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1
المؤلفون: Wenjing Pang, Xiangjun Meng, Yu Wang, Aisen Zhang, Lei Wang, Lei Li, Weiyan Yao, Xin Huang, Lidan Hou, Xin Dai
المصدر: International Journal of Biological Sciences
مصطلحات موضوعية: endocrine system diseases, Cell, Exosomes, Applied Microbiology and Biotechnology, Exosome, Adenylyl cyclase, chemistry.chemical_compound, Cell Line, Tumor, Insulin-Secreting Cells, Pancreatic cancer, Insulin Secretion, microRNA, medicine, Animals, Guanine Nucleotide Exchange Factors, Humans, exosome, Molecular Biology, Ecology, Evolution, Behavior and Systematics, β cell dysfunction, Chemistry, Effector, Pancreatic islets, miR-19a, pancreatic neoplasm, Cell Biology, medicine.disease, Microvesicles, Cell biology, Pancreatic Neoplasms, MicroRNAs, medicine.anatomical_structure, Adenylyl Cyclases, Research Paper, Developmental Biology
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2
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Leptin, medicine.medical_treatment, A Kinase Anchor Proteins, AMP-Activated Protein Kinases, Biochemistry, chemistry.chemical_compound, Adenosine Triphosphate, AMP-activated protein kinase, KATP Channels, Adipocyte, Insulin-Secreting Cells, Insulin Secretion, Fluorescence Resonance Energy Transfer, Glucose homeostasis, Homeostasis, Insulin, Phosphorylation, AC, adenylyl cyclase, biology, Chemistry, Calcineurin, Cell biology, protein kinase A (PKA), Protein Transport, A-kinase anchoring protein (AKAP), hormones, hormone substitutes, and hormone antagonists, Research Article, Signal Transduction, ATP-sensitive potassium channel, NMDAR, N-methyl-D-aspartate receptor, PP2B, protein phosphatase 2B, Primary Cell Culture, AKAP, A-kinase anchoring protein, Calcium-Calmodulin-Dependent Protein Kinase Kinase, FRET, fluorescence resonance energy transfer, Cell Line, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, medicine, Humans, Protein kinase A, Molecular Biology, cyclic AMP (cAMP), 030102 biochemistry & molecular biology, Cell Membrane, Actin remodeling, Cell Biology, Cyclic AMP-Dependent Protein Kinases, CaMKKβ, calcium/calmodulin-dependent kinase kinase β, AMPK, AMP-activated protein kinase, 030104 developmental biology, Glucose, fluorescence resonance energy transfer (FRET), biology.protein, PKA, protein kinase A
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657efb9fa07c0c0ee62cf426ba189d5c
http://europepmc.org/articles/PMC8010710 -
3
المؤلفون: Yue Yu, Rui Guo, Huimin Lu, Xia Chu, Changhao Sun, Yunjin Zhang, Yinling Li
المصدر: American Journal of Physiology-Endocrinology and Metabolism. 318:E430-E439
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Physiology, Endocrinology, Diabetes and Metabolism, Cell, Palmitic Acid, Apoptosis, Fatty Acids, Nonesterified, Protein Serine-Threonine Kinases, Cell Line, Palmitic acid, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Insulin-Secreting Cells, Physiology (medical), Internal medicine, Insulin Secretion, medicine, Animals, Humans, Gene silencing, Cells, Cultured, Tumor Suppressor Proteins, food and beverages, Transfection, Flow Cytometry, Molecular biology, Up-Regulation, Mice, Inbred C57BL, MicroRNAs, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Diabetes Mellitus, Type 2, chemistry, Cell culture, 030220 oncology & carcinogenesis, lipids (amino acids, peptides, and proteins), Stearic acid, Stearic Acids
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6726d45881522b3a864af3fbad2916
https://doi.org/10.1152/ajpendo.00302.2019 -
4
المؤلفون: Bin Yu, Yu Chai, Lei Wang, Fu Zhang, Xiaonan Liu
المصدر: Biochemical and Biophysical Research Communications. 524:22-27
مصطلحات موضوعية: 0301 basic medicine, Senescence, medicine.medical_specialty, Platelet-derived growth factor, medicine.medical_treatment, Biophysics, Transplants, Biochemistry, Bone and Bones, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin-Secreting Cells, Internal medicine, Insulin Secretion, medicine, Animals, Humans, Receptors, Platelet-Derived Growth Factor, Secretion, Molecular Biology, Cell Proliferation, Platelet-Derived Growth Factor, Osteoblasts, biology, Chemistry, Cell growth, Growth factor, Age Factors, Osteoblast, Cell Biology, Mice, Inbred C57BL, Transplantation, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Diabetes Mellitus, Type 2, 030220 oncology & carcinogenesis, Models, Animal, biology.protein, Platelet-derived growth factor receptor, Signal Transduction
