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المؤلفون: Jonathan Harbin, Haily Datz, Michelle Ampofo, Cody A. Boyle, Colin Thomas, Niraj Lodhi, Alexei V. Tulin, Yingbiao Ji, Sarah J. Johnson, Brett MacLeod, Chao Wu, Kate Pechenkina, Shri Patel, Michelle Currie
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: 0301 basic medicine, Transcriptional Activation, Poly ADP ribose polymerase, Protein domain, protein domains, Poly (ADP-Ribose) Polymerase-1, PARP-1, PARP-1 regulation, Histone H4, Histones, 03 medical and health sciences, chemistry.chemical_compound, Transcription (biology), Genetics, Nucleosome, Animals, Zinc finger, Multidisciplinary, poly(ADP-ribose), 030102 biochemistry & molecular biology, Biological Sciences, drosophila, Chromatin, Cell biology, Enzyme Activation, 030104 developmental biology, chemistry, DNA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb50f9a3f3c94f0eba8397e0d65fbd62
http://europepmc.org/articles/PMC6525528 -
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المؤلفون: Brett P. Monia, Steven G. Hughes, Marshelle S. Warren, Jason D. Ferrone, Gwendolyn E. Kaeser, Eugene Schneider, A. Robert MacLeod, Nicholas J. Viney, Brenda F. Baker, Alexey S. Revenko, Frederick Derosier, Gourab Bhattacharjee, Nguyen C. Pham, Thomas A. Zanardi
المصدر: Nucleic Acid Therapeutics. 29:82-91
مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Kininogen, Angioedema, Chemistry, Prekallikrein, Bradykinin, Kallikrein, Pharmacology, medicine.disease, Biochemistry, Blood proteins, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Drug Discovery, Hereditary angioedema, Genetics, medicine, Molecular Medicine, medicine.symptom, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::969051625899292f6463ecc560f45748
https://doi.org/10.1089/nat.2018.0754 -
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المؤلفون: Kenneth G. MacLeod, Bernard H Ramsahoye, Katan Patel, Duncan I. Jodrell, Jacqueline Dickson, Shahida Din
المساهمون: Jodrell, Duncan [0000-0001-9360-1670], Apollo - University of Cambridge Repository
المصدر: Nucleic Acids Research
Patel, K, Dickson, J, Din, S, Macleod, K, Jodrell, D & Ramsahoye, B 2010, ' Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme ', Nucleic Acids Research, vol. 38, no. 13, pp. 4313-4324 . https://doi.org/10.1093/nar/gkq187مصطلحات موضوعية: DNA (Cytosine-5-)-Methyltransferase 1, Proteasome Endopeptidase Complex, Biology, Gene Regulation, Chromatin and Epigenetics, Decitabine, environment and public health, Cell Line, DNA Methyltransferase 3A, chemistry.chemical_compound, Mice, Aphidicolin, MG132, Genetics, medicine, Animals, Ligase activity, DNA (Cytosine-5-)-Methyltransferases, Enzyme Inhibitors, DNA synthesis, urogenital system, DNA, DNA Methylation, Molecular biology, Chromatin, CpG site, chemistry, DNA methylation, embryonic structures, Proteasome inhibitor, Azacitidine, medicine.drug
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76d84808b4c5bb351925cd8b6b21357
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المؤلفون: Bart Versteeg, Anthony W. Solomon, Joanna Houghton, Matthew J. Burton, Oumer Shafi Abdurahman, Hristina Vasileva, Nicholas R. Thomson, David Macleod, Virginia Sarah, Martin J. Holland
المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008449 (2020)مصطلحات موضوعية: 0301 basic medicine, Bacterial Diseases, Eye Diseases, Swine, RC955-962, Cell Membranes, Chlamydia trachomatis, Artificial Gene Amplification and Extension, medicine.disease_cause, Pathology and Laboratory Medicine, Polymerase Chain Reaction, Biochemistry, law.invention, chemistry.chemical_compound, 0302 clinical medicine, law, Arctic medicine. Tropical medicine, Nucleic Acids, Medicine and Health Sciences, Chlamydia, DNA extraction, Polymerase chain reaction, Mammals, biology, Eukaryota, Bacterial