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المؤلفون: L. L. Reys, Mireille M.J.P.E. Sthijns, Adam Stell, Nizar I. Mourad, D. de Bont, Sami G. Mohammed, O.P. da Sliva, Tiago H. Silva, Vijayaganapathy Vaithilingam, Marlon J. Jetten, R G de Vries, Simone S. Silva, Timo Rademakers, Carolin Hermanns, Eduardo Soares, Vanessa L.S. LaPointe, A.A. van Apeldoorn, Pierre Gianello, Rui L. Reis
المساهمون: CBITE, RS: MERLN - Cell Biology - Inspired Tissue Engineering (CBITE), UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale
المصدر: Advanced Functional Materials, 31(35):2011205. Wiley-VCH Verlag
Advanced functional materials, Vol. 31, no. 35, p. 2011205 (2021)مصطلحات موضوعية: endocrine system, EXTRACTION, Materials science, Antioxidant, antioxidant, medicine.medical_treatment, 02 engineering and technology, Bêta-cells, medicine.disease_cause, INSULIN-SECRETION, GLUCOSE, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, LAMINARIA-JAPONICA, fucoidan, Electrochemistry, medicine, Endocrine system, alginate, Beta (finance), 030304 developmental biology, 0303 health sciences, geography, geography.geographical_feature_category, Fucoidan, DERIVATIVES, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Islet, Electronic, Optical and Magnetic Materials, Cell biology, microcapsules, pancreatic cells, chemistry, diabetes type I, ISLETS, Self-healing hydrogels, ACID, beta-cells, SURVIVAL, 0210 nano-technology, TXNIP, Oxidative stress
وصف الملف: application/pdf
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المؤلفون: Domenico Bosco, David Cottet-Dumoulin, Fanny Lebreton, Kevin Bellofatto, Vanessa Lavallard, Thierry Berney, Géraldine Parnaud, Ekaterine Berishvili, Charles H Wassmer
المصدر: Endocrinology
Endocrinology, Vol. 162, No 3 (2021) P. bqaa239مصطلحات موضوعية: Male, medicine.medical_specialty, Cell type, insulin secretion, protein synthesis, 030209 endocrinology & metabolism, O-propargyl-puromycin, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Islets of Langerhans, 0302 clinical medicine, Endocrinology, Biosynthesis, Internal medicine, Insulin-Secreting Cells, medicine, Protein biosynthesis, Animals, Secretion, Cells, Cultured, Research Articles, 030304 developmental biology, ddc:616, 0303 health sciences, geography, Delta cell, geography.geographical_feature_category, Staining and Labeling, ddc:617, Insulin secretion, Islet, Cell biology, Rats, Transplantation, Glucose, chemistry, Protein Biosynthesis, pancreatic islet cell, Pancreatic islet cell, Puromycin, Protein synthesis, AcademicSubjects/MED00250, Hormone
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a74df83c9504995c60a3ba5d024a9e
http://europepmc.org/articles/PMC7940959 -
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المؤلفون: Xiaodong Zhu, Mingyang Yuan, Kung-Hsien Ho, Ruiying Hu, Guoqiang Gu, Irina Kaverina
المصدر: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0241939 (2021)مصطلحات موضوعية: 0301 basic medicine, Physiology, GTP-Binding Protein alpha Subunits, medicine.medical_treatment, Cell, GTP-Binding Protein alpha Subunits, Gi-Go, Biochemistry, Microtubules, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, Insulin-Secreting Cells, Insulin Secretion, Medicine and Health Sciences, Insulin, Electron Microscopy, Cells, Cultured, Cellular Senescence, Mice, Knockout, Microscopy, Mice, Inbred ICR, Multidisciplinary, geography.geographical_feature_category, Chemistry, Organic Compounds, Nocodazole, Monosaccharides, Islet, Cell biology, medicine.anatomical_structure, Physical Sciences, Medicine, Cellular Structures and Organelles, Research Article, Signal Transduction, Science, Carbohydrates, 030209 endocrinology & metabolism, Biosynthesis, Research and Analysis Methods, 03 medical and health sciences, stomatognathic system, Microtubule, medicine, Animals, Secretion, Vesicles, Diabetic Endocrinology, geography, Endocrine Physiology, Secretory Vesicles, Organic Chemistry, Cell Membrane, Chemical Compounds, Biology and Life Sciences, Biological Transport, Cell Biology, Hormones, 030104 developmental biology, Glucose, Metabolism, Transmission Electron Microscopy, Physiological Processes, Function (biology)