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5
المؤلفون: Ewelina Golec, Enming Zhang, Anna M. Blom, Erik Renström, Ben C. King, Rebecca Rosberg
المصدر: FASEB J
مصطلحات موضوعية: 0301 basic medicine, Glycosylation, Oligosaccharides, CD59 Antigens, chemical and pharmacologic phenomena, CHO Cells, Biochemistry, Exocytosis, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, Cytosol, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Genetics, medicine, Animals, Insulin, Molecular Biology, VAMP2, Chemistry, Research, Endoplasmic reticulum, Pancreatic islets, Rats, Cell biology, carbohydrates (lipids), 030104 developmental biology, medicine.anatomical_structure, Membrane protein, Cytoplasm, SNARE Proteins, Complement membrane attack complex, 030217 neurology & neurosurgery, Biotechnology
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6
المؤلفون: Zhenli Shan, Wenjiao Li, Chuanlu Xu, Wangsheng Wang
المصدر: Biochemical and Biophysical Research Communications. 516:402-407
مصطلحات موضوعية: Male, 0301 basic medicine, Platelet-derived growth factor, endocrine system diseases, medicine.medical_treatment, Becaplermin, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Insulin-Secreting Cells, Insulin Secretion, Hyperinsulinemia, Insulin, Platelet-Derived Growth Factor, biology, Gestational diabetes, Protein Transport, 030220 oncology & carcinogenesis, Female, Platelet-derived growth factor receptor, Signal Transduction, Adult, medicine.medical_specialty, Biophysics, 03 medical and health sciences, Insulin resistance, Internal medicine, medicine, Animals, Humans, Molecular Biology, Insulinoma, Cell Proliferation, Cell Nucleus, Homeodomain Proteins, business.industry, Growth factor, Cell Biology, Cell Dedifferentiation, Glucose Tolerance Test, medicine.disease, Rats, Mice, Inbred C57BL, Diabetes, Gestational, 030104 developmental biology, Endocrinology, chemistry, Trans-Activators, biology.protein, business
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7
المؤلفون: Stacey D. Finley, Kate L. White, Scott E. Fraser, Dongqing Zheng, Patrick Gelbach, Nicholas A. J. Graham
مصطلحات موضوعية: Ecology, Chemistry, Metabolite, Systems biology, Metabolic network, Context (language use), Computational biology, Carbon, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Metabolic pathway, Glucose, Metabolomics, Computational Theory and Mathematics, Insulin-Secreting Cells, Modeling and Simulation, Insulin Secretion, Genetics, Insulin, Beta (finance), Molecular Biology, Ecology, Evolution, Behavior and Systematics, Intracellular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b8a1b5c62393068e4d6e4765c63f87
https://doi.org/10.1101/2021.10.23.465576 -
8
المصدر: Molecules, Vol 26, Iss 5167, p 5167 (2021)
Molecules
Volume 26
Issue 17مصطلحات موضوعية: insulin secretion, pancreatic β-cells, Cell Survival, medicine.medical_treatment, Glucose uptake, Pharmaceutical Science, Organic chemistry, Coffee, streptozotocin, Antioxidants, Streptozocin, Article, Cell Line, Analytical Chemistry, kahweol, chemistry.chemical_compound, QD241-441, Downregulation and upregulation, Insulin-Secreting Cells, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Insulin, Viability assay, INS-1 cells, Physical and Theoretical Chemistry, Kahweol, diabetes, NF-kappa B, apoptosis, Streptozotocin, Molecular biology, Rats, Blot, Oxidative Stress, Proto-Oncogene Proteins c-bcl-2, chemistry, Chemistry (miscellaneous), Apoptosis, Molecular Medicine, Diterpenes, Reactive Oxygen Species, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug
وصف الملف: application/pdf
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9
المؤلفون: Nancy Antoine, Lucie Ruiz, Holger Klein, Patrick Gilon, Anne Wojtusciszyn, Fiona M. Gribble, Frank Reimann, Robert Augustin, Bao-Khanh Lai, Bilal Singh, Michael P. Pieper, Eva Gatineau, Nano Rita, Mohammed Bensellam, Pedro Luis Herrera, Birgit Stierstorfer, Firas Khattab, Heeyoung Chae, Lorenzo Piemonti, Davide Brusa, Michael Mark, Eric Mayoux, Christophe Broca
