نتائج البحث - "Gene Expression Regulation, Enzymologic drug effects"

1

Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus

المؤلفون: Camille Hallez, Cristina M. Dorobantu, Mohamed S Bouzidi, Valérie Thiers, Vincent Lucansky, Jean-Pierre Vartanian, Xiongxiong Li, Simon Wain-Hobson, Raphael Gaudin, Rodolphe Suspène

المساهمون: Rétrovirologie moléculaire - Molecular Retrovirology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Collège Doctoral, Sorbonne Université (SU), China National Biotec Group (CNBG), Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Viroclinics Biosciences B. V. [Rotterdam, Netherlands], Biomedical Center Martin [Slovaquie], Jessenius Medical Faculty [Commenius University, Slovaquie] (JFMED), Commenius University in Bratislava - Univerzita Komenského-Commenius University in Bratislava - Univerzita Komenského, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from the Institut Pasteur and Centre National de la Recherche Scientifique. C.H. and M.S.B. were supported by the Allocation de Recherche du Ministère de la Recherche and Ligue contre le Cancer, respectively. X.L. was supported by a stipend from the Lanzhou Institute of Biological Products Co., Ltd, subsidiary company of China National Biotec Group Company Limited and by a stipend from the Pasteur-Paris University International PhD program. V.L. was supported by the Fondation pour la Recherche Medicale (project no. ING20160435328). C.D. was supported by an EMBO Long Term Fellowship (EMBO ALTF 1428–2016). The study of patients was sponsored by the French National Agency for research on AIDS and hepatitis (ANRS). This work has been published within the framework of IdEx Université de Strasbourg and has received funding from the French State via the French National Research Agency (ANR) as part of the program ‘Investissements d’avenir’ to R.G. This work was supported by an ATIP-AVENIR starting grant to R.G., We would like to thank S. Urban for providing HepG2-NTCP cells, P. Pineau and A. Marchio for the cirrhotic liver samples, M.-L. Michel and S. Pol for serum samples, C. Neuveut, P. Moreau, P. Maillard and B. Quioc for HBV infection, Y. Jacob for the HIF-1α and HIF-1β plasmids, J. Krijnse-Locker and C. Schmitt for electron microscopy immunolabelling and V. Caval, N. Frampton and J. McKeating for helpful discussions., Rétrovirologie moléculaire, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Collège doctoral [Sorbonne universités], Vartanian, Jean-Pierre, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

المصدر: Nature Microbiology
Nature Microbiology, 2019, 4 (7), pp.1196-1207. ⟨10.1038/s41564-019-0405-x⟩
Nature Microbiology, Nature Publishing Group, 2019, 4 (7), pp.1196-1207. ⟨10.1038/s41564-019-0405-x⟩

مصطلحات موضوعية: Liver Cirrhosis, viruses, [SDV]Life Sciences [q-bio], MESH: Virus Replication*/drug effects, Gene Expression, medicine.disease_cause, Virus Replication, Applied Microbiology and Biotechnology, chemistry.chemical_compound, Hypoxia, ComputingMilieux_MISCELLANEOUS, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, MESH: Liver Cirrhosis/enzymology, Cytidine, Transfection, Cobalt, Hepatitis B, MESH: Cobalt/pharmacology, MESH: Deoxyribonuclease I/metabolism, Hepatitis B Core Antigens, 3. Good health, [SDV] Life Sciences [q-bio], Capsid, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Hypoxia-Inducible Factor 1, MESH: Deoxyribonuclease I/genetics, Microbiology (medical), Hepatitis B virus, MESH: Mutation, MESH: Gene Expression, MESH: Hepatitis B/enzymology, MESH: Hypoxia-Inducible Factor 1/metabolism, Immunology, Biology, Microbiology, Gene Expression Regulation, Enzymologic, Cell Line, 03 medical and health sciences, Genetics, medicine, Deoxyribonuclease I, Humans, MESH: Gene Expression Regulation, Enzymologic/drug effects, 030304 developmental biology, MESH: Hypoxia*/chemically induced, MESH: Humans, 030306 microbiology, Virion, MESH: Virion/metabolism, MESH: Hepatitis B Core Antigens/metabolism, Cell Biology, medicine.disease, Molecular biology, In vitro, MESH: Cell Line, MESH: DNA, Viral/metabolism, chemistry, DNA, Viral, Mutation, DNA, MESH: Hepatitis B virus/physiology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5b9df1192a8473ace5d62d1f522f99
https://hal-pasteur.archives-ouvertes.fr/pasteur-02424852

