المؤلفون: Casasnovas C; Neuromuscular Unit, Neurology Department, Bellvitge University Hospital, Feixa Llarga s/n, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, Hospital Duran i Reynals, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.; Center for Biomedical Research on Rare Diseases, Institute of Health Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain., Ruiz M; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, Hospital Duran i Reynals, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.; Center for Biomedical Research on Rare Diseases, Institute of Health Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain.; Institute of Neuropathology, Bellvitge Biomedical Research Institute, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Schlüter A; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, Hospital Duran i Reynals, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.; Center for Biomedical Research on Rare Diseases, Institute of Health Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain.; Institute of Neuropathology, Bellvitge Biomedical Research Institute, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Naudí A; Biomedical Research Institute of Lleida, Montserrat Roig 2, 25008, Lleida, Spain., Fourcade S; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, Hospital Duran i Reynals, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.; Center for Biomedical Research on Rare Diseases, Institute of Health Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain.; Institute of Neuropathology, Bellvitge Biomedical Research Institute, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Veciana M; Neurophysiology Unit, Neurology Department, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Castañer S; Centre Bellvitge, Institut de Diagnòstic per la Imatge, Feixa Llarga s/n, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Albertí A; Neuromuscular Unit, Neurology Department, Bellvitge University Hospital, Feixa Llarga s/n, 08908, L'Hospitalet de Llobregat, Barcelona, Spain., Bargalló N; Department of Neuroradiology, Hospital Clínic, Barcelona, Spain.; Magnetic Resonance Imaging Core Facility, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Johnson M; Deparment of Neurology and Pediatrics, University of Minnesota Medical Center, 516 Delaware Street Southeast, Minneapolis, Minnesota, 55455, USA., Raymond GV; Deparment of Neurology and Pediatrics, University of Minnesota Medical Center, 516 Delaware Street Southeast, Minneapolis, Minnesota, 55455, USA., Fatemi A; Kennedy Krieger Institute, 707 North Broadway, Baltimore, Maryland, 21205, USA., Moser AB; Kennedy Krieger Institute, 707 North Broadway, Baltimore, Maryland, 21205, USA., Villarroya F; Departament de Bioquimica i Biologia Molecular and Institute of Biomedicine of the University of Barcelona, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028, Barcelona, Spain.; Center for Biomedical Research in Physiopathology of Obesity and Nutrition, Bellvitge Biomedical Research Institute, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain., Portero-Otín M; Biomedical Research Institute of Lleida, Montserrat Roig 2, 25008, Lleida, Spain., Artuch R; Center for Biomedical Research on Rare Diseases, Institute of Health Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain.; Institut de Recerca Sant Joan de Déu, Passeig de Sant Joan de Déu 2, 08950, Esplugues de Llobregat, Barcelona, Spain., Pamplona R; Biomedical Research Institute of Lleida, Montserrat Roig 2, 25008, Lleida, Spain., Pujol A; Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, Hospital Duran i Reynals, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain. apujol@idibell.cat.; Center for Biomedical Research on Rare Diseases, Institute of Health Carlos III, Monforte de Lemos 3-5, Pabellón 11, 28029, Madrid, Spain. apujol@idibell.cat.; Institute of Neuropathology, Bellvitge Biomedical Research Institute, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain. apujol@idibell.cat.; Catalan Institution of Research and Advanced Studies, Passeig de Lluís Companys 23, 08010, Barcelona, Spain. apujol@idibell.cat.

المصدر: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2019 Oct; Vol. 16 (4), pp. 1167-1182.

نوع المنشور: Clinical Trial, Phase II; Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics Country of Publication: United States NLM ID: 101290381 Publication Model: Print Cited Medium: Internet ISSN: 1878-7479 (Electronic) Linking ISSN: 18787479 NLM ISO Abbreviation: Neurotherapeutics Subsets: MEDLINE

مواضيع طبية MeSH: Adrenoleukodystrophy/*blood , Adrenoleukodystrophy/*drug therapy , Antioxidants/*administration & dosage , Chemokine CCL2/*blood , Hydroxyeicosatetraenoic Acids/*blood, Adrenoleukodystrophy/diagnostic imaging ; Adult ; Biomarkers/blood ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/blood ; Male ; Middle Aged ; Neural Conduction/drug effects ; Neural Conduction/physiology ; Pilot Projects ; Prospective Studies ; Treatment Outcome ; Young Adult

المؤلفون: Raymond, Gerald V, Pasquali, Marzia, Polgreen, Lynda E, Dickson, Patricia I, Miller, Weston P, Orchard, Paul J, Lund, Troy C

المصدر: Scientific reports. 6(1)

مصطلحات موضوعية: Humans, Mucopolysaccharidosis I, Iduronidase, Glucose, Heparitin Sulfate, Adaptor Proteins, Signal Transducing, Nerve Tissue Proteins, Interleukin-8, Gene Expression, Cerebrospinal Fluid Pressure, Mutation, Adolescent, Child, Child, Preschool, Infant, Female, Male, Chemokine CCL2, Chemokine CXCL12, Biomarkers, Adaptor Proteins, Signal Transducing, Preschool

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2p66q6xg