المؤلفون: Kimberly A. Mace, Edward A. McKenzie, Andrew J.M. Boulton, Tanja Torbica, Frank L. Bowling, Hadeel Al Sadoun, Salma Alrdahe

المصدر: Alrdahe, S, Al Sadoun, H, Torbica, T, McKenzie, E A, Bowling, F L, Boulton, A J M & Mace, K A 2019, ' Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction ', PLoS One., vol. 14, no. 10, pp. e0223980 . https://doi.org/10.1371/journal.pone.0223980, https://doi.org/10.1371/journal.pone.0223980
PLoS ONE, Vol 14, Iss 10, p e0223980 (2019)
PLoS ONE

مصطلحات موضوعية: Male, Cellular differentiation, Up-Regulation/drug effects, Pathology and Laboratory Medicine, Biochemistry, Monocytes, Endocrinology, 0302 clinical medicine, Tumor Necrosis Factors/analysis, Animal Cells, Immune Response, Cells, Cultured, Innate Immune System, Antigens, CD/genetics, Up-Regulation, 3. Good health, RUNX1, Cytokines, Medicine, Tumor necrosis factor alpha, Cellular Types, Endocrine Disorders, Immune Cells, Science, Immunology, 03 medical and health sciences, Signs and Symptoms, Antigens, CD, Manchester Institute of Biotechnology, DNA-binding proteins, Diabetes Mellitus, Genetics, Humans, Blood Cells, Macrophages, Core Binding Factor Alpha 2 Subunit/genetics, Antigens, Differentiation, Myelomonocytic/genetics, Biology and Life Sciences, Proteins, Molecular Development, Regulatory Proteins, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, Culture Media, Conditioned, Case-Control Studies, Leukocytes, Mononuclear, Transcription Factors, Developmental Biology, 0301 basic medicine, Myeloid, Physiology, Gene Expression, Cell Maturation, White Blood Cells, chemistry.chemical_compound, Immune Physiology, Medicine and Health Sciences, Leukocytes, Mononuclear/cytology, Multidisciplinary, Cell Differentiation, Middle Aged, Recombinant Proteins, Interleukin-6/analysis, medicine.anatomical_structure, Phenotype, Core Binding Factor Alpha 2 Subunit, Tumor Necrosis Factors, Female, medicine.symptom, Research Article, Cell Survival/drug effects, Adult, Culture Media, Conditioned/chemistry, Cell Survival, Antigens, Differentiation, Myelomonocytic, Bone Marrow Cells, Inflammation, Biology, Downregulation and upregulation, Diagnostic Medicine, medicine, Gene Regulation, Recombinant Proteins/biosynthesis, Homeodomain Proteins, Interleukin-6, Macrophages/cytology, Cell Biology, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Diabetes Mellitus, Type 2/metabolism, Metabolic Disorders, Immune System, Cancer research, Bone marrow, Homeodomain Proteins/genetics, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6ea39074a79895983e43418ef1be36
https://doi.org/10.1371/journal.pone.0223980

المؤلفون: Isabel Silva, Nuno Vale, Henrique Reguengo, Diana Duarte, Filipa Amaro, José Carlos Oliveira, Paula Fresco, Dany Silva, Jorge Gonçalves

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Biomolecules, Vol 9, Iss 9, p 409 (2019)
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Biomolecules
Volume 9
Issue 9

مصطلحات موضوعية: 0301 basic medicine, Indoles, Skin Neoplasms, Cell Survival / drug effects, Indoles / analysis, Metabolite, lcsh:QR1-502, MCF-7 cell line, Breast Neoplasms / metabolism, Biochemistry, lcsh:Microbiology, Kynureninase, chemistry.chemical_compound, 0302 clinical medicine, Melanoma / pathology, Melanoma, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Aromatic L-amino acid decarboxylase, Indoles / metabolism, Skin Neoplasms / metabolism, Carbidopa / pharmacology, indole-3-acetonitrile, 030220 oncology & carcinogenesis, Carbidopa, Breast Neoplasms / pathology, Female, medicine.drug, Spectrometry, Mass, Electrospray Ionization, Cell Survival, Breast Neoplasms, Article, A375 cell line, Tryptophan / metabolism, 03 medical and health sciences, Breast cancer, Cell Line, Tumor, medicine, Humans, tryptophan, carbidopa, Molecular Biology, Cell Proliferation, Skin Neoplasms / pathology, Tryptophan, medicine.disease, Melanoma / metabolism, nervous system diseases, 030104 developmental biology, Enzyme, chemistry, Cancer research, Cell Proliferation / drug effects

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9138061437389dba5962460c6c79f056
https://www.mdpi.com/2218-273X/9/9/409

