نتائج البحث - "Protein-Serine-Threonine Kinases/*metabolism"

1

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

المؤلفون: Handoko, L., Kaczkowski, B., Hon, C. C., Lizio, M., Wakamori, M., Matsuda, T., Ito, T., Jeyamohan, P., Sato, Y., Sakamoto, K., Yokoyama, S., Kimura, Hiroshi, Minoda, A., Umehara, T.

المصدر: Epigenetics. 13(No. 4):410-431

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cage, Cancer Research, Lung Neoplasms, Histones, Mice, Lung Neoplasms/drug therapy/*genetics/metabolism, Carcinoma, Non-Small-Cell Lung, Transcriptional regulation, Histone code, Promoter Regions, Genetic, Azepines/*pharmacology, Triazoles/*pharmacology, Brd2, biology, Chemistry, Acetylation, Azepines, Chromatin, Cell biology, Jq1, Gene Expression Regulation, Neoplastic, Histone, Protein-Serine-Threonine Kinases/*metabolism, Transcription Initiation Site, Proto-Oncogene Proteins c-myc/genetics, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-myc, Histone H4, Chromatin/metabolism, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Enhancer, Molecular Biology, Transcription factor, Promoter Regions, Genetic/drug effects, Transcription Initiation Site/drug effects, Carcinoma, Non-Small-Cell Lung/drug therapy/*genetics/metabolism, Promoter, Triazoles, Acetylation/drug effects, Bromodomain, 030104 developmental biology, Histones/*chemistry/metabolism, Gene Expression Regulation, Neoplastic/drug effects, Bet, biology.protein, Cancer research, H4 hyperacetylation, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed72bd1e8abe48f7e395d18d2ff5bbd
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100822105

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2

Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast

المؤلفون: Jennifer Röhrl, Zuzana Storchova, Stephan Gruber, Karolina Peplowska, Young-Min Soh, Frank Bürmann, Yehui Wu, Galal Yahya Metwaly

المصدر: PLoS genetics, vol. 16, no. 8, pp. e1008569
PLoS Genetics
PLoS Genetics, Vol 16, Iss 8, p e1008569 (2020)

مصطلحات موضوعية: Cancer Research, Condensin, Amino Acid Motifs, Yeast and Fungal Models, QH426-470, Biochemistry, Spindle pole body, Chromosome segregation, 0302 clinical medicine, Medicine and Health Sciences, 570 Biowissenschaften, Biologie, Drug Interactions, Protein Phosphatase 2, Cell Cycle and Cell Division, Phosphorylation, Post-Translational Modification, Genetics (clinical), Adenosine Triphosphatases, Centromeres, 0303 health sciences, biology, Kinetochore, Chromosome Biology, Nuclear Proteins, Eukaryota, Cell biology, DNA-Binding Proteins, Spindle checkpoint, Experimental Organism Systems, Cell Processes, Protein Binding, Research Article, Chromosome Structure and Function, Saccharomyces cerevisiae Proteins, Biorientation, Centromere, Immunoblotting, Molecular Probe Techniques, Mitosis, Saccharomyces cerevisiae, macromolecular substances, Protein Serine-Threonine Kinases, Research and Analysis Methods, Chromosomes, 03 medical and health sciences, Condensin complex, Saccharomyces, Model Organisms, ddc:570, Genetics, Molecular Biology Techniques, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Adenosine Triphosphatases/metabolism, Centromere/metabolism, DNA-Binding Proteins/metabolism, Multiprotein Complexes/metabolism, Nuclear Proteins/chemistry, Nuclear Proteins/genetics, Nuclear Proteins/metabolism, Protein Phosphatase 2/metabolism, Protein Serine-Threonine Kinases/metabolism, Saccharomyces cerevisiae Proteins/chemistry, Saccharomyces cerevisiae Proteins/genetics, Saccharomyces cerevisiae Proteins/metabolism, Pharmacology, Cohesin, Organisms, Fungi, Biology and Life Sciences, Proteins, Cell Biology, Yeast, Spindle apparatus, Multiprotein Complexes, biology.protein, Animal Studies, 030217 neurology & neurosurgery