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المؤلفون: Nancy Antoine, Lucie Ruiz, Holger Klein, Patrick Gilon, Anne Wojtusciszyn, Fiona M. Gribble, Frank Reimann, Robert Augustin, Bao-Khanh Lai, Bilal Singh, Michael P. Pieper, Eva Gatineau, Nano Rita, Mohammed Bensellam, Pedro Luis Herrera, Birgit Stierstorfer, Firas Khattab, Heeyoung Chae, Lorenzo Piemonti, Davide Brusa, Michael Mark, Eric Mayoux, Christophe Broca
المساهمون: Université Catholique de Louvain = Catholic University of Louvain (UCL), Boehringer Ingelheim Pharma GmbH & Co. KG, University of Geneva [Switzerland], Addenbrooke's Hospital, Cambridge University NHS Trust, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Lausanne University Hospital, IRCCS Ospedale San Raffaele [Milan, Italy], Chae, Heeyoung, Augustin, Robert, Gatineau, Eva, Mayoux, Eric, Bensellam, Mohammed, Antoine, Nancy, Khattab, Fira, Lai, Bao-Khanh, Brusa, Davide, Stierstorfer, Birgit, Klein, Holger, Singh, Bilal, Ruiz, Lucie, Pieper, Michael, Mark, Michael, Herrera, Pedro L, Gribble, Fiona M, Reimann, Frank, Wojtusciszyn, Anne, Broca, Christophe, Rita, Nano, Piemonti, Lorenzo, Gilon, Patrick, Gribble, Fiona [0000-0002-4232-2898], Reimann, Frank [0000-0001-9399-6377], Apollo - University of Cambridge Repository
المصدر: Molecular Metabolism
Molecular metabolism, vol. 42, pp. 101071
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 42, pp.101071. ⟨10.1016/j.molmet.2020.101071⟩
Molecular Metabolism (2020) P. 101071
Molecular Metabolism, Vol 42, Iss, Pp 101071-(2020)مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, medicine.medical_treatment, IC50, half maximal inhibitory concentration, SGLT2i, sodium-glucose cotransporter 2 inhibitors, MESH: Insulin Secretion, MESH: Glucosides, MESH: Insulin-Secreting Cells, chemistry.chemical_compound, Mice, αMG, α-methyl-D-glucopyranoside, EGP, endogenous glucose production, 0302 clinical medicine, Glucosides, Glucagon-Like Peptide 1, Insulin-Secreting Cells, FACS, fluorescence-activated cell sorting, Insulin Secretion, Insulin, ddc:576.5, MESH: Animals, Dapagliflozin, geography.geographical_feature_category, Chemistry, MESH: Glucagon, BW, body weight, Diabetes, SGLT2 inhibitor, MESH: Pancreas, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Islet, 3. Good health, SGLT, sodium-glucose cotransporter, MESH: Glucose, MESH: Sodium-Glucose Transporter 2, No direct effect of SGLT2i on α- and β-cells, MESH: Sodium-Glucose Transporter 2 Inhibitors, Ketone bodies, Original Article, medicine.medical_specialty, lcsh:Internal medicine, endocrine system, MESH: Rats, 030209 endocrinology & metabolism, MESH: Insulin, Glucagon, 03 medical and health sciences, Islets of Langerhans, Gliflozins, TPM, transcripts per million, Sodium-Glucose Transporter 2, G, glucose, In vivo, Internal medicine, Empagliflozin, medicine, MESH: Benzhydryl Compounds, Animals, Humans, Benzhydryl Compounds, lcsh:RC31-1245, Molecular Biology, MESH: Mice, Pancreas, Sodium-Glucose Transporter 2 Inhibitors, geography, MESH: Humans, MESH: Islets of Langerhans, Glucose transporter, MESH: Glucagon-Like Peptide 1, Cell Biology, Rats, 030104 developmental biology, Endocrinology, Glucose, Glucagon-Secreting Cells, MESH: Blood Glucose, MESH: Glucagon-Secreting Cells, Cmax, maximum serum concentration, diabetes, glucagon, insulin
وصف الملف: application/pdf
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المؤلفون: Jeffrey S. Isenberg, Keiko Omori, Meirigeng Qi, Youjun Wu, Luis Valiente, Ismail H. Al-Abdullah, Bashar Khiatah, Jiing-Kuan Yee, Rachel Perez, Kuan-Tsen Chen, Fouad Kandeel
المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Embryonic stem cells, Zinc binding, medicine.medical_treatment, Science, Cell, Cell Culture Techniques, chemistry.chemical_element, Cell Separation, Zinc, Article, Islets of Langerhans, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin Secretion, medicine, Humans, Insulin, geography, Multidisciplinary, geography.geographical_feature_category, Temperature, Reproducibility of Results, Cell Differentiation, Islet, Embryonic stem cell, In vitro, Stem-cell research, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Microscopy, Fluorescence, chemistry, Dithizone, Medicine, 030217 neurology & neurosurgery
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المؤلفون: Anne Wojtusciszyn, Eva Gatineau, Blaz Lupse, Amin Ardestani, Huan Liu, Paulina Karen Mendoza Sanchez, Patrick Gilon, Ralf Dringen, Mona Khazaei, Shirin Geravandi, Kathrin Maedler
المساهمون: UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition
المصدر: Biochemical and biophysical research communications, Vol. 568, p. 158-166 (2021)
Biochem Biophys Res Communمصطلحات موضوعية: medicine.medical_specialty, endocrine system, LDH, medicine.medical_treatment, Biophysics, Biochemistry, Glucagon, Article, LDHA, chemistry.chemical_compound, Downregulation and upregulation, Lactate dehydrogenase, Internal medicine, Insulin Secretion, medicine, Humans, Secretion, RNA, Messenger, Molecular Biology, Cells, Cultured, geography, geography.geographical_feature_category, L-Lactate Dehydrogenase, Chemistry, Pancreatic islets, Insulin, Beta-cell, Diabetes, Cell Biology, Islet, Up-Regulation, Endocrinology, medicine.anatomical_structure, Glucose, Diabetes Mellitus, Type 2, Glucagon-Secreting Cells, Lactate, Beta cell, Islets
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a6770995f7d59278ddba34b9970f8d
https://hdl.handle.net/2078.1/249232 -
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المؤلفون: Ali Harajli, Anjaneyulu Kowluru, Sri Aneesha Chundru, Suhadinie Gamage, Vijayalakshmi Thamilselvan
المصدر: Cellular Physiology and Biochemistry, Vol 54, Iss 6, Pp 1218-1230 (2020)
مصطلحات موضوعية: 0301 basic medicine, Male, rac1 GTP-Binding Protein, Physiology, G protein, RAC1, lcsh:Physiology, Cell Line, lcsh:Biochemistry, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Animals, Guanine Nucleotide Exchange Factors, lcsh:QD415-436, LY294002, Gene knockdown, geography, geography.geographical_feature_category, lcsh:QP1-981, Chemistry, Transfection, Islet, Cell biology, Rats, Enzyme Activation, 030104 developmental biology, Glucose, 030220 oncology & carcinogenesis, RhoG, Signal transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf9e4952683cc5a70e1c59b54c433ff
https://pubmed.ncbi.nlm.nih.gov/33347743 -
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المؤلفون: Chun-Kwok Wong, Xiao Yu Tian, Dandan Mao, Di Mao, Clara Bik-San Lau, Sze Wan Hung, Juliana C.N. Chan, Wing Hung Tam, Ronald C.W. Ma, Xing Ming, Huanyi Cao, Chi Chiu Wang, Elaine Chow, Alice P.S. Kong, Paul K.S. Chan, Joshua Jing Xi Li, Heung Man Lee, Guy A. Rutter
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, Interleukin-1beta, Inflammation, IκB kinase, Pharmacology, Biochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Mice, In vivo, Diabetes mellitus, Insulin-Secreting Cells, Insulin Secretion, medicine, Animals, Obesity, Molecular Biology, geography, geography.geographical_feature_category, 030102 biochemistry & molecular biology, Chemistry, Plant Extracts, Ophiopogon, Transcription Factor RelA, NF-κB, Cell Biology, medicine.disease, Islet, Dietary Fats, I-kappa B Kinase, Plant Tubers, 030104 developmental biology, medicine.anatomical_structure, medicine.symptom, Beta cell, Pancreas
