المؤلفون: Stewart A; School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom., Sinclair E; School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom., Ng JC; Randall Centre for Cell & Molecular Biophysics, King's College London, London, United Kingdom., O'Hare JS; School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.; Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Page A; Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Serangeli I; Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, Rome, Italy., Margreitter C; Department of Chemistry, University of Surrey, Guildford, United Kingdom., Orsenigo F; School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.; Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Milan, Italy., Longman K; Department of Chemistry, University of Surrey, Guildford, United Kingdom., Frampas C; Department of Chemistry, University of Surrey, Guildford, United Kingdom., Costa C; Department of Chemistry, University of Surrey, Guildford, United Kingdom., Lewis HM; Department of Chemistry, University of Surrey, Guildford, United Kingdom., Kasar N; School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom., Wu B; Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Kipling D; School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom., Openshaw PJ; Faculty of Medicine, Imperial College London, London, United Kingdom., Chiu C; Faculty of Medicine, Imperial College London, London, United Kingdom., Baillie JK; Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom., Scott JT; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom., Semple MG; Faculty of Health & Life Sciences, University of Liverpool, Liverpool, United Kingdom., Bailey MJ; Department of Chemistry, University of Surrey, Guildford, United Kingdom., Fraternali F; Randall Centre for Cell & Molecular Biophysics, King's College London, London, United Kingdom., Dunn-Walters DK; School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.

المصدر: Frontiers in immunology [Front Immunol] 2022 May 03; Vol. 13, pp. 807104. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Ebolavirus* , Hemorrhagic Fever, Ebola* , Respiratory Syncytial Virus, Human*/genetics, Antibodies, Viral ; Humans ; Pandemics ; SARS-CoV-2

المؤلفون: Alexander Stewart, Emma Sinclair, Joseph Chi-Fung Ng, Joselli Silva O’Hare, Audrey Page, Ilaria Serangeli, Christian Margreitter, Federica Orsenigo, Katherine Longman, Cecile Frampas, Catia Costa, Holly-May Lewis, Nora Kasar, Bryan Wu, David Kipling, Peter JM Openshaw, Christopher Chiu, J Kenneth Baillie, Janet T. Scott, Malcolm G. Semple, Melanie J. Bailey, Franca Fraternali, Deborah K. Dunn-Walters

المصدر: Frontiers in Immunology, Vol 13 (2022)

مصطلحات موضوعية: B cell, COVID-19, ebola, RSV (respiratory syncytial virus), immunity, repertoire, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.807104/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/18d3cd1604444754a30e77ea1c71ef1d

المؤلفون: Samuel Long

المصدر: Methods (San Diego, Calif.)

مصطلحات موضوعية: Viral nucleic acid, Cure research, Human immunodeficiency virus (HIV), HIV Infections, qPCR, quantitative (real time) polymerase chain reaction, Ct, threshold cycle, PCR sensitivity, medicine.disease_cause, HO, high occupancy, miRNA, microRNA, HTLV, human T-cell leukaemia virus, Digital polymerase chain reaction, dPCR, digital PCR, RT-qPCR, quantitative reverse transcription (real time) polymerase chain reaction, SIV, simian immunodeficiency virus, COVID-19, Coronavirus disease 2019, Tm, melting temperature, 0303 health sciences, NHP, non-human primate, cART, combination antiretroviral therapy, 030302 biochemistry & molecular biology, CT, Computed Tomography, SNP, single nucleotide polymorphism, STLV-1, simian T cell lymphotropic viruses type 1, Virus, FFPE, formalin-fixed paraffin-embedded, HIV, human immunodeficiency virus, RT, reverse transcriptase, RNA, Viral, Infectious diseases, dMIQE, Minimum Information for Publication of Quantitative digital PCR experiments, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), HPV, human papillomavirus, Context (language use), Computational biology, LoD, limit of detection, Biology, Real-Time Polymerase Chain Reaction, Sensitivity and Specificity, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Humans, STLV-2, simian T cell lymphotropic viruses type 2, SARS, severe acute respiratory syndrome, ddPCR, droplet digital polymerase chain reaction, Molecular Biology, 030304 developmental biology, SARS-CoV-2, SNV, single nucleotide variant, COVID-19, HIV, NGS, next generation sequencing, DNA, PIV, parainfluenza virus, MGB, minor groove binder, Infectious disease (medical specialty), Nucleic acid, RNA, RSV, respiratory syncytial virus, RT-dPCR, reverse transcription digital polymerase chain reaction, Digital PCR

