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المؤلفون: Carl-Magnus Svensson, Berit Jungnickel, Steffen Ullrich, Gianna Hirth, Katrin Böttcher, Marc Thilo Figge
المصدر: The Journal of Immunology. 203:1493-1501
مصطلحات موضوعية: Male, Immunology, Somatic hypermutation, Lymphocyte Activation, Affinity maturation, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytidine Deaminase, Animals, Immunology and Allergy, Homologous Recombination, Gene, BRCA2 Protein, B-Lymphocytes, Genes, Immunoglobulin, Germinal center, DNA, Cytidine deaminase, Germinal Center, Cell biology, Mice, Inbred C57BL, Immunoglobulin class switching, chemistry, Mutation, Female, Somatic Hypermutation, Immunoglobulin, Homologous recombination, DNA Damage, 030215 immunology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20626ab5159ca4fcc8444175b61c1aa0
https://doi.org/10.4049/jimmunol.1900483 -
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المؤلفون: Aswin Mangerich, Ines Pfeil, Heinrich Leonhardt, Julia Jeschke, Angelika Schmidt, Oliver Mortusewicz, Arthur Fischbach, Berit Jungnickel, Amanda Bello, Thomas Helleday, Sandra Tepper, Svend K Petersen-Mahrt, Ewelina Członka
المصدر: Nucleic Acids Res. 47, 7418-7429 (2019)
Nucleic Acids Researchمصطلحات موضوعية: DNA Repair, DNA damage, DNA repair, Immunoglobulin Variable Region, Poly (ADP-Ribose) Polymerase-1, Somatic hypermutation, Biology, Genome Integrity, Repair and Replication, medicine.disease_cause, Affinity maturation, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cell Line, Tumor, Cytidine Deaminase, ddc:570, Genetics, medicine, Animals, Humans, Gene, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Mutation, B-Lymphocytes, Genes, Immunoglobulin, Mutagenesis, Cell biology, chemistry, 030220 oncology & carcinogenesis, Somatic Hypermutation, Immunoglobulin, DNA, DNA Damage
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82439d45c11a3c91b88f4647b99cc0f
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المؤلفون: Gersende Caron, Fabrice Chatonnet, Emilie Lereclus, Jean-Claude Aldigier, Sandrine Le Noir, Thierry Fest, Sophie Péron, Robin Jeannet, Zeinab Dalloul, Iman Dalloul, Amandine Pignarre, Jeanne Cook-Moreau, Anne Durandy, Michel Cogné, Céline Delaloy, François Boyer, Hend Boutouil
المساهمون: Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Etablissement français du sang [Rennes] (EFS Bretagne), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by grants to MC from Association pour la Recherche sur le Cancer (PGA120150202338), Agence Nationale de la Recherche (ANR grant 16-CE15-0019-01), Institut National du Cancer (INCa grant #9363), Ligue Nationale contre le Cancer and Région Aquitaine-Limousin-Poitou-Charente., ANR-16-CE15-0019,Ig-MemImpact,Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique(2016), Bodescot, Myriam, Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique - - Ig-MemImpact2016 - ANR-16-CE15-0019 - AAPG2016 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 15 (6), pp.e1007721. ⟨10.1371/journal.pgen.1007721⟩
PLoS Genetics, Vol 15, Iss 6, p e1007721 (2019)
PLoS ONE, 2019, 15 (6), pp.e1007721. ⟨10.1371/journal.pgen.1007721⟩
PLoS Geneticsمصطلحات موضوعية: Cancer Research, B Cells, Cellular differentiation, Palatine Tonsil, Artificial Gene Amplification and Extension, Regulatory Sequences, Nucleic Acid, QH426-470, Polymerase Chain Reaction, White Blood Cells, Mice, 0302 clinical medicine, Animal Cells, Medicine and Health Sciences, Genetics (clinical), ComputingMilieux_MISCELLANEOUS, 0303 health sciences, B-Lymphocytes, Gene targeting, Cell Differentiation, Tonsils, Cell biology, Regulatory sequence, Gene Targeting, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cellular Types, Anatomy, Research Article, [SDV.IMM] Life Sciences [q-bio]/Immunology, Lymphoid Tissue, Immune Cells, Immunology, Plasma Cells, Immunoglobulins, Receptors, Antigen, B-Cell, Locus (genetics), Biology, Research and Analysis Methods, Affinity maturation, Throat, 03 medical and health sciences, Cytidine Deaminase, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Genetics, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Allele, Antibody-Producing Cells, Molecular Biology Techniques, Gene, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Alleles, 030304 developmental biology, Blood Cells, Biology and Life Sciences, Cell Biology, Memory B cells, Immunoglobulin Switch Region, Immunoglobulin class switching, Genetic Loci, Artificial Genetic Recombination, 030217 neurology & neurosurgery, Neck, Developmental Biology
وصف الملف: application/pdf
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المؤلفون: William J Boyle, Peter Bowers, Robert Damoiseaux
المصدر: Antibody Engineering ISBN: 9781493986477
مصطلحات موضوعية: 0301 basic medicine, Base Sequence, biology, Antibody Affinity, Somatic hypermutation, Cytidine deaminase, Flow Cytometry, Acquired immune system, Antibodies, Article, In vitro, Cell biology, Affinity maturation, 03 medical and health sciences, HEK293 Cells, 030104 developmental biology, Immune system, Cytidine Deaminase, biology.protein, Humans, Somatic Hypermutation, Immunoglobulin, Antigens, Antibody, Gene, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a22e329b72349e1735039e68dd52b31
https://doi.org/10.1007/978-1-4939-8648-4_24 -