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5c1836a69091431c807a715b7af139
https://serval.unil.ch/resource/serval:BIB_D23C2314CE14.P001/REF.pdf

3

PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning

المؤلفون: Ana Carvalho, Eric J. Lambie, Hai Wei, Daniel S. Osorio, Barbara Conradt

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: PLoS Genetics, Vol 16, Iss 9, p e1008912 (2020)
PLoS Genetics

مصطلحات موضوعية: Cancer Research, DNA-Binding Proteins / genetics, Cell, Apoptosis, Neural Stem Cells / metabolism, Snail, Cell Polarity / physiology, QH426-470, medicine.disease_cause, Myosin Type II / metabolism, Animals, Genetically Modified, 0302 clinical medicine, Neural Stem Cells, Cytoskeletal Proteins / metabolism, Phosphorylation, Genetics (clinical), Caenorhabditis elegans, Neurons, 0303 health sciences, Cell Death, biology, Kinase, Chemistry, Neurons / metabolism, Cell Polarity, Actomyosin, Protein Serine-Threonine Kinases / genetics, Actomyosin / metabolism, Cell biology, DNA-Binding Proteins, medicine.anatomical_structure, Protein Serine-Threonine Kinases / metabolism, Snail Family Transcription Factors / genetics, Snail Family Transcription Factors / metabolism, Context (language use), Protein Serine-Threonine Kinases, Neuroblast division, 03 medical and health sciences, Neuroblast, Transcription Factors / genetics, biology.animal, Caenorhabditis elegans Proteins / metabolism, Genetics, medicine, Animals, Cell Death / physiology, Caenorhabditis elegans Proteins, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Myosin Type II, Transcription Factors / metabolism, fungi, DNA-Binding Proteins / metabolism, biology.organism_classification, Cytoskeletal Proteins, Caenorhabditis elegans Proteins / genetics, Snail Family Transcription Factors, Apoptosis / physiology, Carcinogenesis, 030217 neurology & neurosurgery, Transcription Factors

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e89eb8b227c8d8bb6fd9f36c74a4f95
https://doi.org/10.1101/2020.06.04.133983

4

Activation of SNF1/AMPK mediates the mitochondrial derepression, resistance to oxidative stress and increased lifespan of cells lacking the phosphatase Sit4p

المؤلفون: Andreia T. Pereira, Clara Pereira, Vítor Costa

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Protein-Serine-Threonine Kinases / genetics, Saccharomyces cerevisiae Proteins, Phosphatase, Saccharomyces cerevisiae, Biology, AMP-Activated Protein Kinases, Protein Serine-Threonine Kinases, Research initiative, medicine.disease_cause, 03 medical and health sciences, Saccharomyces cerevisiae / growth & development, 0302 clinical medicine, Regional development, Saccharomyces cerevisiae Proteins / genetics, medicine, Protein Phosphatase 2, Neurologic disease, Molecular Biology, Derepression, AMP-Activated Protein Kinases / genetics, Mitochondria / metabolism, AMPK, Cell Biology, Protein Phosphatase 2 / genetics, Gene deletion, Mitochondria, Oxidative Stress, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Oxidative stress, Gene Deletion, Protein-Serine-Threonine Kinases / metabolism

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885d225738f4eabee224c24127955846
https://hdl.handle.net/10216/130573

5

The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI

المؤلفون: Victor A. Neel, Seung-Hee Jo, G. Paolo Dotto, Maria-Giuseppina Procopio, Sandro Goruppi, Andrea Clocchiatti

المصدر: Cell Reports, Vol 20, Iss 10, Pp 2468-2479 (2017)
Cell reports, vol. 20, no. 10, pp. 2468-2479