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ffd41efd3a3c73b76e2e0fb9f5b477
https://doi.org/10.1016/j.ymeth.2021.04.008

المؤلفون: Yulia Eygeris, Gaurav Sahay, Mohit Gupta, Jeonghwan Kim

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: HPLC, High-performance liquid chromatography, TH1, Type 1 T helper cell, DMG-PEG-2000, 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, IV, Intravenous, Genetic enhancement, APC, Antigen-presenting cell, Pharmaceutical Science, PET-CT, Positron emission tomography- computed tomography, 02 engineering and technology, LNP, Lipid nanoparticle, UTR, Untranslated region, IL, Ionizable lipid, PEG, Poly(ethylene glycol), SARS-CoV-2, Severe acute respiratory syndrome coronavirus-2, ID, Intradermal, ARCA, “Anti-reverse" cap analog, Nanotechnology, IM, Intramuscular, Gene delivery, GMP, Good manufacturing practice, IVT, In vitro transcription, Vaccines, Synthetic, 0303 health sciences, SAXS, Small-angle X-ray scattering, Gene Transfer Techniques, Self-assembly, PBAE, Poly(beta-amino esters), 021001 nanoscience & nanotechnology, DC, Dendritic cell, mRNA, Messenger RNA, Vaccination, DSPC, 1,2-Distearoyl-sn-glycero-3-phosphocholine, HIV, Human immunodeficiency virus, COVID-19, Coronavirus Disease 2019, siRNA, Small interfering RNA, DOTAP, 1,2-Dioleoyl-3-trimethylammonium-propane, RSV, Respiratory syncytial virus, ApoE, Apolipoprotein E, 0210 nano-technology, EUA, Emergency Use Authorization, DOTMA, 1,2-Di-O-octadecenyl-3-trimethylammonium propane, TLR, Toll-like receptor, Immune activation, DODMA, 1,2-Dioleyloxy-3-dimethylaminopropane, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), GC, Germinal center, Computational biology, BCR, B-cell receptor, Biology, DLin-MC3-DMA, MC3, (6Z,9Z,28Z,31Z)-Heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate, Article, Self assembled, saRNA, Self-amplifying RNA, 03 medical and health sciences, PEI, Poly(ethylene imine), DOPE, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, SAR, Structure-activity relationship, mRNA delivery, ACE2, Angiotensin-converting enzyme 2, DGTS, 1,2-Dipalmitoyl-sn-glycero-3-O-4'-(N,N,N-trimethyl)-homoserine, Animals, Humans, RNA, Messenger, IgA, IgG, Immunoglobulin A, G, 030304 developmental biology, MHC, Major histocompatibility complex, Messenger RNA, PLGA, Poly(lactic-co-glycolic acid), SC, Subcutaneous, COVID-19, LN, Lymph node, RBD, Receptor Binding Domain, Immunization, Drug Design, DOGS, N1,N1'-(8-(dioctadecylamino)-5,8-dioxooctane-1,4-diyl)bis(propane-1,3-diaminium), Lipid nanoparticles, Nanoparticles, pDNA, Plasmid DNA, Cryo-(T)EM, Cryogenic (transmission) electron microscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0f88a1e945504ba8b4af825e8da083
https://doi.org/10.1016/j.addr.2020.12.014

المؤلفون: Dezhi Mu, Yi Qu, Xihong Li, Dongqiong Xiao, Xiaojuan Su

المصدر: International Journal of Infectious Diseases, Vol 102, Iss, Pp 196-202 (2021)
International Journal of Infectious Diseases