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المؤلفون: Øystein Sæle, Ivar Hordvik, Kai K. Lie, Sumaira Bilal
المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
9:1101
MAYمصطلحات موضوعية: 0301 basic medicine, lcsh:Immunologic diseases. Allergy, DNA, Complementary, ballan wrasse, activation-induced cytidine deaminase motif, Immunology, Somatic hypermutation, Locus (genetics), Biology, Polymorphism, Single Nucleotide, polymorphism, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Complementary DNA, Immunology and Allergy, Animals, Amino Acid Sequence, Gene, Original Research, Genome, teleost, T-cell receptor, Fishes, Chromosome Mapping, Computational Biology, High-Throughput Nucleotide Sequencing, Cytidine deaminase, Genomics, Molecular biology, TCRα, somatic hypermutation, 030104 developmental biology, Mutation, Somatic Hypermutation, Immunoglobulin, T cell receptor, lcsh:RC581-607, Alpha chain, Genes, T-Cell Receptor alpha, 030215 immunology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0f5aea5491f07fc4770babc0ec833f
http://hdl.handle.net/11250/2560994 -
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المؤلفون: Alexis Marianes, Anastasia M. Zimmerman
المصدر: Immunology. 132:240-255
مصطلحات موضوعية: Genetics, Mutation, biology, Somatic cell, Immunology, Somatic hypermutation, Cytidine deaminase, biology.organism_classification, medicine.disease_cause, Affinity maturation, Germline mutation, medicine, Immunology and Allergy, Gene, Zebrafish
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المؤلفون: Laura Nicolas, Jayanta Chaudhuri, Montserrat Cols, Jee Eun Choi, Bao Q. Vuong
المصدر: F1000Research
مصطلحات موضوعية: 0301 basic medicine, General Immunology and Microbiology, DNA damage, DNA repair, Somatic hypermutation, Review, Articles, General Medicine, Cytidine deaminase, Biology, General Biochemistry, Genetics and Molecular Biology, Immunoglobulin Class Switch Recombination, Cell biology, Affinity maturation, 03 medical and health sciences, 030104 developmental biology, Immunoglobulin class switching, AID, General Pharmacology, Toxicology and Pharmaceutics, Immune Response, immunoglobulin, CSR, Gene
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المؤلفون: Nai Ying Zheng, Kenneth Wilson, Patrick C. Wilson, Matthew Jared
المصدر: The Journal of Experimental Medicine
مصطلحات موضوعية: DNA Repair, DNA polymerase, DNA repair, Molecular Sequence Data, Immunology, Immunoglobulin Variable Region, Somatic hypermutation, DNA-Directed DNA Polymerase, Article, Cytosine Deaminase, Evolution, Molecular, Affinity maturation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cytidine Deaminase, Humans, Immunology and Allergy, Nucleotide, Codon, Gene, 030304 developmental biology, Genetics, chemistry.chemical_classification, B-Lymphocytes, 0303 health sciences, Base Sequence, biology, Cytidine, Sequence Analysis, DNA, Cytidine deaminase, Flow Cytometry, chemistry, Mutation, biology.protein, Somatic Hypermutation, Immunoglobulin, 030215 immunology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94ecc6aeb3c838730a9e45faff5ef07
https://doi.org/10.1084/jem.20042483 -
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المصدر: Current Biology. 12:435-438
مصطلحات موضوعية: Immunoglobulin gene, Molecular Sequence Data, Gene Conversion, Immunoglobulin Variable Region, Somatic hypermutation, Biology, General Biochemistry, Genetics and Molecular Biology, Cell Line, Affinity maturation, Mice, Cytidine Deaminase, medicine, Animals, Humans, Amino Acid Sequence, Gene conversion, Gene, B cell, B-Lymphocytes, Sequence Homology, Amino Acid, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Gene targeting, Gene rearrangement, Molecular biology, medicine.anatomical_structure, Gene Targeting, Rabbits, General Agricultural and Biological Sciences, Chickens
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المؤلفون: David G. Schatz, Jessica J. McDonald, Jean-Marie Buerstedde, Jukka Alinikula, Hiroshi Arakawa
المصدر: PLoS Biology
PLoS Biology, Vol 12, Iss 4, p e1001831 (2014)مصطلحات موضوعية: B Cells, Transcription, Genetic, Lymphocyte Activation, Biochemistry, E-Box Elements, White Blood Cells, Gene Knockout Techniques, Mice, 0302 clinical medicine, Animal Cells, Nucleic Acids, Molecular Cell Biology, Biology (General), Immune Response, 0303 health sciences, B-Lymphocytes, Immune System Proteins, MEF2 Transcription Factors, General Neuroscience, NF-kappa B, Cytidine deaminase, 3. Good health, Enhancer Elements, Genetic, Cellular Types, General Agricultural and Biological Sciences, DNA modification, Research Article, QH301-705.5, Immune Cells, DNA transcription, Immunology, Green Fluorescent Proteins, Somatic hypermutation, Biology, General Biochemistry, Genetics and Molecular Biology, Antibodies, Cell Line, Affinity maturation, 03 medical and health sciences, Immunoglobulin kappa-Chains, Immunoglobulin lambda-Chains, Cytidine Deaminase, Genetics, Animals, Humans, Enhancer, Uracil-DNA Glycosidase, Gene, Transcription factor, 030304 developmental biology, Blood Cells, Binding Sites, General Immunology and Microbiology, Biology and life sciences, Point mutation, Proteins, DNA, Cell Biology, Molecular biology, Mutation, Gene expression, Somatic Hypermutation, Immunoglobulin, Chickens, Sequence Alignment, 030215 immunology
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