المساهمون: Université Catholique de Louvain = Catholic University of Louvain (UCL), Boehringer Ingelheim Pharma GmbH & Co. KG, University of Geneva [Switzerland], Addenbrooke's Hospital, Cambridge University NHS Trust, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Lausanne University Hospital, IRCCS Ospedale San Raffaele [Milan, Italy], Chae, Heeyoung, Augustin, Robert, Gatineau, Eva, Mayoux, Eric, Bensellam, Mohammed, Antoine, Nancy, Khattab, Fira, Lai, Bao-Khanh, Brusa, Davide, Stierstorfer, Birgit, Klein, Holger, Singh, Bilal, Ruiz, Lucie, Pieper, Michael, Mark, Michael, Herrera, Pedro L, Gribble, Fiona M, Reimann, Frank, Wojtusciszyn, Anne, Broca, Christophe, Rita, Nano, Piemonti, Lorenzo, Gilon, Patrick, Gribble, Fiona [0000-0002-4232-2898], Reimann, Frank [0000-0001-9399-6377], Apollo - University of Cambridge Repository
المصدر: Molecular Metabolism
Molecular metabolism, vol. 42, pp. 101071
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 42, pp.101071. ⟨10.1016/j.molmet.2020.101071⟩
Molecular Metabolism (2020) P. 101071
Molecular Metabolism, Vol 42, Iss, Pp 101071-(2020)مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, medicine.medical_treatment, IC50, half maximal inhibitory concentration, SGLT2i, sodium-glucose cotransporter 2 inhibitors, MESH: Insulin Secretion, MESH: Glucosides, MESH: Insulin-Secreting Cells, chemistry.chemical_compound, Mice, αMG, α-methyl-D-glucopyranoside, EGP, endogenous glucose production, 0302 clinical medicine, Glucosides, Glucagon-Like Peptide 1, Insulin-Secreting Cells, FACS, fluorescence-activated cell sorting, Insulin Secretion, Insulin, ddc:576.5, MESH: Animals, Dapagliflozin, geography.geographical_feature_category, Chemistry, MESH: Glucagon, BW, body weight, Diabetes, SGLT2 inhibitor, MESH: Pancreas, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Islet, 3. Good health, SGLT, sodium-glucose cotransporter, MESH: Glucose, MESH: Sodium-Glucose Transporter 2, No direct effect of SGLT2i on α- and β-cells, MESH: Sodium-Glucose Transporter 2 Inhibitors, Ketone bodies, Original Article, medicine.medical_specialty, lcsh:Internal medicine, endocrine system, MESH: Rats, 030209 endocrinology & metabolism, MESH: Insulin, Glucagon, 03 medical and health sciences, Islets of Langerhans, Gliflozins, TPM, transcripts per million, Sodium-Glucose Transporter 2, G, glucose, In vivo, Internal medicine, Empagliflozin, medicine, MESH: Benzhydryl Compounds, Animals, Humans, Benzhydryl Compounds, lcsh:RC31-1245, Molecular Biology, MESH: Mice, Pancreas, Sodium-Glucose Transporter 2 Inhibitors, geography, MESH: Humans, MESH: Islets of Langerhans, Glucose transporter, MESH: Glucagon-Like Peptide 1, Cell Biology, Rats, 030104 developmental biology, Endocrinology, Glucose, Glucagon-Secreting Cells, MESH: Blood Glucose, MESH: Glucagon-Secreting Cells, Cmax, maximum serum concentration, diabetes, glucagon, insulin
وصف الملف: application/pdf
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10
المؤلفون: Dan Ploug Christensen, Jakob Bondo Hansen, Thomas Mandrup-Poulsen, Seyed Mojtaba Ghiasi, Björn Tyrberg
المصدر: International Journal of Molecular Sciences
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124311
International Journal of Molecular Sciences, Vol 21, Iss 4311, p 4311 (2020)
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4311 . https://doi.org/10.3390/ijms21124311
Volume 21
Issue 12مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Connexin, Apoptosis, NF-κB, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Cell Death/drug effects, Insulin-Secreting Cells, Insulin Secretion, Rotigaptide, lcsh:QH301-705.5, Spectroscopy, Peptide analog, Cytokines/genetics, Cell Death, Chemistry, Connexin 43/genetics, NF-kappa B, Gap Junctions, General Medicine, Mitochondria/drug effects, Computer Science Applications, Cell biology, Mitochondria, Islets of Langerhans/cytology, Cytokine, Insulin-Secreting Cells/drug effects, cardiovascular system, Cytokines, medicine.symptom, Beta cell, Gap Junctions/metabolism, Oligopeptides, Programmed cell death, insulin, Insulin/metabolism, Oligopeptides/pharmacology, 0699 Other Biological Sciences, 030209 endocrinology & metabolism, Inflammation, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Islets of Langerhans, Reactive Oxygen Species/metabolism, Stress, Physiological, 0399 Other Chemical Sciences, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, gap junctions, 0604 Genetics, Chemical Physics, Organic Chemistry, Apoptosis/drug effects, Insulin Secretion/drug effects, beta cell, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Gene Expression Regulation, inflammation, Connexin 43, NF-kappa B/metabolism, Reactive Oxygen Species, Biomarkers
وصف الملف: application/pdf