مصطلحات موضوعية: 0301 basic medicine, ARDS, ALI, acute lung injury, viruses, medicine.disease_cause, Renin-Angiotensin System, Pathogenesis, 0302 clinical medicine, Ang I, angiotensin I, Acute lung injury, Medicine, 030212 general & internal medicine, Vitamin D, skin and connective tissue diseases, Receptor, Coronavirus, TGF-β, transforming growth factor β, Respiratory Distress Syndrome, TNF-α, tumour necrosis factor alpha, Ang1-7, angiotensin 1-7, RBM, receptor-binding motif, Type-II Pneumocytes, VDREs, vitamin D responsive elements, virus diseases, General Medicine, respiratory system, HBDs, β‐defensins, Infectious Diseases, Perspective, IL-8, inerleukin-8, VDR, vitamin D receptor, Ang1-9, angiotensin 1-9, Angiotensin-Converting Enzyme 2, hormones, hormone substitutes, and hormone antagonists, Microbiology (medical), 030106 microbiology, Lung injury, CCL3, chemokine (C-C motif) ligand 3, IFN-α, interferon alpha, SARS-CoV, SARS coronavirus, lcsh:Infectious and parasitic diseases, hACE2, human ACE2, RBD, receptor binding domain, 03 medical and health sciences, Renin–angiotensin system, ACE2, angiotensin converting enzyme-2, Vitamin D and neurology, Humans, lcsh:RC109-216, Ang Ⅱ, angiotensin Ⅱ, ARDS, acute respiratory distress syndrome, AP-1, activation protein 1, SARS-CoV-2, business.industry, fungi, COVID-19, RAS, renin-angiotensin system, medicine.disease, respiratory tract diseases, 2019-nCoV, novel coronavirus, Immunology, RSV, respiratory syncytial virus, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891439af67571c75e12b8b020fa43216
https://doi.org/10.1016/j.ijid.2020.10.059

المؤلفون: Konstantina S. Nikita, Eleni S. Adamidi, Konstantinos Mitsis

المصدر: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2833-2850 (2021)
Computational and Structural Biotechnology Journal

مصطلحات موضوعية: LR, Logistic Regression, APTT, Activated Partial Thromboplastin Time, DNN, Deep Neural Networks, GNB, Gaussian Naïve Bayes, RSV, Respiratory Syncytial Virus, SVM, Support Vector Machine, Review, Disease, Biochemistry, WBC, White Blood Cell count, 0302 clinical medicine, Multimodal data, DLC, Density Lipoprotein Cholesterol, Medicine, CPP, COVID-19 Positive Patients, Nadam optimizer, Nesterov Accelerated Adaptive Moment optimizer, 0303 health sciences, CRT, Classification and Regression Decision Tree, Prognosis, LDLC, Low Density Lipoprotein Cholesterol, CRP, C-Reactive Protein, GFS, Gradient boosted feature selection, LDA, Linear Discriminant Analysis, Systematic review, ADA, Adenosine Deaminase, ML, Machine Learning, CNN, Convolutional Neural Networks, 030220 oncology & carcinogenesis, GGT, Glutamyl Transpeptidase, RBP, Retinol Binding Protein, RF, Random Forest, NLP, Natural Language Processing, INR, International Normalized Ratio, LASSO, Least Absolute Shrinkage and Selection Operator, FCV, Fold Cross Validation, SEN, Sensitivity, Biophysics, ABG, Arterial Blood Gas, SRLSR, Sparse Rescaled Linear Square Regression, RBF, Radial Basis Function, AI, Artificial Intelligence, 03 medical and health sciences, PWD, Platelet Distribution Width, RFE, Recursive Feature Elimination, Genetics, OB, Occult Blood test, Paco2, Arterial Carbondioxide Tension, MLP, MultiLayer Perceptron, DL, Deep Learning, ED, Emergency Department, Guideline, CI, Confidence Interval, ANN, Artificial Neural Networks, GFR, Glomerular Filtration Rate, MPV, Mean Platelet Volume, TBA, Total Bile Acid, Adaboost, Adaptive Boosting, TP248.13-248.65, MCV, Mean corpuscular volume, ET, Extra Trees, Artificial intelligence, L1LR, L1 Regularized Logistic Regression, MCHC, Mean Corpuscular Hemoglobin Concentration, ARMED, Attribute Reduction with Multi-objective Decomposition Ensemble optimizer, CK-MB, Creatine Kinase isoenzyme, LSTM, Long-Short Term Memory, FL, Federated Learning, PCT, Thrombocytocrit, Structural Biology, Pandemic, Diagnosis, TTS, Training Test Split, HDLC, High Density Lipoprotein Cholesterol, PPV, Positive Predictive Values, k-NN, K-Nearest Neighbor, Computer Science Applications, BUN, Blood Urea Nitrogen, FiO2, Fraction of Inspiration O2, RBC, Red Blood Cell, SG, Specific Gravity, GDCNN, Genetic Deep Learning Convolutional Neural Network, Screening, XGB, eXtreme Gradient Boost, Apol B, Apolipoprotein B, GBDT, Gradient Boost Decision Tree, PaO2, Arterial Oxygen Tension, Biotechnology, NB, Naïve Bayes, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SMOTE, Synthetic Minority Oversampling Technique, Apol AI, Apolipoprotein AI, CoxPH, Cox Proportional Hazards, Acc, Accuracy, AUC, Area Under the Curve, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, ESR, Erythrocyte Sedimentation Rate, LDH, Lactate Dehydrogenase, BNB, Bernoulli Naïve Bayes, business.industry, RDW, Red blood cell Distribution Width, NPV, Negative Predictive Values, GBM light, Gradient Boosting Machine light, DCNN, Deep Convolutional Neural Networks, SPE, Specificity, COVID-19, Inception Resnet, Inception Residual Neural Network, DT, Decision Tree, MRMR, Maximum Relevance Minimum Redundancy, SaO2, Arterial Oxygen saturation, business, Predictive modelling