Pathogens, Infectious Diseases, Trachoma, Medical Microbiology, Fomites, Vertebrates, Public aspects of medicine, RA1-1270, Pathogens, Cellular Structures and Organelles, Research Article, Neglected Tropical Diseases, DNA, Bacterial, 030231 tropical medicine, Research and Analysis Methods, Microbiology, Pig skin, 03 medical and health sciences, Extraction techniques, medicine, Genetics, Humans, Animals, Molecular Biology Techniques, Molecular Biology, Microbial Pathogens, Chlamydia trachomatis infection, Bacteria, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, DNA, Cell Biology, biology.organism_classification, medicine.disease, Tropical Diseases, Ophthalmology, 030104 developmental biology, chemistry, Amniotes
وصف الملف: application/pdf
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المؤلفون: Priya Sriskandarajah, Neil O. Carragher, Steven R. Whittaker, Kenneth G. MacLeod, Martin Kaiser, Vladimir Kirkin, Alexis De Haven Brandon
المصدر: Sriskandarajah, P, De Haven Brandon, A, MacLeod, K, Carragher, N O, Kirkin, V, Kaiser, M & Whittaker, S R 2020, ' Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma ', BMC Cancer, vol. 20, no. 1, pp. 269 . https://doi.org/10.1186/s12885-020-06735-2
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Pyridones, Antineoplastic Agents, Apoptosis, Cell Cycle Proteins, Pyrimidinones, lcsh:RC254-282, Dexamethasone, 03 medical and health sciences, chemistry.chemical_compound, Receptors, Glucocorticoid, 0302 clinical medicine, Glucocorticoid receptor, Multiple myeloma, Trametinib, Cell Line, Tumor, Genetics, Humans, Propidium iodide, Protein kinase A, Cell growth, MEK inhibitor, Intracellular Signaling Peptides and Proteins, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Drug Synergism, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, MAP Kinase Kinase Kinases, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Mutation, ras Proteins, Cancer research, Drug Therapy, Combination, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Research Article, RAS
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4239fc149b57b39fee55e674d11fa032
https://www.pure.ed.ac.uk/ws/files/143945886/Combined_targeting_of_MEK_and_the_glucocortoid_receptor_for_the_treatment_of_RAS_mutant_multiple_myeloma.pdf -
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المؤلفون: Jingyun Li, G B Schaefer, Charlotte A. Hobbs, Stewart L. MacLeod, Wendy N. Nembhard, Joseph W. Levy, Xinyu Tang
المصدر: American Journal of Medical Genetics Part A. 176:609-617
مصطلحات موضوعية: Adult, Heart Defects, Congenital, Male, 0301 basic medicine, Candidate gene, Genotype, Homocysteine, Offspring, Single-nucleotide polymorphism, Transsulfuration, Biology, Polymorphism, Single Nucleotide, Risk Assessment, Article, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Risk Factors, Genetics, Humans, SNP, Genetic Predisposition to Disease, Genetic Testing, Allele, Alleles, Genetics (clinical), Genetic Variation, Middle Aged, 030104 developmental biology, chemistry, Case-Control Studies, Population Surveillance, Relative risk, Paternal Inheritance, Female, Maternal Inheritance
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المؤلفون: Bjoern Schneider, Stefan Nagel, Robert Geffers, Kenneth S. Thress, Roderick A.F. MacLeod, Jiao Li, Hilmar Quentmeier, Corinna Meyer, Hans G. Drexler, Haiping Dai, Suning Chen, Claudia Pommerenke, Maren Kaufmann
المصدر: Cellular Oncology. 41:93-101
مصطلحات موضوعية: 0301 basic medicine, Acute promyelocytic leukemia, Cancer Research, Oncogene Proteins, Fusion, Microarray, Antineoplastic Agents, Biology, Models, Biological, Arsenicals, Cell Line, Wortmannin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Arsenic Trioxide, Leukemia, Promyelocytic, Acute, medicine, Humans, Cell Proliferation, Mitogen-Activated Protein Kinase 1, Genetics, MALAT1, medicine.diagnostic_test, Cell growth, Oxides, General Medicine, medicine.disease, ETV6, Pyrimidines, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, RNA, Long Noncoding, Ectopic expression, Fluorescence in situ hybridization