المؤلفون: Michael R. Stratton, Eric Padron, Tingting Qin, Kenichi Yoshida, Eric Solary, Seishi Ogawa, Stéphanie Solier, Eric Jourdan, Serge Koscielny, Margot Morabito, William Vainchenker, Emilie Chautard, Dorothée Selimoglu-Buet, Jean-François Deleuze, Thérèse Commes, Kristen Meldi, Stéphane de Botton, Olivier Bernard, Claude Preudhomme, Pierre Fenaux, Marcel E. Dinger, Thorsten Braun, Mark J. Cowley, Bruno Quesnel, Vincent Meyer, Didier Auboeuf, François Artiguenave, Nathalie Droin, Maria E. Figueroa, Noémie Pata-Merci, Raphael Itzykson, Velimir Gayevskiy, Ludmil B. Alexandrov, Jane Merlevede

المساهمون: Hématopoïèse normale et pathologique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Dynamique moléculaire de la transformation hématopoïétique (Dynamo), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, School of Information, University of Michigan, Department of Molecular Diagnosis, Hamamatsu University School of Medicine, Kyoto University [Kyoto], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Avicenne [AP-HP], Département d'hématologie [Gustave Roussy], Institut Gustave Roussy (IGR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cellules souches normales et cancéreuses, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hématopoïèse normale et pathologique (U1170 Inserm), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Garvan Institute of Medical Research [Darlinghurst, Australia], Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service d'Hématologie Cellulaire [Lille], The Wellcome Trust Sanger Institute [Cambridge], Los Alamos National Laboratory (LANL), H. Lee Moffitt Cancer Center and Research Institute, Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), This programme was supported by grants from Ligue Nationale Contre le Cancer (équipe labellisée), Institut National du Cancer (INCa PLBIO, SIRIC SOCRATE), Institut National du Cancer and Direction Générale de l’Offre de Soins (PHRC-K 2011-182),Agence Nationale de la Recherche (Molecular Medicine in Oncology, Paris Alliance Cancer Research Institute: France Génomique National programs funded by ‘Investissements d’avenir’). J.M. was supported by the Fondation pour la Recherche Médicale (FDT20140931007)., Kyoto University, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Garvan Institute of medical research

المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7 (1), ⟨10.1038/ncomms10767⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 2016, 7 (1), ⟨10.1038/ncomms10767⟩

مصطلحات موضوعية: 0301 basic medicine, Male, [SDV]Life Sciences [q-bio], General Physics and Astronomy, medicine.disease_cause, Epigenesis, Genetic, chemistry.chemical_compound, Cancer, Genetics, Aged, 80 and over, Mutation, Multidisciplinary, High-Throughput Nucleotide Sequencing, Cytidine, Leukemia, Myelomonocytic, Chronic, Middle Aged, 3. Good health, Gene Expression Regulation, Neoplastic, Biological sciences, DNA methylation, Azacitidine, Female, medicine.drug, Antimetabolites, Antineoplastic, Cell Survival, Science, Decitabine, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, medicine, Humans, Epigenetics, Allele, Alleles, Aged, Sequence Analysis, RNA, Myelodysplastic syndromes, General Chemistry, Sequence Analysis, DNA, MESH: Aged, 80 and over Alleles Antimetabolites, Antineoplastic / pharmacology* Antimetabolites, Antineoplastic / therapeutic use Azacitidine / analogs & derivatives* Azacitidine / pharmacology* Azacitidine / therapeutic use Cell Survival / drug effects* DNA Methylation / drug effects* Decitabine Epigenesis, Genetic / drug effects* Female Gene Expression Regulation, Neoplastic / drug effects* HEK293 Cells High-Throughput Nucleotide Sequencing Humans Leukemia, Myelomonocytic, Chronic / drug therapy Leukemia, Myelomonocytic, Chronic / genetics* Male Middle Aged Mutation, DNA Methylation, medicine.disease, 030104 developmental biology, HEK293 Cells, chemistry, Cancer research

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c49d85c0bfff4c676a3aec15934499b
https://hal.archives-ouvertes.fr/hal-03130526/document

المؤلفون: Olivier Loréal, Martine Ropert, François Gaboriau, Sylvie Lepage, Vincent Corcé, Isabelle Cannie, David Deniaud, Stéphanie Renaud