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d4904675baf780e5818934ae227323
http://www.sciencedirect.com/science/article/pii/S2001037021001914

المؤلفون: Deborah Pushparajah, Salma Jimenez, Shirley Wong, Hibah Alattas, Roderick A. Slavcev, Nafiseh Nafissi

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: Pharmaceutical Science, Non-replicative viral vaccines, 02 engineering and technology, MVA, modified vaccinia virus Ankara, medicine.disease_cause, HAI, hemagglutinin inhibition, SLE, systemic lupus erythematosus, AAV, adeno-associated virus, Pandemic, Medicine, SARS-CoV-2, severe acute respiratory syndrome 2, Coronavirus, COVID-19, coronavirus disease 2019, 0303 health sciences, Vaccines, TNF, tumor necrosis factor, Clinical Trials as Topic, Vaccines, Synthetic, ADE, antibody dependent enhancement, biology, ACE2, angiotensin converting enzyme 2, EP, electroporation, LNP, lipid nanoparticle, MIV, monovalent inactivated virus, MERS-CoV, Middle East respiratory syndrome coronavirus, OGN, oligodeoxynucleotide, 021001 nanoscience & nanotechnology, Replicative viral vaccines, 3. Good health, ChAd, chimpanzee adenovirus, polyA, polyadenylation, WNV, West Nile virus, IIV, inactivated influenza virus vaccine, 0210 nano-technology, saRNA, self-amplifying RNA, S, spike, VSV, vesicular stomatitis virus, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV, severe acute respiratory syndrome coronavirus, E, envelope, Article, DNA vaccination, Viral vector, DNA vaccines, 03 medical and health sciences, GBV, gene-based vaccine, RBD, receptor binding domain, ORF, open reading frame, RNA vaccines, M, membrane, BGH, bovine growth hormone, Animals, Humans, IFN, interferon, Lunar, lipid-enabled and unlocked nucleomonomer agent modified RNA, TLR, toll-like receptor, Gene, Th, T helper, Pandemics, 030304 developmental biology, business.industry, SARS-CoV-2, COVID-19, Viral Vaccines, CMV, cytomegalovirus, biology.organism_classification, DPP4, dipeptidyl peptidase 4, Virology, MV, measles virus, tPA, tissue plasminogen activator, IL, interleukin, a.a, amino acid, RSV, respiratory syncytial virus, business, GP, glycoprotein, Betacoronavirus, GC, guanine-cytosine, HA, hemagglutinin, N, nucleocapsid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94880f08a67e236cd51c7dda2e6ac22e
http://europepmc.org/articles/PMC7789827

