المؤلفون: Chaojun Zheng, Dongqing Zhu, Jun Li, Jianyuan Jiang, Kai Qiao, Qifeng Yu, Robert Weber, Feizhou Lyu, Yu Zhu

المصدر: Neurophysiologie Clinique. 51:375-386

مصطلحات موضوعية: Motor Disorders, Deltoid curve, Disease, Spinal Muscular Atrophies of Childhood, Biceps, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Dash, Quantitative assessment, Humans, Medicine, 0501 psychology and cognitive sciences, Muscle, Skeletal, Motor Neurons, Electromyography, business.industry, 05 social sciences, Motor unit number, Motor impairment, General Medicine, Motor unit, Treatment Outcome, Neurology, Anesthesia, Neurology (clinical), business, 030217 neurology & neurosurgery

الوصف: To assess the feasibility of motor unit number index (MUNIX) in quantitatively evaluating Hirayama disease (HD) with proximal involvement and to identify the effectiveness of anterior cervical fusion (ACF) in treating atypical HD with proximal involvement.This study included 28 atypical HD patients with proximal involvement (proximal-distal vs. distal-proximal groups: 5 vs. 23) and 41 healthy controls. All patients underwent pre- and postoperative 1-year MUNIX tests on abductor pollicis brevis (APB), abductor digiti minimi (ADM), biceps brachii (BB) and deltoid (Del). The disabilities of arm, shoulder and hand (DASH) and Medical Research Council (MRC) scales were also performed in these patients before and one year after operation.Preoperatively, the patients in the distal-proximal group showed reduced compound muscle action potential (CMAP), decreased MUNIX and increased motor unit size index (MUSIX) in bilateral distal muscles and symptomatic-side proximal muscles (P 0.05), and similar abnormalities were also observed in ADM, BB and Del on the symptomatic side in the proximal-distal groups (P 0.05). Postoperative follow-up analysis identified increased MUNIX in the symptomatic-side proximal muscles with improved motor function in the proximal-distal groups (P 0.05), and distal-proximal group patients showed an increase in both CMAP and MUSIX in the symptomatic-side proximal muscles (P 0.05).MUNIX may serve as an available supplementary test to quantitatively evaluate the motor dysfunction and treatment outcome in HD with proximal involvement. ACF procedures can effectively treat these atypical HD patients, especially for those whose symptoms started in proximal muscles.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26102a71ef352e5c3fa023aef880bd74
https://doi.org/10.1016/j.neucli.2021.02.002

المؤلفون: Hongli Wang, Feizhou Lu, Robert Weber, Yu Zhu, Cong Nie, Chaojun Zheng, Dongqing Zhu, Jianyuan Jiang, Wei Lei

المصدر: Clinical Neurophysiology. 129:2341-2349

مصطلحات موضوعية: Recruitment, Neurophysiological, medicine.medical_specialty, Adolescent, Disease, Spinal Muscular Atrophies of Childhood, Young Adult, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Physiology (medical), Dash, Humans, Medicine, In patient, Motor unit number estimation, 030212 general & internal medicine, Cervical fusion, Natural course, Hand Strength, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Sensory Systems, Spinal Fusion, Neurology, Cervical Vertebrae, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery, Muscle Contraction, Cohort study

الوصف: To clarify the effectiveness of anterior cervical fusion (ACF) in the treatment of Hirayama disease (HD).Sixty-nine HD patients who accepted ACF procedures underwent dynamic F-waves before and soon after operation, and 36 of the 69 patients underwent pre- and postoperative magnetic resonance imaging (MRI). Motor unit number estimation, handgrip strength (HGS) and disabilities of arm, shoulder and hand (DASH) were performed in these 36 HD patients and in the other 24 patients who accepted neither neck-collar support nor operation, and these tests were reassessed about one year after initial test.Postoperatively, dynamic F-wave abnormalities were observed in fewer HD cases (2/69 vs. 25/69), and neck-flexion MRI abnormalities decreased significantly (P 0.05). Compared with motor unit loss in patients who were untreated, follow-up analysis demonstrated no differences in motor unit, HGS or DASH in HD patients who underwent operation (P 0.05), and mild recovery of motor units was observed in patients with preoperative abnormal dynamic F-waves (P 0.05).ACF procedures can immediately remove neck-flexion abnormalities and prevent or delay the progression of HD.ACF procedures may provide effective, reliable and alternative methods for the treatment of HD, especially in HD patients with functional evidence of neck-flexion abnormalities.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6cddb3946b7b1c59ca6ec7ae2a9973
https://doi.org/10.1016/j.clinph.2018.08.024

المؤلفون: Jianyuan Jiang, Xin Li, Kai Qiao, Chaojun Zheng, Feizhou Lyu, Robert Weber, Yu Zhu, Dongqing Zhu, Jian Song

المصدر: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 130(9)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Deltoid curve, Action Potentials, Electromyography, Biceps, Severity of Illness Index, 050105 experimental psychology, Statistics, Nonparametric, Muscular Atrophy, Spinal, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Physiology (medical), Dash, medicine, Quantitative assessment, Humans, 0501 psychology and cognitive sciences, Muscle Strength, Subclinical infection, Motor Neurons, Analysis of Variance, Muscle Weakness, medicine.diagnostic_test, Hand Strength, business.industry, 05 social sciences, Motor unit number, Reproducibility of Results, Middle Aged, Amyotrophy, medicine.disease, Magnetic Resonance Imaging, Sensory Systems, body regions, Muscular Atrophy, Spinal Fusion, Treatment Outcome, Neurology, Case-Control Studies, Feasibility Studies, Neurology (clinical), Spondylosis, business, 030217 neurology & neurosurgery

الوصف: To assess the feasibility of motor unit number index (MUNIX) in the quantitative assessment of the cervical spondylotic amyotrophy (CSA).MUNIX was recorded bilaterally on the abductor pollicis brevis, abductor digiti minimi, biceps brachii and middle deltoid in 41 normal controls and 47 patients with CSA (distal-type to proximal-type ratio: 25 to 22). Additionally, patients were assessed on handgrip strength (HGS), the disabilities of arm, shoulder and hand (DASH) and Medical Research Council (MRC) scales. These examinations were re-evaluated approximately 18 months after surgery in 37 of these CSA patients.MUNIX values were noticeably lower in the mainly affected muscles of CSA patients than those in controls (P 0.05), and 49.0% (51/104) of the tested muscles with abnormal MUNIX measurements showed normal muscle strength. Significant correlations between MUNIX measurements and both DASH and MRC scores were observed in both CSA patient groups (P 0.05). Postoperative longitudinal follow-up analysis identified significant increase in motor unit number in both CSA patient groups within approximately 18 months (P 0.05), with or without improved measures of motor function.A significant reduction in MUNIX values related to motor impairment was observed in CSA patients, even in the subclinical stage. Compared to measures of motor function, the MUNIX measurements in the patients with CSA improved more noticeably after surgical intervention.MUNIX may serve as an available supplementary test to quantitatively evaluate the motor dysfunction in CSA and to track its progression, that is complementary to conventional electromyography.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b066799c07488146b1872c36729edb7
https://pubmed.ncbi.nlm.nih.gov/31288157