المؤلفون: Yu H; Department of Pharmacology, University of Washington, Seattle, WA.; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau., Yuan C; Department of Pharmacology, University of Washington, Seattle, WA., Westenbroek RE; Department of Pharmacology, University of Washington, Seattle, WA., Catterall WA; Department of Pharmacology, University of Washington, Seattle, WA wcatt@uw.edu.

المصدر: The Journal of general physiology [J Gen Physiol] 2018 Jun 04; Vol. 150 (6), pp. 883-889. Date of Electronic Publication: 2018 May 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985110R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-7748 (Electronic) Linking ISSN: 00221295 NLM ISO Abbreviation: J Gen Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Calcium Channels, L-Type/*metabolism , LIM Domain Proteins/*metabolism, Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cells, Cultured ; Cyclic AMP-Dependent Protein Kinases/metabolism ; LIM Domain Proteins/genetics ; Mice ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/physiology ; Receptors, Adrenergic, beta/metabolism

المؤلفون: Yang L; Department of Pharmacology, University of Washington, Seattle, WA 98195., Dai DF; Department of Pathology, University of Washington, Seattle, WA 98195., Yuan C; Department of Pharmacology, University of Washington, Seattle, WA 98195., Westenbroek RE; Department of Pharmacology, University of Washington, Seattle, WA 98195., Yu H; Department of Pharmacology, University of Washington, Seattle, WA 98195., West N; Department of Biology, University of Washington, Seattle, WA 98195., de la Iglesia HO; Department of Biology, University of Washington, Seattle, WA 98195., Catterall WA; Department of Pharmacology, University of Washington, Seattle, WA 98195; wcatt@uw.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Dec 06; Vol. 113 (49), pp. E7976-E7985. Date of Electronic Publication: 2016 Nov 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Calcium Channels, L-Type/*genetics , Cardiomegaly/*genetics , Heart Failure/*genetics , Receptors, Adrenergic, beta/*metabolism, Animals ; Calcineurin/metabolism ; Calcium/metabolism ; Calcium Channels, L-Type/metabolism ; Calcium-Binding Proteins/metabolism ; Cardiomegaly/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Heart/physiopathology ; Heart Failure/metabolism ; Mice, Inbred C57BL ; Motor Activity ; Myocardial Contraction/genetics ; Myocytes, Cardiac/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism ; Troponin I/metabolism

المؤلفون: Dixon RE; Department of Physiology and Biophysics, University of Washington, Seattle, United States., Moreno CM; Department of Physiology and Biophysics, University of Washington, Seattle, United States., Yuan C; Department of Physiology and Biophysics, University of Washington, Seattle, United States., Opitz-Araya X; Department of Physiology and Biophysics, University of Washington, Seattle, United States., Binder MD; Department of Physiology and Biophysics, University of Washington, Seattle, United States., Navedo MF; Department of Pharmacology, University of California, Davis, Davis, United States., Santana LF; Department of Physiology and Biophysics, University of Washington, Seattle, United States.

المصدر: ELife [Elife] 2015 Feb 25; Vol. 4. Date of Electronic Publication: 2015 Feb 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Ion Channel Gating*, Calcium/*metabolism , Calcium Channels, L-Type/*metabolism , Calmodulin/*metabolism, Animals ; Calcium Channels, L-Type/genetics ; Calcium Signaling ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cell Line ; Cells, Cultured ; Fluorescence Resonance Energy Transfer ; Humans ; Markov Chains ; Membrane Potentials ; Mice, Inbred C57BL ; Microscopy, Fluorescence/methods ; Models, Biological ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/physiology ; Patch-Clamp Techniques ; Protein Binding ; Rabbits

المؤلفون: Drum BM; Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA., Dixon RE; Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA., Yuan C; Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA., Cheng EP; Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA., Santana LF; Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: santana@uw.edu.