المؤلفون: Wen-Hsiang Chen, Jeroen Pollet, Ulrich Strych

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: Vaccine delivery, SARS, Severe acute respiratory syndrome, TMPRSS2, Transmembrane protease serine 2, Alum, Aluminum hydroxide, APC, Antigen-presenting cell, Pharmaceutical Science, 02 engineering and technology, medicine.disease_cause, law.invention, Th1, aa, Amino acid, Clinical trials, law, Pandemic, CoV, Coronavirus, Coronavirus, 0303 health sciences, Public information, Clinical Trials as Topic, Vaccines, Synthetic, OWS, Operation Warp Speed, Vaccine production, RBM, Receptor binding motif, 021001 nanoscience & nanotechnology, Recombinant Proteins, HHS, US Department of Health and Human Services, Recombinant DNA, RSV, Respiratory syncytial virus, Health Resources, PTM, Post-translational modification, 0210 nano-technology, ADE, Antibody-dependent enhancement, Coronavirus Infections, 2019-20 coronavirus outbreak, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), RBD, Receptor binding domain, cGMP, Current good manufacturing practices, Neutralizing antibodies, Article, WHO, World Health Organization, Viral vector, 03 medical and health sciences, Drug Development, medicine, Animals, Humans, Adjuvants, NTD, N-terminal domain, Pandemics, 030304 developmental biology, SARS-CoV-2, MERS, Middle East respiratory syndrome, other, COVID-19, Viral Vaccines, S-protein, Spike protein (S1/S2), COVID, Coronavirus disease 2019, Virology, FDA, US Federal Drug Administration, Business, ACE-2, Angiotensin-converting enzyme 2, MNA, Micro-needle array

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc05cf6e45db923a4422845905a5a74f
http://europepmc.org/articles/PMC7788321

المؤلفون: Shaghayegh Haghjooy Javanmard, Abbas Alibakhshi, Elmira Mohammadi, Sahar Esfandyari, Leila Beikmohammadi, Samira Bahrami, Mohammad Mehdi Ranjbar, Shahrzad Ahangarzadeh, Fatemeh Mahmoudian, Kiana Shahzamani

المصدر: International Immunopharmacology

مصطلحات موضوعية: Vaccine delivery, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus-2, APC, Antigen-Presenting Cell, S.C., Subcutaneous, MERS, Middle East Respiratory Syndrome, RSV, Respiratory Syncytial Virus, Disease, SAGE, Strategic Advisory Group of Experts on Immunization, Health Services Accessibility, Delivery methods, Immunology and Allergy, Drug Approval, Vaccine design, CDC, Centers for Disease Control and Prevention, PAMP, Pathogen-Associated Molecular Pattern, LNP, Lipid Nanoparticles, Vaccination, LMH, Live Modified Horsepox, Chimpanzee Adenoviral Vector 1, ChAdOx1, Ad, Adenovirus, GMV, Genetically Modified Viruses, TLR, Toll-Like Receptor, EUA, Emergency Use Authorization, ACE2, Angiotensin Converting Enzyme 2, Coalition for Epidemic Preparedness Innovations, medicine.medical_specialty, 2019-20 coronavirus outbreak, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), I.M., Intramuscular, Emerging technologies, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), VRP, Virion Replicon Particle, Immunology, ASHP, American Society of Health-System Pharmacists, Article, SDG 3 - Good Health and Well-being, medicine, Humans, Intensive care medicine, LAV, Live-Attenuated Virus, Disease burden, Pharmacology, VLP, Virus-Like Particle, SARS-CoV-2, COVID-19, Coronavirus Disease-19, business.industry, COVID-19, RBD, Receptor Binding Domain, PRR, Pattern Recognition Receptors, MVA, Modified Vaccinia Ankara, VEE, Venezuelan Equine Encephalitis, Nanoparticles, business, Vaccine, WCA, Whole-Cell Antigen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c9be9438e08539da23317f11ef7827
http://www.scopus.com/inward/record.url?scp=85113388882&partnerID=8YFLogxK

المؤلفون: Stanford T. Shulman, Anne H. Rowley

المصدر: The Journal of Pediatrics

مصطلحات موضوعية: medicine.medical_specialty, etiology, MEDLINE, Mucocutaneous Lymph Node Syndrome, hemic and lymphatic diseases, Pandemic, medicine, Humans, coronavirus disease-2019 pandemic, cardiovascular diseases, PID, Pediatric infectious disease, Intensive care medicine, skin and connective tissue diseases, Pandemics, COVID-19, Coronavirus disease 2019, Kawasaki disease, business.industry, SARS-CoV-2, COVID-19, medicine.disease, GAS, Group A streptococcal, pediatric infectious disease, MIS-C, Multisystem inflammatory syndrome in children, Pediatrics, Perinatology and Child Health, RSV, Respiratory syncytial virus, Original Article, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33b1325cb83117e3aa1a7f3b7453516
https://pubmed.ncbi.nlm.nih.gov/34324881