Find this article in full text from ProQuest

2

Anti-remodeling effects of xanthohumol-fortified beer in pulmonary arterial hypertension mediated by ERK and AKT inhibition

المؤلفون: Rita Negrão, Ana Filipa Silva, Daniel Moreira-Gonçalves, Tiago Henriques-Coelho, Ilda Rodrigues, Manuel Filipe Santos, Gabriel Faria-Costa, Adelino F. Leite-Moreira, João Tiago Guimarães, Fábio Sousa-Nunes, Manuel J. Ferreira-Pinto, Delfim Duarte

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Nutrients
Volume 11
Issue 3
Nutrients, Vol 11, Iss 3, p 583 (2019)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, Hypertension, Pulmonary / pathology, Flavonoids / administration & dosage, Pharmacology, Pulmonary arterial hypertension, chemistry.chemical_compound, 0302 clinical medicine, Extracellular Signal-Regulated MAP Kinases / genetics, pulmonary arterial hypertension, Medicine, Extracellular Signal-Regulated MAP Kinases, remodeling, Propiophenones / chemistry, Propiophenones, Nutrition and Dietetics, Monocrotaline, Xanthohumol, Beer, Remodeling, 3. Good health, 030220 oncology & carcinogenesis, Sample collection, lcsh:Nutrition. Foods and food supply, Propiophenones / administration & dosage, Polyphenol, Hypertension, Pulmonary, Proto-Oncogene Proteins c-akt / metabolism, lcsh:TX341-641, Context (language use), Vascular Remodeling, Beer / analysis, Article, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Downregulation and upregulation, Proto-Oncogene Proteins c-akt / genetics, Hypertension, Pulmonary / chemically induced, Flavonoids / chemistry, Animals, Viability assay, Rats, Wistar, Protein kinase B, Flavonoids, business.industry, xanthohumol, Monocrotaline / toxicity, Rats, polyphenol, 030104 developmental biology, chemistry, Apoptosis, Vascular Remodeling / drug effects, Extracellular Signal-Regulated MAP Kinases / metabolism, Gene Expression Regulation, Enzymologic / drug effects, business, Proto-Oncogene Proteins c-akt, Food Science

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f5dc9731a19fb5124d569ae143998
https://hdl.handle.net/10216/136302

3

Co-treatment with indole-3-carbinol and resveratrol modify porcine CYP1A and CYP3A activities and expression

المؤلفون: Galia Zamaratskaia, Marjeta Čandek-Potokar, Rebekka Thøgersen, Martin Krøyer Rasmussen

المصدر: Zamaratskaia, G, Thøgersen, R, Candek-Potokar, M & Rasmussen, M K 2018, ' Co-treatment with indole-3-carbinol and resveratrol modify porcine CYP1A and CYP3A activities and expression ', Xenobiotica, vol. 48, no. 3, pp. 232-240 . https://doi.org/10.1080/00498254.2017.1300708