المساهمون: Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Société d'Accélération du Transfert de Technologies (SATT OUEST VALORISATION), Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), CHU Pontchaillou [Rennes], Laboratoire de Toxicologie Biologique et Médico-Légale, Hôpital Pontchaillou-CHU Pontchaillou [Rennes], This work was supported by the development funds SATT Ouest-Valorisation and FEDER Europe (Brittany region). The authors are grateful to the Conseil Régional Pays de la Loire, to the French Ministry of Education, to the Ligue Nationale contre le Cancer (LNCC, Ille et Vilaine/Loire Atlantique), to the Association pour la Recherche sur le Cancer (ARC) and to the Centre National de la Recherche Scientifique (CNRS) for financial support.The authors thank P. Loyer (Inserm UMR991, Rennes, France) and I. Morel (CHU Pontchaillou, Rennes, France) for scientific assistance in the flow cytometry and LC/MSMS analyses, respectively.In vivo experiments were carried out in the animal handling facility of the university, the ARCHE platform of the Structure Fédérative de Recherche BIOSIT in Rennes (BiogenOuest and Cancéropôle Grand Ouest network).The histological analysis were carried out in the histopathological platform H2P2 of the Structure Fédérative de Recherche BIOSIT in Rennes (BiogenOuest and Cancéropôle Grand Ouest network)., Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Jonchère, Laurent

المصدر: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩
Biochemical Pharmacology, 2015, 96 (3), pp.179-189. ⟨10.1016/j.bcp.2015.06.001⟩

مصطلحات موضوعية: MESH: Colonic Neoplasms/pathology, [SDV]Life Sciences [q-bio], MESH: Colonic Neoplasms/drug therapy, Endogeny, polyamine transport system, Biochemistry, Mice, chemistry.chemical_compound, 0302 clinical medicine, MESH: Biological Transport/drug effects, polyamine, MESH: Molecular Targeted Therapy, Polyamines, MESH: Animals, Molecular Targeted Therapy, Cancer, 0303 health sciences, Iron chelator, Chemistry, MESH: Antineoplastic Agents/pharmacology, Cell Cycle, MESH: Iron Chelating Agents/pharmacology, DNA, Neoplasm, Cell cycle, Tumor Burden, 3. Good health, [SDV] Life Sciences [q-bio], 030220 oncology & carcinogenesis, Colonic Neoplasms, Female, Intracellular, MESH: Cell Cycle/drug effects, Eflornithine, Cell Survival, MESH: DNA, Neoplasm/antagonists & inhibitors, MESH: HCT116 Cells, Iron, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, [SDV.CAN]Life Sciences [q-bio]/Cancer, Iron Chelating Agents, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, In vivo, MESH: Mice, Nude, Animals, Humans, MESH: Mice, 030304 developmental biology, Pharmacology, Polyamine transport, Cell growth, MESH: DNA, Neoplasm/biosynthesis, Biological Transport, MESH: Colonic Neoplasms/metabolism, HCT116 Cells, In vitro, MESH: Eflornithine/pharmacology, colon adenocarcinoma, tumor vectorization, Cancer research, MESH: Polyamines/antagonists & inhibitors, Polyamine, MESH: Cell Survival/drug effects, MESH: Female, Neoplasm Transplantation, MESH: Neoplasm Transplantation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca8eaeacdc2a079dd88d9dcdf99544b
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01163245/document

المؤلفون: Maria Stefaniotou, Carol Murphy, Theodore Fotsis, Konstantinos Psillas, Marina Ziche, Lucia Morbidelli, Eleni Bagli

المصدر: Cancer Research. 64:7936-7946

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, Cancer Research, p38 Mitogen-Activated Protein Kinases/metabolism, Angiogenesis, Angiogenesis Inhibitors, p38 Mitogen-Activated Protein Kinases, Angiogenesis Inhibitors/*pharmacology, Mice, chemistry.chemical_compound, Luteolin/*pharmacology, Phosphorylation, Luteolin, Cells, Cultured, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, Kinase, Protein-Serine-Threonine Kinases/metabolism, Vascular endothelial growth factor, Oncology, Biochemistry, Female, Rabbits, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases/metabolism, Cell Division, Cell Survival/drug effects, Ribosomal Protein S6 Kinases/metabolism, Cell Survival, Cell Division/drug effects, P70-S6 Kinase 1, Protein Serine-Threonine Kinases, Biology, Vascular Endothelial Growth Factor A/*antagonists & inhibitors, Proto-Oncogene Proteins, Animals, Humans, Kinase activity, Protein kinase B, PI3K/AKT/mTOR pathway, Ribosomal Protein S6 Kinases, Endothelial Cells, Neoplasms, Experimental, Proto-Oncogene Proteins/metabolism, Phosphatidylinositol 3-Kinases/*antagonists & inhibitors, Endothelial Cells/cytology/*drug effects, chemistry, Neoplasms, Experimental/blood supply/drug therapy, Cancer research, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051f8eebd4e63ff6b21dd5e3e5012aec
https://doi.org/10.1158/0008-5472.can-03-3104