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1
المؤلفون: Patrice Lee, Hibery Ho, David K. Edwards, Selina Qiuying Liu, Angela Rofelty, David Sweeney, Shannon K. McWeeney, Alexey V. Danilov, David Chantry, Stephen E. Spurgeon, Jeffrey W. Tyner, Brian J. Druker, Christopher A. Eide, Marc M. Loriaux, Anupriya Agarwal
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Chronic lymphocytic leukemia, Colony stimulating factor 1 receptor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, colony-stimulating factor 1 receptor, medicine, tumor microenvironment, Tumor microenvironment, Hematology, tumor-associated macrophages, business.industry, Monocyte, medicine.disease, 3. Good health, small-molecule inhibitors, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, chemistry, 030220 oncology & carcinogenesis, Ibrutinib, Cancer research, chronic lymphocytic leukemia, Idelalisib, business, Priority Research Paper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86a0bbd548169c03c3a3266c4841fdd
https://doi.org/10.18632/oncotarget.25191 -
2
المؤلفون: Claire Godbersen, Bhargava Sreekantham, Olga V. Danilova, Scott R Best, Alexey V. Danilov, Cody Paiva, Prabhjot Kaur, Stephen E. Spurgeon, Marc M. Loriaux, Taylor Rowland
المصدر: Haematologica
مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Chronic lymphocytic leukemia, B-cell receptor, Receptors, Antigen, B-Cell, Syk, CHO Cells, Biology, Models, Biological, Article, 03 medical and health sciences, Cricetulus, immune system diseases, Cell Line, Tumor, hemic and lymphatic diseases, B-Cell Activating Factor, medicine, Animals, Cluster Analysis, Humans, Syk Kinase, Chronic Lymphocytic Leukemia, B-cell activating factor, TNF Receptor-Associated Factor 3, Gene Expression Profiling, NF-kappa B, Hematology, TNF Receptor-Associated Factor 2, medicine.disease, Immunohistochemistry, Leukemia, Lymphocytic, Chronic, B-Cell, Cell biology, Leukemia, Crosstalk (biology), 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, Signal transduction, Immunoglobulin Heavy Chains, Protein Binding, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a841e2e303a0a930f0398030f14d15f
https://doi.org/10.3324/haematol.2017.170571 -
3
المؤلفون: Brian J. Druker, Kevin S. Currie, Patricia Maciejewski, Russell T. Burke, Brian J. Lannutti, Julie DiPaolo, Stephen E. Spurgeon, Marc M. Loriaux, Sarah A. Meadows, Scott A. Mitchell, Astrid S. Clarke
المصدر: Oncotarget
مصطلحات موضوعية: Indazoles, Chronic lymphocytic leukemia, B-cell receptor, Syk, Apoptosis, Biology, Fostamatinib, spleen tyrosine kinase, hemic and lymphatic diseases, PI3 kinase, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Syk Kinase, Chronic Lymphocytic Leukemia, Phosphorylation, Protein Kinase Inhibitors, Quinazolinones, breakpoint cluster region, Intracellular Signaling Peptides and Proteins, Drug Synergism, BCR Signaling Pathway, Protein-Tyrosine Kinases, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, signaling pathways, Leukemia, Oncology, Purines, Pyrazines, Cancer research, Idelalisib, medicine.drug, Research Paper, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586b96018817e74b23f80ce982b02789
http://europepmc.org/articles/PMC4011593 -
4
المؤلفون: Elie Traer, Paul Tardi, Tibor Kovacsovics, Stephen E. Spurgeon, Marc M. Loriaux, Max J. Gordon, Lawrence D. Mayer, Jeffrey W. Tyner
المصدر: Leukemia research. 53
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Antimetabolites, Antineoplastic, Daunorubicin, Chronic lymphocytic leukemia, Pharmacology, Biology, 03 medical and health sciences, Inhibitory Concentration 50, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Tumor Cells, Cultured, Cytotoxic T cell, Humans, Antibiotics, Antineoplastic, Cytarabine, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Lymphoma, Leukemia, 030104 developmental biology, Oncology, fms-Like Tyrosine Kinase 3, 030220 oncology & carcinogenesis, Fms-Like Tyrosine Kinase 3, Liposomes, Mutation, Blast Crisis, Ex vivo, medicine.drug
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المؤلفون: Ellen Q. Wang, Brian J. Druker, Luke B Fletcher, Motomi Mori, Wayne F. Yang, Jeffrey W. Tyner, Marc M. Loriaux, Michael Heinrich, Michael W. Deininger, Michael Rutenberg-Schoenberg, Carol Beadling
المصدر: Cancer Research. 70:6233-6237
مصطلحات موضوعية: Cancer Research, Chronic lymphocytic leukemia, Chronic myelomonocytic leukemia, Biology, Bioinformatics, medicine.disease_cause, Polymorphism, Single Nucleotide, Article, Mice, Neoplasms, hemic and lymphatic diseases, medicine, Animals, Humans, Protein Isoforms, Receptors, Growth Factor, Amino Acid Sequence, Phosphorylation, Peptide sequence, Thyroid cancer, Cancer, Myeloid leukemia, Proto-Oncogene Proteins c-met, medicine.disease, Cell Transformation, Neoplastic, Oncology, Hepatocyte Growth Factor Receptor, Carcinogenesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70eb980a8d6784decb9ddfa7c2489574