مصطلحات موضوعية: 0301 basic medicine, Male, Receptors, Steroid, Indoles, CYP3A, Swine, Health, Toxicology and Mutagenesis, Cytochrome P-450 CYP3A Inhibitors/pharmacology, Resveratrol, Pharmacology, Toxicology, Biochemistry, ENTIRE MALE PIGS, HEPATOCYTES, chemistry.chemical_compound, food–drug, Food-Drug Interactions, 0302 clinical medicine, Stilbenes, Indole-3-carbinol, Receptors, Steroid/genetics, Cytochrome P-450 CYP3A, MESSENGER-RNA EXPRESSION, DIETARY INDOLE-3-CARBINOL, DRUG-INTERACTION, Regulation of gene expression, biology, Indoles/pharmacology, Pregnane X Receptor, General Medicine, Cytochrome P-450 CYP3A/genetics, 030220 oncology & carcinogenesis, RED WINE, Microsomes, Liver, Detoxification, Hepatocytes/drug effects, food-drug, Cytochrome P-450 CYP1A1/antagonists & inhibitors, ARYL-HYDROCARBON RECEPTOR, Gene Expression Regulation, Enzymologic/drug effects, METABOLISM, liver, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, gene-regulation, Cytochrome P-450 CYP1A1, Animals, SKATOLE, secondary plant metabolites, Messenger RNA, CYP1A2, Cytochrome P450, CYTOCHROME-P450, Receptors, Aryl Hydrocarbon/genetics, 030104 developmental biology, chemistry, Receptors, Aryl Hydrocarbon, Stilbenes/pharmacology, biology.protein, Microsome, Hepatocytes, Microsomes, Liver/drug effects, Cytochrome P-450 CYP3A Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca17c2bb409623a55f3711d3c49d0c

4

Subzero nonfreezing storage of rat hepatocytes using UW solution and 1,4-butanediol. II- functional testing on rewarming and gene expression of urea cycle enzymes

المؤلفون: Edgardo E. Guibert, María Dolores Pizarro, Luciana L. Almada, Joaquín V. Rodríguez, María E. Mamprin, Cristina Bellarosa, Claudio Tiribelli

المساهمون: Guibert, Ee, Almada, Ll, Mamprin, Me, Bellarosa, Cristina, Pizarro, Md, Tiribelli, Claudio, Rodriguez, J. v.

المصدر: Annals of Hepatology, Vol 8, Iss 2, Pp 129-133 (2009)

مصطلحات موضوعية: Male, Adenosine, Time Factors, Specialties of internal medicine, Carbamyl Phosphate, law.invention, chemistry.chemical_compound, Cryoprotective Agents, law, Insulin, Urea, Butylene Glycols, chemistry.chemical_classification, General Medicine, Adenosine/pharmacology Allopurinol/pharmacology Animals Butylene Glycols/pharmacology* Carbamoyl-Phosphate Synthase (Ammonia)/genetics Carbamoyl-Phosphate Synthase (Ammonia)/metabolism Cell Survival/drug effects Cryopreservation/methods* Cryoprotective Agents/pharmacology* Gene Expression Regulation, Glutathione, Enzymologic/drug effects Glutathione/pharmacology Hepatocytes/drug effects* Hepatocytes/enzymology Insulin/pharmacology L-Lactate Dehydrogenase/metabolism Male Organ Preservation Solutions/pharmacology* Ornithine Carbamoyltransferase/genetics Ornithine Carbamoyltransferase/metabolism Propidium/metabolism Quaternary Ammonium Compounds/metabolism RNA, Biochemistry, RC581-951, Urea cycle, Propidium, Cell Survival, Allopurinol, Organ Preservation Solutions, Ornithine transcarbamylase, Carbamoyl-Phosphate Synthase (Ammonia), Biology, Gene Expression Regulation, Enzymologic, Raffinose, Subzero cold storage, Animals, Ammonium, Viaspan, RNA, Messenger, Adenosine/pharmacology Allopurinol/pharmacology Animals Butylene Glycols/pharmacology* Carbamoyl-Phosphate Synthase (Ammonia)/genetics Carbamoyl-Phosphate Synthase (Ammonia)/metabolism Cell Survival/drug effects Cryopreservation/methods* Cryoprotective Agents/pharmacology* Gene Expression Regulation, Enzymologic/drug effects Glutathione/pharmacology Hepatocytes/drug effects* Hepatocytes/enzymology Insulin/pharmacology L-Lactate Dehydrogenase/metabolism Male Organ Preservation Solutions/pharmacology* Ornithine Carbamoyltransferase/genetics Ornithine Carbamoyltransferase/metabolism Propidium/metabolism Quaternary Ammonium Compounds/metabolism RNA, Messenger/metabolism Raffinose/pharmacology Rats Rats, Wistar Time Factors Urea/metabolism, Rats, Wistar, Ornithine Carbamoyltransferase, Cryopreservation, Hepatology, L-Lactate Dehydrogenase, Messenger/metabolism Raffinose/pharmacology Rats Rats, Bioartificial liver device, Wistar Time Factors Urea/metabolism, Rats, Quaternary Ammonium Compounds, Enzyme, chemistry, Hepatic stellate cell, Hepatocytes, gene expression, urea cycle enzymes