مصطلحات موضوعية: squamous cell carcinoma, 0301 basic medicine, autophagy, Stromal cell, cancer-associated fibroblast, Notch signaling pathway, Fluorescent Antibody Technique, Protein Serine-Threonine Kinases, Biology, Zinc Finger Protein GLI1, Article, General Biochemistry, Genetics and Molecular Biology, Mice, ULK3, 03 medical and health sciences, Cancer-Associated Fibroblasts, Downregulation and upregulation, GLI2, Animals, Humans, tumor microenvironment, Gene silencing, CAF, Autophagy/physiology, Cancer-Associated Fibroblasts/metabolism, Female, Fibroblasts/metabolism, Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism, Signal Transduction/genetics, Signal Transduction/physiology, Zinc Finger Protein GLI1/genetics, Zinc Finger Protein GLI1/metabolism, CSL/RBPJ, GLI, SCC, cancer stroma, lcsh:QH301-705.5, RBPJ, Autophagy, Fibroblasts, 030104 developmental biology, lcsh:Biology (General), Immunoglobulin J Recombination Signal Sequence-Binding Protein, Cancer research, Signal transduction, Signal Transduction

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4684324d12d6bb849ddff53b0ff07fed
https://doi.org/10.1016/j.celrep.2017.08.048

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6

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

المؤلفون: Jawahar Kopparam, Mauro Delorenzi, Etienne Meylan, Paolo Angelino, Nadine Zangger, Alessandra Piersigilli, Johanna Chiffelle

المصدر: Cell death and differentiation, vol. 24, no. 10, pp. 1761-1771
Cell Death and Differentiation

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb48a55b0f04494a1168d71cf2cf056
https://doi.org/10.1038/cdd.2017.81

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7

CD44 Attenuates Activation of the Hippo Signaling Pathway and Is a Prime Therapeutic Target for Glioblastoma

المؤلفون: Yin Xu, Ivan Stamenkovic, Qin Yu

المصدر: Cancer Research, vol. 70, no. 6, pp. 2455-2464

مصطلحات موضوعية: Cancer Research, Recombinant Fusion Proteins, medicine.medical_treatment, Apoptosis, Cell Growth Processes, Protein Serine-Threonine Kinases, Article, Targeted therapy, Mice, Downregulation and upregulation, Cancer stem cell, Glioma, Chlorocebus aethiops, medicine, Animals, Humans, RNA, Small Interfering, Hippo signaling pathway, biology, Brain Neoplasms, CD44, Antigens, CD44/biosynthesis, Antigens, CD44/genetics, Apoptosis/physiology, Brain Neoplasms/drug therapy, Brain Neoplasms/genetics, COS Cells, Cell Growth Processes/physiology, Cercopithecus aethiops, Glioblastoma/drug therapy, Glioblastoma/genetics, Immunoglobulin Fc Fragments/genetics, Immunoglobulin Fc Fragments/pharmacology, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins c-met/metabolism, RNA, Small Interfering/genetics, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/isolation & purification, Signal Transduction, Up-Regulation, Proto-Oncogene Proteins c-met, medicine.disease, nervous system diseases, Immunoglobulin Fc Fragments, Hyaluronan Receptors, Oncology, Cancer cell, biology.protein, Cancer research, Signal transduction, Glioblastoma

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a24c9cee259d8d91ac4f279cecd33b
https://doi.org/10.1158/0008-5472.can-09-2505

8

The p21-activated Kinase 3 Implicated in Mental Retardation Regulates Spine Morphogenesis through a Cdc42-dependent Pathway

المؤلفون: Dominique Muller, Emmanuel Thévenot, Véronique Rousseau, Bernadette Boda, Jean-Vianney Barnier, Patricia Kreis

المصدر: Journal of Biological Chemistry, Vol. 282, No 29 (2007) pp. 21497-21506

مصطلحات موضوعية: rac1 GTP-Binding Protein, Dendritic spine, Hippocampus/metabolism, Synapses/metabolism, Neurons/metabolism, Dendritic spine morphogenesis, Protein Serine-Threonine Kinases, Biology, Hippocampus, Models, Biological, Synaptic Transmission, Biochemistry, Protein-Serine-Threonine Kinases/metabolism/ physiology, Cdc42 GTP-Binding Protein/ metabolism, Cercopithecus aethiops, Rac1 GTP-Binding Protein/metabolism, Mental Retardation/genetics/ metabolism, Intellectual Disability, Chlorocebus aethiops, Animals, Small GTPase, Kinase activity, cdc42 GTP-Binding Protein, p21-activated kinases, Molecular Biology, Neurons, Effector, Cell Biology, ddc:616.8, Rats, Cell biology, P21-Activated Kinases, p21-Activated Kinases, Cdc42 GTP-Binding Protein, COS Cells, Mutation, Synapses, Synaptic plasticity, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3661c681716036ec9b8a068da4795c40
https://doi.org/10.1074/jbc.m703298200

