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1دورية أكاديمية
المؤلفون: Azab, Sandi MAff1, Aff2, Aff3, Shanmuganathan, Meera, de Souza, Russell JAff3, Aff5, Aff6, Kroezen, Zachary, Desai, DipikaAff1, Aff6, Williams, Natalie CAff1, Aff3, Morrison, Katherine MAff6, Aff7, Aff8, Atkinson, Stephanie A, Teo, Koon KAff1, Aff6, Azad, Meghan B, Simons, Elinor, Moraes, Theo J, Mandhane, Piush J, Turvey, Stuart E, Subbarao, PadmajaAff1, Aff10, Britz-McKibbin, Philip, Anand, Sonia SAff1, Aff3, Aff5, Aff6, IDs12916023028868_cor17
المصدر: BMC Medicine. 21(1)
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2دورية أكاديمية
المؤلفون: Sandi M Azab, Meera Shanmuganathan, Russell J de Souza, Zachary Kroezen, Dipika Desai, Natalie C Williams, Katherine M Morrison, Stephanie A Atkinson, Koon K Teo, Meghan B Azad, Elinor Simons, Theo J Moraes, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Philip Britz-McKibbin, Sonia S Anand
المصدر: BMC Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
مصطلحات موضوعية: Childhood overweight, Childhood adiposity, Waist circumference, Serum metabolomics, Sex differences, Aromatic amino acids, Medicine
الوصف: Abstract Background Childhood obesity is a global health concern and can lead to lifetime cardiometabolic disease. New advances in metabolomics can provide biochemical insights into the early development of obesity, so we aimed to characterize serum metabolites associated with overweight and adiposity in early childhood and to stratify associations by sex. Methods Nontargeted metabolite profiling was conducted in the Canadian CHILD birth cohort (discovery cohort) at age 5 years (n = 900) by multisegment injection-capillary electrophoresis-mass spectrometry. Clinical outcome was defined using novel combined measures of overweight (WHO-standardized body mass index ≥ 85th percentile) and/or adiposity (waist circumference ≥ 90th percentile). Associations between circulating metabolites and child overweight/adiposity (binary and continuous outcomes) were determined by multivariable linear and logistic regression, adjusting for covariates and false discovery rate, and by subsequent sex-stratified analysis. Replication was assessed in an independent replication cohort called FAMILY at age 5 years (n = 456). Results In the discovery cohort, each standard deviation (SD) increment of branched-chain and aromatic amino acids, glutamic acid, threonine, and oxoproline was associated with 20–28% increased odds of overweight/adiposity, whereas each SD increment of the glutamine/glutamic acid ratio was associated with 20% decreased odds. All associations were significant in females but not in males in sex-stratified analyses, except for oxoproline that was not significant in either subgroup. Similar outcomes were confirmed in the replication cohort, where associations of aromatic amino acids, leucine, glutamic acid, and the glutamine/glutamic acid ratio with childhood overweight/adiposity were independently replicated. Conclusions Our findings show the utility of combining measures of both overweight and adiposity in young children. Childhood overweight/adiposity at age 5 years has a specific serum metabolic phenotype, with the profile being more prominent in females compared to males.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1741-7015
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3دورية أكاديمية
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