https://doi.org/10.1158/0008-5472.can-10-0429 -
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المؤلفون: Russell T. Burke, Stephen E. Spurgeon, Brian J. Druker, Marc M. Loriaux, Renee C. Prins, Jeffrey W. Tyner
المصدر: Leukemia. 27:2094-2096
مصطلحات موضوعية: Cancer Research, animal structures, Chronic lymphocytic leukemia, B-cell receptor, Receptors, Antigen, B-Cell, Antineoplastic Agents, Biology, Pharmacology, Piperidines, Antigen, Casein, medicine, Humans, Naphthyridines, Casein Kinase II, Receptor, Quinazolinones, Adenine, Drug Synergism, Hematology, Prognosis, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Fludarabine, Leukemia, Pyrimidines, Oncology, Purines, Hematologic Neoplasms, Immunoglobulin G, Phenazines, Pyrazoles, Casein kinase 2, Vidarabine, Signal Transduction, medicine.drug
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المؤلفون: Stanley J. Hollenbach, Stephen E. Spurgeon, Greg Coffey, Yvonne Pak, Marc M. Loriaux, Dale Baker, Andreas Betz, Brian J. Druker, Anjali Pandey, Russell T. Burke, Francis DeGuzman, Luke B. Fletcher, Uma Sinha, Jeffrey W. Tyner
المصدر: The Journal of pharmacology and experimental therapeutics. 344(2)
مصطلحات موضوعية: Cell Survival, Chronic lymphocytic leukemia, Syk, Antineoplastic Agents, Apoptosis, Mice, SCID, Biology, Mice, immune system diseases, hemic and lymphatic diseases, Cell Line, Tumor, medicine, Animals, Humans, Syk Kinase, Kinase activity, Phosphorylation, B cell, Pharmacology, B-Lymphocytes, Cyclohexylamines, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Kinase, Lymphoma, Non-Hodgkin, breakpoint cluster region, Intracellular Signaling Peptides and Proteins, Drug Synergism, Protein-Tyrosine Kinases, medicine.disease, Flow Cytometry, Leukemia, Lymphocytic, Chronic, B-Cell, Xenograft Model Antitumor Assays, Chemotherapy, Antibiotics, and Gene Therapy, Fludarabine, Leukemia, medicine.anatomical_structure, Pyrimidines, Cancer research, Molecular Medicine, Spleen, Vidarabine, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9cc5daf62643ad3b3014c5f8778f29
https://pubmed.ncbi.nlm.nih.gov/23220742 -
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المؤلفون: D. Gary Gilliland, Scott A. Armstrong, M. Beran, Brian J. Druker, Michael W. Deininger, Eric P. Stoffregen, Mignon L. Loh, Roland Berger, Stephanie G. Willis, Brian J. P. Huntly, Ross L. Levine, A. Thomas Look, Jennifer J. Clark, Olivier Bernard, Nikki J. Flores, Michael Heinrich, Kim Nguyen, James D. Griffin, Elihu H. Estey, Norbert Gattermann, Marc M. Loriaux
المصدر: Blood. 106(10)
مصطلحات موضوعية: Male, Clinical Trials and Observations, Chronic lymphocytic leukemia, Immunology, Chronic myelomonocytic leukemia, Biochemistry, Acute lymphocytic leukemia, hemic and lymphatic diseases, Proto-Oncogene Proteins, medicine, CD135, Humans, Point Mutation, Myelofibrosis, Alleles, Aged, business.industry, Myeloid leukemia, Leukemia, Myelomonocytic, Chronic, Cell Biology, Hematology, Janus Kinase 2, Middle Aged, Protein-Tyrosine Kinases, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Lymphoid, Enzyme Activation, Leukemia, Amino Acid Substitution, Leukemia, Myeloid, Case-Control Studies, Cancer research, Female, business, Chronic myelogenous leukemia
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b87b1d2aa9bd51db6dee94d8f27979
https://pubmed.ncbi.nlm.nih.gov/16081687 -
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المصدر: Blood. 120:2471-2471
مصطلحات موضوعية: Phosphoinositide 3-kinase, biology, Chronic lymphocytic leukemia, Immunology, breakpoint cluster region, Cell Biology, Hematology, Pharmacology, BCR Signaling Pathway, medicine.disease, Biochemistry, Fludarabine, biology.protein, medicine, Casein kinase 2, Protein kinase B, PI3K/AKT/mTOR pathway, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2b985774d84c24fbd5c76c7872a8162d
https://doi.org/10.1182/blood.v120.21.2471.2471 -
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المؤلفون: Astrid S. Clarke, Jennifer Dunlap, Stephen E. Spurgeon, Marc M. Loriaux, Russell T. Burke, Patricia Maciejewski, Julie Di Paolo, Brian J. Druker, Sarah A. Meadows, Guang Fan, Brian Lannutti
المصدر: Blood. 120:3876-3876
مصطلحات موضوعية: biology, business.industry, Chronic lymphocytic leukemia, Immunology, breakpoint cluster region, Syk, Cell Biology, Hematology, Pharmacology, medicine.disease, Biochemistry, chemistry.chemical_compound, Cell killing, chemistry, hemic and lymphatic diseases, biology.protein, Medicine, Bruton's tyrosine kinase, Growth inhibition, business, Protein kinase B, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ca2df5411cac20e599eb9ffef50dfd23
https://doi.org/10.1182/blood.v120.21.3876.3876