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a01f4a484be6b7c014547dcbbd4276
https://pubmed.ncbi.nlm.nih.gov/32605924 -
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المؤلفون: Jordi Altirriba, Sarah Mouche, Charlotte Barbieux, Ildiko Szanto, Christelle Veyrat-Durebex, Chris R. J. Kennedy, Domenico Bosco, Gerhard Christofori, Chet E. Holterman, Jenny E. Gunton, Thierry Berney, Alexis Forterre, Michel Pinget, Karim Bouzakri, William Bietiger, Mohamed Alibashe, Benjamin B. Tournier, Caroline Arous
المساهمون: Diabète et thérapies cellulaires (DIATHEC), Université de Strasbourg (UNISTRA)
المصدر: Antioxidants and Redox Signaling
Antioxidants and Redox Signaling, Mary Ann Liebert, 2020, 32 (9), pp.618-635. ⟨10.1089/ars.2018.7579⟩مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Physiology, medicine.medical_treatment, Clinical Biochemistry, Diet, High-Fat, Biochemistry, Islets of Langerhans, Mice, 03 medical and health sciences, chemistry.chemical_compound, Diabetes mellitus, Internal medicine, Insulin Secretion, medicine, Animals, Humans, Molecular Biology, Cells, Cultured, General Environmental Science, chemistry.chemical_classification, Oxidase test, Reactive oxygen species, geography, NADPH oxidase, geography.geographical_feature_category, 030102 biochemistry & molecular biology, biology, Insulin, Cell Biology, medicine.disease, Islet, 3. Good health, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, NADPH Oxidase 5, chemistry, Mice, Inbred CBA, biology.protein, General Earth and Planetary Sciences, Female, Beta cell, Nicotinamide adenine dinucleotide phosphate, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfd6911e073298d180d271322f3a5c8
https://hal.archives-ouvertes.fr/hal-03336125 -
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المؤلفون: Grant M. Kelly, Kathryn A. Carbajal, Dudley W. Lamming, Michelle E. Kimple, Erin Guthery, Shannon J. Gallagher, Allison L. Brill, Joshua C. Neuman, Darby C. Peter, Cara L Green, Molly L. Wehner, Michael D. Schaid, Austin Reuter, Jeffrey M. Harrington
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: IBMX, 3-isobutyl-1-methylxanthine, Blood Glucose, Male, 0301 basic medicine, insulin secretion, HFD, high-fat diet, FBKO, Gαz full-body KO mice on the B6N background, Biochemistry, AUC, area under the curve, Mice, chemistry.chemical_compound, insulin resistance, Insulin-Secreting Cells, Prostaglandin E2, OGTTs, oral glucose tolerance tests, Mice, Knockout, Regulation of gene expression, EIA, enzyme immunoassay, geography.geographical_feature_category, diabetes, Chemistry, SDE, significantly differentially expressed, Ex4, exendin-4, HRP, horseradish peroxidase, qRT-PCR, quantitative real-time PCR, Gαz, G protein alpha-subunit, Islet, GTP-Binding Protein alpha Subunits, GPCRs, G protein–coupled receptors, CD, control diet, EP3, prostaglandin EP3 receptor, Beta cell, Research Article, medicine.drug, medicine.medical_specialty, G protein, βKO, beta-cell–specific Gαz-null, Prostaglandin, T2D, type 2 diabetes, Diet, High-Fat, KEGG, Kyoto Encyclopedia of Genes and Genomes, B6N, C57BL/6N, GLP1R, glucagon-like peptide 1 receptor, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, Insulin resistance, Downregulation and upregulation, cAMP, B6J, C57BL/6J, Internal medicine, PGE2, prostaglandin E2, medicine, cell signaling, Animals, Obesity, Molecular Biology, geography, 030102 biochemistry & molecular biology, G protein–coupled receptor (GPCR), Cell Biology, medicine.disease, BCA, bicinchoninic acid, Mice, Inbred C57BL, Disease Models, Animal, HA-EP3γ, hemagglutinin-tagged EP3γ, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, ITTs, insulin tolerance tests, KRBB, Krebs-Ringer bicarbonate buffer, RIA, radioimmunoassay
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d299e7f361025fcb5f8c430f86202b
https://doi.org/10.1074/jbc.ra120.015585