المصدر: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2014 Jan; Vol. 66, pp. 63-71. Date of Electronic Publication: 2013 Nov 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE

مواضيع طبية MeSH: Calcium/*metabolism , Calcium Channels, L-Type/*metabolism , Heart Ventricles/*metabolism , Long QT Syndrome/*metabolism , Myocytes, Cardiac/*metabolism , Syndactyly/*metabolism, Action Potentials/physiology ; Animals ; Autistic Disorder ; Calcium Channels, L-Type/genetics ; Disease Models, Animal ; Excitation Contraction Coupling ; Gene Expression ; Heart Ventricles/pathology ; Long QT Syndrome/genetics ; Long QT Syndrome/pathology ; Mice ; Myocytes, Cardiac/pathology ; Sarcoplasmic Reticulum/metabolism ; Syndactyly/genetics ; Syndactyly/pathology

SCR Disease Name: Timothy syndrome

المؤلفون: Dixon RE; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA., Yuan C, Cheng EP, Navedo MF, Santana LF

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Jan 31; Vol. 109 (5), pp. 1749-54. Date of Electronic Publication: 2012 Jan 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Calcium Signaling*, Biopolymers/*metabolism , Calcium Channels, L-Type/*metabolism, Animals ; Calcium Channels, L-Type/genetics ; Heart Ventricles/metabolism ; Ion Channel Gating ; Mutation

المؤلفون: Cheng EP; Department of Physiology & Biophysics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA., Yuan C, Navedo MF, Dixon RE, Nieves-Cintrón M, Scott JD, Santana LF

المصدر: Circulation research [Circ Res] 2011 Jul 22; Vol. 109 (3), pp. 255-61. Date of Electronic Publication: 2011 Jun 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

مواضيع طبية MeSH: A Kinase Anchor Proteins/*genetics , Calcium Channels, L-Type/*genetics , Long QT Syndrome/*genetics , Long QT Syndrome/*physiopathology , Myocytes, Cardiac/*physiology , Syndactyly/*genetics , Syndactyly/*physiopathology, A Kinase Anchor Proteins/chemistry ; A Kinase Anchor Proteins/metabolism ; Action Potentials/physiology ; Age Factors ; Animals ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Arrhythmias, Cardiac/physiopathology ; Autistic Disorder ; Calcium/metabolism ; Calcium Channels, L-Type/chemistry ; Calcium Channels, L-Type/metabolism ; Cardiomegaly/genetics ; Cardiomegaly/metabolism ; Cardiomegaly/physiopathology ; Ion Channel Gating/physiology ; Long QT Syndrome/metabolism ; Mice ; Mice, Transgenic ; Myocardial Contraction/physiology ; Protein Interaction Domains and Motifs/physiology ; Syndactyly/metabolism

SCR Disease Name: Timothy syndrome

المؤلفون: Navedo MF; Department of Physiology & Biophysics, University of Washington-Seattle, 1705 NE Pacific Street, Seattle, WA 98195, USA., Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF

المصدر: Circulation research [Circ Res] 2010 Mar 05; Vol. 106 (4), pp. 748-56. Date of Electronic Publication: 2010 Jan 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

مواضيع طبية MeSH: Calcium Signaling*/drug effects , Ion Channel Gating*/drug effects, Calcium Channels, L-Type/*metabolism , Hypertension/*metabolism , Long QT Syndrome/*metabolism , Muscle, Smooth, Vascular/*metabolism , Myocytes, Cardiac/*metabolism , Myocytes, Smooth Muscle/*metabolism, A Kinase Anchor Proteins/genetics ; A Kinase Anchor Proteins/metabolism ; Animals ; Calcium Channels, L-Type/drug effects ; Calcium Channels, L-Type/genetics ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Calmodulin/metabolism ; Cells, Cultured ; Enzyme Activation ; Enzyme Activators/pharmacology ; Fluorescence Resonance Energy Transfer ; Humans ; Hypertension/genetics ; Hypertension/physiopathology ; Long QT Syndrome/genetics ; Long QT Syndrome/physiopathology ; Membrane Potentials ; Mice ; Mice, Knockout ; Microscopy, Confocal ; Muscle, Smooth, Vascular/drug effects ; Mutation ; Myocytes, Cardiac/drug effects ; Myocytes, Smooth Muscle/drug effects ; Patch-Clamp Techniques ; Protein Kinase C-alpha/genetics ; Protein Kinase C-alpha/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Structure, Tertiary ; Protein Transport ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Recombinant Fusion Proteins/metabolism ; Time Factors ; Transfection