المؤلفون: Alexander Stein, Maurice Michel, Jens U. Marquardt, Helge Schroeder, Oliver Waidmann, Marcus-Alexander Woerns, Arndt Weinmann, Markus Moehler, Martin Maenz, Joseph Tintelnot, Friedrich Foerster, Joerg Trojan

المصدر: Future Oncology. 17:3309-3319

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Pyrrolidines, Maximum Tolerated Dose, Pyridines, Colorectal cancer, Administration, Oral, Trifluridine, Drug Administration Schedule, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Refractory, Regorafenib, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Dose escalation, Humans, Response Evaluation Criteria in Solid Tumors, Aged, Tipiracil, Dose-Response Relationship, Drug, business.industry, Phenylurea Compounds, General Medicine, Middle Aged, medicine.disease, Progression-Free Survival, Drug Combinations, 030104 developmental biology, chemistry, Third line, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Hypertension, Toxicity, Feasibility Studies, Female, Colorectal Neoplasms, business, Thymine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2cde2e1bcd22c3bd2bdf2e561d4671
https://doi.org/10.2217/fon-2021-0278

المؤلفون: Thomas Helleday, Bishoy M. F. Hanna, Javier Benitez, Helge Gad, Carlos Benitez-Buelga, Sarah Müller, Raúl Torres-Ruiz, Olov A. Wallner, Sandra Rodriguez-Perales, Maurice Michel, Olga Loseva, Juan Miguel Baquero, Ana Osorio, Varshni Rajagopal, Torkild Visnes, Zhao Zhenjun

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Genome instability, Antimetabolites, Antineoplastic, Cancer therapy, DNA Repair, Science, Oxidative phosphorylation, medicine.disease_cause, Article, Genomic Instability, DNA Glycosylases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Telomere Homeostasis, Piperidines, Cell Line, Tumor, medicine, Humans, Enzyme Inhibitors, Multidisciplinary, Chemistry, DNA damage and repair, Cell Cycle, Drug Synergism, Base excision repair, Telomere, 3. Good health, Oxidative Stress, Telomeres, Methotrexate, 030104 developmental biology, DNA glycosylase, 030220 oncology & carcinogenesis, Cancer research, Medicine, Benzimidazoles, Reactive Oxygen Species, Oxidation-Reduction, DNA, Oxidative stress

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37261330c3e621d2cdb6f7342b81d66f
https://doaj.org/article/1b489d3921bb4809ad1aa6047fd0bc20

المؤلفون: Thomas Helleday, Evert Homan, Ann-Sofie Jemth, Maurice Michel, Emma Rose Scaletti, Pål Stenmark

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Biochemistry, Kinase, Ribavirin, RNA, Enzyme kinetics, Prodrug, Nudix hydrolase, Active metabolite, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8afed35df562cee990fda28c09b874ca
https://doi.org/10.1101/2021.11.16.468802

المؤلفون: Karl S. A. Vallin, Cynthia B.J. Paulin, Olov A. Wallner, Thomas Helleday, Jiaxi Zhang, Brinton Seashore-Ludlow, Maurice Michel, Martin Scobie, Ulrika Warpman Berglund, Evert Homan, Mattias Hedenström, Torkild Visnes, Andreas Schmidt, Elisee Wiita, Annika Jenmalm-Jensen

المصدر: 11642-11656
ACS Omega
ACS Omega, Vol 4, Iss 7, Pp 11642-11656 (2019)

مصطلحات موضوعية: Thermal shift assay, Human dna, General Chemical Engineering, Druggability, NEIL1, Computational biology, 010402 general chemistry, 01 natural sciences, Article, lcsh:Chemistry, 03 medical and health sciences, Endonuclease, chemistry.chemical_compound, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Assay, Biochemistry and Molecular Biology, General Chemistry, 0104 chemical sciences, lcsh:QD1-999, DNA glycosylase, biology.protein, DNA, Biokemi och molekylärbiologi

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a979a2138e18910e81cb3df15c169a00
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164548

المؤلفون: A Thonig, Marcus Hollenbach, Cristina Ripoll, Maurice Michel, Alexander Zipprich, S Pohl

المصدر: PLoS ONE, Vol 12, Iss 2, p e0171260 (2017)
PLoS ONE

مصطلحات موضوعية: Liver Cirrhosis, Male, 0301 basic medicine, Cirrhosis, lcsh:Medicine, Pathology and Laboratory Medicine, Epithelium, Lactoylglutathione lyase, chemistry.chemical_compound, Liver disease, 0302 clinical medicine, Animal Cells, Fibrosis, Medicine and Health Sciences, lcsh:Science, Immune Response, Cells, Cultured, Mammals, Multidisciplinary, biology, Liver Diseases, Methylglyoxal, Lactoylglutathione Lyase, NF-kappa B, Animal Models, Pyruvaldehyde, Glutathione, Liver, Experimental Organism Systems, 030220 oncology & carcinogenesis, Vertebrates, Cytokines, Cellular Types, Anatomy, Research Article, medicine.medical_specialty, Wistar Rats, Inflammatory Diseases, Immunology, CCL4, Gastroenterology and Hepatology, Research and Analysis Methods, Rodents, 03 medical and health sciences, Signs and Symptoms, Model Organisms, Diagnostic Medicine, Internal medicine, medicine, Animals, Rats, Wistar, Sirius Red, Inflammation, Tumor Necrosis Factor-alpha, lcsh:R, Organisms, Biology and Life Sciences, Endothelial Cells, Epithelial Cells, Cell Biology, medicine.disease, Rats, Biological Tissue, 030104 developmental biology, Endocrinology, chemistry, Amniotes, Hepatocytes, biology.protein, Hepatic stellate cell, lcsh:Q, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4a4fec74b995f0da4c6e32a8893fb1
http://europepmc.org/articles/PMC5322979?pdf=render