9

Luteolin Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis; Inhibition of Endothelial Cell Survival and Proliferation by Targeting Phosphatidylinositol 3′-Kinase Activity

المؤلفون: Maria Stefaniotou, Carol Murphy, Theodore Fotsis, Konstantinos Psillas, Marina Ziche, Lucia Morbidelli, Eleni Bagli

المصدر: Cancer Research. 64:7936-7946

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, Cancer Research, p38 Mitogen-Activated Protein Kinases/metabolism, Angiogenesis, Angiogenesis Inhibitors, p38 Mitogen-Activated Protein Kinases, Angiogenesis Inhibitors/*pharmacology, Mice, chemistry.chemical_compound, Luteolin/*pharmacology, Phosphorylation, Luteolin, Cells, Cultured, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, Kinase, Protein-Serine-Threonine Kinases/metabolism, Vascular endothelial growth factor, Oncology, Biochemistry, Female, Rabbits, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases/metabolism, Cell Division, Cell Survival/drug effects, Ribosomal Protein S6 Kinases/metabolism, Cell Survival, Cell Division/drug effects, P70-S6 Kinase 1, Protein Serine-Threonine Kinases, Biology, Vascular Endothelial Growth Factor A/*antagonists & inhibitors, Proto-Oncogene Proteins, Animals, Humans, Kinase activity, Protein kinase B, PI3K/AKT/mTOR pathway, Ribosomal Protein S6 Kinases, Endothelial Cells, Neoplasms, Experimental, Proto-Oncogene Proteins/metabolism, Phosphatidylinositol 3-Kinases/*antagonists & inhibitors, Endothelial Cells/cytology/*drug effects, chemistry, Neoplasms, Experimental/blood supply/drug therapy, Cancer research, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051f8eebd4e63ff6b21dd5e3e5012aec
https://doi.org/10.1158/0008-5472.can-03-3104

10

Myofibroblastic stromal reaction and lymph node status in invasive breast carcinoma: possible role of the TGF-β1/TGF-βR1 pathway

المؤلفون: Jean Christophe Noël, Xavier Catteau, Philippe Simon

المصدر: BMC cancer, 14 (1
BMC Cancer

مصطلحات موضوعية: Cancer Research, Pathology, Receptor, Transforming Growth Factor-beta Type I, Transforming Growth Factor beta1 -- metabolism, CD34, Antigens, CD34, Actins -- metabolism, Metastasis, Tumor Microenvironment, SMA, Myofibroblasts, skin and connective tissue diseases, Lymph node, Aged, 80 and over, Carcinoma, Ductal, Breast, Fibrocytes, Middle Aged, medicine.anatomical_structure, Oncology, Lymphatic Metastasis, Female, Protein-Serine-Threonine Kinases -- metabolism, Breast carcinoma, Biologie, Research Article, Signal Transduction, Adult, medicine.medical_specialty, Stromal cell, Antigens, CD34 -- metabolism, Breast Neoplasms, Protein Serine-Threonine Kinases, Stromal Cells -- metabolism -- pathology, Transforming Growth Factor beta1, Breast cancer, Carcinoma, Ductal, Breast -- metabolism -- pathology, Receptors, Transforming Growth Factor beta -- metabolism, Genetics, medicine, Humans, Lymphatic Metastasis -- pathology, Aged, Myofibroblasts -- cytology -- metabolism -- pathology, Tumor microenvironment, business.industry, medicine.disease, Actins, Cancérologie, TGF-ß, Stromal Cells, business, Receptors, Transforming Growth Factor beta, Breast Neoplasms -- metabolism -- pathology

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed2a16c389305071681a65f0f3f6705
https://doi.org/10.1186/1471-2407-14-499

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