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bf8311b28d76346bb5a769ec4470ed
https://doi.org/10.1007/s13402-017-0356-2 -
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المؤلفون: Olivia J. S. Macleod, Angela Schwede, Paula MacGregor, Mark Carrington
المساهمون: Macleod, Olivia [0000-0002-5747-8019], MacGregor, Paula [0000-0003-0919-3745], Carrington, Mark [0000-0002-6435-7266], Apollo - University of Cambridge Repository
المصدر: PLoS Pathogens, Vol 11, Iss 12, p e1005259 (2015)
PLoS Pathogensمصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, Glycosylation, Protein Conformation, Immunology, Population, Trypanosoma brucei brucei, Review, Trypanosoma brucei, Microbiology, Epitope, Host-Parasite Interactions, chemistry.chemical_compound, Protein structure, Virology, parasitic diseases, Genetics, Humans, education, Molecular Biology, lcsh:QH301-705.5, chemistry.chemical_classification, education.field_of_study, biology, biology.organism_classification, Cell biology, Trypanosomiasis, African, chemistry, Membrane protein, lcsh:Biology (General), Trypanosoma, Parasitology, Glycoprotein, lcsh:RC581-607, Variant Surface Glycoproteins, Trypanosoma
وصف الملف: application/pdf
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المؤلفون: Robin Coope, Robert A. Holt, Pawan Pandoh, Andrew J. Mungall, Simon Haile, Marco A. Marra, Martin Jones, Martin Hirst, David W. Scott, Steve Bilobram, Philip Tsao, Christian Steidl, Helen McDonald, Richard Corbett, Yongjun Zhao, Yussanne Ma, Duane E Smailus, Tina MacLeod, Richard A. Moore, Miruna Bala, Diane Miller, Heather Kirk, Steven J.M. Jones, Denise Brooks
المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 6, p e0178706 (2017)مصطلحات موضوعية: 0301 basic medicine, cDNA libraries, Tissue Fixation, Computer science, Molecular biology, lcsh:Medicine, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Automation, Database and Informatics Methods, 0302 clinical medicine, Sequencing techniques, DNA library construction, DNA libraries, lcsh:Science, Throughput (business), Multidisciplinary, Paraffin Embedding, Nucleic acid methods, High-Throughput Nucleotide Sequencing, RNA sequencing, Complementary DNA, Genomic Library Construction, 3. Good health, Nucleic acids, Ribosomal RNA, 030220 oncology & carcinogenesis, RNA extraction, Sequence Analysis, Research Article, Cell biology, Cellular structures and organelles, Formalin fixed paraffin embedded, Forms of DNA, Bioinformatics, Sequence alignment, Computational biology, DNA construction, DNA sequencing, 03 medical and health sciences, Extraction techniques, Formaldehyde, microRNA, medicine, Genetics, Non-coding RNA, Biology and life sciences, cDNA library, lcsh:R, RNA, DNA, Gene regulation, Research and analysis methods, MicroRNAs, 030104 developmental biology, Molecular biology techniques, chemistry, Nucleic acid, lcsh:Q, Gene expression, Carcinogenesis, Ribosomes, Sequence Alignment
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المؤلفون: Jingyun Li, Charlotte A. Hobbs, Ming Li, Sadia Malik, Xinyu Tang, Stewart L. MacLeod, Stephen W. Erickson, Todd G. Nick, Mario A. Cleves
المصدر: Birth Defects Research Part A: Clinical and Molecular Teratology. 100:116-126
مصطلحات موضوعية: Genetics, Embryology, Pregnancy, Fetus, Homocysteine, Case-control study, Single-nucleotide polymorphism, Transsulfuration, General Medicine, Biology, medicine.disease, chemistry.chemical_compound, chemistry, Pediatrics, Perinatology and Child Health, medicine, SNP, Gene, Developmental Biology
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