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe91d865492ca8ecdb28a770084c6b5
http://www.sciencedirect.com/science/article/pii/S1665268119317910

5

Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response

المؤلفون: Apostolos Zarros, Stamatios Theocharis, Panagiota Galanopoulou, Dimitrios Segos, Maria Konstandi, Charis Liapi, Marios Marselos, Matti A. Lang

المصدر: Journal of Applied Toxicology. 29:101-109

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b97dd08025883594307fb89c0a92995
https://doi.org/10.1002/jat.1386

View record at Wiley

6

Aldosterone, but not increased Na+ influx or NF-kappaB activation, increases kidney-specific WNK1 gene expression in renal collecting duct cells

المؤلفون: Manlio Vinciguerra

المصدر: Hormone and Metabolic Research, Vol. 41, No 1 (2009) pp. 67-70
Scopus-Elsevier

مصطلحات موضوعية: Lipopolysaccharides, Protein-Serine-Threonine Kinases/genetics/metabolism, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Up-Regulation/drug effects, Biochemistry, chemistry.chemical_compound, Mice, Endocrinology, WNK Lysine-Deficient Protein Kinase 1, Kidney Tubules, Collecting/drug effects/metabolism, Gene expression, Aldosterone, Cell Line, Transformed, Kidney, Kinase, NF-kappa B, General Medicine, WNK1, Up-Regulation, Sodium/metabolism/pharmacology, medicine.anatomical_structure, Organ Specificity, Nf κb activation, medicine.medical_specialty, Sodium, chemistry.chemical_element, Gene Expression Regulation, Enzymologic/drug effects, Protein Serine-Threonine Kinases, Biology, Aldosterone/pharmacology, Gene Expression Regulation, Enzymologic, Minor Histocompatibility Antigens, Amphotericin B/pharmacology, Amphotericin B, Internal medicine, medicine, Animals, Kidney Tubules, Collecting, ddc:612, Biological Transport/physiology, Ionophores, Organ Specificity/drug effects/genetics, Biochemistry (medical), Biological Transport, Lipopolysaccharides/pharmacology, chemistry, Ionophores/pharmacology, NF-kappa B/metabolism, Duct (anatomy)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d353333905b23d2d8e61df4b6a637493
https://archive-ouverte.unige.ch/unige:1387

7

NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

المؤلفون: Andrzej Sienkiewicz, László Forró, Botond Banfi, Olivier Plastre, Lena Serrander, Werner Schlegel, Karl-Heinz Krause, Karen Bedard, Bernard Lardy, Laetitia Cartier

المساهمون: Facultad de Medicina, GREPI, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Ecole Polytechnique Fédérale de Lausanne (EPFL)

المصدر: Biochemical Journal
Biochemical Journal, Portland Press, 2007, 406 (1), pp.105-14. ⟨10.1042/BJ20061903⟩
Biochemical Journal, Vol. 406, No 1 (2007) pp. 105-114

