient follow-up appointments as much as possible.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17aaa1737fe6734f22b899be0a5be24
http://europepmc.org/articles/PMC8089456

10

Clinical Profile and Prediction of Response to Treatment in Childhood Epilepsy - A Single-Centre Experience from Eastern India

المؤلفون: Gautam Ganguly, Prakash Chandra Ghosh, Debshankar Guin, Alak Pandit, Mitali Bera, Sananda Majumder, Arijit Roy, Punyabrata Barma

المصدر: Journal of Evidence Based Medicine and Healthcare, Vol 8, Iss 15, Pp 977-981 (2021)

مصطلحات موضوعية: Childhood epilepsy, medicine.medical_specialty, paediatric, business.industry, R5-130.5, clinical profile, Response to treatment, Eastern india, Single centre, General works, Family medicine, medicine, epilepsy, business

الوصف: BACKGROUND Though epilepsy remains a significant problem for children and adolescents in our country, studies delineating the clinical profile and response to treatment in childhood epilepsy are lacking. The current study was carried out for obtaining a baseline profile and to predict the response to treatment in childhood epilepsy in India that may be helpful in planning management strategies from a public health point of view. METHODS Patients with clinical suggestion of active epilepsy (N = 141) from one month to 12 years, were enrolled into the study over a period of 1 year (February 2010 to January 2011) from the out-patient department and epilepsy clinic of Bangur Institute of Neurology. Detailed history was taken along with neurological examination. Electroencephalography (EEG) and neuroimaging (MRI / CT scan) were done on all patients. Each patient included in the study was kept in followup for a period of 6 months and their response to the treatment was recorded. RESULTS About 48.9 % (N = 69) patients had localisation related epilepsy while the rest had generalised epilepsy. Of those with generalised epilepsy, generalised tonicclonic seizures (GTCS) was by far the most common type. Of those with focal EEG activity, the highest proportion (50 %), were localised to the temporal lobe. Symptomatic aetiology accounted for 59.6 % (N = 84) of the patients. 20.6 % (N = 29) had poor response to treatment at 6 months follow-up. Abnormal neuroimaging (OR = 6.708) and abnormal EEG (OR = 6.357) were effective factors in predicting poor response to treatment. CONCLUSIONS Our study highlights the need to link specialised epilepsy services with primary health centres for early detection and treatment. EEG is an essential cost-effective modality in determining seizure localisation and response to treatment. KEYWORDS Paediatric, Epilepsy, Clinical Profile, Response to Treatment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67160d08d87f330d8a23c6221b39de89
https://jebmh.com/assets/data_pdf/Arjit_Roy--Issue_15--Mamatha--Rathna.pdf

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