مصطلحات موضوعية: Time Factors, Mitochondrion, ddc:616.07, Enzyme Induction/drug effects, MESH: Superoxides, Biochemistry, MESH: Tetracycline, Cell Membrane/drug effects/enzymology, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cytosol, MESH: Cytosol, Superoxides, Ethidium, MESH: Animals, Enzyme Inhibitors, MESH: NADPH Oxidase, chemistry.chemical_classification, Enzyme Inhibitors/pharmacology, 0303 health sciences, NADPH oxidase, biology, Superoxide, MESH: Gene Expression Regulation, Enzymologic, NOX4, MESH: NAD, MESH: Reactive Oxygen Species, Mitochondria/drug effects, Mitochondria, MESH: Nitroblue Tetrazolium, MESH: Enzyme Inhibitors, NADPH Oxidase 4, Enzyme Induction, cardiovascular system, MESH: Hydrogen Peroxide, NAD/metabolism, Superoxides/metabolism, MESH: NADP, Intracellular, Hydrogen Peroxide/pharmacology, Research Article, MESH: Enzyme Induction, RNA, Messenger/genetics/metabolism, MESH: Mitochondria, Gene Expression Regulation, Enzymologic/drug effects, Gene Expression Regulation, Enzymologic, Tetracycline/pharmacology, Cell Line, 03 medical and health sciences, Ethidium/analogs & derivatives/pharmacology, Animals, Humans, Cytosol/drug effects/enzymology, RNA, Messenger, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Molecular Biology, MESH: Mice, 030304 developmental biology, MESH: RNA, Messenger, Reactive oxygen species, MESH: Humans, urogenital system, NADPH Oxidase/ genetics, Nitroblue Tetrazolium, MESH: Time Factors, Cell Membrane, Electron Spin Resonance Spectroscopy, NADPH Oxidases, Cell Biology, Hydrogen Peroxide, Tetracycline, NADP/metabolism, NAD, Molecular biology, MESH: Ethidium, MESH: Cell Line, chemistry, biology.protein, Reactive Oxygen Species/ metabolism, MESH: Electron Spin Resonance Spectroscopy, NAD+ kinase, Reactive Oxygen Species, Nitroblue Tetrazolium/pharmacology, 030217 neurology & neurosurgery, NADP, MESH: Cell Membrane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bb68c120cdcace87036c6870419862
https://pubmed.ncbi.nlm.nih.gov/17501721

8

Divergent light-, ascorbate-, and oxidative stress-dependent regulation of expression of the peroxiredoxin gene family in Arabidopsis

المؤلفون: Karl-Josef Dietz, Andrea Kandlbinder, Frank Horling, Iris Finkemeier, Janine König, Margarete Baier, Petra Lamkemeyer

مصطلحات موضوعية: Peroxiredoxins Peroxidases/*genetics/metabolism Plant Shoots/metabolism Oxidative Stress/*physiology Oxidation-Reduction Gene Expression Regulation Enzymologic/drug effects/radiation effects Hydrogen Peroxide/pharmacology Multigene Family/genetics Light Plant/drug effects/radiation effects Gene Expression Regulation Ascorbic Acid/*pharmacology Arabidopsis Proteins/*genetics/metabolism Arabidopsis/drug effects/*genetics/radiation effects, Light, Physiology, Arabidopsis, Context (language use), Plant Science, Ascorbic Acid, Dithiothreitol, Gene Expression Regulation, Enzymologic, chemistry.chemical_compound, Gene Expression Regulation, Plant, Gene expression, Genetics, Arabidopsis thaliana, biology, Arabidopsis Proteins, Hydrogen Peroxide, Peroxiredoxins, biology.organism_classification, Ascorbic acid, Oxidative Stress, chemistry, Biochemistry, Peroxidases, Multigene Family, biology.protein, Thioredoxin, Peroxiredoxin, Oxidation-Reduction, Plant Shoots, Peroxidase, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9d0a80d407926a776fca66436e8a02
https://doi.org/10.1104/pp.010017

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